Details for: TRPV2

Gene ID: 51393

Symbol: TRPV2

Ensembl ID: ENSG00000187688

Description: transient receptor potential cation channel subfamily V member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.0036
    Cell Significance Index: -8.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.4334
    Cell Significance Index: -9.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 21.3080
    Cell Significance Index: -10.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.7821
    Cell Significance Index: -10.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.3435
    Cell Significance Index: -5.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9183
    Cell Significance Index: -8.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.1971
    Cell Significance Index: -8.6700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.1016
    Cell Significance Index: -5.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.0984
    Cell Significance Index: 128.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.8807
    Cell Significance Index: 50.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4941
    Cell Significance Index: -3.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4362
    Cell Significance Index: 42.1800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.3548
    Cell Significance Index: 11.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1581
    Cell Significance Index: 25.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7562
    Cell Significance Index: 34.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5950
    Cell Significance Index: 38.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5864
    Cell Significance Index: 111.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3888
    Cell Significance Index: 38.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3387
    Cell Significance Index: 305.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2018
    Cell Significance Index: 32.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1645
    Cell Significance Index: 4.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1538
    Cell Significance Index: 19.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1515
    Cell Significance Index: 2.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1475
    Cell Significance Index: 16.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1287
    Cell Significance Index: 15.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1170
    Cell Significance Index: 80.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1085
    Cell Significance Index: 21.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0719
    Cell Significance Index: 25.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0656
    Cell Significance Index: 7.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0635
    Cell Significance Index: 3.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0581
    Cell Significance Index: 4.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0514
    Cell Significance Index: 1.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0187
    Cell Significance Index: 1.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0153
    Cell Significance Index: 0.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0083
    Cell Significance Index: 0.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0044
    Cell Significance Index: -0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0059
    Cell Significance Index: -9.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0109
    Cell Significance Index: -8.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0133
    Cell Significance Index: -7.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0140
    Cell Significance Index: -6.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0143
    Cell Significance Index: -10.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0170
    Cell Significance Index: -3.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0172
    Cell Significance Index: -9.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0177
    Cell Significance Index: -11.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0216
    Cell Significance Index: -9.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0216
    Cell Significance Index: -3.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0217
    Cell Significance Index: -0.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0247
    Cell Significance Index: -7.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0307
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0339
    Cell Significance Index: -3.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0380
    Cell Significance Index: -5.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0450
    Cell Significance Index: -1.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0461
    Cell Significance Index: -8.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0491
    Cell Significance Index: -10.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0530
    Cell Significance Index: -0.3200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0628
    Cell Significance Index: -0.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0656
    Cell Significance Index: -9.5400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0693
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0736
    Cell Significance Index: -9.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0791
    Cell Significance Index: -2.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0796
    Cell Significance Index: -10.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0819
    Cell Significance Index: -8.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0829
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0866
    Cell Significance Index: -9.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0931
    Cell Significance Index: -7.1500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0977
    Cell Significance Index: -1.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1130
    Cell Significance Index: -5.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1152
    Cell Significance Index: -4.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1237
    Cell Significance Index: -7.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1277
    Cell Significance Index: -3.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1322
    Cell Significance Index: -6.8900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1328
    Cell Significance Index: -1.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1352
    Cell Significance Index: -8.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1363
    Cell Significance Index: -3.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1373
    Cell Significance Index: -10.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1394
    Cell Significance Index: -9.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1396
    Cell Significance Index: -7.3300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1432
    Cell Significance Index: -4.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1507
    Cell Significance Index: -7.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1552
    Cell Significance Index: -3.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1593
    Cell Significance Index: -8.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1641
    Cell Significance Index: -5.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1658
    Cell Significance Index: -7.7300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1689
    Cell Significance Index: -5.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1812
    Cell Significance Index: -2.2600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1920
    Cell Significance Index: -1.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1944
    Cell Significance Index: -2.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2089
    Cell Significance Index: -9.2400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.2128
    Cell Significance Index: -0.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2169
    Cell Significance Index: -5.4100
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2259
    Cell Significance Index: -1.9900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2276
    Cell Significance Index: -4.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2318
    Cell Significance Index: -8.5100
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2402
    Cell Significance Index: -1.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TRPV2 structure:** TRPV2 is a non-selective cation channel with a molecular weight of approximately 50 kDa. It contains six transmembrane domains and a pore-forming region that allows the passage of monovalent cations. 2. **Expression:** TRPV2 is highly expressed in immune cells, including polychromatophilic erythroblast, mucosal type mast cell, and hematopoietic oligopotent progenitor cell. 3. **Function:** TRPV2 regulates calcium ion transport across the plasma membrane, which is essential for various cellular processes, including cell signaling, differentiation, and survival. 4. **Regulation:** TRPV2 is activated by cold temperatures, heat, and mechanical stimuli, which triggers a signaling cascade that regulates calcium ion import and transport. **Pathways and Functions:** 1. **Calcium ion transport:** TRPV2 regulates calcium ion transport across the plasma membrane, which is essential for various cellular processes, including cell signaling, differentiation, and survival. 2. **Axonal growth cone formation:** TRPV2 plays a crucial role in axonal growth cone formation, which is essential for neuronal development and regeneration. 3. **Sensory perception:** TRPV2 is involved in sensory perception, particularly in the detection of temperature, pain, and inflammation. 4. **Immune response:** TRPV2 is expressed in various immune cells, including polychromatophilic erythroblast, mucosal type mast cell, and hematopoietic oligopotent progenitor cell, and regulates immune response, including the regulation of calcium ion transport and cell signaling. **Clinical Significance:** 1. **Pain management:** TRPV2 has been implicated in pain management, particularly in the detection of temperature, pain, and inflammation. 2. **Inflammatory diseases:** TRPV2 has been implicated in inflammatory diseases, including arthritis, asthma, and allergies, due to its involvement in immune response and calcium regulation. 3. **Neurological disorders:** TRPV2 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, due to its involvement in axonal growth cone formation and calcium regulation. 4. **Cancer:** TRPV2 has been implicated in cancer, particularly in the regulation of cell growth, differentiation, and survival, due to its involvement in calcium regulation and cell signaling. In conclusion, TRPV2 plays a crucial role in regulating calcium ion transport across the plasma membrane, which is essential for various cellular processes, including cell signaling, differentiation, and survival. Its involvement in immune response, sensory perception, and neurological disorders makes it an attractive target for further research.

Genular Protein ID: 3405928628

Symbol: TRPV2_HUMAN

Name: Transient receptor potential cation channel subfamily V member 2

UniProtKB Accession Codes:

Q9Y5S1 A6NML2 A8K0Z0 Q9Y670

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10201375

Title: A capsaicin-receptor homologue with a high threshold for noxious heat.

PubMed ID: 10201375

DOI: 10.1038/18906

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16882997

Title: Crystal structure of the human TRPV2 channel ankyrin repeat domain.

PubMed ID: 16882997

DOI: 10.1110/ps.062357206

Sequence Information:

  • Length: 764
  • Mass: 85981
  • Checksum: A73E3696E70F91E9
  • Sequence:
    • MTSPSSSPVF RLETLDGGQE DGSEADRGKL DFGSGLPPME SQFQGEDRKF APQIRVNLNY 
RKGTGASQPD PNRFDRDRLF NAVSRGVPED LAGLPEYLSK TSKYLTDSEY TEGSTGKTCL 
MKAVLNLKDG VNACILPLLQ IDRDSGNPQP LVNAQCTDDY YRGHSALHIA IEKRSLQCVK 
LLVENGANVH ARACGRFFQK GQGTCFYFGE LPLSLAACTK QWDVVSYLLE NPHQPASLQA 
TDSQGNTVLH ALVMISDNSA ENIALVTSMY DGLLQAGARL CPTVQLEDIR NLQDLTPLKL 
AAKEGKIEIF RHILQREFSG LSHLSRKFTE WCYGPVRVSL YDLASVDSCE ENSVLEIIAF 
HCKSPHRHRM VVLEPLNKLL QAKWDLLIPK FFLNFLCNLI YMFIFTAVAY HQPTLKKQAA 
PHLKAEVGNS MLLTGHILIL LGGIYLLVGQ LWYFWRRHVF IWISFIDSYF EILFLFQALL 
TVVSQVLCFL AIEWYLPLLV SALVLGWLNL LYYTRGFQHT GIYSVMIQKV ILRDLLRFLL 
IYLVFLFGFA VALVSLSQEA WRPEAPTGPN ATESVQPMEG QEDEGNGAQY RGILEASLEL 
FKFTIGMGEL AFQEQLHFRG MVLLLLLAYV LLTYILLLNM LIALMSETVN SVATDSWSIW 
KLQKAISVLE MENGYWWCRK KQRAGVMLTV GTKPDGSPDE RWCFRVEEVN WASWEQTLPT 
LCEDPSGAGV PRTLENPVLA SPPKEDEDGA SEENYVPVQL LQSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.