Details for: PDE4A

Gene ID: 5141

Symbol: PDE4A

Ensembl ID: ENSG00000065989

Description: phosphodiesterase 4A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.0195
    Cell Significance Index: -20.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.2952
    Cell Significance Index: -20.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.4608
    Cell Significance Index: -17.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 39.0563
    Cell Significance Index: -20.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.4290
    Cell Significance Index: -17.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.6835
    Cell Significance Index: -20.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4617
    Cell Significance Index: -17.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3167
    Cell Significance Index: -16.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2128
    Cell Significance Index: -20.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5736
    Cell Significance Index: 315.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2611
    Cell Significance Index: -2.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1561
    Cell Significance Index: 220.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8606
    Cell Significance Index: 32.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8434
    Cell Significance Index: 302.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8351
    Cell Significance Index: 36.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7927
    Cell Significance Index: 41.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5955
    Cell Significance Index: 537.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5845
    Cell Significance Index: 404.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5296
    Cell Significance Index: 11.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4386
    Cell Significance Index: 5.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3924
    Cell Significance Index: 63.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3663
    Cell Significance Index: 39.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3424
    Cell Significance Index: 39.9000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.2466
    Cell Significance Index: 3.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2432
    Cell Significance Index: 14.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2260
    Cell Significance Index: 17.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1887
    Cell Significance Index: 18.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1546
    Cell Significance Index: 7.2100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1391
    Cell Significance Index: 9.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1289
    Cell Significance Index: 16.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0967
    Cell Significance Index: 17.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0404
    Cell Significance Index: 6.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0232
    Cell Significance Index: 1.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0218
    Cell Significance Index: 2.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0204
    Cell Significance Index: 2.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0106
    Cell Significance Index: 19.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0058
    Cell Significance Index: 0.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0033
    Cell Significance Index: -0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0076
    Cell Significance Index: -11.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0080
    Cell Significance Index: -0.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0090
    Cell Significance Index: -0.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0107
    Cell Significance Index: -19.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0124
    Cell Significance Index: -7.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0155
    Cell Significance Index: -3.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0177
    Cell Significance Index: -9.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0182
    Cell Significance Index: -13.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0231
    Cell Significance Index: -16.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0260
    Cell Significance Index: -0.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0282
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0305
    Cell Significance Index: -22.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0329
    Cell Significance Index: -14.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0393
    Cell Significance Index: -22.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0398
    Cell Significance Index: -5.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0461
    Cell Significance Index: -0.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0558
    Cell Significance Index: -1.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0561
    Cell Significance Index: -1.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0585
    Cell Significance Index: -16.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0654
    Cell Significance Index: -6.6800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1082
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1114
    Cell Significance Index: -12.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1115
    Cell Significance Index: -23.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1290
    Cell Significance Index: -2.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1292
    Cell Significance Index: -6.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1319
    Cell Significance Index: -2.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1440
    Cell Significance Index: -18.6100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1443
    Cell Significance Index: -3.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1586
    Cell Significance Index: -18.7000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1606
    Cell Significance Index: -3.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1610
    Cell Significance Index: -12.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1728
    Cell Significance Index: -2.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1957
    Cell Significance Index: -4.0600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1967
    Cell Significance Index: -2.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1972
    Cell Significance Index: -20.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1993
    Cell Significance Index: -12.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2022
    Cell Significance Index: -6.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2035
    Cell Significance Index: -6.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2188
    Cell Significance Index: -4.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2213
    Cell Significance Index: -15.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2240
    Cell Significance Index: -4.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2285
    Cell Significance Index: -10.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2348
    Cell Significance Index: -12.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2384
    Cell Significance Index: -18.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2447
    Cell Significance Index: -8.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2519
    Cell Significance Index: -7.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2649
    Cell Significance Index: -2.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2705
    Cell Significance Index: -5.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2955
    Cell Significance Index: -7.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3027
    Cell Significance Index: -19.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3109
    Cell Significance Index: -9.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3355
    Cell Significance Index: -22.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3420
    Cell Significance Index: -11.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3489
    Cell Significance Index: -19.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3540
    Cell Significance Index: -9.6400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3597
    Cell Significance Index: -15.6400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.3696
    Cell Significance Index: -6.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4078
    Cell Significance Index: -9.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4295
    Cell Significance Index: -11.0400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4303
    Cell Significance Index: -8.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic activity**: PDE4A is a phosphodiesterase enzyme that hydrolyzes cAMP and cGMP, thereby regulating the levels of these second messengers in the cell. 2. **Tissue specificity**: PDE4A is highly expressed in the cerebral cortex, particularly in glutamatergic and GABAergic neurons, suggesting a specialized role in regulating neuronal function in this region. 3. **Signaling pathway involvement**: PDE4A is implicated in various signaling pathways, including those mediated by GPCRs, opioid receptors, and adenylate cyclase-activating GPCRs, highlighting its broad functional significance. 4. **Darpp-32 events**: PDE4A is involved in the regulation of the dopamine-regulated phosphoprotein, dopamine and cAMP-regulated phosphoprotein 32 (Darpp-32), which plays a critical role in synaptic plasticity and learning. **Pathways and Functions:** 1. **G protein-coupled receptor signaling pathway**: PDE4A regulates the signaling events mediated by GPCRs, including those involved in sensory perception, such as the detection of smell. 2. **Opioid signaling pathway**: PDE4A is involved in the regulation of opioid receptor-mediated signaling, which is critical for pain modulation and reward processing. 3. **Adenylate cyclase-activating GPCR signaling pathway**: PDE4A regulates the signaling events mediated by adenylate cyclase-activating GPCRs, which play a critical role in various physiological processes, including cardiovascular function and inflammation. 4. **Protein kinase A signaling pathway**: PDE4A regulates the activity of protein kinase A (PKA), a key enzyme involved in various cellular processes, including gene transcription and protein phosphorylation. **Clinical Significance:** 1. **Neurological disorders**: Alterations in PDE4A expression or activity have been implicated in various neurological disorders, including schizophrenia, bipolar disorder, and Parkinson's disease. 2. **Pain modulation**: PDE4A inhibitors have been investigated as potential therapeutic agents for the treatment of chronic pain, as they can modulate opioid receptor-mediated signaling. 3. **Cognitive function**: PDE4A is involved in regulating cognitive processes, including learning and memory, and alterations in its expression or activity may contribute to cognitive dysfunction in various neurological disorders. 4. **Neuroprotection**: PDE4A inhibitors have been shown to exhibit neuroprotective effects in various models of neurodegeneration, suggesting potential therapeutic applications for the treatment of neurodegenerative diseases. In conclusion, the PDE4A gene plays a critical role in regulating cellular signaling pathways and function in the brain. Its involvement in various physiological processes, including pain modulation, cognitive function, and neuroprotection, highlights its importance in maintaining normal brain function and preventing neurological disorders. Further research is needed to fully elucidate the functional significance of PDE4A and to explore its therapeutic potential in various clinical applications.

Genular Protein ID: 1818344816

Symbol: PDE4A_HUMAN

Name: DPDE2

UniProtKB Accession Codes:

P27815 O75522 O76092 Q16255 Q16691 Q5DM53 Q6PMT2 Q8IVA7 Q8WUQ3 Q9H3H2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 47 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 19 DrugCentral 1 EC 7 EMBL 32 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 2 RefSeq 6 Rhea 14 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8413254

Title: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

PubMed ID: 8413254

DOI: 10.1128/mcb.13.10.6558-6571.1993

PubMed ID: 7888306

Title: Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1).

PubMed ID: 7888306

DOI: 10.1016/0898-6568(94)00039-5

PubMed ID: 7772058

Title: Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19.

PubMed ID: 7772058

DOI: 10.1042/bj3080683

PubMed ID: 9677330

Title: Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase 4A variant RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2.

PubMed ID: 9677330

DOI: 10.1042/bj3330693

PubMed ID: 11306681

Title: Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic AMP-specific phosphodiesterase PDE4A10.

PubMed ID: 11306681

DOI: 10.1124/mol.59.5.996

PubMed ID: 15738310

Title: Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.

PubMed ID: 15738310

DOI: 10.1124/mol.104.009423

PubMed ID: 18095939

Title: Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change.

PubMed ID: 18095939

DOI: 10.1042/bj20071251

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2160582

Title: Cloning and expression of cDNA for a human low-Km, rolipram-sensitive cyclic AMP phosphodiesterase.

PubMed ID: 2160582

DOI: 10.1128/mcb.10.6.2678-2686.1990

PubMed ID: 11566027

Title: Purification and characterization of the human pde4a catalytic domain (pde4a(330-723)) expressed in sf9 cells.

PubMed ID: 11566027

DOI: 10.1006/abbi.2001.2513

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20196770

Title: Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

PubMed ID: 20196770

DOI: 10.1042/bj20091672

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17727341

Title: Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.

PubMed ID: 17727341

DOI: 10.1042/bj20070970

Sequence Information:

  • Length: 886
  • Mass: 98143
  • Checksum: 92BB9B98BED711E7
  • Sequence:
    • MEPPTVPSER SLSLSLPGPR EGQATLKPPP QHLWRQPRTP IRIQQRGYSD SAERAERERQ 
PHRPIERADA MDTSDRPGLR TTRMSWPSSF HGTGTGSGGA GGGSSRRFEA ENGPTPSPGR 
SPLDSQASPG LVLHAGAATS QRRESFLYRS DSDYDMSPKT MSRNSSVTSE AHAEDLIVTP 
FAQVLASLRS VRSNFSLLTN VPVPSNKRSP LGGPTPVCKA TLSEETCQQL ARETLEELDW 
CLEQLETMQT YRSVSEMASH KFKRMLNREL THLSEMSRSG NQVSEYISTT FLDKQNEVEI 
PSPTMKEREK QQAPRPRPSQ PPPPPVPHLQ PMSQITGLKK LMHSNSLNNS NIPRFGVKTD 
QEELLAQELE NLNKWGLNIF CVSDYAGGRS LTCIMYMIFQ ERDLLKKFRI PVDTMVTYML 
TLEDHYHADV AYHNSLHAAD VLQSTHVLLA TPALDAVFTD LEILAALFAA AIHDVDHPGV 
SNQFLINTNS ELALMYNDES VLENHHLAVG FKLLQEDNCD IFQNLSKRQR QSLRKMVIDM 
VLATDMSKHM TLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLRNMVHCA DLSNPTKPLE 
LYRQWTDRIM AEFFQQGDRE RERGMEISPM CDKHTASVEK SQVGFIDYIV HPLWETWADL 
VHPDAQEILD TLEDNRDWYY SAIRQSPSPP PEEESRGPGH PPLPDKFQFE LTLEEEEEEE 
ISMAQIPCTA QEALTAQGLS GVEEALDATI AWEASPAQES LEVMAQEASL EAELEAVYLT 
QQAQSTGSAP VAPDEFSSRE EFVVAVSHSS PSALALQSPL LPAWRTLSVS EHAPGLPGLP 
STAAEVEAQR EHQAAKRACS ACAGTFGEDT SALPAPGGGG SGGDPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.