ANAPC7 | ENSG00000196510 | NCBI 51434

Details for: ANAPC7

Gene ID: 51434

Symbol: ANAPC7

Ensembl ID: ENSG00000196510

Description: anaphase promoting complex subunit 7

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Brain development
(GO:0007420)
Cell division
(GO:0051301)
Cytosol
(GO:0005829)
Enzyme-substrate adaptor activity
(GO:0140767)
Heterochromatin
(GO:0000792)
Microtubule cytoskeleton
(GO:0015630)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein phosphatase binding
(GO:0019903)
Protein ubiquitination
(GO:0016567)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)
Spindle
(GO:0005819)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 149.8600
Cell Significance Index: -23.3100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 89.2198
Cell Significance Index: -22.6300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 57.9443
Cell Significance Index: -23.8700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 57.4427
Cell Significance Index: -27.1200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 49.6321
Cell Significance Index: -25.5300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.1849
Cell Significance Index: -26.1200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.9068
Cell Significance Index: -23.8600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.8043
Cell Significance Index: -26.8500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.7069
Cell Significance Index: -20.6000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.4334
Cell Significance Index: -14.0800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5066
Cell Significance Index: 149.0400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.4531
Cell Significance Index: 40.6100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2707
Cell Significance Index: 252.1800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9918
Cell Significance Index: 198.9500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9466
Cell Significance Index: 12.9200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8293
Cell Significance Index: 134.8800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5669
Cell Significance Index: 43.5100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5580
Cell Significance Index: 503.8700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5117
Cell Significance Index: 353.9000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.4411
Cell Significance Index: 16.7100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4291
Cell Significance Index: 153.9200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4241
Cell Significance Index: 18.7600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4050
Cell Significance Index: 21.0400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4043
Cell Significance Index: 72.8800
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4021
Cell Significance Index: 8.6000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3882
Cell Significance Index: 47.7400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3726
Cell Significance Index: 20.9100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3341
Cell Significance Index: 21.5600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3227
Cell Significance Index: 142.6900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2937
Cell Significance Index: 40.3400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2887
Cell Significance Index: 157.6500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2546
Cell Significance Index: 11.8700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2469
Cell Significance Index: 46.9800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.2438
Cell Significance Index: 7.1800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2087
Cell Significance Index: 14.7600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1983
Cell Significance Index: 6.8900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1532
Cell Significance Index: 4.1700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1184
Cell Significance Index: 13.9600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1006
Cell Significance Index: 4.5600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0840
Cell Significance Index: 5.1600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0825
Cell Significance Index: 2.2100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0692
Cell Significance Index: 3.2500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0620
Cell Significance Index: 2.1800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0511
Cell Significance Index: 3.2200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0451
Cell Significance Index: 5.7800
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0377
Cell Significance Index: 0.8200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0304
Cell Significance Index: 0.8800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0144
Cell Significance Index: 27.1300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0024
Cell Significance Index: 0.0400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0022
Cell Significance Index: -0.0600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0028
Cell Significance Index: -5.0900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0063
Cell Significance Index: -0.8200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0079
Cell Significance Index: -0.5300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0080
Cell Significance Index: -3.6300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0082
Cell Significance Index: -12.6400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0110
Cell Significance Index: -6.9600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0110
Cell Significance Index: -14.9500
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0129
Cell Significance Index: -0.3400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0158
Cell Significance Index: -11.6200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0184
Cell Significance Index: -13.9300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0278
Cell Significance Index: -20.5600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0428
Cell Significance Index: -24.1500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0443
Cell Significance Index: -0.9600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0487
Cell Significance Index: -30.4300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0496
Cell Significance Index: -7.2100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0504
Cell Significance Index: -8.6000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0608
Cell Significance Index: -6.2100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0624
Cell Significance Index: -1.3300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0643
Cell Significance Index: -2.0600
Cell Name: germ cell (CL0000586)
Fold Change: -0.0728
Cell Significance Index: -0.5500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0800
Cell Significance Index: -23.0100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0916
Cell Significance Index: -6.8300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0974
Cell Significance Index: -11.3500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1195
Cell Significance Index: -2.0000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1233
Cell Significance Index: -3.1500
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1299
Cell Significance Index: -2.7000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1431
Cell Significance Index: -30.1500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1553
Cell Significance Index: -17.7900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1868
Cell Significance Index: -5.3300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1941
Cell Significance Index: -4.9900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2270
Cell Significance Index: -23.6400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2495
Cell Significance Index: -13.1000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2527
Cell Significance Index: -5.2900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2544
Cell Significance Index: -6.3600
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2802
Cell Significance Index: -2.5800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2860
Cell Significance Index: -22.6500
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2910
Cell Significance Index: -6.9800
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3011
Cell Significance Index: -4.4500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3049
Cell Significance Index: -8.1600
Cell Name: peg cell (CL4033014)
Fold Change: -0.3099
Cell Significance Index: -7.1600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3294
Cell Significance Index: -9.6800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3369
Cell Significance Index: -20.6600
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4275
Cell Significance Index: -10.4300
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.4406
Cell Significance Index: -6.1800
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4459
Cell Significance Index: -5.3200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4518
Cell Significance Index: -9.5900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4606
Cell Significance Index: -15.0800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4697
Cell Significance Index: -14.9600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4919
Cell Significance Index: -8.4300
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.5252
Cell Significance Index: -5.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Cell Cycle Regulation**: ANAPC7 is a subunit of the APC, which plays a central role in the regulation of the mitotic cell cycle. The APC complex is responsible for the ubiquitination and degradation of key mitotic proteins, ensuring the proper progression of the cell cycle. 2. **Antigen Processing and Presentation**: ANAPC7 is involved in the ubiquitination and proteasomal degradation of antigens, which is essential for the adaptive immune response. This process involves the recognition and processing of proteins by the APC complex, leading to the presentation of antigens to T-cells. 3. **Immune Cell Development and Function**: ANAPC7 is expressed in various immune cells, including hematopoietic oligopotent progenitor cells, embryonic stem cells, and peripheral blood mononuclear cells. Its expression is also observed in epithelial cells, suggesting a broader role in immune regulation. 4. **Cancer and Disease Association**: Alterations in ANAPC7 expression have been linked to various cancers, including colorectal and breast cancer. Additionally, ANAPC7 has been implicated in the development of immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. **Pathways and Functions:** 1. **Activation of the APC Complex**: ANAPC7 is involved in the activation of the APC complex, which is essential for the ubiquitination and degradation of mitotic proteins. 2. **Regulation of the Mitotic Cell Cycle**: ANAPC7 plays a critical role in the regulation of the mitotic cell cycle, ensuring the proper progression of the cell cycle and preventing aberrant cell division. 3. **Antigen Processing and Presentation**: ANAPC7 is involved in the ubiquitination and proteasomal degradation of antigens, which is essential for the adaptive immune response. 4. **Regulation of Immune Cell Development and Function**: ANAPC7 is expressed in various immune cells and plays a critical role in their development and function. **Clinical Significance:** 1. **Cancer Therapy**: ANAPC7 has been identified as a potential therapeutic target in cancer treatment. Inhibitors of the APC complex, including ANAPC7, have shown promise in preclinical studies, suggesting a potential role in cancer therapy. 2. **Immunological Disorders**: Alterations in ANAPC7 expression have been linked to various immunological disorders, including autoimmune diseases and immunodeficiency syndromes. Understanding the role of ANAPC7 in these disorders may lead to the development of novel therapeutic strategies. 3. **Vaccine Development**: ANAPC7 has been identified as a potential antigen processing and presentation pathway in vaccine development. Understanding the role of ANAPC7 in antigen processing and presentation may lead to the development of novel vaccines. In conclusion, ANAPC7 is a multifunctional protein that plays a critical role in the regulation of the mitotic cell cycle, antigen processing, and adaptive immune responses. Its involvement in various diseases, including cancer and immunological disorders, highlights the importance of further research into the mechanisms underlying ANAPC7 function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Q4KMX6_HUMAN
Q69YV3_HUMAN

Genular Protein ID: 3394018863

Symbol: Q4KMX6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4KMX6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 564
Mass: 63002
Checksum: 1153DC45FC59303D
Sequence:

NVIDHVRDMA AAGLHSNVRL LSSLLLTMSN NNPELFSPPQ KYQLLVYHAD SLFHDKEYRN 
AVSKYTMALQ QKKALSKTSK VRPSTGNSAS TPQSQCLPSE IEVKYKMAEC YTMLKQDKDA 
IAILDGIPSR QRTPKINMML ANLYKKAGQE RPSVTSYKEV LRQCPLALDA ILGLLSLSVK 
GAEVASMTMN VIQTVPNLDW LSVWIKAYAF VHTGDNSRAI STICSLEKKS LLRDNVDLLG 
SLADLYFRAG DNKNSVLKFE QAQMLDPYLI KGMDVYGYLL AREGRLEDVE NLGCRLFNIS 
DQHAEPWVVS GCHSFYSKRY SRALYLGAKA IQLNSNSVQA LLLKGAALRN MGRVQEAIIH 
FREAIRLAPC RLDCYEGLIE CYLASNSIRE AMVMANNVYK TLGANAQTLT LLATVCLEDP 
VTQEKAKTLL DKALTQRPDY IKAVVKKAEL LSREQKYEDG IALLRNALAN QSDCVLHRIL 
GDFLVAVNEY QEAMDQYSIA LSLDPNDQKS LEGMQKMEKE ESPTDATQEE DVDDMEGSGE 
EGDLEGSDSE AAQWADQEQW FGMQ

Genular Protein ID: 2993807373

Symbol: Q69YV3_HUMAN