Details for: HPCAL4

Gene ID: 51440

Symbol: HPCAL4

Ensembl ID: ENSG00000116983

Description: hippocalcin like 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.8195
    Cell Significance Index: -12.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9436
    Cell Significance Index: -12.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4279
    Cell Significance Index: -13.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1293
    Cell Significance Index: 226.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0683
    Cell Significance Index: 71.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9324
    Cell Significance Index: 334.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8869
    Cell Significance Index: 25.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6445
    Cell Significance Index: 9.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5911
    Cell Significance Index: 14.7800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5472
    Cell Significance Index: 7.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5160
    Cell Significance Index: 27.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4220
    Cell Significance Index: 15.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4087
    Cell Significance Index: 5.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3141
    Cell Significance Index: 6.8100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2644
    Cell Significance Index: 3.2800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1854
    Cell Significance Index: 4.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1793
    Cell Significance Index: 7.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1609
    Cell Significance Index: 30.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1308
    Cell Significance Index: 8.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1115
    Cell Significance Index: 1.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0935
    Cell Significance Index: 3.0000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0214
    Cell Significance Index: 19.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0154
    Cell Significance Index: 0.3700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0004
    Cell Significance Index: -0.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0022
    Cell Significance Index: -0.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0031
    Cell Significance Index: -2.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0075
    Cell Significance Index: -10.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0118
    Cell Significance Index: -0.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0130
    Cell Significance Index: -0.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0152
    Cell Significance Index: -1.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0213
    Cell Significance Index: -11.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0227
    Cell Significance Index: -10.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0252
    Cell Significance Index: -0.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0307
    Cell Significance Index: -1.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0326
    Cell Significance Index: -9.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0356
    Cell Significance Index: -5.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0427
    Cell Significance Index: -7.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0534
    Cell Significance Index: -9.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0577
    Cell Significance Index: -12.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0643
    Cell Significance Index: -12.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0674
    Cell Significance Index: -9.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0712
    Cell Significance Index: -1.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0719
    Cell Significance Index: -4.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0794
    Cell Significance Index: -9.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0795
    Cell Significance Index: -10.9200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0809
    Cell Significance Index: -1.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0833
    Cell Significance Index: -8.2400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0908
    Cell Significance Index: -0.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0926
    Cell Significance Index: -4.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0936
    Cell Significance Index: -1.0200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1024
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1030
    Cell Significance Index: -11.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1043
    Cell Significance Index: -8.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1049
    Cell Significance Index: -12.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1056
    Cell Significance Index: -12.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1088
    Cell Significance Index: -3.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1124
    Cell Significance Index: -11.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1173
    Cell Significance Index: -2.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1191
    Cell Significance Index: -3.9000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1214
    Cell Significance Index: -12.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1264
    Cell Significance Index: -4.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1302
    Cell Significance Index: -9.9900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1306
    Cell Significance Index: -1.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1730
    Cell Significance Index: -1.6400
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.1734
    Cell Significance Index: -1.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1833
    Cell Significance Index: -4.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1852
    Cell Significance Index: -4.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1902
    Cell Significance Index: -12.2700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1954
    Cell Significance Index: -2.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1992
    Cell Significance Index: -6.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2004
    Cell Significance Index: -12.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2016
    Cell Significance Index: -10.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2039
    Cell Significance Index: -10.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2155
    Cell Significance Index: -12.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2156
    Cell Significance Index: -10.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2219
    Cell Significance Index: -4.7300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2315
    Cell Significance Index: -3.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2515
    Cell Significance Index: -11.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2618
    Cell Significance Index: -3.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2726
    Cell Significance Index: -5.6900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2796
    Cell Significance Index: -4.8200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2843
    Cell Significance Index: -3.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2970
    Cell Significance Index: -10.3200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3120
    Cell Significance Index: -6.1400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3170
    Cell Significance Index: -4.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3258
    Cell Significance Index: -11.9600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3405
    Cell Significance Index: -6.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3526
    Cell Significance Index: -10.3900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3788
    Cell Significance Index: -5.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3823
    Cell Significance Index: -9.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3910
    Cell Significance Index: -10.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3930
    Cell Significance Index: -12.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular expression**: HPCAL4 is expressed in a diverse range of cell types, including polychromatophilic erythroblast, orthochromatic erythroblast, CD8-positive T cells, alpha-beta regulatory T cells, and various neural cells, such as L2/3-6 intratelencephalic projecting glutamatergic neurons, hippocampal granule cells, and enteroendocrine cells of the small intestine. 2. **Protein structure**: The protein structure of HPCAL4 is characterized by calcium channel regulator activity, calcium ion binding, and protein domain-specific binding, suggesting its involvement in calcium signaling and regulation of signal transduction pathways. 3. **Pathway involvement**: HPCAL4 is implicated in various cellular processes, including central nervous system development, protein binding, and regulation of signal transduction, highlighting its complex role in cellular development and function. **Pathways and Functions:** 1. **Calcium channel regulator activity**: HPCAL4 is involved in regulating calcium channels, which is crucial for maintaining calcium homeostasis within cells. This function is essential for various cellular processes, including neural development, muscle contraction, and immune cell activation. 2. **Calcium ion binding**: HPCAL4 binds to calcium ions, which can influence various cellular processes, including cell signaling, proliferation, and differentiation. 3. **Protein binding**: HPCAL4 interacts with various proteins, including calcium channels, receptors, and signaling molecules, which can modulate its activity and influence cellular processes. 4. **Regulation of signal transduction**: HPCAL4 regulates signal transduction pathways, including those involved in immune cell activation, neural development, and cellular proliferation. **Clinical Significance:** 1. **Immunoregulation**: HPCAL4's role in regulating immune cell activation and differentiation suggests its potential involvement in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurological disorders**: The expression of HPCAL4 in various neural cells and its involvement in calcium signaling pathways make it a potential candidate for studying neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer research**: HPCAL4's expression in enteroendocrine cells and its involvement in cellular development and proliferation suggest its potential role in cancer research, particularly in the study of gastrointestinal cancers. 4. **Gene therapy**: Further research on HPCAL4's function and regulation may lead to the development of gene therapies targeting this protein, which could potentially treat various diseases associated with its dysregulation. In conclusion, HPCAL4 is a multifunctional protein with significant implications in immunoregulation, cellular development, and calcium signaling pathways. Further research on this protein is essential to unravel its complex role in various cellular processes and its potential applications in treating diseases associated with its dysregulation.

Genular Protein ID: 468463297

Symbol: HPCL4_HUMAN

Name: Hippocalcin-like protein 4

UniProtKB Accession Codes:

Q9UM19 B2R5U2 D3DPU1 Q5TG97 Q8N611

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10520747

Title: Isolation of two human cDNAs, HLP3 and HLP4, homologous to the neuron-specific calcium-binding protein genes.

PubMed ID: 10520747

DOI: 10.3109/10425179809072192

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 191
  • Mass: 22202
  • Checksum: F705065604A8A38D
  • Sequence:
    • MGKTNSKLAP EVLEDLVQNT EFSEQELKQW YKGFLKDCPS GILNLEEFQQ LYIKFFPYGD 
ASKFAQHAFR TFDKNGDGTI DFREFICALS VTSRGSFEQK LNWAFEMYDL DGDGRITRLE 
MLEIIEAIYK MVGTVIMMRM NQDGLTPQQR VDKIFKKMDQ DKDDQITLEE FKEAAKSDPS 
IVLLLQCDMQ K

Genular Protein ID: 799572904

Symbol: B4DGW9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DGW9

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 119
  • Mass: 13854
  • Checksum: F80EEB979A581AAC
  • Sequence:
    • MGKTNSKLAP EVLEDLVQNT EFSEQELKQW YKGFLKDCPS GILNLEEFQQ LYIKAIYKMV 
GTVIMMRMNQ DGLTPQQRVD KIFKKMDQDK DDQITLEEFK EAAKSDPSIV LLLQCDMQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.