IP6K2 | ENSG00000068745 | NCBI 51447

Details for: IP6K2

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Inositol phosphate metabolism
(R-HSA-1483249)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Metabolism
(R-HSA-1430728)
Synthesis of ips in the nucleus
(R-HSA-1855191)
Atp binding
(GO:0005524)
Cell junction
(GO:0030054)
Cellular response to flavonoid
(GO:1905396)
Cytoplasm
(GO:0005737)
Diphosphoinositol pentakisphosphate kinase activity
(GO:0000829)
Diphosphoinositol tetrakisphosphate kinase activity
(GO:0052839)
Fibrillar center
(GO:0001650)
Flavonoid binding
(GO:0097243)
Inositol-1,3,4,5,6-pentakisphosphate kinase activity
(GO:0000827)
Inositol 5-diphosphate pentakisphosphate 5-kinase activity
(GO:0052836)
Inositol hexakisphosphate 5-kinase activity
(GO:0000832)
Inositol hexakisphosphate kinase activity
(GO:0000828)
Inositol phosphate biosynthetic process
(GO:0032958)
Inositol phosphate metabolic process
(GO:0043647)
Negative regulation of cell growth
(GO:0030308)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Phosphorylation
(GO:0016310)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

peripheral nervous system neuron CL2000032

CSI 26.18

rCSI 35.68%

PRS 22.05
keratinocyte CL0000312

CSI 16

rCSI 13.42%

PRS 29.95
CD1c-positive myeloid dendritic cell CL0002399

CSI 12.5

rCSI 15.09%

PRS 30.64
tracheobronchial smooth muscle cell CL0019019

CSI 11.88

rCSI 20.95%

PRS 32.52
lung secretory cell CL1000272

CSI 11.68

rCSI 28.91%

PRS 23.66
regular atrial cardiac myocyte CL0002129

CSI 10.12

rCSI 32.58%

PRS 26.14
paneth cell CL0000510

CSI 9.81

rCSI 14.48%

PRS 39.05
effector CD4-positive, alpha-beta T cell CL0001044

CSI 9.59

rCSI 27.51%

PRS 37.97
CD8-positive, alpha-beta thymocyte CL0000811

CSI 9.34

rCSI 14.56%

PRS 53.06
lung pericyte CL0009089

CSI 8.25

rCSI 21.78%

PRS 30.27
blood vessel smooth muscle cell CL0019018

CSI 6.5

rCSI 52.89%

PRS 24.27
erythrocyte CL0000232

CSI 6.49

rCSI 14.73%

PRS 32.56
acinar cell CL0000622

CSI 6.18

rCSI 9.06%

PRS 33.1
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 6.01

rCSI 5.47%

PRS 38.23
adventitial cell CL0002503

CSI 5.84

rCSI 13.96%

PRS 36.79
double negative thymocyte CL0002489

CSI 5.68

rCSI 3.95%

PRS 30.69
enterocyte of epithelium of large intestine CL0002071

CSI 5.34

rCSI 28.03%

PRS 41.46
promonocyte CL0000559

CSI 5.12

rCSI 8.77%

PRS 34.04
adipocyte CL0000136

CSI 4.9

rCSI 6.29%

PRS 24.5
intestinal epithelial cell CL0002563

CSI 4.86

rCSI 5.08%

PRS 26.22
skin fibroblast CL0002620

CSI 4.77

rCSI 4.11%

PRS 37
placental villous trophoblast CL2000060

CSI 4.35

rCSI 6.72%

PRS 23.84
cerebral cortex GABAergic interneuron CL0010011

CSI 4.28

rCSI 12.63%

PRS 29.59
erythroid progenitor cell CL0000038

CSI 4.01

rCSI 23.01%

PRS 36.37
immature B cell CL0000816

CSI 3.92

rCSI 2.91%

PRS 36.74
common lymphoid progenitor CL0000051

CSI 3.91

rCSI 5.23%

PRS 46.04
ionocyte CL0005006

CSI 3.88

rCSI 4.15%

PRS 23.43
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.6

rCSI 2.88%

PRS 43.8
mesenchymal stem cell CL0000134

CSI 3.58

rCSI 39.21%

PRS 42.99
retinal blood vessel endothelial cell CL0002585

CSI 3.48

rCSI 5.56%

PRS 27.83
intestinal crypt stem cell of colon CL0009043

CSI 3.37

rCSI 25.29%

PRS 44.63
myeloid dendritic cell CL0000782

CSI 3.36

rCSI 4.87%

PRS 38.04
epithelial cell of lung CL0000082

CSI 3.28

rCSI 2.72%

PRS 24.18
cerebral cortex endothelial cell CL1001602

CSI 3.14

rCSI 5.42%

PRS 19.48
cerebellar granule cell CL0001031

CSI 3.13

rCSI 4.61%

PRS 23.38
squamous epithelial cell CL0000076

CSI 3.07

rCSI 7.28%

PRS 30.92
small pre-B-II cell CL0000954

CSI 3

rCSI 2.88%

PRS 48.5
lung macrophage CL1001603

CSI 2.99

rCSI 6.67%

PRS 29.87
astrocyte of the cerebral cortex CL0002605

CSI 2.98

rCSI 6.68%

PRS 15.97
enteric neuron CL0007011

CSI 2.89

rCSI 42.68%

PRS 52.95
glutamatergic neuron CL0000679

CSI 2.77

rCSI 5.69%

PRS 24.27
retinal pigment epithelial cell CL0002586

CSI 2.74

rCSI 5.44%

PRS 26.32
lung neuroendocrine cell CL1000223

CSI 2.66

rCSI 3.94%

PRS 28.89
colonocyte CL1000347

CSI 2.64

rCSI 3.79%

PRS 33.45
stem cell CL0000034

CSI 2.6

rCSI 2.51%

PRS 18.8
perivascular cell CL4033054

CSI 2.6

rCSI 3.55%

PRS 28.66
lamp5 GABAergic cortical interneuron CL4023011

CSI 2.57

rCSI 4.31%

PRS 15.36
renal alpha-intercalated cell CL0005011

CSI 2.55

rCSI 3.41%

PRS 32.38
ciliated cell CL0000064

CSI 2.52

rCSI 4.08%

PRS 25.41
type EC enteroendocrine cell CL0000577

CSI 2.49

rCSI 8.83%

PRS 39.76
effector CD8-positive, alpha-beta T cell CL0001050

CSI 2.48

rCSI 1.89%

PRS 33.64
hematopoietic precursor cell CL0008001

CSI 2.47

rCSI 2.54%

PRS 39.96
cardiac neuron CL0010022

CSI 2.37

rCSI 7.59%

PRS 21.41
class switched memory B cell CL0000972

CSI 2.37

rCSI 1.77%

PRS 41.5
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 2.37

rCSI 5.4%

PRS 25.83
mature T cell CL0002419

CSI 2.33

rCSI 1.81%

PRS 37.25
melanocyte CL0000148

CSI 2.26

rCSI 1.67%

PRS 21.81
plasmacytoid dendritic cell, human CL0001058

CSI 2.23

rCSI 1.56%

PRS 27.04
interstitial cell of Cajal CL0002088

CSI 2.21

rCSI 2.81%

PRS 29.22
unswitched memory B cell CL0000970

CSI 2.2

rCSI 1.85%

PRS 39.58
ciliated epithelial cell CL0000067

CSI 2.2

rCSI 1.93%

PRS 18.6
interneuron CL0000099

CSI 2.16

rCSI 4.35%

PRS 18.85
T follicular helper cell CL0002038

CSI 2.15

rCSI 1.61%

PRS 39.03
neuroblast (sensu Vertebrata) CL0000031

CSI 2.15

rCSI 2.75%

PRS 24.28
myofibroblast cell CL0000186

CSI 2.12

rCSI 2.93%

PRS 33.82
vascular associated smooth muscle cell CL0000359

CSI 2.11

rCSI 6.84%

PRS 29.95
respiratory hillock cell CL4030023

CSI 2.1

rCSI 3.75%

PRS 40.45
alveolar type 1 fibroblast cell CL4028004

CSI 2.1

rCSI 2.3%

PRS 28.4
epithelial cell of lower respiratory tract CL0002632

CSI 2.07

rCSI 1.6%

PRS 24.71
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.06

rCSI 10.32%

PRS 33.49
fibroblast of lung CL0002553

CSI 2.01

rCSI 1.87%

PRS 25.43
goblet cell CL0000160

CSI 2.01

rCSI 1.9%

PRS 26.6
blood vessel endothelial cell CL0000071

CSI 2.01

rCSI 4.17%

PRS 25.17
subcutaneous adipocyte CL0002521

CSI 1.97

rCSI 10.1%

PRS 27.57
secretory cell CL0000151

CSI 1.96

rCSI 2.05%

PRS 26.05
luminal cell of prostate epithelium CL0002340

CSI 1.95

rCSI 10.46%

PRS 42.2
small intestine goblet cell CL1000495

CSI 1.94

rCSI 4.24%

PRS 33.53
neural crest cell CL0011012

CSI 1.91

rCSI 1.51%

PRS 17.5
activated type II NK T cell CL0000931

CSI 1.89

rCSI 2.12%

PRS 39.89
intestinal crypt stem cell of small intestine CL0009017

CSI 1.87

rCSI 5.03%

PRS 32.76
pancreatic D cell CL0000173

CSI 1.86

rCSI 1.83%

PRS 27.25
luminal epithelial cell of mammary gland CL0002326

CSI 1.84

rCSI 3.34%

PRS 38.4
precursor B cell CL0000817

CSI 1.83

rCSI 1.6%

PRS 33.37
fibroblast of breast CL4006000

CSI 1.82

rCSI 7.65%

PRS 54.58
colon epithelial cell CL0011108

CSI 1.81

rCSI 1.9%

PRS 23.73
early lymphoid progenitor CL0000936

CSI 1.81

rCSI 1.59%

PRS 29.28
forebrain radial glial cell CL0013000

CSI 1.77

rCSI 5.68%

PRS 34.46
T-helper 17 cell CL0000899

CSI 1.72

rCSI 1.37%

PRS 44.15
ependymal cell CL0000065

CSI 1.72

rCSI 3.49%

PRS 13.97
mucous neck cell CL0000651

CSI 1.68

rCSI 2.42%

PRS 38.94
hepatic stellate cell CL0000632

CSI 1.67

rCSI 6.27%

PRS 21.36
double-positive, alpha-beta thymocyte CL0000809

CSI 1.67

rCSI 1.71%

PRS 35.85
intestine goblet cell CL0019031

CSI 1.67

rCSI 1.49%

PRS 25.68
ON-bipolar cell CL0000749

CSI 1.67

rCSI 2.49%

PRS 29.21
CD4-positive, alpha-beta memory T cell CL0000897

CSI 1.67

rCSI 1.2%

PRS 34.86
choroid plexus epithelial cell CL0000706

CSI 1.66

rCSI 2.72%

PRS 19.65
naive T cell CL0000898

CSI 1.64

rCSI 1.14%

PRS 35.52
elicited macrophage CL0000861

CSI 1.64

rCSI 1.5%

PRS 30.27
hematopoietic stem cell CL0000037

CSI 1.63

rCSI 1.08%

PRS 30
myeloid leukocyte CL0000766

CSI 1.61

rCSI 1.48%

PRS 26.58

cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.7%

PRS 36.8%
pluripotent stem cell CL0002248

CSI 0.2

rCSI 4.9%

PRS 50.7%
enterocyte of epithelium of small intestine CL1000334

CSI 0.2

rCSI 3.0%

PRS 55.5%
acinar cell of salivary gland CL0002623

CSI 0.2

rCSI 5.1%

PRS 46.0%
tracheal goblet cell CL1000329

CSI 0.2

rCSI 0.5%

PRS 46.3%
myeloid lineage restricted progenitor cell CL0000839

CSI 0.2

rCSI 1.2%

PRS 47.6%
neuroplacodal cell CL0000032

CSI 0.3

rCSI 2.3%

PRS 53.9%
paneth cell of colon CL0009009

CSI 0.3

rCSI 2.5%

PRS 56.7%
medium spiny neuron CL1001474

CSI 0.3

rCSI 2.2%

PRS 14.7%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 2.9%

PRS 46.2%
eye photoreceptor cell CL0000287

CSI 0.3

rCSI 3.1%

PRS 54.8%
primitive red blood cell CL0002355

CSI 0.3

rCSI 1.5%

PRS 40.9%
brush cell CL0002204

CSI 0.3

rCSI 0.6%

PRS 55.2%
enteroendocrine cell of colon CL0009042

CSI 0.3

rCSI 1.5%

PRS 55.6%
duct epithelial cell CL0000068

CSI 0.3

rCSI 0.5%

PRS 27.0%
epithelial cell of nephron CL1000449

CSI 0.3

rCSI 3.3%

PRS 73.8%
parietal epithelial cell CL1000452

CSI 0.4

rCSI 1.0%

PRS 21.1%
P/D1 enteroendocrine cell CL0002268

CSI 0.4

rCSI 2.2%

PRS 52.6%
amacrine cell CL0000561

CSI 0.4

rCSI 1.2%

PRS 19.9%
microcirculation associated smooth muscle cell CL0008035

CSI 0.4

rCSI 1.2%

PRS 28.4%
tracheobronchial serous cell CL0019001

CSI 0.4

rCSI 1.8%

PRS 43.7%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.4

rCSI 2.5%

PRS 16.2%
dopaminergic neuron CL0000700

CSI 0.4

rCSI 2.4%

PRS 15.5%
paneth cell of epithelium of small intestine CL1000343

CSI 0.4

rCSI 1.2%

PRS 38.7%
IgG plasma cell CL0000985

CSI 0.5

rCSI 0.5%

PRS 42.8%
hair follicular keratinocyte CL2000092

CSI 0.5

rCSI 7.9%

PRS 70.5%
late pro-B cell CL0002048

CSI 0.5

rCSI 1.1%

PRS 59.7%
mature B cell CL0000785

CSI 0.5

rCSI 0.4%

PRS 32.0%
type B pancreatic cell CL0000169

CSI 0.5

rCSI 1.1%

PRS 23.5%
pancreatic epsilon cell CL0005019

CSI 0.5

rCSI 2.2%

PRS 50.9%
neuroendocrine cell CL0000165

CSI 0.5

rCSI 1.8%

PRS 45.8%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.5

rCSI 2.3%

PRS 67.6%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.5

rCSI 1.9%

PRS 16.0%
fibroblast of cardiac tissue CL0002548

CSI 0.5

rCSI 2.4%

PRS 21.7%
glycinergic amacrine cell CL4030028

CSI 0.5

rCSI 1.3%

PRS 25.3%
transit amplifying cell of small intestine CL0009012

CSI 0.5

rCSI 2.3%

PRS 44.7%
ON midget ganglion cell CL4033046

CSI 0.5

rCSI 10.7%

PRS 21.1%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.9%

PRS 19.5%
invaginating midget bipolar cell CL4033034

CSI 0.5

rCSI 3.1%

PRS 26.7%
pancreatic stellate cell CL0002410

CSI 0.5

rCSI 3.1%

PRS 36.7%
pancreatic PP cell CL0002275

CSI 0.5

rCSI 2.1%

PRS 41.5%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 0.6

rCSI 1.1%

PRS 41.5%
regular ventricular cardiac myocyte CL0002131

CSI 0.6

rCSI 3.5%

PRS 20.2%
pancreatic ductal cell CL0002079

CSI 0.6

rCSI 1.1%

PRS 26.2%
bronchial goblet cell CL1000312

CSI 0.6

rCSI 2.4%

PRS 49.4%
enteroendocrine cell of small intestine CL0009006

CSI 0.6

rCSI 1.3%

PRS 37.7%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.6

rCSI 1.5%

PRS 39.5%
common dendritic progenitor CL0001029

CSI 0.6

rCSI 0.8%

PRS 32.8%
neural progenitor cell CL0011020

CSI 0.6

rCSI 2.7%

PRS 22.9%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 0.6

rCSI 1.6%

PRS 23.5%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.6

rCSI 2.3%

PRS 14.5%
retinal ganglion cell CL0000740

CSI 0.7

rCSI 1.4%

PRS 18.2%
thymocyte CL0000893

CSI 0.7

rCSI 2.4%

PRS 65.8%
stromal cell of ovary CL0002132

CSI 0.7

rCSI 1.9%

PRS 40.4%
syncytiotrophoblast cell CL0000525

CSI 0.7

rCSI 2.0%

PRS 44.0%
Purkinje cell CL0000121

CSI 0.7

rCSI 9.2%

PRS 73.3%
skeletal muscle satellite cell CL0000594

CSI 0.7

rCSI 2.1%

PRS 62.0%
progenitor cell CL0011026

CSI 0.7

rCSI 1.5%

PRS 35.6%
indirect pathway medium spiny neuron CL4023029

CSI 0.7

rCSI 17.2%

PRS 15.0%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.7

rCSI 1.3%

PRS 15.1%
nasal mucosa goblet cell CL0002480

CSI 0.7

rCSI 0.9%

PRS 36.1%
enterocyte CL0000584

CSI 0.8

rCSI 1.2%

PRS 36.9%
ON parasol ganglion cell CL4033052

CSI 0.8

rCSI 11.2%

PRS 20.3%
extravillous trophoblast CL0008036

CSI 0.8

rCSI 1.0%

PRS 22.4%
intrahepatic cholangiocyte CL0002538

CSI 0.8

rCSI 2.0%

PRS 42.7%
mammary gland epithelial cell CL0002327

CSI 0.8

rCSI 2.9%

PRS 42.2%
type L enteroendocrine cell CL0002279

CSI 0.8

rCSI 1.6%

PRS 46.8%
fraction A pre-pro B cell CL0002045

CSI 0.8

rCSI 1.0%

PRS 48.2%
M cell of gut CL0000682

CSI 0.8

rCSI 0.9%

PRS 41.4%
mononuclear phagocyte CL0000113

CSI 0.9

rCSI 1.9%

PRS 29.1%
VIP GABAergic cortical interneuron CL4023016

CSI 0.9

rCSI 1.0%

PRS 15.2%
large pre-B-II cell CL0000957

CSI 0.9

rCSI 2.5%

PRS 40.6%
respiratory epithelial cell CL0002368

CSI 0.9

rCSI 5.4%

PRS 65.4%
renal interstitial pericyte CL1001318

CSI 0.9

rCSI 2.4%

PRS 23.7%
kidney connecting tubule epithelial cell CL1000768

CSI 0.9

rCSI 2.2%

PRS 19.4%
H1 horizontal cell CL0004217

CSI 0.9

rCSI 3.5%

PRS 32.0%
cardiac muscle cell CL0000746

CSI 0.9

rCSI 1.3%

PRS 19.9%
corneal epithelial cell CL0000575

CSI 0.9

rCSI 2.6%

PRS 42.7%
peptic cell CL0000155

CSI 0.9

rCSI 9.1%

PRS 57.2%
pancreatic acinar cell CL0002064

CSI 0.9

rCSI 1.2%

PRS 27.9%
intermediate monocyte CL0002393

CSI 1.0

rCSI 1.4%

PRS 26.0%
transit amplifying cell of colon CL0009011

CSI 1.0

rCSI 1.1%

PRS 29.0%
sst GABAergic cortical interneuron CL4023017

CSI 1.0

rCSI 1.2%

PRS 16.0%
OFF-bipolar cell CL0000750

CSI 1.0

rCSI 1.3%

PRS 37.3%
centrilobular region hepatocyte CL0019029

CSI 1.0

rCSI 2.5%

PRS 36.8%
cardiac endothelial cell CL0010008

CSI 1.0

rCSI 3.9%

PRS 23.7%
differentiation-committed oligodendrocyte precursor CL4023059

CSI 1.0

rCSI 1.8%

PRS 21.6%
conjunctival epithelial cell CL1000432

CSI 1.0

rCSI 1.5%

PRS 25.6%
basal cell CL0000646

CSI 1.0

rCSI 1.3%

PRS 27.6%
tuft cell of colon CL0009041

CSI 1.0

rCSI 2.3%

PRS 46.2%
granulocyte CL0000094

CSI 1.0

rCSI 1.5%

PRS 32.8%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.0

rCSI 1.3%

PRS 14.4%
colon goblet cell CL0009039

CSI 1.0

rCSI 2.4%

PRS 37.0%
lymphoid lineage restricted progenitor cell CL0000838

CSI 1.0

rCSI 4.0%

PRS 41.2%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 1.0

rCSI 1.5%

PRS 23.5%
glandular epithelial cell CL0000150

CSI 1.0

rCSI 2.7%

PRS 47.0%
podocyte CL0000653

CSI 1.0

rCSI 4.6%

PRS 24.7%
mesenchymal cell CL0008019

CSI 1.0

rCSI 2.7%

PRS 24.9%
sncg GABAergic cortical interneuron CL4023015

CSI 1.1

rCSI 1.7%

PRS 16.8%
transit amplifying cell CL0009010

CSI 1.1

rCSI 1.6%

PRS 40.2%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [IP6K2](/details-gene/51447) (inositol hexakisphosphate kinase 2) is a protein-coding gene located on chromosome 3p21.31. It functions as a kinase that catalyzes the phosphorylation of inositol polyphosphates, key second messengers in a multitude of cellular processes. As a central enzyme in inositol phosphate metabolism, [IP6K2](/details-gene/51447) is involved in fundamental cellular activities including protein stabilization, regulation of cell growth, and apoptosis. **Overall**, expression data reveals its widespread significance across diverse and functionally distinct cell types, with particularly high expression in the [peripheral nervous system neuron](/details-cell/CL2000032), [keratinocyte](/details-cell/CL0000312), and various immune cells such as the [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399), suggesting a pleiotropic role in maintaining cellular homeostasis across multiple tissues. ## Cellular Roles and Expression Landscape The expression profile of [IP6K2](/details-gene/51447) indicates its importance in a wide array of cell lineages, pointing to a foundational role in cellular signaling rather than a specific lineage-defining function. Its highest significance is observed in the [peripheral nervous system neuron](/details-cell/CL2000032) (CSI: 26.18), consistent with the critical role of inositol phosphate signaling in neuronal function and plasticity. Beyond the nervous system, [IP6K2](/details-gene/51447) is also highly significant in structural and barrier cells, as shown by its high CSI in [keratinocyte](/details-cell/CL0000312) (CSI: 16.00). Its expression extends to contractile and stromal cells, including [tracheobronchial smooth muscle cell](/details-cell/CL0019019) (CSI: 11.88), [regular atrial cardiac myocyte](/details-cell/CL0002129) (CSI: 10.12), and [lung pericyte](/details-cell/CL0009089) (CSI: 8.25), suggesting a role in regulating the function of these structural tissue components. Furthermore, [IP6K2](/details-gene/51447) is prominently expressed within the immune system. It shows high significance in antigen-presenting cells like the [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) (CSI: 12.50) and in multiple T cell subsets, including the [effector CD4-positive, alpha-beta T cell](/details-cell/CL0001044) (CSI: 9.59), [CD8-positive, alpha-beta thymocyte](/details-cell/CL0000811) (CSI: 9.34), and [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (CSI: 6.01). This broad expression pattern within both the innate and adaptive immune systems is consistent with its annotated roles in cytokine signaling pathways. ## Pathways and Molecular Function [IP6K2](/details-gene/51447) is an enzyme with inositol hexakisphosphate kinase activity ([GO:0000828](https://www.ebi.ac.uk/QuickGO/term/GO:0000828)), responsible for synthesizing higher inositol polyphosphates and diphosphoinositol polyphosphates ([Link](https://doi.org/10.1016/s0960-9822(00)80055-x), [Link](https://doi.org/10.1074/jbc.m106842200)). These molecules are crucial signaling messengers, and accordingly, the gene's primary annotated function is within the [Inositol phosphate metabolism](https://reactome.org/content/detail/R-HSA-1483249) pathway ([R-HSA-1483249](https://reactome.org/content/detail/R-HSA-1483249)). Consistent with its expression in immune cells, [IP6K2](/details-gene/51447) is implicated in the [Immune system](https://reactome.org/content/detail/R-HSA-168256) ([R-HSA-168256](https://reactome.org/content/detail/R-HSA-168256)) super-pathway, with specific roles in [Cytokine signaling in immune system](https://reactome.org/content/detail/R-HSA-1280215) ([R-HSA-1280215](https://reactome.org/content/detail/R-HSA-1280215)) and [Interferon signaling](https://reactome.org/content/detail/R-HSA-913531) ([R-HSA-913531](https://reactome.org/content/detail/R-HSA-913531)). These pathways are fundamental to coordinating cellular responses to pathogens and inflammation. Functionally, this kinase activity is linked to the regulation of key cellular decisions, including the [Positive regulation of apoptotic process](https://www.ebi.ac.uk/QuickGO/term/GO:0043065) ([GO:0043065](https://www.ebi.ac.uk/QuickGO/term/GO:0043065)) and the [Negative regulation of cell growth](https://www.ebi.ac.uk/QuickGO/term/GO:0030308) ([GO:0030308](https://www.ebi.ac.uk/QuickGO/term/GO:0030308)). At the molecular level, its function requires [ATP binding](https://www.ebi.ac.uk/QuickGO/term/GO:0005524) ([GO:0005524](https://www.ebi.ac.uk/QuickGO/term/GO:0005524)) and its activity can be modulated by flavonoids, as it possesses a [Flavonoid binding](https://www.ebi.ac.uk/QuickGO/term/GO:0097243) ([GO:0097243](https://www.ebi.ac.uk/QuickGO/term/GO:0097243)) capability ([Link](https://doi.org/10.1021/acs.jmedchem.8b01593)). ## Research Directions The widespread and significant expression of [IP6K2](/details-gene/51447) across diverse cell types, coupled with its central role in generating second messengers, suggests it may act as a critical signaling hub that integrates external stimuli into cell-type-specific responses. Based on the available data, several testable hypotheses can be proposed: 1. Given its top significance in [peripheral nervous system neuron](/details-cell/CL2000032), [IP6K2](/details-gene/51447) may be a critical regulator of neuronal excitability or survival. Its dysregulation could contribute to the pathology of neurodegenerative or neuropathic disorders. 2. The high expression of [IP6K2](/details-gene/51447) in dendritic cells and T cells, combined with its role in interferon signaling, suggests that it is a key modulator of antiviral immunity. [IP6K2](/details-gene/51447) may fine-tune the magnitude or duration of type I interferon responses following pathogen recognition. A compelling experimental approach to test the second hypothesis would be to use CRISPR-Cas9 to knock out [IP6K2](/details-gene/51447) in primary human monocyte-derived dendritic cells. These knockout and control cells could then be stimulated with a viral mimic, such as poly(I:C) or a live virus. The impact of [IP6K2](/details-gene/51447) loss on the interferon response could be quantified by measuring the secretion of IFN-alpha and IFN-beta using ELISA and by profiling the expression of interferon-stimulated genes (ISGs) via RNA-sequencing. This would clarify its specific role in the antiviral signaling cascade. As a therapeutic target, [IP6K2](/details-gene/51447) presents a complex but promising profile. Its nature as a kinase makes it a druggable target, and research has already demonstrated its inhibition by flavonoids and related small molecules ([Link](https://doi.org/10.1021/acs.jmedchem.8b01593)). Given its role in negatively regulating cell growth and promoting apoptosis, inhibition of [IP6K2](/details-gene/51447) could be a viable strategy in certain cancers that have become dependent on altered inositol phosphate signaling. Conversely, targeted activation or modulation could be explored in autoimmune or inflammatory conditions where fine-tuning interferon or cytokine signaling is desirable. The broad expression of [IP6K2](/details-gene/51447) suggests that any therapeutic intervention would require highly targeted delivery or compounds with a favorable therapeutic window to avoid off-target effects in healthy tissues.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Inositol hexakisphosphate kinase 2

Genular Protein ID: 2032050411

Symbol: IP6K2_HUMAN

Name: Inositol hexakisphosphate kinase 2

UniProtKB Accession Codes:

Q9UHH9 A8K3B1 B4E3G6 G8JLL6 Q6P0N8 Q9BSZ6 Q9BUW3 Q9H4P7 Q9NT63 Q9UFU6

Database IDs:

Citations:

PubMed ID: 10574768

Title: Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.

PubMed ID: 10574768

DOI: 10.1016/s0960-9822(00)80055-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11502751

Title: Identification and characterization of a novel inositol hexakisphosphate kinase.

PubMed ID: 11502751

DOI: 10.1074/jbc.m106842200

PubMed ID: 30624931

Title: Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

PubMed ID: 30624931

DOI: 10.1021/acs.jmedchem.8b01593

Sequence Information:

Length: 426
Mass: 49186
Checksum: 11BDFF12C22EECFB
Sequence:

MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 
KFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGIVDIVD NSDCEPKSKL LRWTTNKKHH 
VLETEKTPKD WVRQHRKEEK MKSHKLEEEF EWLKKSEVLY YTVEKKGNIS SQLKHYNPWS 
MKCHQQQLQR MKENAKHRNQ YKFILLENLT SRYEVPCVLD LKMGTRQHGD DASEEKAANQ 
IRKCQQSTSA VIGVRVCGMQ VYQAGSGQLM FMNKYHGRKL SVQGFKEALF QFFHNGRYLR 
RELLGPVLKK LTELKAVLER QESYRFYSSS LLVIYDGKER PEVVLDSDAE DLEDLSEESA 
DESAGAYAYK PIGASSVDVR MIDFAHTTCR LYGEDTVVHE GQDAGYIFGL QSLIDIVTEI 
SEESGE

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Axilla UBERON0009472
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Chronic kidney disease MONDO0005300
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Pancreas UBERON0001264
	\|— Pancreas Healthy UBERON0001264_PATO0000461
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: IP6K2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. PubMed ID: 10574768

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Identification and characterization of a novel inositol hexakisphosphate kinase. PubMed ID: 11502751