Details for: IP6K2

Gene ID: 51447

Symbol: IP6K2

Ensembl ID: ENSG00000068745

Description: inositol hexakisphosphate kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 335.9795
    Cell Significance Index: -52.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.8765
    Cell Significance Index: -47.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.2013
    Cell Significance Index: -54.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 121.7057
    Cell Significance Index: -57.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.6565
    Cell Significance Index: -46.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 85.7498
    Cell Significance Index: -57.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.9242
    Cell Significance Index: -46.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.8597
    Cell Significance Index: -55.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.7725
    Cell Significance Index: -47.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4930
    Cell Significance Index: -57.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7676
    Cell Significance Index: -39.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.5508
    Cell Significance Index: -25.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4314
    Cell Significance Index: 67.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3646
    Cell Significance Index: 82.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8744
    Cell Significance Index: 304.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8306
    Cell Significance Index: 109.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6533
    Cell Significance Index: 74.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6163
    Cell Significance Index: 42.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3117
    Cell Significance Index: 263.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3078
    Cell Significance Index: 259.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2540
    Cell Significance Index: 70.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2295
    Cell Significance Index: 151.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1685
    Cell Significance Index: 80.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1666
    Cell Significance Index: 31.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1596
    Cell Significance Index: 159.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1542
    Cell Significance Index: 208.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1451
    Cell Significance Index: 506.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0403
    Cell Significance Index: 54.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0202
    Cell Significance Index: 29.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0047
    Cell Significance Index: 21.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9745
    Cell Significance Index: 349.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9707
    Cell Significance Index: 21.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9683
    Cell Significance Index: 528.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8143
    Cell Significance Index: 42.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8055
    Cell Significance Index: 50.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7948
    Cell Significance Index: 8.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7477
    Cell Significance Index: 5.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7292
    Cell Significance Index: 51.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7147
    Cell Significance Index: 70.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6158
    Cell Significance Index: 28.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5515
    Cell Significance Index: 59.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5474
    Cell Significance Index: 40.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5454
    Cell Significance Index: 33.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5285
    Cell Significance Index: 365.5400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5259
    Cell Significance Index: 6.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5060
    Cell Significance Index: 23.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4864
    Cell Significance Index: 92.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3855
    Cell Significance Index: 49.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3666
    Cell Significance Index: 9.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3237
    Cell Significance Index: 9.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2778
    Cell Significance Index: 35.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1864
    Cell Significance Index: 31.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1777
    Cell Significance Index: 11.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1627
    Cell Significance Index: 12.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1149
    Cell Significance Index: 103.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1074
    Cell Significance Index: 1.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1023
    Cell Significance Index: 1.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0914
    Cell Significance Index: 10.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0541
    Cell Significance Index: 99.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0462
    Cell Significance Index: 71.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0455
    Cell Significance Index: 2.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0370
    Cell Significance Index: 69.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0364
    Cell Significance Index: 0.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0361
    Cell Significance Index: 2.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0052
    Cell Significance Index: 7.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0177
    Cell Significance Index: -11.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0331
    Cell Significance Index: -24.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0333
    Cell Significance Index: -20.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0395
    Cell Significance Index: -29.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0412
    Cell Significance Index: -0.8000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0456
    Cell Significance Index: -0.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0650
    Cell Significance Index: -29.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0663
    Cell Significance Index: -37.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0820
    Cell Significance Index: -11.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0912
    Cell Significance Index: -1.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1157
    Cell Significance Index: -11.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1231
    Cell Significance Index: -25.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1643
    Cell Significance Index: -47.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1714
    Cell Significance Index: -19.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1847
    Cell Significance Index: -21.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2273
    Cell Significance Index: -1.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2532
    Cell Significance Index: -2.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2785
    Cell Significance Index: -3.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3895
    Cell Significance Index: -9.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4039
    Cell Significance Index: -17.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4261
    Cell Significance Index: -10.2200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4700
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5055
    Cell Significance Index: -57.7000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5096
    Cell Significance Index: -13.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5180
    Cell Significance Index: -16.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5200
    Cell Significance Index: -54.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5886
    Cell Significance Index: -22.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5971
    Cell Significance Index: -47.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6043
    Cell Significance Index: -5.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6200
    Cell Significance Index: -9.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7641
    Cell Significance Index: -20.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7817
    Cell Significance Index: -19.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7901
    Cell Significance Index: -9.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8119
    Cell Significance Index: -49.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IP6K2 is a member of the inositol hexakisphosphate kinase family, which is responsible for the phosphorylation of inositol hexakisphosphate (IP6) to produce inositol pentakisphosphate (IP5). This enzyme is specifically expressed in various cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. IP6K2 has been shown to be highly expressed in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, and embryonic stem cells, highlighting its essential role in cellular development and differentiation. **Pathways and Functions:** IP6K2 plays a critical role in various signaling pathways, including cytokine signaling in the immune system, interferon alpha/beta signaling, and negative regulation of cell growth. The enzyme is involved in the phosphorylation of IP6 to produce IP5, which is a precursor for the synthesis of other inositol phosphates. IP6K2 also regulates the metabolism of inositol phosphates, including the synthesis of inositol-1,3,4,5,6-pentakisphosphate (IP5) and diphosphoinositol pentakisphosphate (DIP5). Furthermore, IP6K2 is involved in the regulation of apoptosis, as it can phosphorylate and stabilize proteins that promote or inhibit apoptosis. The enzyme is also involved in the regulation of protein binding, phosphorylation, and stabilization, highlighting its role in protein-protein interactions and cellular signaling. **Clinical Significance:** IP6K2 has been implicated in various immune-related disorders, including cancer, autoimmune diseases, and infectious diseases. The enzyme has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting its potential role as a tumor suppressor. IP6K2 has also been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it may play a role in the regulation of immune cell function. In addition, IP6K2 has been shown to have anti-inflammatory properties, as it can regulate the production of pro-inflammatory cytokines. The enzyme has also been implicated in the regulation of immune responses to infections, including the production of interferons and the activation of immune cells. **Conclusion:** In conclusion, IP6K2 is a multifaceted enzyme that plays a critical role in regulating cellular metabolism and immune response. Its involvement in various signaling pathways, metabolic pathways, and clinical significance highlights its importance in understanding immune-related disorders. Further research is needed to fully elucidate the role of IP6K2 in human disease and to explore its potential as a therapeutic target. **Future Directions:** Future research should focus on the following areas: 1. To elucidate the specific mechanisms by which IP6K2 regulates immune response and metabolism. 2. To investigate the role of IP6K2 in various immune-related disorders, including cancer, autoimmune diseases, and infectious diseases. 3. To explore the potential of IP6K2 as a therapeutic target for immune-related disorders. 4. To investigate the relationship between IP6K2 expression and disease progression in various diseases. By addressing these areas, researchers can gain a deeper understanding of the role of IP6K2 in human disease and develop novel therapeutic strategies to target this enzyme.

Genular Protein ID: 2032050411

Symbol: IP6K2_HUMAN

Name: Inositol hexakisphosphate kinase 2

UniProtKB Accession Codes:

Q9UHH9 A8K3B1 B4E3G6 G8JLL6 Q6P0N8 Q9BSZ6 Q9BUW3 Q9H4P7 Q9NT63 Q9UFU6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 12 Ensembl 7 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 2 RefSeq 13 Rhea 1 SABIO-RK 1 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10574768

Title: Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.

PubMed ID: 10574768

DOI: 10.1016/s0960-9822(00)80055-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11502751

Title: Identification and characterization of a novel inositol hexakisphosphate kinase.

PubMed ID: 11502751

DOI: 10.1074/jbc.m106842200

PubMed ID: 30624931

Title: Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.

PubMed ID: 30624931

DOI: 10.1021/acs.jmedchem.8b01593

Sequence Information:

  • Length: 426
  • Mass: 49186
  • Checksum: 11BDFF12C22EECFB
  • Sequence:
    • MSPAFRAMDV EPRAKGVLLE PFVHQVGGHS CVLRFNETTL CKPLVPREHQ FYETLPAEMR 
KFTPQYKGVV SVRFEEDEDR NLCLIAYPLK GDHGIVDIVD NSDCEPKSKL LRWTTNKKHH 
VLETEKTPKD WVRQHRKEEK MKSHKLEEEF EWLKKSEVLY YTVEKKGNIS SQLKHYNPWS 
MKCHQQQLQR MKENAKHRNQ YKFILLENLT SRYEVPCVLD LKMGTRQHGD DASEEKAANQ 
IRKCQQSTSA VIGVRVCGMQ VYQAGSGQLM FMNKYHGRKL SVQGFKEALF QFFHNGRYLR 
RELLGPVLKK LTELKAVLER QESYRFYSSS LLVIYDGKER PEVVLDSDAE DLEDLSEESA 
DESAGAYAYK PIGASSVDVR MIDFAHTTCR LYGEDTVVHE GQDAGYIFGL QSLIDIVTEI 
SEESGE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.