Details for: GPR89B

Gene ID: 51463

Symbol: GPR89B

Ensembl ID: ENSG00000188092

Description: G protein-coupled receptor 89B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.5022
    Cell Significance Index: -13.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.4716
    Cell Significance Index: -14.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.6702
    Cell Significance Index: -12.4600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.1135
    Cell Significance Index: -12.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7502
    Cell Significance Index: -14.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.3420
    Cell Significance Index: -13.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7316
    Cell Significance Index: -14.7300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 3.6385
    Cell Significance Index: 115.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5821
    Cell Significance Index: 26.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0434
    Cell Significance Index: 942.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9610
    Cell Significance Index: 192.7800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.8813
    Cell Significance Index: 8.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6597
    Cell Significance Index: 71.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6179
    Cell Significance Index: 100.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6032
    Cell Significance Index: 119.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5913
    Cell Significance Index: 35.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4387
    Cell Significance Index: 12.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4351
    Cell Significance Index: 156.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3931
    Cell Significance Index: 11.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3670
    Cell Significance Index: 25.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3489
    Cell Significance Index: 4.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3053
    Cell Significance Index: 17.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2701
    Cell Significance Index: 14.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2106
    Cell Significance Index: 14.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2074
    Cell Significance Index: 20.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2068
    Cell Significance Index: 4.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1913
    Cell Significance Index: 34.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1899
    Cell Significance Index: 14.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1819
    Cell Significance Index: 11.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1682
    Cell Significance Index: 19.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1578
    Cell Significance Index: 22.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1535
    Cell Significance Index: 4.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1508
    Cell Significance Index: 3.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1454
    Cell Significance Index: 6.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1437
    Cell Significance Index: 78.4700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1406
    Cell Significance Index: 0.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1394
    Cell Significance Index: 19.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1379
    Cell Significance Index: 16.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1283
    Cell Significance Index: 2.8100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0979
    Cell Significance Index: 1.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0947
    Cell Significance Index: 4.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0803
    Cell Significance Index: 15.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0794
    Cell Significance Index: 2.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0790
    Cell Significance Index: 9.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0652
    Cell Significance Index: 2.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0632
    Cell Significance Index: 27.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0568
    Cell Significance Index: 7.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0541
    Cell Significance Index: 83.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0531
    Cell Significance Index: 1.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0440
    Cell Significance Index: 81.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0358
    Cell Significance Index: 0.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0257
    Cell Significance Index: 0.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0225
    Cell Significance Index: 30.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0201
    Cell Significance Index: 37.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0171
    Cell Significance Index: 1.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0050
    Cell Significance Index: 3.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0035
    Cell Significance Index: 0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0014
    Cell Significance Index: 0.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0034
    Cell Significance Index: -0.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0079
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0147
    Cell Significance Index: -10.7900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0193
    Cell Significance Index: -0.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0209
    Cell Significance Index: -1.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0216
    Cell Significance Index: -12.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0242
    Cell Significance Index: -15.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0256
    Cell Significance Index: -0.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0272
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0319
    Cell Significance Index: -5.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0347
    Cell Significance Index: -1.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0366
    Cell Significance Index: -0.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0536
    Cell Significance Index: -5.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0609
    Cell Significance Index: -6.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0659
    Cell Significance Index: -2.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0685
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0707
    Cell Significance Index: -14.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0996
    Cell Significance Index: -6.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1205
    Cell Significance Index: -12.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1286
    Cell Significance Index: -6.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1340
    Cell Significance Index: -9.4800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1368
    Cell Significance Index: -1.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1522
    Cell Significance Index: -2.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1711
    Cell Significance Index: -13.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1920
    Cell Significance Index: -5.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1934
    Cell Significance Index: -11.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1974
    Cell Significance Index: -3.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1988
    Cell Significance Index: -2.9400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1992
    Cell Significance Index: -2.8400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2125
    Cell Significance Index: -2.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2224
    Cell Significance Index: -7.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2295
    Cell Significance Index: -7.3100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2430
    Cell Significance Index: -2.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2441
    Cell Significance Index: -5.1800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2588
    Cell Significance Index: -3.8200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2611
    Cell Significance Index: -3.7500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2726
    Cell Significance Index: -3.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2782
    Cell Significance Index: -6.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2846
    Cell Significance Index: -9.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: GPR89B is a transmembrane receptor belonging to the G protein-coupled receptor family, with a characteristic seven-transmembrane helix structure. 2. **Expression**: GPR89B is expressed in a wide range of cell types, including hematopoietic oligopotent progenitor cells, mucosal type mast cells, and epithelial cells of the pancreas. 3. **Signaling Pathways**: The receptor is involved in multiple signaling pathways, including those related to protein binding, protein transport, and voltage-gated monoatomic anion channel activity. 4. **Cellular Functions**: GPR89B plays a role in cellular processes such as cell differentiation, protein transport, and ion channel activity. **Pathways and Functions** 1. **Golgi Cisterna Membrane and Golgi Membrane**: GPR89B is involved in protein binding and transport within the Golgi apparatus, suggesting its role in regulating protein secretion and processing. 2. **Intracellular pH Reduction**: The receptor may play a role in maintaining intracellular pH homeostasis by regulating the activity of monoatomic anion channels. 3. **Monoatomic Anion Transmembrane Transport**: GPR89B is involved in the transport of monoatomic anions across the cell membrane, which may be essential for maintaining cellular homeostasis. 4. **Monoatomic Ion Channel Complex**: The receptor forms a complex with monoatomic ion channels, suggesting its role in regulating ion flow and maintaining cellular homeostasis. 5. **T Cell Differentiation**: GPR89B may play a role in the regulation of T cell differentiation, a critical process in the development of the immune system. **Clinical Significance** 1. **Immunological Disorders**: Abnormalities in GPR89B expression or function may contribute to immunological disorders, such as autoimmune diseases or immune deficiencies. 2. **Cancer**: Alterations in GPR89B expression or function may be associated with cancer development or progression, particularly in hematological malignancies. 3. **Neurological Disorders**: GPR89B may play a role in the regulation of cellular processes in the nervous system, and abnormalities in its expression or function may contribute to neurological disorders, such as Alzheimer's disease or Parkinson's disease. 4. **Pancreatic Disease**: GPR89B expression in pancreatic epithelial cells suggests its potential role in pancreatic disease, including diabetes and pancreatic cancer. In conclusion, GPR89B is a multifunctional receptor involved in various cellular processes, including protein binding, protein transport, and ion channel activity. Its expression in multiple cell types and its involvement in multiple signaling pathways underscore its potential significance in multiple biological contexts. Further research is needed to fully elucidate the role of GPR89B in health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 3953951051

Symbol: GPHRA_HUMAN

Name: Protein GPR89A

UniProtKB Accession Codes:

B7ZAQ6 A6NN37 B2RUV3 B3KMN3 B4DLT3 B4DXE7 Q53FQ9 Q5T2V8 Q5T5P5 Q659E2 Q6NVY5 Q9P0S4 Q9Y302

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CTD 2 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 23 Ensembl 5 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 2 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 15 Rhea 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18794847

Title: GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

PubMed ID: 18794847

DOI: 10.1038/ncb1773

PubMed ID: 19135895

Title: Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis.

PubMed ID: 19135895

DOI: 10.1016/j.cell.2008.12.026

Sequence Information:

  • Length: 455
  • Mass: 52917
  • Checksum: D831F66E682643F9
  • Sequence:
    • MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF SCTMFELIIF 
EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS NIRLLHKQRL LFSCLLWLTF 
MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN 
VTDTDILALE RRLLQTMDMI ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG 
SENLTLIQQE VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK 
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL 
ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN 
FYHRWFDVIF LVSALSSILF LYLAHKQAPE KQMAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.