Details for: DTL

Gene ID: 51514

Symbol: DTL

Ensembl ID: ENSG00000143476

Description: denticleless E3 ubiquitin protein ligase homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.4939
    Cell Significance Index: -6.7200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 20.8036
    Cell Significance Index: -8.5700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.9299
    Cell Significance Index: -3.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.0982
    Cell Significance Index: -6.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.6531
    Cell Significance Index: -6.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.2788
    Cell Significance Index: 71.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9684
    Cell Significance Index: 50.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8529
    Cell Significance Index: 84.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8248
    Cell Significance Index: 49.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7320
    Cell Significance Index: 145.2700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.6560
    Cell Significance Index: 8.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6229
    Cell Significance Index: 67.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6142
    Cell Significance Index: 16.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5840
    Cell Significance Index: 94.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5174
    Cell Significance Index: 14.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5098
    Cell Significance Index: -1.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4415
    Cell Significance Index: 4.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4037
    Cell Significance Index: 10.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3595
    Cell Significance Index: 324.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2844
    Cell Significance Index: 7.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2824
    Cell Significance Index: 33.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2683
    Cell Significance Index: 7.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2558
    Cell Significance Index: 8.8900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2232
    Cell Significance Index: 1.6900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1895
    Cell Significance Index: 1.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1609
    Cell Significance Index: 4.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1041
    Cell Significance Index: 2.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0925
    Cell Significance Index: 10.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0902
    Cell Significance Index: 2.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0759
    Cell Significance Index: 2.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0647
    Cell Significance Index: 35.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0567
    Cell Significance Index: 10.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0467
    Cell Significance Index: 20.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0395
    Cell Significance Index: 1.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0332
    Cell Significance Index: 2.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0270
    Cell Significance Index: 18.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0188
    Cell Significance Index: 0.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0123
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0025
    Cell Significance Index: 0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0021
    Cell Significance Index: 0.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0020
    Cell Significance Index: 0.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0012
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0056
    Cell Significance Index: -10.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0095
    Cell Significance Index: -7.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0143
    Cell Significance Index: -0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0152
    Cell Significance Index: -3.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0154
    Cell Significance Index: -8.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0165
    Cell Significance Index: -7.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0181
    Cell Significance Index: -3.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0211
    Cell Significance Index: -6.0800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0220
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0241
    Cell Significance Index: -3.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0241
    Cell Significance Index: -1.7100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0251
    Cell Significance Index: -0.3600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0303
    Cell Significance Index: -0.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0330
    Cell Significance Index: -4.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0352
    Cell Significance Index: -3.6000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0388
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0396
    Cell Significance Index: -5.7600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0429
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0454
    Cell Significance Index: -9.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0460
    Cell Significance Index: -7.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0472
    Cell Significance Index: -0.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0548
    Cell Significance Index: -7.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0726
    Cell Significance Index: -7.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0731
    Cell Significance Index: -8.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0783
    Cell Significance Index: -1.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0855
    Cell Significance Index: -0.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0869
    Cell Significance Index: -5.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0914
    Cell Significance Index: -7.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0963
    Cell Significance Index: -7.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0966
    Cell Significance Index: -7.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1011
    Cell Significance Index: -2.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1016
    Cell Significance Index: -1.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1053
    Cell Significance Index: -2.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1079
    Cell Significance Index: -5.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1115
    Cell Significance Index: -7.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1235
    Cell Significance Index: -7.5700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.1240
    Cell Significance Index: -1.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1250
    Cell Significance Index: -3.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1255
    Cell Significance Index: -3.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1650
    Cell Significance Index: -8.6700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1656
    Cell Significance Index: -1.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1673
    Cell Significance Index: -7.4000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1694
    Cell Significance Index: -1.4400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1696
    Cell Significance Index: -1.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1913
    Cell Significance Index: -8.9200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1920
    Cell Significance Index: -1.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2052
    Cell Significance Index: -7.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2111
    Cell Significance Index: -5.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2165
    Cell Significance Index: -3.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DTL is an E3 ubiquitin protein ligase, which plays a pivotal role in the ubiquitination of target proteins. This process is essential for protein degradation, cell cycle regulation, and DNA damage response. DTL is highly expressed in hematopoietic oligopotent progenitor cells, embryonic stem cells, and various types of immune cells, including mast cells and endothelial cells. Its expression is also observed in neoplastic cells, suggesting a potential role in tumorigenesis. **Pathways and Functions:** DTL is involved in multiple cellular pathways, including: 1. **DNA Damage Response:** DTL regulates the ubiquitination of PCNA (Proliferating Cell Nuclear Antigen), which is essential for the recognition of DNA damage by the PCNA-containing replication complex. 2. **Cell Cycle Regulation:** DTL promotes the positive regulation of the G2/M transition of the mitotic cell cycle, ensuring proper cell division and preventing aberrant cell growth. 3. **Protein Degradation:** DTL is involved in the ubiquitin-dependent protein catabolic process, regulating the degradation of proteins involved in DNA repair and cell cycle progression. 4. **Neddylation:** DTL is also involved in the regulation of neddylation, a post-translational modification that plays a crucial role in protein degradation and cell cycle regulation. **Clinical Significance:** The dysregulation of DTL has been implicated in various human diseases, including: 1. **Cancer:** Overexpression of DTL has been observed in various types of cancer, including leukemia and lymphoma, suggesting a potential role in tumorigenesis. 2. **Immune Disorders:** DTL's involvement in immune cell development and function has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological Disorders:** Abnormal expression of DTL has been observed in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, DTL is a multifunctional gene that plays a crucial role in DNA damage response, cell cycle regulation, and protein degradation. Its dysregulation has been implicated in various human diseases, highlighting the importance of further research into the mechanisms underlying DTL's function and its potential therapeutic applications.

Genular Protein ID: 973285067

Symbol: DTL_HUMAN

Name: Denticleless protein homolog

UniProtKB Accession Codes:

Q9NZJ0 A8K8H8 D3DT98 Q5VT77 Q96SN0 Q9NW03 Q9NW34 Q9NWM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 15 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11278750

Title: Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation.

PubMed ID: 11278750

DOI: 10.1074/jbc.m010802200

PubMed ID: 16861906

Title: L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage.

PubMed ID: 16861906

DOI: 10.4161/cc.5.15.3149

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17106265

Title: Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma.

PubMed ID: 17106265

DOI: 10.4161/cc.5.22.3500

PubMed ID: 17085480

Title: DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.

PubMed ID: 17085480

DOI: 10.1101/gad.1482106

PubMed ID: 16949367

Title: A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1.

PubMed ID: 16949367

DOI: 10.1016/j.molcel.2006.08.010

PubMed ID: 17041588

Title: CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.

PubMed ID: 17041588

DOI: 10.1038/ncb1490

PubMed ID: 16964240

Title: Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery.

PubMed ID: 16964240

DOI: 10.1038/nature05175

PubMed ID: 18794347

Title: PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.

PubMed ID: 18794347

DOI: 10.1101/gad.1676108

PubMed ID: 18794348

Title: The CRL4Cdt2 ubiquitin ligase targets the degradation of p21Cip1 to control replication licensing.

PubMed ID: 18794348

DOI: 10.1101/gad.1703708

PubMed ID: 18703516

Title: CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.

PubMed ID: 18703516

DOI: 10.1074/jbc.m806045200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19332548

Title: Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells.

PubMed ID: 19332548

DOI: 10.1074/jbc.m808810200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20129063

Title: CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis.

PubMed ID: 20129063

DOI: 10.1016/j.molcel.2009.12.018

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23213251

Title: TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21.

PubMed ID: 23213251

DOI: 10.1073/pnas.1214156110

PubMed ID: 23892434

Title: Regulation of TGF-beta signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.

PubMed ID: 23892434

DOI: 10.4161/cc.25314

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23478445

Title: CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.

PubMed ID: 23478445

DOI: 10.1016/j.molcel.2013.02.003

PubMed ID: 23478441

Title: Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase.

PubMed ID: 23478441

DOI: 10.1016/j.molcel.2013.02.004

PubMed ID: 23677613

Title: The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.

PubMed ID: 23677613

DOI: 10.1093/nar/gkt397

PubMed ID: 26431207

Title: CUL4-DDB1-CDT2 E3 ligase regulates the molecular clock activity by promoting ubiquitination-dependent degradation of the mammalian CRY1.

PubMed ID: 26431207

DOI: 10.1371/journal.pone.0139725

PubMed ID: 27906959

Title: PCNA-dependent cleavage and degradation of SDE2 regulates response to replication stress.

PubMed ID: 27906959

DOI: 10.1371/journal.pgen.1006465

Sequence Information:

  • Length: 730
  • Mass: 79468
  • Checksum: CE8D54234D44F002
  • Sequence:
    • MLFNSVLRQP QLGVLRNGWS SQYPLQSLLT GYQCSGNDEH TSYGETGVPV PPFGCTFSSA 
PNMEHVLAVA NEEGFVRLYN TESQSFRKKC FKEWMAHWNA VFDLAWVPGE LKLVTAAGDQ 
TAKFWDVKAG ELIGTCKGHQ CSLKSVAFSK FEKAVFCTGG RDGNIMVWDT RCNKKDGFYR 
QVNQISGAHN TSDKQTPSKP KKKQNSKGLA PSVDFQQSVT VVLFQDENTL VSAGAVDGII 
KVWDLRKNYT AYRQEPIASK SFLYPGSSTR KLGYSSLILD STGSTLFANC TDDNIYMFNM 
TGLKTSPVAI FNGHQNSTFY VKSSLSPDDQ FLVSGSSDEA AYIWKVSTPW QPPTVLLGHS 
QEVTSVCWCP SDFTKIATCS DDNTLKIWRL NRGLEEKPGG DKLSTVGWAS QKKKESRPGL 
VTVTSSQSTP AKAPRAKCNP SNSSPSSAAC APSCAGDLPL PSNTPTFSIK TSPAKARSPI 
NRRGSVSSVS PKPPSSFKMS IRNWVTRTPS SSPPITPPAS ETKIMSPRKA LIPVSQKSSQ 
AEACSESRNR VKRRLDSSCL ESVKQKCVKS CNCVTELDGQ VENLHLDLCC LAGNQEDLSK 
DSLGPTKSSK IEGAGTSISE PPSPISPYAS ESCGTLPLPL RPCGEGSEMV GKENSSPENK 
NWLLAMAAKR KAENPSPRSP SSQTPNSRRQ SGKKLPSPVT ITPSSMRKIC TYFHRKSQED 
FCGPEHSTEL

Genular Protein ID: 3483840694

Symbol: B4E0E6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0E6

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 688
  • Mass: 75012
  • Checksum: EFCD91681DCF4E6A
  • Sequence:
    • MLFNSVLRQP QLGVLRNAPN MEHVLAVANE EGFVRLYDTE SQSFRKKCFK EWMAHWNAVF 
DLAWVPGELK LVTAAGDQTA KFWDVKAGEL IGTCKGHQCS LKSVAFSKFE KAVFCTGGRD 
GNIMVWDTRC NKKDGFYRQV NQISGAHNTS DKQTPSKPKK KQNSKGLAPS VDFQQSVTVV 
LFQDENTLVS AGAVDGIIKV WDLRKNYTAY RQEPIASKSF LYPGSSTRKL GYSSLILDST 
GSTLFANCTD DNIYMFNMTG LKTSPVAIFN GHQNSTFYVK SSLSPDDQFL VSGSSDEAAY 
IWKVSTPWQP PTVLLGHSQE VTSVCWCPSD FTKIATCSDD NTLKIWRLNR GLEEKPGGDK 
LSTVGWASQK KKESRPGLVT VTSSQSTPAK APRVKCNPSN SSPSSAACAP SCAGDLPLPS 
NTPTFSIKTS PAKARSPINR RGSVSSVSPK PPSSFKMSIR NWVTRTPSSS PPITPPAPET 
KIMSPRKALI PVSQKSSQAE ACSESRNRVK RRLDSSCLES VKQKCVKSCN CVTELDGQVE 
NLHLDLCCLA GNQEDLSKDS LGPTKSSKIE GAGTSISEPP SPISPYASES CGTLPLPLRP 
CGEGSEMVGK ENSSPENKNW LLAMAAKRKA ENPSPRSPSS QTPNSRRQSG KTLPSPVTIT 
PSSMRKICTY FHRKSQEDFC GPEHSTEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.