Details for: ZC3HC1

Gene ID: 51530

Symbol: ZC3HC1

Ensembl ID: ENSG00000091732

Description: zinc finger C3HC-type containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 91.8704
    Cell Significance Index: -14.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.1168
    Cell Significance Index: -13.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.7963
    Cell Significance Index: -13.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 23.8293
    Cell Significance Index: -15.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.5065
    Cell Significance Index: -15.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3680
    Cell Significance Index: -14.3800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.6909
    Cell Significance Index: 77.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9635
    Cell Significance Index: -15.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6660
    Cell Significance Index: -11.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9049
    Cell Significance Index: 147.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7935
    Cell Significance Index: 157.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7299
    Cell Significance Index: 659.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5524
    Cell Significance Index: 110.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5482
    Cell Significance Index: 59.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5439
    Cell Significance Index: 14.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5020
    Cell Significance Index: 30.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4076
    Cell Significance Index: 31.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3197
    Cell Significance Index: 17.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2721
    Cell Significance Index: 97.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2665
    Cell Significance Index: 9.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2629
    Cell Significance Index: 18.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2046
    Cell Significance Index: 5.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1939
    Cell Significance Index: 5.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1925
    Cell Significance Index: 4.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1808
    Cell Significance Index: 4.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1514
    Cell Significance Index: 14.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1487
    Cell Significance Index: 3.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1320
    Cell Significance Index: 2.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1184
    Cell Significance Index: 13.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1133
    Cell Significance Index: 2.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1075
    Cell Significance Index: 74.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1025
    Cell Significance Index: 2.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0863
    Cell Significance Index: 38.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0699
    Cell Significance Index: 9.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0685
    Cell Significance Index: 37.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0680
    Cell Significance Index: 12.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0671
    Cell Significance Index: 12.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0635
    Cell Significance Index: 3.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0616
    Cell Significance Index: 0.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0602
    Cell Significance Index: 7.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0597
    Cell Significance Index: 3.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0358
    Cell Significance Index: 2.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0283
    Cell Significance Index: 1.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0259
    Cell Significance Index: 0.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0257
    Cell Significance Index: 0.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0233
    Cell Significance Index: 0.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0225
    Cell Significance Index: 0.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0127
    Cell Significance Index: 0.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0112
    Cell Significance Index: 7.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0100
    Cell Significance Index: 18.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0053
    Cell Significance Index: 0.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0038
    Cell Significance Index: 0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0009
    Cell Significance Index: 1.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0061
    Cell Significance Index: -0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0119
    Cell Significance Index: -0.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0133
    Cell Significance Index: -0.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0137
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0139
    Cell Significance Index: -2.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0144
    Cell Significance Index: -2.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0150
    Cell Significance Index: -0.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0168
    Cell Significance Index: -12.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0184
    Cell Significance Index: -13.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0278
    Cell Significance Index: -17.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0317
    Cell Significance Index: -3.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0362
    Cell Significance Index: -1.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0461
    Cell Significance Index: -13.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0502
    Cell Significance Index: -6.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0602
    Cell Significance Index: -1.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0608
    Cell Significance Index: -0.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0626
    Cell Significance Index: -4.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0631
    Cell Significance Index: -7.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0633
    Cell Significance Index: -4.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0723
    Cell Significance Index: -5.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0817
    Cell Significance Index: -17.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0896
    Cell Significance Index: -10.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1386
    Cell Significance Index: -14.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1389
    Cell Significance Index: -4.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1471
    Cell Significance Index: -6.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1503
    Cell Significance Index: -7.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1622
    Cell Significance Index: -3.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1740
    Cell Significance Index: -13.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1812
    Cell Significance Index: -2.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1905
    Cell Significance Index: -11.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2147
    Cell Significance Index: -5.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2192
    Cell Significance Index: -6.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2194
    Cell Significance Index: -11.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2441
    Cell Significance Index: -5.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2456
    Cell Significance Index: -6.5700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2590
    Cell Significance Index: -3.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2653
    Cell Significance Index: -8.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2744
    Cell Significance Index: -8.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2764
    Cell Significance Index: -1.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2956
    Cell Significance Index: -2.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3071
    Cell Significance Index: -10.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZC3HC1 is a member of the polymeric immunoglobulin receptor (Pir) superfamily, characterized by its zinc finger C3HC-type domain. This domain is essential for the protein's ability to bind to specific DNA sequences and regulate gene expression. The ZC3HC1 protein is also known to interact with various proteins, including protein kinases, ubiquitin ligases, and other transcription factors, thereby influencing cellular signaling pathways. **Pathways and Functions:** The ZC3HC1 protein is involved in multiple signaling pathways, including: 1. **Cell division**: ZC3HC1 regulates the expression of genes involved in cell cycle progression, ensuring proper cell division and preventing uncontrolled cell growth. 2. **Disease signaling**: ZC3HC1 interacts with proteins involved in the signaling of growth factor receptors and second messengers, modulating cellular responses to external stimuli. 3. **Cancer signaling**: ZC3HC1 is involved in the regulation of signaling pathways activated by alkylations in cancer cells, influencing tumor growth and progression. 4. **Protein binding**: ZC3HC1 interacts with various proteins, including protein kinases, ubiquitin ligases, and transcription factors, regulating protein interactions and signaling. **Clinical Significance:** The ZC3HC1 gene has been implicated in various diseases, including: 1. **Cancer**: Alterations in ZC3HC1 expression have been linked to cancer development and progression, highlighting its potential as a therapeutic target. 2. **Immunological disorders**: ZC3HC1 is expressed in immune cells, suggesting its involvement in immune responses and potentially contributing to immunological disorders, such as autoimmune diseases. 3. **Hematological disorders**: ZC3HC1 is highly expressed in hematopoietic cells, indicating its potential role in hematological disorders, such as leukemia and lymphoma. In conclusion, the ZC3HC1 gene plays a crucial role in regulating cellular processes, including cell division, signaling, and protein binding. Its involvement in various diseases highlights its potential as a therapeutic target and underscores the importance of further research into its mechanisms of action.

Genular Protein ID: 1426863559

Symbol: ZC3C1_HUMAN

Name: Zinc finger C3HC-type protein 1

UniProtKB Accession Codes:

Q86WB0 A6NH66 Q75MF3 Q75MF4 Q8N330 Q96F75 Q9HA34 Q9NVX4 Q9P0R0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12748172

Title: Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA).

PubMed ID: 12748172

DOI: 10.1074/jbc.m300883200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16009132

Title: NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry.

PubMed ID: 16009132

DOI: 10.1016/j.cell.2005.04.034

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 34440706

Title: ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR.

PubMed ID: 34440706

DOI: 10.3390/cells10081937

Sequence Information:

  • Length: 502
  • Mass: 55262
  • Checksum: D5DEDF9E30070586
  • Sequence:
    • MAAPCEGQAF AVGVEKNWGA VVRSPEGTPQ KIRQLIDEGI APEEGGVDAK DTSATSQSVN 
GSPQAEQPSL ESTSKEAFFS RVETFSSLKW AGKPFELSPL VCAKYGWVTV ECDMLKCSSC 
QAFLCASLQP AFDFDRYKQR CAELKKALCT AHEKFCFWPD SPSPDRFGML PLDEPAILVS 
EFLDRFQSLC HLDLQLPSLR PEDLKTMCLT EDKISLLLHL LEDELDHRTD ERKTTIKLGS 
DIQVHVTACI LSVCGWACSS SLESMQLSLI TCSQCMRKVG LWGFQQIESS MTDLDASFGL 
TSSPIPGLEG RPERLPLVPE SPRRMMTRSQ DATFSPGSEQ AEKSPGPIVS RTRSWDSSSP 
VDRPEPEAAS PTTRTRPVTR SMGTGDTPGL EVPSSPLRKA KRARLCSSSS SDTSSRSFFD 
PTSQHRDWCP WVNITLGKES RENGGTEPDA SAPAEPGWKA VLTILLAHKQ SSQPAETDSM 
SLSEKSRKVF RIFRQWESLC SC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.