Details for: PHF7

Gene ID: 51533

Symbol: PHF7

Ensembl ID: ENSG00000010318

Description: PHD finger protein 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 65.6401
    Cell Significance Index: -10.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.3252
    Cell Significance Index: -8.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.4519
    Cell Significance Index: -10.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.8825
    Cell Significance Index: -10.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.8219
    Cell Significance Index: -12.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5206
    Cell Significance Index: -12.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.1627
    Cell Significance Index: -12.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0083
    Cell Significance Index: -9.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8860
    Cell Significance Index: 40.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8473
    Cell Significance Index: 83.8200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.6832
    Cell Significance Index: 9.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6525
    Cell Significance Index: 39.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6352
    Cell Significance Index: 573.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6127
    Cell Significance Index: 7.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6037
    Cell Significance Index: 65.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5126
    Cell Significance Index: 83.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4875
    Cell Significance Index: 31.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4845
    Cell Significance Index: 6.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4173
    Cell Significance Index: 83.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4158
    Cell Significance Index: 11.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4104
    Cell Significance Index: 11.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3062
    Cell Significance Index: 19.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3021
    Cell Significance Index: 20.9000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2582
    Cell Significance Index: 4.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2581
    Cell Significance Index: 19.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2234
    Cell Significance Index: 4.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1781
    Cell Significance Index: 35.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1607
    Cell Significance Index: 4.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1265
    Cell Significance Index: 45.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1246
    Cell Significance Index: 3.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1185
    Cell Significance Index: 5.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1171
    Cell Significance Index: 21.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1043
    Cell Significance Index: 3.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0982
    Cell Significance Index: 5.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0937
    Cell Significance Index: 4.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0921
    Cell Significance Index: 1.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0897
    Cell Significance Index: 11.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0875
    Cell Significance Index: 2.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0826
    Cell Significance Index: 9.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0803
    Cell Significance Index: 1.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0796
    Cell Significance Index: 1.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0676
    Cell Significance Index: 3.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0673
    Cell Significance Index: 12.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0660
    Cell Significance Index: 45.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0626
    Cell Significance Index: 7.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0613
    Cell Significance Index: 2.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0542
    Cell Significance Index: 102.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0517
    Cell Significance Index: 0.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0508
    Cell Significance Index: 22.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0362
    Cell Significance Index: 0.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0359
    Cell Significance Index: 19.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0307
    Cell Significance Index: 1.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0284
    Cell Significance Index: 52.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0273
    Cell Significance Index: 17.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0259
    Cell Significance Index: 3.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0251
    Cell Significance Index: 0.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0171
    Cell Significance Index: 26.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0166
    Cell Significance Index: 1.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0095
    Cell Significance Index: 4.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0063
    Cell Significance Index: 1.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0039
    Cell Significance Index: 5.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0042
    Cell Significance Index: -0.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0055
    Cell Significance Index: -0.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0073
    Cell Significance Index: -5.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0077
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0153
    Cell Significance Index: -11.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0164
    Cell Significance Index: -9.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0169
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0219
    Cell Significance Index: -13.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0311
    Cell Significance Index: -3.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0338
    Cell Significance Index: -9.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0400
    Cell Significance Index: -0.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0551
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0592
    Cell Significance Index: -12.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0625
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0717
    Cell Significance Index: -8.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0770
    Cell Significance Index: -5.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0855
    Cell Significance Index: -5.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0865
    Cell Significance Index: -9.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0904
    Cell Significance Index: -5.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0941
    Cell Significance Index: -2.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1040
    Cell Significance Index: -1.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1254
    Cell Significance Index: -3.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1290
    Cell Significance Index: -6.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1314
    Cell Significance Index: -10.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1431
    Cell Significance Index: -2.0500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1466
    Cell Significance Index: -1.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1512
    Cell Significance Index: -3.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1583
    Cell Significance Index: -4.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1850
    Cell Significance Index: -5.2800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1965
    Cell Significance Index: -2.4500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2097
    Cell Significance Index: -3.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2124
    Cell Significance Index: -6.7700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2156
    Cell Significance Index: -5.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2201
    Cell Significance Index: -6.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2217
    Cell Significance Index: -7.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2322
    Cell Significance Index: -8.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2338
    Cell Significance Index: -8.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHF7 is a member of the PHD finger protein family, characterized by its PHD finger domain, which is a conserved structural motif involved in protein-protein interactions and binding to specific DNA sequences. The protein's expression is widespread, with significant levels found in hematopoietic cells, epithelial cells, and immune cells, including T cells and mast cells. Its cellular localization is diverse, with detection in the cytosol, nucleus, and plasma membrane. **Pathways and Functions:** PHF7's functional pathways are not yet fully elucidated, but its involvement in various cellular processes suggests its potential role in: 1. **Chromatin remodeling**: PHF7's PHD finger domain may interact with histone-modifying enzymes, influencing chromatin structure and gene expression. 2. **Transcriptional regulation**: PHF7 may act as a transcriptional regulator, modulating the expression of specific genes involved in cell growth, differentiation, and survival. 3. **Protein-protein interactions**: PHF7's PHD finger domain may interact with other proteins, influencing cellular signaling pathways and protein stability. 4. **Cellular stress response**: PHF7 may play a role in regulating cellular responses to environmental stressors, such as oxidative stress and DNA damage. **Clinical Significance:** PHF7's involvement in various cellular processes and its expression in diverse cell types suggest its potential role in maintaining cellular homeostasis and regulating cellular responses to environmental stimuli. However, the clinical significance of PHF7 remains largely unknown. Further research is needed to elucidate the protein's function and to determine its potential involvement in human diseases. Potential areas of investigation include: 1. **Cancer research**: PHF7's involvement in chromatin remodeling and transcriptional regulation may make it a potential target for cancer therapy. 2. **Immunological disorders**: PHF7's expression in immune cells may suggest its potential role in regulating immune responses and modulating autoimmune diseases. 3. **Neurological disorders**: PHF7's involvement in protein-protein interactions and cellular stress response may make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PHF7 is a gene with a complex and multifaceted role in cellular processes. Further research is needed to elucidate its function and to determine its potential clinical significance.

Genular Protein ID: 412889340

Symbol: PHF7_HUMAN

Name: PHD finger protein 7

UniProtKB Accession Codes:

Q9BWX1 K4DI82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11829468

Title: NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis.

PubMed ID: 11829468

DOI: 10.1006/bbrc.2002.6396

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 381
  • Mass: 43767
  • Checksum: 5219D262D8135B8D
  • Sequence:
    • MKTVKEKKEC QRLRKSAKTR RVTQRKPSSG PVCWLCLREP GDPEKLGEFL QKDNISVHYF 
CLILSSKLPQ RGQSNRGFHG FLPEDIKKEA ARASRKICFV CKKKGAAINC QKDQCLRNFH 
LPCGQERGCL SQFFGEYKSF CDKHRPTQNI QHGHVGEESC ILCCEDLSQQ SVENIQSPCC 
SQAIYHRKCI QKYAHTSAKH FFKCPQCNNR KEFPQEMLRM GIHIPDRDAA WELEPGAFSD 
LYQRYQHCDA PICLYEQGRD SFEDEGRWCL ILCATCGSHG THRDCSSLRS NSKKWECEEC 
SPAAATDYIP ENSGDIPCCS STFHPEEHFC RDNTLEENPG LSWTDWPEPS LLEKPESSRG 
RRSYSWRSKG VRITNSCKKS K

Genular Protein ID: 4031032111

Symbol: A8K856_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K856

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 Pfam 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 381
  • Mass: 43751
  • Checksum: 3E030904EA7BF299
  • Sequence:
    • MKTVKEKKEC QRLRKSAKTR RVTQRKPSSG PVCWLCLREP GDPEKLGEFL QKDNISVHYF 
CLILSSKLPQ RGQSNRGFHG FLPEDIKKEA ARASRKICFV CKKKGAAINC QKDQCLRNFH 
LPCGQERGCL SQFFGEYKSF CDKHRPTQNI QHGHVGEESC ILCCEDLSQQ SVENIQSPCC 
SQAIYHRKCI QKYAHTSAKH FFKCPQCNNR KEFPQEMPRM GIHIPDRDAA WELEPGAFSD 
LYQRYQHCDA PICLYEQGRD SFEDEGRWCL ILCATCGSHG THRDCSSLRS NSKKWECEEC 
SPAAATDYIP ENSGDIPCCS STFHPEEHFC RDNTLEENPG LSWTDWPEPS LLEKPESSRG 
RRSYSWRSKG VRITNSCKKS K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.