Details for: PPHLN1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 352.3413
Cell Significance Index: -54.8100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 200.7149
Cell Significance Index: -50.9100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 161.5133
Cell Significance Index: -66.5400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 143.0349
Cell Significance Index: -67.5300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 138.8037
Cell Significance Index: -56.3900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 127.1226
Cell Significance Index: -65.3900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 59.7334
Cell Significance Index: -57.0300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 52.0822
Cell Significance Index: -64.2200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 20.1696
Cell Significance Index: -61.9500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.6576
Cell Significance Index: -52.6600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 16.8548
Cell Significance Index: -66.5100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.8113
Cell Significance Index: -25.8500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.3799
Cell Significance Index: 477.4000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.0660
Cell Significance Index: 410.0100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.8477
Cell Significance Index: 25.2100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.5136
Cell Significance Index: 42.3000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.5111
Cell Significance Index: 542.0200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.4328
Cell Significance Index: 37.6800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.3730
Cell Significance Index: 77.0500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3087
Cell Significance Index: 905.1300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.2855
Cell Significance Index: 48.6800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.2235
Cell Significance Index: 54.1200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1728
Cell Significance Index: 127.5700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9688
Cell Significance Index: 174.6500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9144
Cell Significance Index: 112.4300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.8938
Cell Significance Index: 60.1000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8362
Cell Significance Index: 114.8400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.8199
Cell Significance Index: 362.4800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7972
Cell Significance Index: 94.0200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.7813
Cell Significance Index: 16.7000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.7619
Cell Significance Index: 49.1600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7600
Cell Significance Index: 58.3300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7538
Cell Significance Index: 46.3400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6922
Cell Significance Index: 625.0300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6524
Cell Significance Index: 356.3000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.6080
Cell Significance Index: 63.3000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6029
Cell Significance Index: 16.4100 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.5872
Cell Significance Index: 11.4600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5014
Cell Significance Index: 23.5700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4770
Cell Significance Index: 61.6300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.4329
Cell Significance Index: 55.5000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3989
Cell Significance Index: 29.7300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3570
Cell Significance Index: 35.3200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3126
Cell Significance Index: 16.2400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3098
Cell Significance Index: 8.8400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2168
Cell Significance Index: 408.2600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.2130
Cell Significance Index: 7.4000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2085
Cell Significance Index: 9.7200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1806
Cell Significance Index: 12.7700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1630
Cell Significance Index: 4.1900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1577
Cell Significance Index: 4.5500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1524
Cell Significance Index: 29.0000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1513
Cell Significance Index: 68.6600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1283
Cell Significance Index: 197.4500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1255
Cell Significance Index: 2.1500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1178
Cell Significance Index: 217.2900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0824
Cell Significance Index: 52.3100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0737
Cell Significance Index: 2.5900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0420
Cell Significance Index: 7.1700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0397
Cell Significance Index: 53.9200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0183
Cell Significance Index: 0.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0079
Cell Significance Index: 0.2100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0007
Cell Significance Index: -0.1100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0337
Cell Significance Index: -24.9500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0447
Cell Significance Index: -32.7900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0566
Cell Significance Index: -3.5700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0575
Cell Significance Index: -43.5100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0696
Cell Significance Index: -43.4400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0770
Cell Significance Index: -43.4000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1030
Cell Significance Index: -5.4100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1080
Cell Significance Index: -11.0300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1577
Cell Significance Index: -4.2200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1927
Cell Significance Index: -40.5800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1935
Cell Significance Index: -55.6900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2165
Cell Significance Index: -5.5300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2188
Cell Significance Index: -25.5000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2223
Cell Significance Index: -11.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2245
Cell Significance Index: -32.6400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2420
Cell Significance Index: -4.0500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2486
Cell Significance Index: -7.3000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3263
Cell Significance Index: -3.8900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3491
Cell Significance Index: -39.9900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4328
Cell Significance Index: -10.8200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5105
Cell Significance Index: -58.2700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5164
Cell Significance Index: -16.5400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.6160
Cell Significance Index: -27.9200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6363
Cell Significance Index: -13.2000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6753
Cell Significance Index: -14.6300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7121
Cell Significance Index: -56.4000 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.8145
Cell Significance Index: -12.0300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8558
Cell Significance Index: -52.4700 - Cell Name: peg cell (CL4033014)
Fold Change: -0.8765
Cell Significance Index: -20.2500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.9259
Cell Significance Index: -19.7200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.9578
Cell Significance Index: -8.8200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.0358
Cell Significance Index: -21.6800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.0465
Cell Significance Index: -30.0000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0858
Cell Significance Index: -29.0500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0993
Cell Significance Index: -35.0100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1006
Cell Significance Index: -23.3600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1526
Cell Significance Index: -33.9500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2282487819
Symbol: PPHLN_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12087473
Title: Serological identification and expression analysis of gastric cancer-associated genes.
PubMed ID: 12087473
PubMed ID: 12853457
Title: Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope.
PubMed ID: 12853457
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15474462
Title: Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest.
PubMed ID: 15474462
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17963697
Title: CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.
PubMed ID: 17963697
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 26022416
Title: Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
PubMed ID: 26022416
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30487602
Title: NP220 mediates silencing of unintegrated retroviral DNA.
PubMed ID: 30487602
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 458
- Mass: 52737
- Checksum: FE5AAC9A6875A455
- Sequence:
MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.