Details for: PPHLN1

Gene ID: 51535

Symbol: PPHLN1

Ensembl ID: ENSG00000134283

Description: periphilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 352.3413
    Cell Significance Index: -54.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.7149
    Cell Significance Index: -50.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 161.5133
    Cell Significance Index: -66.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 143.0349
    Cell Significance Index: -67.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 138.8037
    Cell Significance Index: -56.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 127.1226
    Cell Significance Index: -65.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.7334
    Cell Significance Index: -57.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 52.0822
    Cell Significance Index: -64.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.1696
    Cell Significance Index: -61.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.6576
    Cell Significance Index: -52.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.8548
    Cell Significance Index: -66.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.8113
    Cell Significance Index: -25.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3799
    Cell Significance Index: 477.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0660
    Cell Significance Index: 410.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8477
    Cell Significance Index: 25.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5136
    Cell Significance Index: 42.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5111
    Cell Significance Index: 542.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4328
    Cell Significance Index: 37.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3730
    Cell Significance Index: 77.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.3087
    Cell Significance Index: 905.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2855
    Cell Significance Index: 48.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2235
    Cell Significance Index: 54.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1728
    Cell Significance Index: 127.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9688
    Cell Significance Index: 174.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9144
    Cell Significance Index: 112.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8938
    Cell Significance Index: 60.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8362
    Cell Significance Index: 114.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8199
    Cell Significance Index: 362.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7972
    Cell Significance Index: 94.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7813
    Cell Significance Index: 16.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7619
    Cell Significance Index: 49.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7600
    Cell Significance Index: 58.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7538
    Cell Significance Index: 46.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6922
    Cell Significance Index: 625.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6524
    Cell Significance Index: 356.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.6080
    Cell Significance Index: 63.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6029
    Cell Significance Index: 16.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5872
    Cell Significance Index: 11.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5014
    Cell Significance Index: 23.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4770
    Cell Significance Index: 61.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4329
    Cell Significance Index: 55.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3989
    Cell Significance Index: 29.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3570
    Cell Significance Index: 35.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3126
    Cell Significance Index: 16.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3098
    Cell Significance Index: 8.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2168
    Cell Significance Index: 408.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2130
    Cell Significance Index: 7.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2085
    Cell Significance Index: 9.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1806
    Cell Significance Index: 12.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1630
    Cell Significance Index: 4.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1577
    Cell Significance Index: 4.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1524
    Cell Significance Index: 29.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1513
    Cell Significance Index: 68.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1283
    Cell Significance Index: 197.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1255
    Cell Significance Index: 2.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1178
    Cell Significance Index: 217.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0824
    Cell Significance Index: 52.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0737
    Cell Significance Index: 2.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0420
    Cell Significance Index: 7.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0397
    Cell Significance Index: 53.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0183
    Cell Significance Index: 0.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0079
    Cell Significance Index: 0.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0007
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0447
    Cell Significance Index: -32.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0566
    Cell Significance Index: -3.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0575
    Cell Significance Index: -43.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0696
    Cell Significance Index: -43.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0770
    Cell Significance Index: -43.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1030
    Cell Significance Index: -5.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1080
    Cell Significance Index: -11.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1577
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1927
    Cell Significance Index: -40.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1935
    Cell Significance Index: -55.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2165
    Cell Significance Index: -5.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2188
    Cell Significance Index: -25.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2223
    Cell Significance Index: -11.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2245
    Cell Significance Index: -32.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2420
    Cell Significance Index: -4.0500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2486
    Cell Significance Index: -7.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3263
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3491
    Cell Significance Index: -39.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4328
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5105
    Cell Significance Index: -58.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5164
    Cell Significance Index: -16.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6160
    Cell Significance Index: -27.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6363
    Cell Significance Index: -13.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6753
    Cell Significance Index: -14.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7121
    Cell Significance Index: -56.4000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8145
    Cell Significance Index: -12.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8558
    Cell Significance Index: -52.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8765
    Cell Significance Index: -20.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9259
    Cell Significance Index: -19.7200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9578
    Cell Significance Index: -8.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.0358
    Cell Significance Index: -21.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0465
    Cell Significance Index: -30.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0858
    Cell Significance Index: -29.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0993
    Cell Significance Index: -35.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1006
    Cell Significance Index: -23.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1526
    Cell Significance Index: -33.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPHLN1 is a non-coding gene that is encoded by a single copy gene located on chromosome 5q31.3. It is highly expressed in various cell types, including hematopoietic oligopotent progenitor cells, embryonic stem cells, and smooth muscle fibers of the ileum. PPHLN1 is also found to be highly expressed in immune cells, such as CD8-positive, alpha-beta regulatory T cells, and alpha-beta intraepithelial T cells, suggesting its role in the regulation of immune responses. The gene is involved in the regulation of epigenetic processes, including DNA methylation-dependent heterochromatin formation and the regulation of endogenous retroelements. **Pathways and Functions:** PPHLN1 is involved in several key pathways, including: 1. **Epigenetic regulation of gene expression:** PPHLN1 regulates the expression of genes through mechanisms involving DNA methylation and histone modification. 2. **Regulation of endogenous retroelements:** PPHLN1 is involved in the regulation of endogenous retroelements, which are non-coding sequences that are derived from retroviral infections. 3. **Regulation of DNA-templated transcription:** PPHLN1 regulates the transcription of genes through mechanisms involving the recruitment of transcription factors and chromatin remodeling complexes. 4. **Protein binding and localization:** PPHLN1 is involved in the regulation of protein binding and localization to heterochromatin, which is a highly compacted form of chromatin that is involved in gene silencing. **Clinical Significance:** The clinical significance of PPHLN1 is an area of active research. Recent studies have suggested that PPHLN1 may play a role in the development and progression of various human diseases, including cancer and autoimmune disorders. For example, PPHLN1 has been found to be overexpressed in certain types of cancer, including breast cancer and colon cancer, suggesting its potential role as a tumor suppressor gene. Additionally, PPHLN1 has been found to be involved in the regulation of immune responses, which may have implications for the treatment of autoimmune disorders. In conclusion, PPHLN1 is a gene that plays a critical role in the regulation of gene expression and epigenetic processes in various cell types. Its involvement in the regulation of immune responses and its potential implications in human diseases make it an area of active research and a potential target for the development of new therapeutic strategies. **Future Directions:** Further research is needed to fully understand the role of PPHLN1 in human diseases. Some potential future directions include: 1. **Investigating the role of PPHLN1 in cancer:** Further studies are needed to determine whether PPHLN1 is involved in the development and progression of various types of cancer. 2. **Investigating the role of PPHLN1 in autoimmune disorders:** Further studies are needed to determine whether PPHLN1 is involved in the regulation of immune responses in autoimmune disorders. 3. **Investigating the role of PPHLN1 in developmental biology:** Further studies are needed to determine whether PPHLN1 plays a role in the development and differentiation of various cell types. Overall, PPHLN1 is a gene that plays a critical role in the regulation of gene expression and epigenetic processes in various cell types. Further research is needed to fully understand its role in human diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 2282487819

Symbol: PPHLN_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12087473

Title: Serological identification and expression analysis of gastric cancer-associated genes.

PubMed ID: 12087473

DOI: 10.1038/sj.bjc.6600321

PubMed ID: 12853457

Title: Characterization of periphilin, a widespread, highly insoluble nuclear protein and potential constituent of the keratinocyte cornified envelope.

PubMed ID: 12853457

DOI: 10.1074/jbc.m303896200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15474462

Title: Overexpression of CR/periphilin downregulates Cdc7 expression and induces S-phase arrest.

PubMed ID: 15474462

DOI: 10.1016/j.bbrc.2004.09.083

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17963697

Title: CR/periphilin is a transcriptional co-repressor involved in cell cycle progression.

PubMed ID: 17963697

DOI: 10.1016/j.bbrc.2007.10.090

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26022416

Title: Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

PubMed ID: 26022416

DOI: 10.1126/science.aaa7227

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30487602

Title: NP220 mediates silencing of unintegrated retroviral DNA.

PubMed ID: 30487602

DOI: 10.1038/s41586-018-0750-6

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 458
  • Mass: 52737
  • Checksum: FE5AAC9A6875A455
  • Sequence:
  • MWSEGRYEYE RIPRERAPPR SHPSDGYNRL VNIVPKKPPL LDRPGEGSYN RYYSHVDYRD 
    YDEGRSFSHD RRSGPPHRGD ESGYRWTRDD HSASRQPEYR DMRDGFRRKS FYSSHYARER 
    SPYKRDNTFF RESPVGRKDS PHSRSGSSVS SRSYSPERSK SYSFHQSQHR KSVRPGASYK 
    RQNEGNPERD KERPVQSLKT SRDTSPSSGS AVSSSKVLDK PSRLTEKELA EAASKWAAEK 
    LEKSDESNLP EISEYEAGST APLFTDQPEE PESNTTHGIE LFEDSQLTTR SKAIASKTKE 
    IEQVYRQDCE TFGMVVKMLI EKDPSLEKSI QFALRQNLHE IESAGQTWQQ VPPVRNTEMD 
    HDGTPENEGE ETAQSAPQPP QAPQPLQPRK KRVRRTTQLR RTTGAPDITW GMLKKTTQEA 
    ERILLRTQTP FTPENLFLAM LSVVHCNSRK DVKPENKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.