Details for: SIRT6

Gene ID: 51548

Symbol: SIRT6

Ensembl ID: ENSG00000077463

Description: sirtuin 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 81.2304
    Cell Significance Index: -12.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 54.9985
    Cell Significance Index: -13.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.0148
    Cell Significance Index: -14.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.5885
    Cell Significance Index: -16.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.6883
    Cell Significance Index: -16.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.4403
    Cell Significance Index: -16.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.9674
    Cell Significance Index: -14.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.6343
    Cell Significance Index: -15.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1981
    Cell Significance Index: -13.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0876
    Cell Significance Index: -16.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.2753
    Cell Significance Index: -10.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.2023
    Cell Significance Index: -4.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5807
    Cell Significance Index: 25.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2729
    Cell Significance Index: 57.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1967
    Cell Significance Index: 1080.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9849
    Cell Significance Index: 59.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8693
    Cell Significance Index: 13.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7978
    Cell Significance Index: 129.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5070
    Cell Significance Index: 35.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4631
    Cell Significance Index: 13.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4601
    Cell Significance Index: 13.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4219
    Cell Significance Index: 9.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4199
    Cell Significance Index: 49.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3918
    Cell Significance Index: 5.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3579
    Cell Significance Index: 18.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3454
    Cell Significance Index: 65.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2941
    Cell Significance Index: 8.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2779
    Cell Significance Index: 7.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2645
    Cell Significance Index: 17.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2387
    Cell Significance Index: 47.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2098
    Cell Significance Index: 114.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2092
    Cell Significance Index: 20.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2080
    Cell Significance Index: 2.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1904
    Cell Significance Index: 34.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1726
    Cell Significance Index: 9.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1725
    Cell Significance Index: 23.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1560
    Cell Significance Index: 19.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1424
    Cell Significance Index: 51.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1338
    Cell Significance Index: 2.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1305
    Cell Significance Index: 57.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1274
    Cell Significance Index: 8.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1183
    Cell Significance Index: 3.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1123
    Cell Significance Index: 22.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1011
    Cell Significance Index: 2.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0963
    Cell Significance Index: 4.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0927
    Cell Significance Index: 11.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0800
    Cell Significance Index: 2.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0800
    Cell Significance Index: 5.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0791
    Cell Significance Index: 54.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0695
    Cell Significance Index: 1.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0574
    Cell Significance Index: 0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0308
    Cell Significance Index: 5.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0174
    Cell Significance Index: 0.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0114
    Cell Significance Index: 0.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0025
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0100
    Cell Significance Index: -15.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0105
    Cell Significance Index: -0.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0108
    Cell Significance Index: -1.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0117
    Cell Significance Index: -15.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0125
    Cell Significance Index: -0.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0137
    Cell Significance Index: -8.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0141
    Cell Significance Index: -10.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0168
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0179
    Cell Significance Index: -2.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0226
    Cell Significance Index: -10.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0256
    Cell Significance Index: -14.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0274
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0275
    Cell Significance Index: -17.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0455
    Cell Significance Index: -13.0900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0540
    Cell Significance Index: -0.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0543
    Cell Significance Index: -3.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0549
    Cell Significance Index: -7.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0549
    Cell Significance Index: -1.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0590
    Cell Significance Index: -6.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0743
    Cell Significance Index: -5.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0832
    Cell Significance Index: -17.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1064
    Cell Significance Index: -2.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1246
    Cell Significance Index: -3.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1440
    Cell Significance Index: -9.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1453
    Cell Significance Index: -8.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1502
    Cell Significance Index: -15.6400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1648
    Cell Significance Index: -1.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1787
    Cell Significance Index: -14.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2013
    Cell Significance Index: -3.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2060
    Cell Significance Index: -2.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2162
    Cell Significance Index: -4.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2323
    Cell Significance Index: -14.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2332
    Cell Significance Index: -1.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2351
    Cell Significance Index: -6.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2565
    Cell Significance Index: -11.3500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2607
    Cell Significance Index: -2.1900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2638
    Cell Significance Index: -1.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2665
    Cell Significance Index: -6.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2710
    Cell Significance Index: -7.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2976
    Cell Significance Index: -11.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2979
    Cell Significance Index: -8.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Deacetylase enzyme**: SIRT6 is a member of the sirtuin family of proteins, which are characterized by their ability to remove acetyl groups from lysine residues on target proteins. 2. **DNA damage response**: SIRT6 is involved in the regulation of DNA damage response pathways, including base-excision repair, double-strand break repair, and homologous recombination. 3. **Metabolic regulation**: SIRT6 regulates metabolic processes, including glucose homeostasis, ketone biosynthesis, and lipid catabolism. 4. **Cell cycle regulation**: SIRT6 regulates cell cycle progression, including the regulation of the cell cycle checkpoint and the maintenance of telomeres. 5. **Stem cell maintenance**: SIRT6 is involved in the regulation of stem cell maintenance, including the regulation of stem cell proliferation, differentiation, and self-renewal. **Pathways and Functions** SIRT6 is involved in various pathways, including: 1. **Base-excision repair**: SIRT6 regulates the activity of DNA repair enzymes involved in base-excision repair, including OGG1 and APE1. 2. **Double-strand break repair**: SIRT6 regulates the activity of DNA repair enzymes involved in double-strand break repair, including BRCA1 and BRCA2. 3. **Homologous recombination**: SIRT6 regulates the activity of DNA repair enzymes involved in homologous recombination, including RAD51 and BRCA1. 4. **Glucose homeostasis**: SIRT6 regulates glucose homeostasis by regulating the activity of key enzymes involved in glucose metabolism, including PDK1 and AMPK. 5. **Ketone biosynthesis**: SIRT6 regulates ketone biosynthesis by regulating the activity of key enzymes involved in ketone metabolism, including PDK1 and HMGCS1. **Clinical Significance** Dysregulation of SIRT6 has been implicated in various diseases, including: 1. **Cancer**: SIRT6 dysregulation has been implicated in the development and progression of various cancers, including breast cancer, colon cancer, and lung cancer. 2. **Metabolic disorders**: SIRT6 dysregulation has been implicated in the development of metabolic disorders, including type 2 diabetes, metabolic syndrome, and obesity. 3. **Neurodegenerative diseases**: SIRT6 dysregulation has been implicated in the development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Aging**: SIRT6 dysregulation has been implicated in the aging process, including the regulation of telomere length and the maintenance of cellular homeostasis. In conclusion, SIRT6 is a multifunctional protein that plays a critical role in regulating various cellular processes, including DNA repair, metabolism, and cell cycle regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of SIRT6 in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 242669005

Symbol: SIR6_HUMAN

Name: SIR2-like protein 6

UniProtKB Accession Codes:

Q8N6T7 B2RCD0 O75291 Q6IAF5 Q6PK99 Q8NCD2 Q9BSI5 Q9BWP3 Q9NRC7 Q9UQD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 45 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 10 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 9 Rhea 20 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873683

Title: Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins.

PubMed ID: 10873683

DOI: 10.1006/bbrc.2000.3000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16079181

Title: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

PubMed ID: 16079181

DOI: 10.1091/mbc.e05-01-0033

PubMed ID: 18337721

Title: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

PubMed ID: 18337721

DOI: 10.1038/nature06736

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19135889

Title: SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

PubMed ID: 19135889

DOI: 10.1016/j.cell.2008.10.052

PubMed ID: 19625767

Title: Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

PubMed ID: 19625767

DOI: 10.4161/cc.8.16.9367

PubMed ID: 20829486

Title: Human SIRT6 promotes DNA end resection through CtIP deacetylation.

PubMed ID: 20829486

DOI: 10.1126/science.1192049

PubMed ID: 30975768

Title:

PubMed ID: 30975768

DOI: 10.1126/science.aax4558

PubMed ID: 21847107

Title: SIRT6 is required for maintenance of telomere position effect in human cells.

PubMed ID: 21847107

DOI: 10.1038/ncomms1443

PubMed ID: 21680843

Title: SIRT6 promotes DNA repair under stress by activating PARP1.

PubMed ID: 21680843

DOI: 10.1126/science.1202723

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23217706

Title: The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

PubMed ID: 23217706

DOI: 10.1016/j.cell.2012.10.047

PubMed ID: 23142079

Title: The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

PubMed ID: 23142079

DOI: 10.1016/j.molcel.2012.09.030

PubMed ID: 22753495

Title: Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

PubMed ID: 22753495

DOI: 10.1073/pnas.1200583109

PubMed ID: 24012758

Title: Multiple regulatory layers of SREBP1/2 by SIRT6.

PubMed ID: 24012758

DOI: 10.1016/j.celrep.2013.08.006

PubMed ID: 23653361

Title: The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells.

PubMed ID: 23653361

DOI: 10.1074/jbc.m112.405928

PubMed ID: 24052263

Title: Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.

PubMed ID: 24052263

DOI: 10.1074/jbc.c113.511261

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23911928

Title: SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

PubMed ID: 23911928

DOI: 10.1016/j.molcel.2013.06.018

PubMed ID: 24043303

Title: The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.

PubMed ID: 24043303

DOI: 10.1128/mcb.00480-13

PubMed ID: 23892288

Title: SIRT6 exhibits nucleosome-dependent deacetylase activity.

PubMed ID: 23892288

DOI: 10.1093/nar/gkt642

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25541994

Title: SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

PubMed ID: 25541994

DOI: 10.1371/journal.pone.0115616

PubMed ID: 25009184

Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

PubMed ID: 25009184

DOI: 10.1073/pnas.1411026111

PubMed ID: 25915124

Title: The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

PubMed ID: 25915124

DOI: 10.1038/ncb3147

PubMed ID: 26748705

Title: Reciprocal regulation between SIRT6 and miR-122 controls liver metabolism and predicts hepatocarcinoma prognosis.

PubMed ID: 26748705

DOI: 10.1016/j.celrep.2015.12.023

PubMed ID: 27568560

Title: JNK phosphorylates SIRT6 to stimulate DNA double-strand break repair in response to oxidative stress by recruiting PARP1 to DNA Breaks.

PubMed ID: 27568560

DOI: 10.1016/j.celrep.2016.08.006

PubMed ID: 27912097

Title: LncPRESS1 is a p53-regulated lncRNA that safeguards pluripotency by disrupting SIRT6-mediated de-acetylation of histone H3K56.

PubMed ID: 27912097

DOI: 10.1016/j.molcel.2016.10.039

PubMed ID: 27322069

Title: Identifying the functional contribution of the defatty-acylase activity of SIRT6.

PubMed ID: 27322069

DOI: 10.1038/nchembio.2106

PubMed ID: 27043296

Title: SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.

PubMed ID: 27043296

DOI: 10.1038/nsmb.3202

PubMed ID: 26898756

Title: A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.

PubMed ID: 26898756

DOI: 10.1038/onc.2016.24

PubMed ID: 26787900

Title: SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.

PubMed ID: 26787900

DOI: 10.1073/pnas.1520045113

PubMed ID: 29474172

Title: Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.

PubMed ID: 29474172

DOI: 10.7554/elife.32127

PubMed ID: 28406396

Title: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.

PubMed ID: 28406396

DOI: 10.7554/elife.25158

PubMed ID: 27180906

Title: SIRT6 suppresses pancreatic cancer through control of Lin28b.

PubMed ID: 27180906

DOI: 10.1016/j.cell.2016.04.033

PubMed ID: 31995034

Title: SIRT6 is a DNA double-strand break sensor.

PubMed ID: 31995034

DOI: 10.7554/elife.51636

PubMed ID: 32538779

Title: Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.

PubMed ID: 32538779

DOI: 10.7554/elife.55828

PubMed ID: 33122195

Title: Nitro-fatty acids as activators of hSIRT6 deacetylase activity.

PubMed ID: 33122195

DOI: 10.1074/jbc.ra120.014883

PubMed ID: 33067423

Title: Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6.

PubMed ID: 33067423

DOI: 10.1038/s41467-020-19018-y

PubMed ID: 32789493

Title: The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.

PubMed ID: 32789493

DOI: 10.1093/nar/gkaa661

PubMed ID: 37023208

Title: Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1).

PubMed ID: 37023208

DOI: 10.1371/journal.ppat.1011324

PubMed ID: 21362626

Title: Structure and biochemical functions of SIRT6.

PubMed ID: 21362626

DOI: 10.1074/jbc.m111.218990

PubMed ID: 23552949

Title: SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine.

PubMed ID: 23552949

DOI: 10.1038/nature12038

PubMed ID: 27990725

Title: Structural basis of sirtuin 6 activation by synthetic small molecules.

PubMed ID: 27990725

DOI: 10.1002/anie.201610082

PubMed ID: 30395713

Title: Structural basis of sirtuin 6 inhibition by the hydroxamate trichostatin A: implications for protein deacylase drug development.

PubMed ID: 30395713

DOI: 10.1021/acs.jmedchem.8b01455

PubMed ID: 30374165

Title: Identification of a cellularly active SIRT6 allosteric activator.

PubMed ID: 30374165

DOI: 10.1038/s41589-018-0150-0

PubMed ID: 31844103

Title: Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.

PubMed ID: 31844103

DOI: 10.1038/s41598-019-55654-1

PubMed ID: 33214841

Title: Structural basis for activation of human sirtuin 6 by fluvastatin.

PubMed ID: 33214841

DOI: 10.1021/acsmedchemlett.0c00407

PubMed ID: 33649599

Title: Binding site for activator MDL-801 on SIRT6.

PubMed ID: 33649599

DOI: 10.1038/s41589-021-00749-y

PubMed ID: 33649600

Title: Reply to: Binding site for MDL-801 on SIRT6.

PubMed ID: 33649600

DOI: 10.1038/s41589-021-00750-5

PubMed ID: 26456828

Title: Identification of and molecular basis for SIRT6 loss-of-function point mutations in cancer.

PubMed ID: 26456828

DOI: 10.1016/j.celrep.2015.09.022

PubMed ID: 29555651

Title: An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

PubMed ID: 29555651

DOI: 10.1101/gad.307330.117

Sequence Information:

  • Length: 355
  • Mass: 39119
  • Checksum: 0C86AAC497130BBF
  • Sequence:
    • MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG 
IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV 
RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE 
LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN 
LQPTKHDRHA DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK 
EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS

Genular Protein ID: 942459007

Symbol: M0QXA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0QXA0

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 187
  • Mass: 20078
  • Checksum: 7410BAB73DB086B2
  • Sequence:
    • MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG 
IPDFRDKLAE LHGNMFVEEC AKCKTQYVRD TVVGTMGLKA TGRLCTVAKA RGLRACRGEL 
RDTILDWEDS LPDRDLALAD EASRSGPAGT CRWLPSAGEA AWSSSTCSPP STTAMLTSAS 
MATLTRS

Genular Protein ID: 3488448542

Symbol: B4DDV3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDV3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 IntAct 1 InterPro 4 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 283
  • Mass: 31319
  • Checksum: 775740F80DA0ACE4
  • Sequence:
    • MEERGLAPKF DTTFESARPT QTHMALVQLE RVGLLRFLVS QNVDGLHVRS GFPRDKLAEL 
HGNMFVEECA KCKTQYVRDT VVGTMGLKAT GRLCTVAKAR GLRACRGELR DTILDWEDSL 
PDRDLALADE ASRNADLSIT LGTSLQIRPS GNLPLATKRR GGRLVIVNLQ PTKHDRHADL 
RIHGYVDEVM TRLMKHLGLE IPAWDGPRVL ERALPPLPRP PTPKLEPKEE SPTRINGSIP 
AGPKQEPCAQ HNGSEPASPK RERPTSPAPH RPPKRVKAKA VPS

Genular Protein ID: 1247378192

Symbol: M0R1N9_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0R1N9

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 176
  • Mass: 19135
  • Checksum: D6F6E03CE6780C47
  • Sequence:
    • MEERGLAPKF DTTFESARPT QTHMALVQLE RVGLLRFLVS QNVDGLHVRS GFPRDKLAEL 
HGNMFVEECA KCKTQYVRDT VVGTMGLKAT GRLCTVAKAR GLRACRGELR DTILDWEDSL 
PDRDLALADE ASRSGPAGTC RWLPSAGEAA WSSSTCSPPS TTAMLTSASM ATLTRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.