Details for: SIRT6

Gene ID: 51548

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: SIRT6

Ensembl ID: ENSG00000077463

Description: sirtuin 6

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • colon epithelial cell CL0011108
    CSI 13.83
    rCSI 14.48%
    PRS 90.04
  • basal cell of epidermis CL0002187
    CSI 7.36
    rCSI 13.05%
    PRS 65.07
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 4.38
    rCSI 4.3%
    PRS 98.15
  • interneuron CL0000099
    CSI 4.22
    rCSI 8.48%
    PRS 86.92
  • myeloid leukocyte CL0000766
    CSI 4.12
    rCSI 3.8%
    PRS 93.33
  • intestine goblet cell CL0019031
    CSI 3.9
    rCSI 3.46%
    PRS 89.87
  • rod bipolar cell CL0000751
    CSI 3.54
    rCSI 6.37%
    PRS 87.77
  • colonocyte CL1000347
    CSI 3.48
    rCSI 4.99%
    PRS 90.25
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.94
    rCSI 8.68%
    PRS 91.66
  • plasmacytoid dendritic cell, human CL0001058
    CSI 2.88
    rCSI 2.01%
    PRS 94.91
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 2.87
    rCSI 1.91%
    PRS 96.43
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.84
    rCSI 2.19%
    PRS 94.85
  • erythrocyte CL0000232
    CSI 2.83
    rCSI 6.42%
    PRS 90.1
  • goblet cell CL0000160
    CSI 2.69
    rCSI 2.54%
    PRS 90.16
  • extravillous trophoblast CL0008036
    CSI 2.62
    rCSI 3.25%
    PRS 90.72
  • mesodermal cell CL0000222
    CSI 2.62
    rCSI 3.14%
    PRS 91.14
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.5
    rCSI 2.89%
    PRS 85.32
  • CD14-positive monocyte CL0001054
    CSI 2.44
    rCSI 3.04%
    PRS 96.76
  • melanocyte of skin CL1000458
    CSI 2.35
    rCSI 3.2%
    PRS 64.81
  • club cell CL0000158
    CSI 2.07
    rCSI 3.04%
    PRS 88.35
  • peripheral nervous system neuron CL2000032
    CSI 1.85
    rCSI 2.52%
    PRS 86.25
  • retina horizontal cell CL0000745
    CSI 1.7
    rCSI 2.6%
    PRS 89.18
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 1.69
    rCSI 2.16%
    PRS 88.81
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.6
    rCSI 2.69%
    PRS 80.9
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.38
    rCSI 2.44%
    PRS 80.25
  • mesenchymal cell CL0008019
    CSI 1.32
    rCSI 3.34%
    PRS 87.74
  • suprabasal keratinocyte CL4033013
    CSI 1.07
    rCSI 1.75%
    PRS 65.19
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 0.5
    rCSI 1.81%
    PRS 79

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [SIRT6](/details-gene/51548) is a protein-coding gene located on chromosome 19p13.3 that encodes Sirtuin 6, a member of the sirtuin family of NAD+-dependent protein deacetylases. Functionally, [SIRT6](/details-gene/51548) is a critical chromatin-associated enzyme involved in a wide array of fundamental cellular processes, including [DNA repair](/details-pathway/R-HSA-73894), particularly [double-strand break repair](/details-pathway/GO:0006302), [chromatin remodeling](/details-pathway/GO:0006338), and the maintenance of genomic stability. It acts as a histone H3 lysine 9 (H3K9) and H3K56 deacetylase, contributing to telomeric chromatin structure and epigenetic gene silencing ([Link](https://doi.org/10.1038/nature06736), [Link](https://doi.org/10.4161/cc.8.16.9367)). Reflecting its core role in cellular maintenance and stress response, its expression is significant across diverse cell types, with particularly high importance noted in [colon epithelial cell](/details-cell/CL0011108) and [basal cell of epidermis](/details-cell/CL0002187), suggesting a key function in tissues with high cellular turnover. ## Cellular Roles and Expression Landscape The expression profile of [SIRT6](/details-gene/51548) suggests a broad but vital role in cellular homeostasis across multiple organ systems. **Overall**, its most significant expression is observed in epithelial barrier tissues, as indicated by its top ranking in [colon epithelial cell](/details-cell/CL0011108) (CSI: 13.83) and [basal cell of epidermis](/details-cell/CL0002187) (CSI: 7.36). This is consistent with its function in maintaining genomic integrity through DNA repair, a process essential for rapidly proliferating cell populations that are constantly exposed to environmental insults. Beyond epithelial tissues, [SIRT6](/details-gene/51548) shows significant expression in various components of the immune system. This includes both adaptive immunity, highlighted by its role in [CD4-positive, CD25-positive, alpha-beta regulatory T cell](/details-cell/CL0000792), and innate immunity, with high significance in [myeloid leukocyte](/details-cell/CL0000766), [plasmacytoid dendritic cell, human](/details-cell/CL0001058), and [CD14-low, CD16-positive monocyte](/details-cell/CL0002396). This pattern suggests that its epigenetic and metabolic regulatory functions are important for immune cell function and differentiation. Furthermore, a notable role in the central nervous system is suggested by its significance in neuronal populations such as [interneuron](/details-cell/CL0000099) and [cerebral cortex GABAergic interneuron](/details-cell/CL0010011). This points to a potential involvement in neuronal maintenance, metabolism, and longevity, aligning with its established connection to the [determination of adult lifespan](/details-pathway/GO:0008340). ## Pathways and Molecular Function The molecular functions of [SIRT6](/details-gene/51548) are centered on its activity as an NAD+-dependent enzyme with multiple catalytic activities, including [protein deacetylation](/details-pathway/GO:0006476) and [NAD+-protein ADP-ribosyltransferase activity](/details-pathway/GO:1990404). As a nuclear protein, it primarily targets chromatin ([GO:0000785](https://www.ebi.ac.uk/QuickGO/term/GO:0000785)), where it binds DNA ([GO:0003677](https://www.ebi.ac.uk/QuickGO/term/GO:0003677)) and acts as a [histone H3K9 deacetylase](/details-pathway/GO:0032129), leading to [negative regulation of gene expression, epigenetic](/details-pathway/GO:0045814). A primary annotated role for [SIRT6](/details-gene/51548) is in the maintenance of genomic stability through its involvement in [DNA repair](/details-pathway/R-HSA-73894). It functions in both [base-excision repair](/details-pathway/GO:0006284) and [DNA double-strand break repair](/details-pathway/R-HSA-5693532). Research indicates it promotes DNA end resection and activates PARP1 under stress, facilitating efficient repair ([Link](https://doi.org/10.1126/science.1192049), [Link](https://doi.org/10.1126/science.1202723)). This function is critical for preventing mutations in high-turnover cells where the gene is prominently expressed. In addition to DNA repair, [SIRT6](/details-gene/51548) is a key metabolic regulator. It is involved in [glucose homeostasis](/details-pathway/GO:0042593) by negatively regulating multiple steps in glucose metabolism, including [gluconeogenesis](/details-pathway/GO:0045721) and the [glycolytic process](/details-pathway/GO:0045820). This metabolic control is linked to its tumor suppressor function, as it helps prevent the metabolic shift towards aerobic glycolysis (the Warburg effect) seen in cancer cells ([Link](https://doi.org/10.1016/j.cell.2012.10.047)). ## Research Directions The widespread importance of [SIRT6](/details-gene/51548) in DNA repair, epigenetic regulation, and metabolism opens several avenues for future investigation, particularly concerning its role in disease pathogenesis. Based on the available data, the following hypotheses can be proposed: 1. Given its exceptionally high significance in [colon epithelial cell](/details-cell/CL0011108) and its established role as a tumor suppressor ([Link](https://doi.org/10.1016/j.cell.2012.10.047)), loss of [SIRT6](/details-gene/51548) function or expression in the colonic epithelium may be a critical initiating event in colorectal cancer. This loss could lead to increased genomic instability and a metabolic switch favoring tumorigenesis. 2. The notable expression of [SIRT6](/details-gene/51548) in [CD4-positive, CD25-positive, alpha-beta regulatory T cell](/details-cell/CL0000792) suggests it is required for maintaining the stability and suppressive function of this lineage. Its deacetylase activity may be necessary to silence pro-inflammatory gene loci or maintain the expression of key regulatory T cell transcription factors. To test the first hypothesis regarding its role in colorectal cancer, a key experimental approach would be to use a conditional knockout mouse model. One could cross mice with a floxed *Sirt6* allele to mice expressing Cre recombinase under the control of a colon-specific promoter (e.g., Villin-Cre). These colon-specific *Sirt6* knockout mice could then be subjected to a chemical carcinogenesis model, such as azoxymethane/dextran sodium sulfate (AOM/DSS). Tumor incidence, size, and grade would be compared with control mice. Subsequent analysis of tumor tissues using single-cell RNA sequencing and metabolomics would elucidate the specific changes in gene expression and metabolic pathways driven by the loss of [SIRT6](/details-gene/51548). Given its function as a tumor suppressor that is often downregulated in cancer, the therapeutic potential of [SIRT6](/details-gene/51548) lies in its **activation**. The development of small-molecule activators of [SIRT6](/details-gene/51548) could represent a novel therapeutic strategy for cancers, such as colorectal cancer. By enhancing [SIRT6](/details-gene/51548) activity, such compounds could potentially restore genomic stability, reverse the Warburg effect, and promote cancer cell death or senescence.

Genular Protein ID: 242669005

Symbol: SIR6_HUMAN

Name: SIR2-like protein 6

UniProtKB Accession Codes:

Q8N6T7 B2RCD0 O75291 Q6IAF5 Q6PK99 Q8NCD2 Q9BSI5 Q9BWP3 Q9NRC7 Q9UQD1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 45 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 10 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 80 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 9 Rhea 20 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873683

Title: Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins.

PubMed ID: 10873683

DOI: 10.1006/bbrc.2000.3000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16079181

Title: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

PubMed ID: 16079181

DOI: 10.1091/mbc.e05-01-0033

PubMed ID: 18337721

Title: SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin.

PubMed ID: 18337721

DOI: 10.1038/nature06736

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19135889

Title: SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

PubMed ID: 19135889

DOI: 10.1016/j.cell.2008.10.052

PubMed ID: 19625767

Title: Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

PubMed ID: 19625767

DOI: 10.4161/cc.8.16.9367

PubMed ID: 20829486

Title: Human SIRT6 promotes DNA end resection through CtIP deacetylation.

PubMed ID: 20829486

DOI: 10.1126/science.1192049

PubMed ID: 30975768

Title:

PubMed ID: 30975768

DOI: 10.1126/science.aax4558

PubMed ID: 21847107

Title: SIRT6 is required for maintenance of telomere position effect in human cells.

PubMed ID: 21847107

DOI: 10.1038/ncomms1443

PubMed ID: 21680843

Title: SIRT6 promotes DNA repair under stress by activating PARP1.

PubMed ID: 21680843

DOI: 10.1126/science.1202723

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23217706

Title: The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

PubMed ID: 23217706

DOI: 10.1016/j.cell.2012.10.047

PubMed ID: 23142079

Title: The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

PubMed ID: 23142079

DOI: 10.1016/j.molcel.2012.09.030

PubMed ID: 22753495

Title: Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.

PubMed ID: 22753495

DOI: 10.1073/pnas.1200583109

PubMed ID: 24012758

Title: Multiple regulatory layers of SREBP1/2 by SIRT6.

PubMed ID: 24012758

DOI: 10.1016/j.celrep.2013.08.006

PubMed ID: 23653361

Title: The role of SIRT6 protein in aging and reprogramming of human induced pluripotent stem cells.

PubMed ID: 23653361

DOI: 10.1074/jbc.m112.405928

PubMed ID: 24052263

Title: Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.

PubMed ID: 24052263

DOI: 10.1074/jbc.c113.511261

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23911928

Title: SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

PubMed ID: 23911928

DOI: 10.1016/j.molcel.2013.06.018

PubMed ID: 24043303

Title: The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination.

PubMed ID: 24043303

DOI: 10.1128/mcb.00480-13

PubMed ID: 23892288

Title: SIRT6 exhibits nucleosome-dependent deacetylase activity.

PubMed ID: 23892288

DOI: 10.1093/nar/gkt642

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25541994

Title: SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

PubMed ID: 25541994

DOI: 10.1371/journal.pone.0115616

PubMed ID: 25009184

Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

PubMed ID: 25009184

DOI: 10.1073/pnas.1411026111

PubMed ID: 25915124

Title: The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

PubMed ID: 25915124

DOI: 10.1038/ncb3147

PubMed ID: 26748705

Title: Reciprocal regulation between SIRT6 and miR-122 controls liver metabolism and predicts hepatocarcinoma prognosis.

PubMed ID: 26748705

DOI: 10.1016/j.celrep.2015.12.023

PubMed ID: 27568560

Title: JNK phosphorylates SIRT6 to stimulate DNA double-strand break repair in response to oxidative stress by recruiting PARP1 to DNA Breaks.

PubMed ID: 27568560

DOI: 10.1016/j.celrep.2016.08.006

PubMed ID: 27912097

Title: LncPRESS1 is a p53-regulated lncRNA that safeguards pluripotency by disrupting SIRT6-mediated de-acetylation of histone H3K56.

PubMed ID: 27912097

DOI: 10.1016/j.molcel.2016.10.039

PubMed ID: 27322069

Title: Identifying the functional contribution of the defatty-acylase activity of SIRT6.

PubMed ID: 27322069

DOI: 10.1038/nchembio.2106

PubMed ID: 27043296

Title: SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.

PubMed ID: 27043296

DOI: 10.1038/nsmb.3202

PubMed ID: 26898756

Title: A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity.

PubMed ID: 26898756

DOI: 10.1038/onc.2016.24

PubMed ID: 26787900

Title: SIRT6 deacetylates PKM2 to suppress its nuclear localization and oncogenic functions.

PubMed ID: 26787900

DOI: 10.1073/pnas.1520045113

PubMed ID: 29474172

Title: Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.

PubMed ID: 29474172

DOI: 10.7554/elife.32127

PubMed ID: 28406396

Title: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.

PubMed ID: 28406396

DOI: 10.7554/elife.25158

PubMed ID: 27180906

Title: SIRT6 suppresses pancreatic cancer through control of Lin28b.

PubMed ID: 27180906

DOI: 10.1016/j.cell.2016.04.033

PubMed ID: 31995034

Title: SIRT6 is a DNA double-strand break sensor.

PubMed ID: 31995034

DOI: 10.7554/elife.51636

PubMed ID: 32538779

Title: Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.

PubMed ID: 32538779

DOI: 10.7554/elife.55828

PubMed ID: 33122195

Title: Nitro-fatty acids as activators of hSIRT6 deacetylase activity.

PubMed ID: 33122195

DOI: 10.1074/jbc.ra120.014883

PubMed ID: 33067423

Title: Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6.

PubMed ID: 33067423

DOI: 10.1038/s41467-020-19018-y

PubMed ID: 32789493

Title: The deacetylase SIRT6 promotes the repair of UV-induced DNA damage by targeting DDB2.

PubMed ID: 32789493

DOI: 10.1093/nar/gkaa661

PubMed ID: 37023208

Title: Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1).

PubMed ID: 37023208

DOI: 10.1371/journal.ppat.1011324

PubMed ID: 21362626

Title: Structure and biochemical functions of SIRT6.

PubMed ID: 21362626

DOI: 10.1074/jbc.m111.218990

PubMed ID: 23552949

Title: SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine.

PubMed ID: 23552949

DOI: 10.1038/nature12038

PubMed ID: 27990725

Title: Structural basis of sirtuin 6 activation by synthetic small molecules.

PubMed ID: 27990725

DOI: 10.1002/anie.201610082

PubMed ID: 30395713

Title: Structural basis of sirtuin 6 inhibition by the hydroxamate trichostatin A: implications for protein deacylase drug development.

PubMed ID: 30395713

DOI: 10.1021/acs.jmedchem.8b01455

PubMed ID: 30374165

Title: Identification of a cellularly active SIRT6 allosteric activator.

PubMed ID: 30374165

DOI: 10.1038/s41589-018-0150-0

PubMed ID: 31844103

Title: Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives.

PubMed ID: 31844103

DOI: 10.1038/s41598-019-55654-1

PubMed ID: 33214841

Title: Structural basis for activation of human sirtuin 6 by fluvastatin.

PubMed ID: 33214841

DOI: 10.1021/acsmedchemlett.0c00407

PubMed ID: 33649599

Title: Binding site for activator MDL-801 on SIRT6.

PubMed ID: 33649599

DOI: 10.1038/s41589-021-00749-y

PubMed ID: 33649600

Title: Reply to: Binding site for MDL-801 on SIRT6.

PubMed ID: 33649600

DOI: 10.1038/s41589-021-00750-5

PubMed ID: 26456828

Title: Identification of and molecular basis for SIRT6 loss-of-function point mutations in cancer.

PubMed ID: 26456828

DOI: 10.1016/j.celrep.2015.09.022

PubMed ID: 29555651

Title: An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

PubMed ID: 29555651

DOI: 10.1101/gad.307330.117

Sequence Information:

  • Length: 355
  • Mass: 39119
  • Checksum: 0C86AAC497130BBF
  • Sequence:
    • MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG 
IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV 
RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE 
LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN 
LQPTKHDRHA DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK 
EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS

Genular Protein ID: 942459007

Symbol: M0QXA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0QXA0

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 187
  • Mass: 20078
  • Checksum: 7410BAB73DB086B2
  • Sequence:
    • MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG 
IPDFRDKLAE LHGNMFVEEC AKCKTQYVRD TVVGTMGLKA TGRLCTVAKA RGLRACRGEL 
RDTILDWEDS LPDRDLALAD EASRSGPAGT CRWLPSAGEA AWSSSTCSPP STTAMLTSAS 
MATLTRS

Genular Protein ID: 3488448542

Symbol: B4DDV3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDV3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 IntAct 1 InterPro 4 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 283
  • Mass: 31319
  • Checksum: 775740F80DA0ACE4
  • Sequence:
    • MEERGLAPKF DTTFESARPT QTHMALVQLE RVGLLRFLVS QNVDGLHVRS GFPRDKLAEL 
HGNMFVEECA KCKTQYVRDT VVGTMGLKAT GRLCTVAKAR GLRACRGELR DTILDWEDSL 
PDRDLALADE ASRNADLSIT LGTSLQIRPS GNLPLATKRR GGRLVIVNLQ PTKHDRHADL 
RIHGYVDEVM TRLMKHLGLE IPAWDGPRVL ERALPPLPRP PTPKLEPKEE SPTRINGSIP 
AGPKQEPCAQ HNGSEPASPK RERPTSPAPH RPPKRVKAKA VPS

Genular Protein ID: 1247378192

Symbol: M0R1N9_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0R1N9

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 176
  • Mass: 19135
  • Checksum: D6F6E03CE6780C47
  • Sequence:
    • MEERGLAPKF DTTFESARPT QTHMALVQLE RVGLLRFLVS QNVDGLHVRS GFPRDKLAEL 
HGNMFVEECA KCKTQYVRDT VVGTMGLKAT GRLCTVAKAR GLRACRGELR DTILDWEDSL 
PDRDLALADE ASRSGPAGTC RWLPSAGEAA WSSSTCSPPS TTAMLTSASM ATLTRS