Details for: CINP

Gene ID: 51550

Symbol: CINP

Ensembl ID: ENSG00000100865

Description: cyclin dependent kinase 2 interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.5829
    Cell Significance Index: -18.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.4422
    Cell Significance Index: -20.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.9992
    Cell Significance Index: -24.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.2483
    Cell Significance Index: -20.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.7451
    Cell Significance Index: -24.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.2992
    Cell Significance Index: -21.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9342
    Cell Significance Index: -23.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1131
    Cell Significance Index: -19.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3488
    Cell Significance Index: -19.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2265
    Cell Significance Index: -24.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.7239
    Cell Significance Index: -8.1500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6368
    Cell Significance Index: 182.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2781
    Cell Significance Index: 265.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6992
    Cell Significance Index: 32.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6393
    Cell Significance Index: 33.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6120
    Cell Significance Index: 8.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6077
    Cell Significance Index: 331.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5727
    Cell Significance Index: 78.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4375
    Cell Significance Index: 78.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3568
    Cell Significance Index: 7.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3519
    Cell Significance Index: 43.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3382
    Cell Significance Index: 43.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3259
    Cell Significance Index: 8.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3214
    Cell Significance Index: 15.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3154
    Cell Significance Index: 40.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3112
    Cell Significance Index: 62.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2975
    Cell Significance Index: 106.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2938
    Cell Significance Index: 47.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2851
    Cell Significance Index: 18.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2842
    Cell Significance Index: 12.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2705
    Cell Significance Index: 7.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2383
    Cell Significance Index: 47.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2281
    Cell Significance Index: 100.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2207
    Cell Significance Index: 26.0300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2000
    Cell Significance Index: 1.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1917
    Cell Significance Index: 1.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1515
    Cell Significance Index: 136.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1476
    Cell Significance Index: 9.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1306
    Cell Significance Index: 9.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1296
    Cell Significance Index: 3.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1118
    Cell Significance Index: 3.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1087
    Cell Significance Index: 3.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0678
    Cell Significance Index: 6.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0615
    Cell Significance Index: 4.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0548
    Cell Significance Index: 1.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0518
    Cell Significance Index: 8.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0514
    Cell Significance Index: 2.7000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0377
    Cell Significance Index: 0.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0324
    Cell Significance Index: 0.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0284
    Cell Significance Index: 0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0223
    Cell Significance Index: 1.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0203
    Cell Significance Index: 1.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0139
    Cell Significance Index: 0.3200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0112
    Cell Significance Index: 0.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0095
    Cell Significance Index: 7.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0054
    Cell Significance Index: 1.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0029
    Cell Significance Index: 5.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0074
    Cell Significance Index: -0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0153
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0160
    Cell Significance Index: -21.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0177
    Cell Significance Index: -11.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0229
    Cell Significance Index: -2.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0244
    Cell Significance Index: -16.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0272
    Cell Significance Index: -20.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0363
    Cell Significance Index: -16.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0388
    Cell Significance Index: -21.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0435
    Cell Significance Index: -27.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0508
    Cell Significance Index: -5.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0563
    Cell Significance Index: -16.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0606
    Cell Significance Index: -1.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0751
    Cell Significance Index: -2.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0775
    Cell Significance Index: -1.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0905
    Cell Significance Index: -3.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0998
    Cell Significance Index: -6.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1048
    Cell Significance Index: -2.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1123
    Cell Significance Index: -16.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1180
    Cell Significance Index: -1.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1309
    Cell Significance Index: -27.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2193
    Cell Significance Index: -17.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2287
    Cell Significance Index: -23.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2381
    Cell Significance Index: -13.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2416
    Cell Significance Index: -6.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3022
    Cell Significance Index: -4.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3069
    Cell Significance Index: -2.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3287
    Cell Significance Index: -14.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3577
    Cell Significance Index: -6.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3587
    Cell Significance Index: -7.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3708
    Cell Significance Index: -22.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3793
    Cell Significance Index: -14.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3799
    Cell Significance Index: -4.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3951
    Cell Significance Index: -5.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3992
    Cell Significance Index: -24.4800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4050
    Cell Significance Index: -11.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4303
    Cell Significance Index: -5.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4453
    Cell Significance Index: -4.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4610
    Cell Significance Index: -11.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4880
    Cell Significance Index: -13.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CINP is a small protein that belongs to the protein-binding family. It is specifically designed to interact with CDK2, a kinase that regulates the progression of the cell cycle by phosphorylating and activating downstream targets. CINP is highly expressed in cells that require rapid cell division, such as hematopoietic cells and smooth muscle cells. The protein is also found in various types of immune cells, including T cells and mast cells, where it may play a role in regulating immune responses. **Pathways and Functions:** CINP is involved in several cellular pathways, including: 1. **Cell Division:** CINP interacts with CDK2 to regulate the progression of the cell cycle. CDK2 is a key regulator of the G1-S transition, and CINP may modulate the activity of this kinase to control cell proliferation. 2. **DNA Repair:** CINP may play a role in DNA repair mechanisms by interacting with proteins involved in the repair process, such as DNA polymerase and DNA ligase. 3. **DNA Replication:** CINP may regulate DNA replication by interacting with proteins involved in the initiation and elongation phases of DNA synthesis. 4. **Protein Binding:** CINP interacts with a wide range of proteins, including CDK2, DNA polymerase, and DNA ligase, to regulate their activity and function. **Clinical Significance:** Dysregulation of CINP has been implicated in various human diseases, including: 1. **Cancer:** Overexpression of CINP has been observed in various types of cancer, including breast, lung, and colon cancer. This may contribute to the development and progression of cancer by promoting cell proliferation and survival. 2. **Immune Disorders:** Alterations in CINP expression have been linked to immune disorders, such as rheumatoid arthritis and multiple sclerosis. CINP may play a role in regulating immune responses and modulating the activity of immune cells. 3. **Neurological Disorders:** CINP has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. The protein may play a role in regulating cellular processes, such as cell death and survival, that are affected in these diseases. In conclusion, CINP is a crucial protein that plays a significant role in various cellular processes, including cell division, DNA repair, and DNA replication. Its dysregulation has been implicated in various human diseases, highlighting the importance of CINP in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the role of CINP in human diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3360489420

Symbol: CINP_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BW66 F5H7P3 F5H8A7 Q9NPF9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 6 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16082200

Title: A novel Cdk2 interactor is phosphorylated by Cdc7 and associates with components of the replication complexes.

PubMed ID: 16082200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19889979

Title: Functional genomic screens identify CINP as a genome maintenance protein.

PubMed ID: 19889979

DOI: 10.1073/pnas.0909345106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21131973

Title: CEP152 is a genome maintenance protein disrupted in Seckel syndrome.

PubMed ID: 21131973

DOI: 10.1038/ng.725

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35354024

Title: Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly.

PubMed ID: 35354024

DOI: 10.1016/j.celrep.2022.110597

PubMed ID: 38554706

Title: The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.

PubMed ID: 38554706

DOI: 10.1016/j.cell.2024.03.002

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 212
  • Mass: 24324
  • Checksum: 3678E123B8C206B1
  • Sequence:
    • MEAKTLGTVT PRKPVLSVSA RKIKDNAADW HNLILKWETL NDAGFTTANN IANLKISLLN 
KDKIELDSSS PASKENEEKV CLEYNEELEK LCEELQATLD GLTKIQVKME KLSSTTKGIC 
ELENYHYGEE SKRPPLFHTW PTTHFYEVSH KLLEMYRKEL LLKRTVAKEL AHTGDPDLTL 
SYLSMWLHQP YVESDSRLHL ESMLLETGHR AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.