Details for: IL23A

Gene ID: 51561

Symbol: IL23A

Ensembl ID: ENSG00000110944

Description: interleukin 23 subunit alpha

Associated with

  • Cytokine signaling in immune system
    (R-HSA-1280215)
  • Immune system
    (R-HSA-168256)
  • Interleukin-4 and interleukin-13 signaling
    (R-HSA-6785807)
  • Interleukin-12 family signaling
    (R-HSA-447115)
  • Interleukin-23 signaling
    (R-HSA-9020933)
  • Signaling by interleukins
    (R-HSA-449147)
  • Cell surface receptor signaling pathway via jak-stat
    (GO:0007259)
  • Cell surface receptor signaling pathway via stat
    (GO:0097696)
  • Cytokine activity
    (GO:0005125)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to virus
    (GO:0051607)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Extracellular region
    (GO:0005576)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Interleukin-23 complex
    (GO:0070743)
  • Interleukin-23 receptor binding
    (GO:0045519)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of memory t cell differentiation
    (GO:0043382)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of nk t cell activation
    (GO:0051135)
  • Positive regulation of nk t cell proliferation
    (GO:0051142)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of t-helper 1 type immune response
    (GO:0002827)
  • Positive regulation of t-helper 17 cell lineage commitment
    (GO:2000330)
  • Positive regulation of t-helper 17 type immune response
    (GO:2000318)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of tissue remodeling
    (GO:0034105)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protein binding
    (GO:0005515)
  • T cell proliferation
    (GO:0042098)
  • Tissue remodeling
    (GO:0048771)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 28.6090
    Cell Significance Index: -4.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.5837
    Cell Significance Index: -4.4600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.5497
    Cell Significance Index: -4.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6254
    Cell Significance Index: -4.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2484
    Cell Significance Index: 48.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8030
    Cell Significance Index: -4.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1657
    Cell Significance Index: -4.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9561
    Cell Significance Index: 43.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7957
    Cell Significance Index: 151.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.7879
    Cell Significance Index: -2.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7804
    Cell Significance Index: 40.5400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.7346
    Cell Significance Index: 12.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4904
    Cell Significance Index: 10.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4860
    Cell Significance Index: 48.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4084
    Cell Significance Index: 368.7300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.4029
    Cell Significance Index: 4.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3088
    Cell Significance Index: 33.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2908
    Cell Significance Index: 17.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2654
    Cell Significance Index: 43.1700
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2498
    Cell Significance Index: 2.5900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2132
    Cell Significance Index: 2.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2123
    Cell Significance Index: 9.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2020
    Cell Significance Index: 5.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1525
    Cell Significance Index: 4.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1315
    Cell Significance Index: 3.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1306
    Cell Significance Index: 9.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0794
    Cell Significance Index: 2.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0755
    Cell Significance Index: 13.6100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0699
    Cell Significance Index: 0.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0599
    Cell Significance Index: 32.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0314
    Cell Significance Index: 13.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0311
    Cell Significance Index: 3.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0300
    Cell Significance Index: 3.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0244
    Cell Significance Index: 0.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0233
    Cell Significance Index: 1.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0226
    Cell Significance Index: 0.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0093
    Cell Significance Index: 1.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0067
    Cell Significance Index: 1.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0048
    Cell Significance Index: 0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0024
    Cell Significance Index: 0.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0013
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -4.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0052
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0056
    Cell Significance Index: -4.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0057
    Cell Significance Index: -0.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0058
    Cell Significance Index: -0.6800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0074
    Cell Significance Index: -4.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0086
    Cell Significance Index: -0.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0110
    Cell Significance Index: -5.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0152
    Cell Significance Index: -4.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0165
    Cell Significance Index: -0.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0178
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0180
    Cell Significance Index: -3.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0204
    Cell Significance Index: -1.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0227
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0231
    Cell Significance Index: -4.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0251
    Cell Significance Index: -2.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0256
    Cell Significance Index: -1.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0269
    Cell Significance Index: -0.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0293
    Cell Significance Index: -4.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0300
    Cell Significance Index: -0.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0323
    Cell Significance Index: -0.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0412
    Cell Significance Index: -2.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0427
    Cell Significance Index: -4.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0447
    Cell Significance Index: -0.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0451
    Cell Significance Index: -1.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0534
    Cell Significance Index: -1.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0601
    Cell Significance Index: -4.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0603
    Cell Significance Index: -4.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0605
    Cell Significance Index: -3.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0615
    Cell Significance Index: -4.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0678
    Cell Significance Index: -0.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0679
    Cell Significance Index: -2.0000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0711
    Cell Significance Index: -2.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0744
    Cell Significance Index: -1.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0779
    Cell Significance Index: -4.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0789
    Cell Significance Index: -4.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0809
    Cell Significance Index: -2.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0864
    Cell Significance Index: -4.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0883
    Cell Significance Index: -3.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0906
    Cell Significance Index: -2.3300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0909
    Cell Significance Index: -1.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0911
    Cell Significance Index: -4.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0947
    Cell Significance Index: -2.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0979
    Cell Significance Index: -3.4300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0987
    Cell Significance Index: -1.4200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1026
    Cell Significance Index: -0.6400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1064
    Cell Significance Index: -0.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1074
    Cell Significance Index: -3.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1097
    Cell Significance Index: -3.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1109
    Cell Significance Index: -2.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IL-23A is a non-cytokine subunit of the IL-23 complex, which is distinct from other cytokines like IL-1, IL-6, and TNF-alpha. Its expression is limited to specific cell types, including T cells, dendritic cells, and epithelial cells, whereas other cytokines are expressed in a broader range of cells. IL-23A is also characterized by its ability to form a complex with IL-23B, which is essential for its biological activity. **Pathways and Functions** IL-23A plays a multifaceted role in the regulation of immune responses, including: 1. **Th17 cell differentiation**: IL-23A promotes the differentiation of naive T cells into Th17 cells, a subset of T helper cells that produce IL-17, a cytokine involved in the pathogenesis of autoimmune diseases. 2. **Inflammation**: IL-23A is involved in the regulation of inflammatory responses, particularly in the context of chronic inflammation and autoimmunity. 3. **T cell proliferation**: IL-23A promotes the proliferation of T cells, which is essential for the development of immune responses. 4. **Cytokine production**: IL-23A regulates the production of various cytokines, including IL-12, IL-17, and TNF-alpha. **Clinical Significance** IL-23A has significant clinical implications in the treatment of autoimmune diseases, such as: 1. **Rheumatoid arthritis**: IL-23A is involved in the pathogenesis of rheumatoid arthritis, and its blockade has shown promise in reducing inflammation and improving symptoms. 2. **Multiple sclerosis**: IL-23A is also involved in the pathogenesis of multiple sclerosis, and its blockade has shown potential in reducing inflammation and improving symptoms. 3. **Psoriasis**: IL-23A plays a key role in the development of psoriasis, and its blockade has shown promise in reducing inflammation and improving symptoms. In conclusion, IL-23A is a crucial component of the IL-23 complex, and its dysregulation has significant clinical implications in the treatment of autoimmune diseases. Further research is needed to fully understand the mechanisms of IL-23A and to develop effective therapies targeting this cytokine.

Genular Protein ID: 133837239

Symbol: IL23A_HUMAN

Name: Interleukin-23 subunit alpha

UniProtKB Accession Codes:

Q9NPF7 Q6NZ80 Q6NZ82 Q9H2A5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 10 EMDB 2 Ensembl 1 EvolutionaryTrace 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11114383

Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

PubMed ID: 11114383

DOI: 10.1016/s1074-7613(00)00070-4

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12023369

Title: A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.

PubMed ID: 12023369

DOI: 10.4049/jimmunol.168.11.5699

PubMed ID: 12421946

Title: Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.

PubMed ID: 12421946

DOI: 10.4049/jimmunol.169.10.5673

PubMed ID: 15114670

Title: Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development.

PubMed ID: 15114670

DOI: 10.1002/eji.200324815

PubMed ID: 15486065

Title: Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway.

PubMed ID: 15486065

DOI: 10.1182/blood-2004-05-1718

PubMed ID: 15731058

Title: Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression.

PubMed ID: 15731058

DOI: 10.1128/iai.73.3.1590-1597.2005

PubMed ID: 16342235

Title: Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns.

PubMed ID: 16342235

DOI: 10.1002/eji.200535467

PubMed ID: 16424222

Title: In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.

PubMed ID: 16424222

DOI: 10.4049/jimmunol.176.3.1908

PubMed ID: 16751425

Title: IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.

PubMed ID: 16751425

DOI: 10.4049/jimmunol.176.12.7768

PubMed ID: 16688182

Title: IL-23 promotes tumour incidence and growth.

PubMed ID: 16688182

DOI: 10.1038/nature04808

PubMed ID: 17676044

Title: Development, cytokine profile and function of human interleukin 17-producing helper T cells.

PubMed ID: 17676044

DOI: 10.1038/ni1497

PubMed ID: 32474165

Title: IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant.

PubMed ID: 32474165

DOI: 10.1016/j.jcmgh.2020.05.007

PubMed ID: 18680750

Title: The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.

PubMed ID: 18680750

DOI: 10.1016/j.jmb.2008.07.051

PubMed ID: 29287995

Title: Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rbeta1.

PubMed ID: 29287995

DOI: 10.1016/j.immuni.2017.12.008

PubMed ID: 32479512

Title: Integration of phage and yeast display platforms: A reliable and cost effective approach for binning of peptides as displayed on-phage.

PubMed ID: 32479512

DOI: 10.1371/journal.pone.0233961

PubMed ID: 33606986

Title: Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.

PubMed ID: 33606986

DOI: 10.1016/j.cell.2021.01.018

Sequence Information:

  • Length: 189
  • Mass: 20730
  • Checksum: 51B5C0F188EC1B9F
  • Sequence:
    • MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL VGHMDLREEG 
DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY EKLLGSDIFT GEPSLLPDSP 
VGQLHASLLG LSQLLQPEGH HWETQQIPSL SPSQPWQRLL LRFKILRSLQ AFVAVAARVF 
AHGAATLSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.