Details for: TDP2

Gene ID: 51567

Symbol: TDP2

Ensembl ID: ENSG00000111802

Description: tyrosyl-DNA phosphodiesterase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.8611
    Cell Significance Index: -26.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.7858
    Cell Significance Index: -25.3100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 70.1060
    Cell Significance Index: -28.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.1681
    Cell Significance Index: -26.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.3477
    Cell Significance Index: -30.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.9332
    Cell Significance Index: -29.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 45.4083
    Cell Significance Index: -30.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.9526
    Cell Significance Index: -26.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8556
    Cell Significance Index: -28.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.7556
    Cell Significance Index: -23.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2832
    Cell Significance Index: -28.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.0878
    Cell Significance Index: -21.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0209
    Cell Significance Index: -8.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.2190
    Cell Significance Index: 33.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0555
    Cell Significance Index: 93.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0000
    Cell Significance Index: 69.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9345
    Cell Significance Index: 187.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7879
    Cell Significance Index: 22.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7738
    Cell Significance Index: 76.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6019
    Cell Significance Index: 108.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5733
    Cell Significance Index: 113.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5228
    Cell Significance Index: 13.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4998
    Cell Significance Index: 61.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4517
    Cell Significance Index: 73.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4502
    Cell Significance Index: 161.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3227
    Cell Significance Index: 35.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2907
    Cell Significance Index: 55.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2740
    Cell Significance Index: 149.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2671
    Cell Significance Index: 2.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2531
    Cell Significance Index: 34.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2340
    Cell Significance Index: 10.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2331
    Cell Significance Index: 12.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2309
    Cell Significance Index: 27.2300
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.2120
    Cell Significance Index: 1.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2019
    Cell Significance Index: 89.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1705
    Cell Significance Index: 21.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1527
    Cell Significance Index: 4.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1519
    Cell Significance Index: 5.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1309
    Cell Significance Index: 4.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1072
    Cell Significance Index: 18.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1027
    Cell Significance Index: 92.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0909
    Cell Significance Index: 1.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0893
    Cell Significance Index: 5.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0805
    Cell Significance Index: 55.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0789
    Cell Significance Index: 5.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0789
    Cell Significance Index: 4.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0700
    Cell Significance Index: 1.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0643
    Cell Significance Index: 3.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0116
    Cell Significance Index: 21.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0055
    Cell Significance Index: 3.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0077
    Cell Significance Index: -14.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0172
    Cell Significance Index: -10.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0183
    Cell Significance Index: -24.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0205
    Cell Significance Index: -15.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0214
    Cell Significance Index: -16.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0231
    Cell Significance Index: -0.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0243
    Cell Significance Index: -11.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0333
    Cell Significance Index: -18.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0346
    Cell Significance Index: -1.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0356
    Cell Significance Index: -5.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0392
    Cell Significance Index: -4.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0465
    Cell Significance Index: -3.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0621
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0685
    Cell Significance Index: -14.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0708
    Cell Significance Index: -8.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0730
    Cell Significance Index: -2.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0780
    Cell Significance Index: -1.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0802
    Cell Significance Index: -2.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0857
    Cell Significance Index: -24.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0879
    Cell Significance Index: -3.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0917
    Cell Significance Index: -5.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0940
    Cell Significance Index: -6.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1003
    Cell Significance Index: -7.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1008
    Cell Significance Index: -5.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1032
    Cell Significance Index: -4.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1345
    Cell Significance Index: -17.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1476
    Cell Significance Index: -17.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1505
    Cell Significance Index: -3.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1511
    Cell Significance Index: -2.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1511
    Cell Significance Index: -11.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1601
    Cell Significance Index: -18.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1898
    Cell Significance Index: -1.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2326
    Cell Significance Index: -6.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2627
    Cell Significance Index: -27.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2772
    Cell Significance Index: -6.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2996
    Cell Significance Index: -23.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3124
    Cell Significance Index: -7.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3541
    Cell Significance Index: -21.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3593
    Cell Significance Index: -7.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3697
    Cell Significance Index: -10.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3710
    Cell Significance Index: -9.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3730
    Cell Significance Index: -8.9500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3901
    Cell Significance Index: -2.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4523
    Cell Significance Index: -8.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5077
    Cell Significance Index: -13.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5159
    Cell Significance Index: -14.7900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.5179
    Cell Significance Index: -5.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5558
    Cell Significance Index: -17.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TDP2 is a phosphodiesterase enzyme that exhibits a unique ability to hydrolyze tyrosyl-DNA phosphodiester bonds, thereby regulating the stability of DNA. This enzyme is characterized by its high specificity for tyrosyl-DNA phosphodiester bonds, which sets it apart from other phosphodiesterases. TDP2's molecular structure consists of a catalytic domain, a C-terminal domain, and a variable domain, allowing it to interact with various cellular components. **Pathways and Functions:** TDP2 is involved in several essential cellular processes, including: 1. **DNA repair and maintenance**: TDP2 plays a crucial role in the repair of double-strand breaks in DNA, particularly through the nonhomologous end-joining (NHEJ) pathway. 2. **Transcription regulation**: TDP2 acts as a transcription corepressor, modulating the expression of genes involved in cell development, differentiation, and survival. 3. **Aggresome formation**: TDP2 is associated with the formation of aggresomes, which are protein aggregates that contribute to cellular stress and disease. 4. **Cell surface receptor signaling**: TDP2 interacts with cell surface receptors, influencing signaling pathways that regulate cell growth, differentiation, and survival. **Significantly Expressed Cells:** TDP2 is expressed in various cell types, including: 1. **Hematopoietic cells**: TDP2 is highly expressed in hematopoietic cells, including polychromatophilic erythroblast and hematopoietic oligopotent progenitor cells. 2. **Neurons**: TDP2 is expressed in neurons, particularly in the brain, where it may play a role in neuronal development and function. 3. **Immune cells**: TDP2 is expressed in immune cells, including CD8-alpha-beta-positive T cells and alpha-beta intraepithelial T cells. **Clinical Significance:** Dysregulation of TDP2 has been implicated in various diseases, including: 1. **Cancer**: TDP2's role in DNA repair and transcription regulation makes it a potential target for cancer therapy. 2. **Neurological disorders**: TDP2's involvement in neuronal development and function suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immunological disorders**: TDP2's expression in immune cells implies its potential role in immunological disorders, such as autoimmune diseases and immunodeficiency diseases. In conclusion, TDP2 is a multifunctional enzyme with far-reaching implications for human health. Further research is needed to fully elucidate the mechanisms by which TDP2 regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1243921434

Symbol: TYDP2_HUMAN

Name: Tyrosyl-DNA phosphodiesterase 2

UniProtKB Accession Codes:

O95551 B4DKL8 B4DQ95 Q2TBE2 Q5JYM0 Q7Z6U5 Q9NUK5 Q9NYY9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTC 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10764746

Title: TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

PubMed ID: 10764746

DOI: 10.1074/jbc.m000531200

PubMed ID: 12743594

Title: EAPII interacts with ETS1 and modulates its transcriptional function.

PubMed ID: 12743594

DOI: 10.1038/sj.onc.1206374

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14609633

Title: Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.

PubMed ID: 14609633

DOI: 10.1016/j.virusres.2003.09.001

PubMed ID: 18039968

Title: Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.

PubMed ID: 18039968

DOI: 10.1242/dev.000026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19794497

Title: A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.

PubMed ID: 19794497

DOI: 10.1038/nature08444

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21030584

Title: TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.

PubMed ID: 21030584

DOI: 10.1074/jbc.m110.181016

PubMed ID: 21980489

Title: TTRAP is a novel component of the non-canonical TRAF6-TAK1 TGF-beta signaling pathway.

PubMed ID: 21980489

DOI: 10.1371/journal.pone.0025548

PubMed ID: 22405347

Title: Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction.

PubMed ID: 22405347

DOI: 10.1186/1756-0500-5-134

PubMed ID: 21921940

Title: The PML nuclear bodies-associated protein TTRAP regulates ribosome biogenesis in nucleolar cavities upon proteasome inhibition.

PubMed ID: 21921940

DOI: 10.1038/cdd.2011.118

PubMed ID: 22822062

Title: Biochemical characterization of human Tyrosyl DNA Phosphodiesterase 2 (TDP2/TTRAP): a Mg2+/Mn2+-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.

PubMed ID: 22822062

DOI: 10.1074/jbc.m112.393983

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22908287

Title: An RNA virus hijacks an incognito function of a DNA repair enzyme.

PubMed ID: 22908287

DOI: 10.1073/pnas.1208096109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24658003

Title: TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.

PubMed ID: 24658003

DOI: 10.1038/ng.2929

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 27099339

Title: Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

PubMed ID: 27099339

DOI: 10.1042/bcj20160180

PubMed ID: 27060144

Title: Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.

PubMed ID: 27060144

DOI: 10.1093/nar/gkw228

Sequence Information:

  • Length: 362
  • Mass: 40930
  • Checksum: 37892E125DB64410
  • Sequence:
    • MELGSCLEGG REAAEEEGEP EVKKRRLLCV EFASVASCDA AVAQCFLAEN DWEMERALNS 
YFEPPVEESA LERRPETISE PKTYVDLTNE ETTDSTTSKI SPSEDTQQEN GSMFSLITWN 
IDGLDLNNLS ERARGVCSYL ALYSPDVIFL QEVIPPYYSY LKKRSSNYEI ITGHEEGYFT 
AIMLKKSRVK LKSQEIIPFP STKMMRNLLC VHVNVSGNEL CLMTSHLEST RGHAAERMNQ 
LKMVLKKMQE APESATVIFA GDTNLRDREV TRCGGLPNNI VDVWEFLGKP KHCQYTWDTQ 
MNSNLGITAA CKLRFDRIFF RAAAEEGHII PRSLDLLGLE KLDCGRFPSD HWGLLCNLDI 
IL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.