Details for: DPH5

Gene ID: 51611

Symbol: DPH5

Ensembl ID: ENSG00000117543

Description: diphthamide biosynthesis 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.3508
    Cell Significance Index: -18.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.9019
    Cell Significance Index: -12.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.5223
    Cell Significance Index: -21.0200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.2698
    Cell Significance Index: -20.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8873
    Cell Significance Index: -18.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.3265
    Cell Significance Index: -16.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2305
    Cell Significance Index: -20.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1302
    Cell Significance Index: 67.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0624
    Cell Significance Index: 105.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8386
    Cell Significance Index: 91.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7815
    Cell Significance Index: 91.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7415
    Cell Significance Index: 669.5300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6991
    Cell Significance Index: 7.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6459
    Cell Significance Index: 128.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5867
    Cell Significance Index: 95.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5177
    Cell Significance Index: 103.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5015
    Cell Significance Index: 68.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4794
    Cell Significance Index: 12.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4587
    Cell Significance Index: 32.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4312
    Cell Significance Index: 235.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4247
    Cell Significance Index: 8.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4096
    Cell Significance Index: 14.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3986
    Cell Significance Index: 30.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3866
    Cell Significance Index: 26.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3613
    Cell Significance Index: 9.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3582
    Cell Significance Index: 2.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3540
    Cell Significance Index: 18.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3011
    Cell Significance Index: 133.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2854
    Cell Significance Index: 51.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2600
    Cell Significance Index: 93.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2583
    Cell Significance Index: 16.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2553
    Cell Significance Index: 31.3900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2080
    Cell Significance Index: 2.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1906
    Cell Significance Index: 4.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1789
    Cell Significance Index: 10.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1746
    Cell Significance Index: 120.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1684
    Cell Significance Index: 7.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1565
    Cell Significance Index: 20.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1288
    Cell Significance Index: 3.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1220
    Cell Significance Index: 3.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1215
    Cell Significance Index: 3.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1175
    Cell Significance Index: 22.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0791
    Cell Significance Index: 10.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0662
    Cell Significance Index: 3.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0612
    Cell Significance Index: 0.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0562
    Cell Significance Index: 2.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0483
    Cell Significance Index: 90.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0412
    Cell Significance Index: 7.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0363
    Cell Significance Index: 49.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0276
    Cell Significance Index: 1.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0269
    Cell Significance Index: 0.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0218
    Cell Significance Index: 33.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0211
    Cell Significance Index: 38.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0193
    Cell Significance Index: 0.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0145
    Cell Significance Index: 0.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0108
    Cell Significance Index: 0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0084
    Cell Significance Index: 5.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0041
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0120
    Cell Significance Index: -0.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0124
    Cell Significance Index: -9.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0124
    Cell Significance Index: -0.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0213
    Cell Significance Index: -15.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0286
    Cell Significance Index: -0.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0303
    Cell Significance Index: -0.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0314
    Cell Significance Index: -17.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0371
    Cell Significance Index: -23.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0398
    Cell Significance Index: -2.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0425
    Cell Significance Index: -5.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0474
    Cell Significance Index: -4.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0514
    Cell Significance Index: -1.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0529
    Cell Significance Index: -3.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0542
    Cell Significance Index: -0.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0576
    Cell Significance Index: -1.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0589
    Cell Significance Index: -16.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0593
    Cell Significance Index: -4.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1083
    Cell Significance Index: -22.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1221
    Cell Significance Index: -13.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1270
    Cell Significance Index: -3.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1684
    Cell Significance Index: -17.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1844
    Cell Significance Index: -9.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1943
    Cell Significance Index: -11.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2226
    Cell Significance Index: -17.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2270
    Cell Significance Index: -2.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2301
    Cell Significance Index: -5.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2655
    Cell Significance Index: -4.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3258
    Cell Significance Index: -4.9100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3387
    Cell Significance Index: -2.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3911
    Cell Significance Index: -11.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3938
    Cell Significance Index: -5.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4059
    Cell Significance Index: -13.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4082
    Cell Significance Index: -13.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4122
    Cell Significance Index: -4.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4206
    Cell Significance Index: -9.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4500
    Cell Significance Index: -16.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4573
    Cell Significance Index: -23.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4667
    Cell Significance Index: -16.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DPH5 Encodes Diphthine Methyl Ester Synthase**: The DPH5 gene encodes the Diphthine methyl ester synthase enzyme, which catalyzes the biosynthesis of diphthamide, a critical post-translational modification of histidine residues. 2. **Significant Expression in Immunological Cells**: DPH5 is significantly expressed in various immunological cells, including CD8-alpha-beta-positive T cells, alpha-beta regulatory T cells, and hematopoietic oligopotent progenitor cells, highlighting its potential role in immune regulation. 3. **Diphthamide Biosynthesis Pathways**: DPH5 is involved in a complex network of pathways, including gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, which are essential for protein modification and cellular homeostasis. **Pathways and Functions:** 1. **Protein Modification**: DPH5 is involved in the biosynthesis of diphthamide, which is a critical post-translational modification of histidine residues in proteins. This modification can alter protein function, stability, and interactions. 2. **Immune Regulation**: The significant expression of DPH5 in immunological cells suggests its potential role in regulating immune responses, including T cell activation, proliferation, and differentiation. 3. **Cellular Homeostasis**: DPH5 is involved in the regulation of cellular homeostasis, including the metabolism of proteins, methylation, and post-translational protein modification. **Clinical Significance:** 1. **Diphthia Toxin Pathogenesis**: The diphthamide biosynthesis pathway, mediated by DPH5, is exploited by the diphthia toxin, which causes a range of systemic and local complications, including respiratory and cardiac failure. 2. **Immunological Disorders**: The dysregulation of DPH5 and diphthamide biosynthesis may contribute to various immunological disorders, including autoimmune diseases, allergies, and immune deficiencies. 3. **Cancer and Metabolic Diseases**: The role of DPH5 in protein modification and cellular homeostasis may also be relevant to cancer and metabolic diseases, including obesity, diabetes, and cardiovascular disease. In conclusion, the DPH5 gene plays a critical role in the biosynthesis of diphthamide, a post-translational modification of histidine residues in proteins. The significant expression of DPH5 in immunological cells highlights its potential role in immune regulation, and its involvement in various cellular pathways underscores its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the functions and clinical significance of DPH5 in human health and disease.

Genular Protein ID: 1481058220

Symbol: DPH5_HUMAN

Name: Diphthine methyl ester synthase

UniProtKB Accession Codes:

Q9H2P9 A8JZY6 D3DT62 Q9P017 Q9P0I4 Q9Y319

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23486472

Title: A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene.

PubMed ID: 23486472

DOI: 10.1074/jbc.m113.461343

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 35482014

Title: A novel DPH5-related diphthamide-deficiency syndrome causing embryonic lethality or profound neurodevelopmental disorder.

PubMed ID: 35482014

DOI: 10.1016/j.gim.2022.03.014

PubMed ID: 36205747

Title:

PubMed ID: 36205747

DOI: 10.1016/j.gim.2022.07.021

Sequence Information:

  • Length: 285
  • Mass: 31651
  • Checksum: 1348631C25BC624E
  • Sequence:
    • MLYLIGLGLG DAKDITVKGL EVVRRCSRVY LEAYTSVLTV GKEALEEFYG RKLVVADREE 
VEQEADNILK DADISDVAFL VVGDPFGATT HSDLVLRATK LGIPYRVIHN ASIMNAVGCC 
GLQLYKFGET VSIVFWTDTW RPESFFDKVK KNRQNGMHTL CLLDIKVKEQ SLENLIKGRK 
IYEPPRYMSV NQAAQQLLEI VQNQRIRGEE PAVTEETLCV GLARVGADDQ KIAAGTLRQM 
CTVDLGEPLH SLIITGGSIH PMEMEMLSLF SIPENSSESQ SINGL

Genular Protein ID: 3568424350

Symbol: B3KWP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KWP1 D3DT65

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 PharmGKB 1 RefSeq 6 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 172
  • Mass: 19244
  • Checksum: 5DF014FE59EF0339
  • Sequence:
    • MNAVGCCGLQ LYKFGETVSI VFWTDTWRPE SFFDKVKKNR QNGMHTLCLL DIKVKEQSLE 
NLIKGRKIYE PPRYMSVNQA AQQLLEIVQN QRIRGEEPAV TEETLCVGLA RVGADDQKIA 
AGTLRQMCTV DLGEPLHSLI ITGGSIHPME MEMLSLFSIP ENSSESQSIN GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.