Details for: OTUD6B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 100.8388
Cell Significance Index: -15.6900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 59.8084
Cell Significance Index: -15.1700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 40.1265
Cell Significance Index: -16.5300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 33.5994
Cell Significance Index: -13.6500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 24.1274
Cell Significance Index: -16.1900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 14.4437
Cell Significance Index: -13.7900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.1919
Cell Significance Index: -16.2700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.6442
Cell Significance Index: -15.1200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.1763
Cell Significance Index: -16.4800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.9265
Cell Significance Index: -12.0600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1555
Cell Significance Index: 114.3000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0598
Cell Significance Index: 14.4600 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.9056
Cell Significance Index: 14.9200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7664
Cell Significance Index: 46.0100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7438
Cell Significance Index: 80.9100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6424
Cell Significance Index: 104.4800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5682
Cell Significance Index: 112.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5057
Cell Significance Index: 101.4400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4671
Cell Significance Index: 21.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4443
Cell Significance Index: 12.8000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3277
Cell Significance Index: 59.0800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3213
Cell Significance Index: 6.9600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2965
Cell Significance Index: 15.4000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2827
Cell Significance Index: 53.8000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2605
Cell Significance Index: 16.4200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2402
Cell Significance Index: 13.4800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2310
Cell Significance Index: 82.8600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2296
Cell Significance Index: 6.2500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2196
Cell Significance Index: 4.7000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2155
Cell Significance Index: 26.5000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1995
Cell Significance Index: 88.2200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1926
Cell Significance Index: 173.9100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1866
Cell Significance Index: 9.7200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.1840
Cell Significance Index: 4.6000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1577
Cell Significance Index: 5.5400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1339
Cell Significance Index: 10.2800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1321
Cell Significance Index: 3.5400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1318
Cell Significance Index: 71.9800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1256
Cell Significance Index: 8.1000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1156
Cell Significance Index: 15.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1084
Cell Significance Index: 6.6600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1049
Cell Significance Index: 4.6400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0974
Cell Significance Index: 3.6900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0937
Cell Significance Index: 6.6300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0861
Cell Significance Index: 1.6800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0640
Cell Significance Index: 4.3100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0430
Cell Significance Index: 2.0200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0376
Cell Significance Index: 1.0500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0363
Cell Significance Index: 66.9400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0359
Cell Significance Index: 0.7500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0339
Cell Significance Index: 4.0000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0319
Cell Significance Index: 60.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0266
Cell Significance Index: 16.9200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0255
Cell Significance Index: 39.1900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0086
Cell Significance Index: 0.4000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0077
Cell Significance Index: 0.9900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0070
Cell Significance Index: 3.1900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0065
Cell Significance Index: 8.8200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0005
Cell Significance Index: -0.0100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0011
Cell Significance Index: -0.0300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0036
Cell Significance Index: -0.0600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0095
Cell Significance Index: -6.9500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0160
Cell Significance Index: -12.1200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0164
Cell Significance Index: -2.3900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0181
Cell Significance Index: -13.3900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0232
Cell Significance Index: -13.0800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0289
Cell Significance Index: -18.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0355
Cell Significance Index: -6.0700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0472
Cell Significance Index: -4.8200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0476
Cell Significance Index: -13.6900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0555
Cell Significance Index: -7.1700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.0555
Cell Significance Index: -0.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0618
Cell Significance Index: -7.2000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0696
Cell Significance Index: -7.9700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0840
Cell Significance Index: -17.7000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0878
Cell Significance Index: -2.5100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0920
Cell Significance Index: -1.9600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0959
Cell Significance Index: -3.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0975
Cell Significance Index: -7.2700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1314
Cell Significance Index: -13.6800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1451
Cell Significance Index: -3.7300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1471
Cell Significance Index: -7.7300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1482
Cell Significance Index: -3.5600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1640
Cell Significance Index: -5.7000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1644
Cell Significance Index: -1.9600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1706
Cell Significance Index: -4.8900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1741
Cell Significance Index: -13.7900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1841
Cell Significance Index: -4.9300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1884
Cell Significance Index: -1.7400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1993
Cell Significance Index: -5.2400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2002
Cell Significance Index: -3.4300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2163
Cell Significance Index: -13.2600 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.2624
Cell Significance Index: -2.2300 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.2645
Cell Significance Index: -3.7100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2724
Cell Significance Index: -6.9600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2781
Cell Significance Index: -1.6800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2795
Cell Significance Index: -8.2100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2939
Cell Significance Index: -14.8500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2940
Cell Significance Index: -4.3400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2944
Cell Significance Index: -9.6400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4177647740
Symbol: OTU6B_HUMAN
Name: DUBA-5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10810093
Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.
PubMed ID: 10810093
DOI: 10.1101/gr.10.5.703
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 23827681
Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.
PubMed ID: 23827681
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21267069
Title: Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.
PubMed ID: 21267069
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 28343629
Title: Biallelic variants in OTUD6B cause an intellectual disability syndrome associated with seizures and dysmorphic features.
PubMed ID: 28343629
PubMed ID: 27864334
Title: Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation.
PubMed ID: 27864334
Sequence Information:
- Length: 293
- Mass: 33813
- Checksum: 468DB88E2637D869
- Sequence:
MEAVLTEELD EEEQLLRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE DVAKLEKEME QKHREELEQL KLTTKENKID SVAVNISNLV LENQPPRISK AQKRREKKAA LEKEREERIA EAEIENLTGA RHMESEKLAQ ILAARQLEIK QIPSDGHCMY KAIEDQLKEK DCALTVVALR SQTAEYMQSH VEDFLPFLTN PNTGDMYTPE EFQKYCEDIV NTAAWGGQLE LRALSHILQT PIEIIQADSP PIIVGEEYSK KPLILVYMRH AYGLGEHYNS VTRLVNIVTE NCS
Genular Protein ID: 1865110023
Symbol: A0A087X0W9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
Sequence Information:
- Length: 323
- Mass: 37326
- Checksum: BAD169986EC47B6F
- Sequence:
MEPRVRVEGW KVPTSRCRFL LARVLGYLVV MEAVLTEELD EEEQLLRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE DVAKLEKEME QKHREELEQL KLTTKENKID SVAVNISNLV LENQPPRISK AQKRREKKAA LEKEREERIA EAEIENLTGA RHMESEKLAQ ILAARQLEIK QIPSDGHCMY KAIEDQLKEK DCALTVVALR SQTAEYMQSH VEDFLPFLTN PNTGDMYTPE EFQKYCEDIV NTAAWGGQLE LRALSHILQT PIEIIQADSP PIIVGEEYSK KPLILVYMRH AYGLGEHYNS VTRLVNIVTE NCS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.