Details for: OTUD6B

Gene ID: 51633

Symbol: OTUD6B

Ensembl ID: ENSG00000155100

Description: OTU deubiquitinase 6B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 100.8388
    Cell Significance Index: -15.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.8084
    Cell Significance Index: -15.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 40.1265
    Cell Significance Index: -16.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.5994
    Cell Significance Index: -13.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.1274
    Cell Significance Index: -16.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.4437
    Cell Significance Index: -13.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.1919
    Cell Significance Index: -16.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6442
    Cell Significance Index: -15.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.1763
    Cell Significance Index: -16.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9265
    Cell Significance Index: -12.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1555
    Cell Significance Index: 114.3000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0598
    Cell Significance Index: 14.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.9056
    Cell Significance Index: 14.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7664
    Cell Significance Index: 46.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7438
    Cell Significance Index: 80.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6424
    Cell Significance Index: 104.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5682
    Cell Significance Index: 112.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5057
    Cell Significance Index: 101.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4671
    Cell Significance Index: 21.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4443
    Cell Significance Index: 12.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3277
    Cell Significance Index: 59.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3213
    Cell Significance Index: 6.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2965
    Cell Significance Index: 15.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2827
    Cell Significance Index: 53.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2605
    Cell Significance Index: 16.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2402
    Cell Significance Index: 13.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2310
    Cell Significance Index: 82.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2296
    Cell Significance Index: 6.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2196
    Cell Significance Index: 4.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2155
    Cell Significance Index: 26.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1995
    Cell Significance Index: 88.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1926
    Cell Significance Index: 173.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1866
    Cell Significance Index: 9.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1840
    Cell Significance Index: 4.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1577
    Cell Significance Index: 5.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1339
    Cell Significance Index: 10.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1321
    Cell Significance Index: 3.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1318
    Cell Significance Index: 71.9800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1256
    Cell Significance Index: 8.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1156
    Cell Significance Index: 15.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1084
    Cell Significance Index: 6.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1049
    Cell Significance Index: 4.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0974
    Cell Significance Index: 3.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0937
    Cell Significance Index: 6.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0861
    Cell Significance Index: 1.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0640
    Cell Significance Index: 4.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0430
    Cell Significance Index: 2.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0376
    Cell Significance Index: 1.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0363
    Cell Significance Index: 66.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0359
    Cell Significance Index: 0.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0339
    Cell Significance Index: 4.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0319
    Cell Significance Index: 60.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0266
    Cell Significance Index: 16.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0255
    Cell Significance Index: 39.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0086
    Cell Significance Index: 0.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0077
    Cell Significance Index: 0.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0070
    Cell Significance Index: 3.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0065
    Cell Significance Index: 8.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0036
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0160
    Cell Significance Index: -12.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0164
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0181
    Cell Significance Index: -13.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0232
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0289
    Cell Significance Index: -18.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0355
    Cell Significance Index: -6.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0472
    Cell Significance Index: -4.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0476
    Cell Significance Index: -13.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0555
    Cell Significance Index: -7.1700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0555
    Cell Significance Index: -0.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0618
    Cell Significance Index: -7.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0696
    Cell Significance Index: -7.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0840
    Cell Significance Index: -17.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0878
    Cell Significance Index: -2.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0920
    Cell Significance Index: -1.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0959
    Cell Significance Index: -3.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0975
    Cell Significance Index: -7.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1314
    Cell Significance Index: -13.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1451
    Cell Significance Index: -3.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1471
    Cell Significance Index: -7.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1482
    Cell Significance Index: -3.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1640
    Cell Significance Index: -5.7000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1644
    Cell Significance Index: -1.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1706
    Cell Significance Index: -4.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1741
    Cell Significance Index: -13.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1841
    Cell Significance Index: -4.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1884
    Cell Significance Index: -1.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1993
    Cell Significance Index: -5.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2002
    Cell Significance Index: -3.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2163
    Cell Significance Index: -13.2600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2624
    Cell Significance Index: -2.2300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2645
    Cell Significance Index: -3.7100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2724
    Cell Significance Index: -6.9600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2781
    Cell Significance Index: -1.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2795
    Cell Significance Index: -8.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2939
    Cell Significance Index: -14.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2940
    Cell Significance Index: -4.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2944
    Cell Significance Index: -9.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell-specific expression:** OTUD6B is expressed in a wide range of cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, embryonic stem cell, and various immune cells. 2. **Deubiquitination activity:** OTUD6B is a member of the OTU deubiquitinase family, which is characterized by its ability to remove ubiquitin from target proteins. 3. **Regulation of translation:** OTUD6B has been implicated in the regulation of translation, affecting the positive and negative regulation of translation. 4. **Protein binding:** OTUD6B interacts with various proteins, including eukaryotic translation initiation factor 4f complex, which is involved in the initiation of translation. **Pathways and Functions:** 1. **Cell population proliferation:** OTUD6B's expression in hematopoietic cells and stem cells suggests its potential role in regulating cell proliferation. 2. **Cysteine-type deubiquitinase activity:** OTUD6B's deubiquitination activity is specific to cysteine residues, which is essential for the removal of ubiquitin from target proteins. 3. **Proteasome assembly:** OTUD6B's interaction with the proteasome assembly complex suggests its role in regulating protein degradation. 4. **Protein binding:** OTUD6B's interactions with various proteins, including eukaryotic translation initiation factor 4f complex, highlight its role in regulating translation and protein homeostasis. **Clinical Significance:** 1. **Hematological disorders:** OTUD6B's expression in hematopoietic cells and its role in regulating cell proliferation and protein homeostasis make it a potential candidate for studying hematological disorders, such as leukemia and lymphoma. 2. **Immune system regulation:** OTUD6B's expression in immune cells and its role in regulating translation and protein homeostasis suggest its potential role in immune system regulation and diseases, such as autoimmune disorders. 3. **Cancer therapy:** OTUD6B's involvement in protein degradation and translation regulation makes it a potential target for cancer therapy. 4. **Neurological disorders:** OTUD6B's expression in neuronal cells and its role in regulating protein homeostasis suggest its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, OTUD6B is a multifaceted gene involved in the regulation of protein deubiquitination and translation. Its expression in various cell types and its interactions with various proteins highlight its potential role in maintaining cellular homeostasis. Further studies are necessary to fully elucidate the clinical significance of OTUD6B and its potential applications in human disease.

Genular Protein ID: 4177647740

Symbol: OTU6B_HUMAN

Name: DUBA-5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 23827681

Title: OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

PubMed ID: 23827681

DOI: 10.1016/j.cell.2013.05.046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21267069

Title: Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.

PubMed ID: 21267069

DOI: 10.1371/journal.pone.0014514

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 28343629

Title: Biallelic variants in OTUD6B cause an intellectual disability syndrome associated with seizures and dysmorphic features.

PubMed ID: 28343629

DOI: 10.1016/j.ajhg.2017.03.001

PubMed ID: 27864334

Title: Deubiquitinase OTUD6B isoforms are important regulators of growth and proliferation.

PubMed ID: 27864334

DOI: 10.1158/1541-7786.mcr-16-0281-t

Sequence Information:

  • Length: 293
  • Mass: 33813
  • Checksum: 468DB88E2637D869
  • Sequence:
  • MEAVLTEELD EEEQLLRRHR KEKKELQAKI QGMKNAVPKN DKKRRKQLTE DVAKLEKEME 
    QKHREELEQL KLTTKENKID SVAVNISNLV LENQPPRISK AQKRREKKAA LEKEREERIA 
    EAEIENLTGA RHMESEKLAQ ILAARQLEIK QIPSDGHCMY KAIEDQLKEK DCALTVVALR 
    SQTAEYMQSH VEDFLPFLTN PNTGDMYTPE EFQKYCEDIV NTAAWGGQLE LRALSHILQT 
    PIEIIQADSP PIIVGEEYSK KPLILVYMRH AYGLGEHYNS VTRLVNIVTE NCS

Genular Protein ID: 1865110023

Symbol: A0A087X0W9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 323
  • Mass: 37326
  • Checksum: BAD169986EC47B6F
  • Sequence:
  • MEPRVRVEGW KVPTSRCRFL LARVLGYLVV MEAVLTEELD EEEQLLRRHR KEKKELQAKI 
    QGMKNAVPKN DKKRRKQLTE DVAKLEKEME QKHREELEQL KLTTKENKID SVAVNISNLV 
    LENQPPRISK AQKRREKKAA LEKEREERIA EAEIENLTGA RHMESEKLAQ ILAARQLEIK 
    QIPSDGHCMY KAIEDQLKEK DCALTVVALR SQTAEYMQSH VEDFLPFLTN PNTGDMYTPE 
    EFQKYCEDIV NTAAWGGQLE LRALSHILQT PIEIIQADSP PIIVGEEYSK KPLILVYMRH 
    AYGLGEHYNS VTRLVNIVTE NCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.