Details for: MRPL48

Gene ID: 51642

Symbol: MRPL48

Ensembl ID: ENSG00000175581

Description: mitochondrial ribosomal protein L48

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 168.0540
    Cell Significance Index: -26.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.3882
    Cell Significance Index: -23.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.1936
    Cell Significance Index: -29.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.5460
    Cell Significance Index: -31.8900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 60.2467
    Cell Significance Index: -30.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.5692
    Cell Significance Index: -31.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.7130
    Cell Significance Index: -30.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9665
    Cell Significance Index: -24.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.7255
    Cell Significance Index: -26.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0181
    Cell Significance Index: -31.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1370
    Cell Significance Index: 347.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.5243
    Cell Significance Index: 38.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2094
    Cell Significance Index: 16.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7932
    Cell Significance Index: 54.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7876
    Cell Significance Index: 21.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7390
    Cell Significance Index: 148.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6194
    Cell Significance Index: 122.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5894
    Cell Significance Index: 20.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5853
    Cell Significance Index: 16.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5827
    Cell Significance Index: 26.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5724
    Cell Significance Index: 26.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5707
    Cell Significance Index: 29.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5650
    Cell Significance Index: 101.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5404
    Cell Significance Index: 487.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5282
    Cell Significance Index: 288.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4830
    Cell Significance Index: 59.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4822
    Cell Significance Index: 3.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4658
    Cell Significance Index: 59.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4349
    Cell Significance Index: 51.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3609
    Cell Significance Index: 18.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3567
    Cell Significance Index: 9.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3506
    Cell Significance Index: 9.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3334
    Cell Significance Index: 45.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3314
    Cell Significance Index: 7.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3311
    Cell Significance Index: 118.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3163
    Cell Significance Index: 4.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2692
    Cell Significance Index: 186.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2459
    Cell Significance Index: 31.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2222
    Cell Significance Index: 98.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2189
    Cell Significance Index: 16.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2077
    Cell Significance Index: 35.4700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1966
    Cell Significance Index: 19.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1826
    Cell Significance Index: 11.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1435
    Cell Significance Index: 8.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1276
    Cell Significance Index: 2.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1162
    Cell Significance Index: 5.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0984
    Cell Significance Index: 2.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0753
    Cell Significance Index: 5.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0554
    Cell Significance Index: 1.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0511
    Cell Significance Index: 9.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0469
    Cell Significance Index: 2.8800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0328
    Cell Significance Index: 61.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0291
    Cell Significance Index: 0.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0144
    Cell Significance Index: 22.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0124
    Cell Significance Index: 9.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0069
    Cell Significance Index: 12.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0080
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0119
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0139
    Cell Significance Index: -8.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0185
    Cell Significance Index: -8.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0330
    Cell Significance Index: -4.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0342
    Cell Significance Index: -0.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0378
    Cell Significance Index: -21.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0453
    Cell Significance Index: -4.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0461
    Cell Significance Index: -0.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0656
    Cell Significance Index: -2.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0864
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0908
    Cell Significance Index: -19.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0909
    Cell Significance Index: -3.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0930
    Cell Significance Index: -6.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0954
    Cell Significance Index: -27.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1020
    Cell Significance Index: -6.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1050
    Cell Significance Index: -12.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1101
    Cell Significance Index: -12.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1104
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2674
    Cell Significance Index: -30.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2818
    Cell Significance Index: -29.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3040
    Cell Significance Index: -24.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3436
    Cell Significance Index: -5.7500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3670
    Cell Significance Index: -3.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3980
    Cell Significance Index: -10.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4449
    Cell Significance Index: -27.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4614
    Cell Significance Index: -10.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5226
    Cell Significance Index: -5.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5713
    Cell Significance Index: -12.5100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6005
    Cell Significance Index: -5.5300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6037
    Cell Significance Index: -12.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6188
    Cell Significance Index: -14.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6658
    Cell Significance Index: -9.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6659
    Cell Significance Index: -21.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6780
    Cell Significance Index: -19.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6798
    Cell Significance Index: -21.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7038
    Cell Significance Index: -24.6600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7088
    Cell Significance Index: -10.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7209
    Cell Significance Index: -15.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7279
    Cell Significance Index: -26.7200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.7454
    Cell Significance Index: -7.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: MRPL48 is a mitochondrial ribosomal protein, which means it is embedded within the mitochondrial inner membrane and plays a crucial role in mitochondrial translation. 2. **Conserved sequence**: MRPL48 shares high sequence homology with other mitochondrial ribosomal proteins, indicating its conserved function across different species. 3. **High expression levels**: MRPL48 is highly expressed in various cell types, including hematopoietic cells, stem cells, and smooth muscle fibers. 4. **Tight regulation**: The expression of MRPL48 is tightly regulated, and alterations in its expression have been implicated in several diseases. **Pathways and Functions:** 1. **Mitochondrial translation**: MRPL48 is involved in the translation of mitochondrial mRNAs into proteins essential for energy production and cellular homeostasis. 2. **Mitochondrial inner membrane**: MRPL48 is embedded within the mitochondrial inner membrane, where it plays a crucial role in mitochondrial translation and energy production. 3. **Metabolic pathways**: MRPL48 is involved in various metabolic pathways, including fatty acid oxidation, glucose metabolism, and oxidative phosphorylation. 4. **Cellular homeostasis**: MRPL48 plays a crucial role in maintaining cellular homeostasis, particularly in the regulation of energy metabolism and oxidative stress. **Clinical Significance:** 1. **Hematological malignancies**: Alterations in MRPL48 expression have been implicated in several hematological malignancies, including leukemia and lymphoma. 2. **Metabolic disorders**: MRPL48 has been linked to various metabolic disorders, including type 2 diabetes and metabolic syndrome. 3. **Mitochondrial diseases**: MRPL48 has been implicated in mitochondrial diseases, including mitochondrial myopathies and neurodegenerative disorders. 4. **Cancer therapy**: MRPL48 has been identified as a potential target for cancer therapy, particularly in the treatment of hematological malignancies. In conclusion, MRPL48 is a critical component of the mitochondrial ribosome, playing a vital role in mitochondrial translation and energy production. Its expression is tightly regulated, and alterations in its expression have been implicated in several diseases, including hematological malignancies, metabolic disorders, and mitochondrial diseases. Further research is needed to fully understand the role of MRPL48 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 569468912

Symbol: RM48_HUMAN

Name: 39S ribosomal protein L48, mitochondrial

UniProtKB Accession Codes:

Q96GC5 B4DN34 Q49AK7 Q4U2Q4 Q9P091 Q9Y5J0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 55 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 58 PDBsum 58 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 212
  • Mass: 23935
  • Checksum: 0663B1751B57FFF5
  • Sequence:
    • MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT KPTHGIGKYK 
HLIKAEEPKK KKGKVEVRAI NLGTDYEYGV LNIHLTAYDM TLAESYAQYV HNLCNSLSIK 
VEESYAMPTK TIEVLQLQDQ GSKMLLDSVL TTHERVVQIS GLSATFAEIF LEIIQSSLPE 
GVRLSVKEHT EEDFKGRFKA RPELEELLAK LK

Genular Protein ID: 3449058171

Symbol: F5H8D0_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H8D0

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 121
  • Mass: 13651
  • Checksum: FF2572EB37A98733
  • Sequence:
    • MSGTLEKVLC LRNNTIFKQA FSLLRFRTSG EKPIYSVGGI LLSISRPYKT KPTHGIGKYK 
HLIKAEEISG LSATFAEIFL EIIQSSLPEG VRLSVKEHTE EDFKGRFKAR PELEELLAKL 
K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.