Details for: PPIL1

Gene ID: 51645

Symbol: PPIL1

Ensembl ID: ENSG00000137168

Description: peptidylprolyl isomerase like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.5288
    Cell Significance Index: -12.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.6901
    Cell Significance Index: -15.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.2695
    Cell Significance Index: -18.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0354
    Cell Significance Index: -17.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9036
    Cell Significance Index: -15.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5615
    Cell Significance Index: -18.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7895
    Cell Significance Index: 177.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3292
    Cell Significance Index: 14.4500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1660
    Cell Significance Index: 9.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1443
    Cell Significance Index: 39.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.7801
    Cell Significance Index: 19.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7589
    Cell Significance Index: 45.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6972
    Cell Significance Index: 75.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6909
    Cell Significance Index: 43.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6802
    Cell Significance Index: 614.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6607
    Cell Significance Index: 13.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5914
    Cell Significance Index: 96.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5201
    Cell Significance Index: 60.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4403
    Cell Significance Index: 22.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3618
    Cell Significance Index: 9.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3481
    Cell Significance Index: 4.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3295
    Cell Significance Index: 22.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3153
    Cell Significance Index: 8.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2740
    Cell Significance Index: 52.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2667
    Cell Significance Index: 52.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2451
    Cell Significance Index: 133.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2415
    Cell Significance Index: 33.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2003
    Cell Significance Index: 40.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1949
    Cell Significance Index: 23.9600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1868
    Cell Significance Index: 5.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1830
    Cell Significance Index: 21.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1811
    Cell Significance Index: 1.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1741
    Cell Significance Index: 4.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1669
    Cell Significance Index: 12.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1495
    Cell Significance Index: 53.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1457
    Cell Significance Index: 6.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1452
    Cell Significance Index: 64.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1409
    Cell Significance Index: 25.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1385
    Cell Significance Index: 3.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1051
    Cell Significance Index: 7.4300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0983
    Cell Significance Index: 3.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0885
    Cell Significance Index: 61.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0739
    Cell Significance Index: 3.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0499
    Cell Significance Index: 6.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0378
    Cell Significance Index: 1.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0364
    Cell Significance Index: 0.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0324
    Cell Significance Index: 4.1900
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.0191
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0153
    Cell Significance Index: 28.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0007
    Cell Significance Index: 0.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0097
    Cell Significance Index: -17.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0111
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0146
    Cell Significance Index: -19.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0176
    Cell Significance Index: -3.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0196
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0217
    Cell Significance Index: -16.1100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0218
    Cell Significance Index: -0.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0266
    Cell Significance Index: -1.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0300
    Cell Significance Index: -16.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0338
    Cell Significance Index: -15.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0341
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0371
    Cell Significance Index: -23.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0390
    Cell Significance Index: -0.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0401
    Cell Significance Index: -1.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0439
    Cell Significance Index: -12.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0470
    Cell Significance Index: -4.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0507
    Cell Significance Index: -1.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0727
    Cell Significance Index: -1.6800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0884
    Cell Significance Index: -1.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0951
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0968
    Cell Significance Index: -11.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0984
    Cell Significance Index: -20.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0993
    Cell Significance Index: -5.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1168
    Cell Significance Index: -7.1800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1202
    Cell Significance Index: -1.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1306
    Cell Significance Index: -5.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1327
    Cell Significance Index: -5.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1363
    Cell Significance Index: -2.0700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1382
    Cell Significance Index: -1.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1503
    Cell Significance Index: -5.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1700
    Cell Significance Index: -4.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1716
    Cell Significance Index: -17.8700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1741
    Cell Significance Index: -2.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1797
    Cell Significance Index: -14.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1806
    Cell Significance Index: -4.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1923
    Cell Significance Index: -12.9300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2109
    Cell Significance Index: -1.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2284
    Cell Significance Index: -14.0000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2286
    Cell Significance Index: -1.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2360
    Cell Significance Index: -6.9500
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2470
    Cell Significance Index: -1.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2785
    Cell Significance Index: -7.1600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.2912
    Cell Significance Index: -1.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3236
    Cell Significance Index: -7.0900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3426
    Cell Significance Index: -3.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3520
    Cell Significance Index: -2.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3649
    Cell Significance Index: -3.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PPIL1 is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which consists of enzymes that catalyze the isomerization of proline residues in proteins. PPIL1 is a small, multifunctional enzyme that is expressed in various cell types, including hematopoietic cells, smooth muscle cells, and epithelial cells. Its expression is regulated by various transcriptional factors, suggesting a complex interplay between PPIL1 and other cellular processes. **Pathways and Functions:** PPIL1 is involved in several cellular pathways, including: 1. **Protein folding:** PPIL1 plays a crucial role in the folding of proteins, particularly those containing proline residues. Its enzymatic activity helps to maintain the native conformation of proteins, ensuring proper protein function. 2. **Spliceosome-mediated mRNA processing:** PPIL1 is involved in the processing of pre-mRNA, particularly in the 2' splice site of introns. Its catalytic activity is required for the efficient removal of introns and the production of mature mRNA. 3. **Disordered domain-specific binding:** PPIL1 interacts with disordered domains, which are regions of proteins that lack a fixed structure. This interaction is essential for the proper functioning of these domains, which often play critical roles in protein-protein interactions. 4. **Immune response:** PPIL1 has been shown to be involved in the regulation of immune responses, particularly in the context of T-cell activation and differentiation. **Clinical Significance:** PPIL1 has been implicated in various diseases, including: 1. **Autoimmune disorders:** Abnormalities in PPIL1 expression have been linked to autoimmune disorders, such as multiple sclerosis and type 1 diabetes. 2. **Cancer:** PPIL1 has been shown to be overexpressed in certain types of cancer, including breast and colon cancer. 3. **Neurodegenerative diseases:** PPIL1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In conclusion, PPIL1 is a multifunctional enzyme that plays a crucial role in various cellular processes, including protein folding, mRNA processing, and immune response. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of PPIL1 and its clinical significance.

Genular Protein ID: 631089671

Symbol: PPIL1_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase-like 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8978786

Title: Cloning, expression and chromosomal mapping of a novel cyclophilin-related gene (PPIL1) from human fetal brain.

PubMed ID: 8978786

DOI: 10.1159/000134199

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16595688

Title: Solution structure of human peptidyl prolyl isomerase-like protein 1 and insights into its interaction with SKIP.

PubMed ID: 16595688

DOI: 10.1074/jbc.m511155200

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 20368803

Title: The crystal structure of PPIL1 bound to cyclosporine A suggests a binding mode for a linear epitope of the SKIP protein.

PubMed ID: 20368803

DOI: 10.1371/journal.pone.0010013

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 33220177

Title: Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.

PubMed ID: 33220177

DOI: 10.1016/j.neuron.2020.10.035

Sequence Information:

  • Length: 166
  • Mass: 18237
  • Checksum: 2872DC3336CD05E4
  • Sequence:
  • MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF 
    MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ 
    WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.