Details for: ZFR

Gene ID: 51663

Symbol: ZFR

Ensembl ID: ENSG00000056097

Description: zinc finger RNA binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 521.3918
    Cell Significance Index: -81.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 314.5755
    Cell Significance Index: -79.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 183.4269
    Cell Significance Index: -86.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 171.7139
    Cell Significance Index: -69.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 153.0954
    Cell Significance Index: -78.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 73.4753
    Cell Significance Index: -70.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 68.9157
    Cell Significance Index: -84.9700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.1990
    Cell Significance Index: -78.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.0738
    Cell Significance Index: -70.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.7230
    Cell Significance Index: -85.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.6095
    Cell Significance Index: -38.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.2824
    Cell Significance Index: 382.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4251
    Cell Significance Index: 481.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3951
    Cell Significance Index: 480.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2108
    Cell Significance Index: 124.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8012
    Cell Significance Index: 93.8200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.7829
    Cell Significance Index: 45.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7752
    Cell Significance Index: 49.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6848
    Cell Significance Index: 604.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6841
    Cell Significance Index: 129.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.3480
    Cell Significance Index: 26.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1863
    Cell Significance Index: 71.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1613
    Cell Significance Index: 142.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1578
    Cell Significance Index: 77.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1215
    Cell Significance Index: 202.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0233
    Cell Significance Index: 62.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9878
    Cell Significance Index: 683.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8846
    Cell Significance Index: 39.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8430
    Cell Significance Index: 115.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7571
    Cell Significance Index: 28.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6741
    Cell Significance Index: 368.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5606
    Cell Significance Index: 26.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3840
    Cell Significance Index: 11.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3790
    Cell Significance Index: 17.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3518
    Cell Significance Index: 662.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3319
    Cell Significance Index: 15.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3034
    Cell Significance Index: 134.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2768
    Cell Significance Index: 7.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2532
    Cell Significance Index: 160.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2361
    Cell Significance Index: 30.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2183
    Cell Significance Index: 41.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2142
    Cell Significance Index: 3.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2030
    Cell Significance Index: 13.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1884
    Cell Significance Index: 85.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1809
    Cell Significance Index: 21.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1740
    Cell Significance Index: 17.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1320
    Cell Significance Index: 203.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1189
    Cell Significance Index: 20.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1169
    Cell Significance Index: 215.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1080
    Cell Significance Index: 5.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1026
    Cell Significance Index: 139.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0237
    Cell Significance Index: -17.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0305
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0407
    Cell Significance Index: -30.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0589
    Cell Significance Index: -36.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0887
    Cell Significance Index: -67.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0920
    Cell Significance Index: -2.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0956
    Cell Significance Index: -3.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1078
    Cell Significance Index: -13.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1079
    Cell Significance Index: -60.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1768
    Cell Significance Index: -4.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2069
    Cell Significance Index: -21.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2121
    Cell Significance Index: -44.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2318
    Cell Significance Index: -6.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2611
    Cell Significance Index: -75.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2675
    Cell Significance Index: -38.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2679
    Cell Significance Index: -16.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3723
    Cell Significance Index: -19.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3883
    Cell Significance Index: -63.1600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4502
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4583
    Cell Significance Index: -52.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4598
    Cell Significance Index: -13.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4618
    Cell Significance Index: -34.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4816
    Cell Significance Index: -10.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4969
    Cell Significance Index: -35.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5411
    Cell Significance Index: -15.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5555
    Cell Significance Index: -57.8400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5578
    Cell Significance Index: -3.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5818
    Cell Significance Index: -8.5900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6372
    Cell Significance Index: -9.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6964
    Cell Significance Index: -11.6600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6970
    Cell Significance Index: -79.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7056
    Cell Significance Index: -22.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7509
    Cell Significance Index: -26.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8192
    Cell Significance Index: -21.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8477
    Cell Significance Index: -67.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0807
    Cell Significance Index: -66.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.1702
    Cell Significance Index: -16.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2042
    Cell Significance Index: -16.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2415
    Cell Significance Index: -26.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3504
    Cell Significance Index: -29.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.4059
    Cell Significance Index: -41.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.5047
    Cell Significance Index: -32.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.5586
    Cell Significance Index: -36.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5769
    Cell Significance Index: -42.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6316
    Cell Significance Index: -51.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.6456
    Cell Significance Index: -27.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6726
    Cell Significance Index: -54.7600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.7972
    Cell Significance Index: -43.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.8064
    Cell Significance Index: -37.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc Finger Domain:** The ZFR protein contains a highly conserved zinc finger motif, which is essential for its RNA-binding activity and DNA interaction capabilities. 2. **RNA-Binding Specificity:** ZFR exhibits specificity towards double-stranded and single-stranded RNAs, influencing RNA stability, localization, and translation. 3. **Cellular Expression:** ZFR is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle cells, epithelial cells, and immune cells, underscoring its role in various cellular processes. 4. **Post-Transcriptional Regulation:** ZFR's RNA-binding activity allows it to modulate RNA stability, translation, and localization, thereby influencing protein levels and cellular behavior. **Pathways and Functions:** 1. **RNA Regulation:** ZFR modulates RNA stability, translation, and localization, influencing the expression of genes involved in immune regulation, cellular differentiation, and tissue homeostasis. 2. **DNA Binding:** The zinc finger motif enables ZFR to bind to specific DNA sequences, influencing gene expression and chromatin remodeling. 3. **Protein Interactions:** ZFR interacts with various proteins, including RNA-binding proteins, transcription factors, and signaling molecules, modulating cellular processes and signaling pathways. 4. **Immune Regulation:** ZFR's expression in immune cells, such as T cells and B cells, suggests its involvement in immune regulation, including T cell differentiation, cytokine production, and immune response modulation. **Clinical Significance:** 1. **Immunodeficiency Disorders:** Dysregulation of ZFR expression or function may contribute to immunodeficiency disorders, such as autoimmune diseases, cancer, and infectious diseases. 2. **Cancer:** ZFR's role in cancer development and progression is complex, as it can modulate tumor suppressor genes and oncogenes, influencing tumor growth and metastasis. 3. **Neurological Disorders:** ZFR's involvement in neurological disorders, such as neurodegenerative diseases, may be related to its role in RNA regulation and protein interactions. 4. **Therapeutic Targeting:** Understanding ZFR's mechanisms of action and its role in disease may lead to the development of novel therapeutic strategies, targeting its RNA-binding activity, DNA binding, or protein interactions. In conclusion, the Zinc Finger RNA Binding Protein (ZFR) is a multifunctional protein that plays a crucial role in immune regulation, cellular differentiation, and tissue homeostasis. Further research is necessary to elucidate its mechanisms of action and its clinical significance, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 2087304437

Symbol: ZFR_HUMAN

Name: Zinc finger RNA-binding protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11574164

Title: Cloning and expression of the human single copy homologue of the mouse zinc finger protein zfr.

PubMed ID: 11574164

DOI: 10.1016/s0378-1119(01)00620-5

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 24482476

Title: Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders.

PubMed ID: 24482476

DOI: 10.1126/science.1247363

Sequence Information:

  • Length: 1074
  • Mass: 117012
  • Checksum: 3E43654E7134E9FC
  • Sequence:
  • MIPICPVVSF TYVPSRLGED AKMATGNYFG FTHSGAAAAA AAAQYSQQPA SGVAYSHPTT 
    VASYTVHQAP VAAHTVTAAY APAAATVAVA RPAPVAVAAA ATAAAYGGYP TAHTATDYGY 
    TQRQQEAPPP PPPATTQNYQ DSYSYVRSTA PAVAYDSKQY YQQPTATAAA VAAAAQPQPS 
    VAETYYQTAP KAGYSQGATQ YTQAQQTRQV TAIKPATPSP ATTTFSIYPV SSTVQPVAAA 
    ATVVPSYTQS ATYSTTAVTY SGTSYSGYEA AVYSAASSYY QQQQQQQKQA AAAAAAAAAT 
    AAWTGTTFTK KAPFQNKQLK PKQPPKPPQI HYCDVCKISC AGPQTYKEHL EGQKHKKKEA 
    ALKASQNTSS SNSSTRGTQN QLRCELCDVS CTGADAYAAH IRGAKHQKVV KLHTKLGKPI 
    PSTEPNVVSQ ATSSTAVSAS KPTASPSSIA ANNCTVNTSS VATSSMKGLT TTGNSSLNST 
    SNTKVSAVPT NMAAKKTSTP KINFVGGNKL QSTGNKAEDI KGTECVKSTP VTSAVQIPEV 
    KQDTVSEPVT PASLAALQSD VQPVGHDYVE EVRNDEGKVI RFHCKLCECS FNDPNAKEMH 
    LKGRRHRLQY KKKVNPDLQV EVKPSIRARK IQEEKMRKQM QKEEYWRRRE EEERWRMEMR 
    RYEEDMYWRR MEEEQHHWDD RRRMPDGGYP HGPPGPLGLL GVRPGMPPQP QGPAPLRRPD 
    SSDDRYVMTK HATIYPTEEE LQAVQKIVSI TERALKLVSD SLSEHEKNKN KEGDDKKEGG 
    KDRALKGVLR VGVLAKGLLL RGDRNVNLVL LCSEKPSKTL LSRIAENLPK QLAVISPEKY 
    DIKCAVSEAA IILNSCVEPK MQVTITLTSP IIREENMREG DVTSGMVKDP PDVLDRQKCL 
    DALAALRHAK WFQARANGLQ SCVIIIRILR DLCQRVPTWS DFPSWAMELL VEKAISSASS 
    PQSPGDALRR VFECISSGII LKGSPGLLDP CEKDPFDTLA TMTDQQREDI TSSAQFALRL 
    LAFRQIHKVL GMDPLPQMSQ RFNIHNNRKR RRDSDGVDGF EAEGKKDKKD YDNF

Genular Protein ID: 4100967066

Symbol: Q05D65_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 189
  • Mass: 19521
  • Checksum: 8B892F7116B7B1E6
  • Sequence:
  • MIPICPVVSF TYVPSRLGED AKMATGNYFG FTHSGAAAAA AAAQYSQQPA SGVAYSHPTT 
    VASYTVHQAP VAAHTVTAAY APAAATVAVA RPAPVAVAAA ATAAAYGGYP TAHTATDYGY 
    TQRQQEAPPP PPPATTQNYQ DSYSYVRSTA PAVAYDSKQY YQQPAATEAG SSSSCCCCCN 
    SCLDRDHLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.