Details for: IFT25

Gene ID: 51668

Symbol: IFT25

Ensembl ID: ENSG00000081870

Description: intraflagellar transport 25

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 187.7268
    Cell Significance Index: -29.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 119.6168
    Cell Significance Index: -30.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 107.2224
    Cell Significance Index: -44.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.8104
    Cell Significance Index: -44.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.4005
    Cell Significance Index: -42.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.5965
    Cell Significance Index: -40.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.0298
    Cell Significance Index: -34.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6562
    Cell Significance Index: -42.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.9111
    Cell Significance Index: -27.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.5900
    Cell Significance Index: -18.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.3879
    Cell Significance Index: 32.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8393
    Cell Significance Index: 1660.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5268
    Cell Significance Index: 91.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4625
    Cell Significance Index: 159.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4405
    Cell Significance Index: 39.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3892
    Cell Significance Index: 163.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3204
    Cell Significance Index: 68.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3158
    Cell Significance Index: 718.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2495
    Cell Significance Index: 203.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1669
    Cell Significance Index: 160.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1550
    Cell Significance Index: 142.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1524
    Cell Significance Index: 30.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0749
    Cell Significance Index: 28.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0361
    Cell Significance Index: 23.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9781
    Cell Significance Index: 176.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8755
    Cell Significance Index: 605.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8744
    Cell Significance Index: 386.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7778
    Cell Significance Index: 156.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7327
    Cell Significance Index: 21.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6978
    Cell Significance Index: 49.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6792
    Cell Significance Index: 43.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6725
    Cell Significance Index: 46.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6352
    Cell Significance Index: 81.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6000
    Cell Significance Index: 12.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5733
    Cell Significance Index: 205.6200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.5123
    Cell Significance Index: 3.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5095
    Cell Significance Index: 101.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5044
    Cell Significance Index: 17.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4400
    Cell Significance Index: 43.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3164
    Cell Significance Index: 14.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3092
    Cell Significance Index: 39.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3044
    Cell Significance Index: 57.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3026
    Cell Significance Index: 15.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2725
    Cell Significance Index: 20.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2655
    Cell Significance Index: 12.3800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2014
    Cell Significance Index: 2.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1966
    Cell Significance Index: 4.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1929
    Cell Significance Index: 262.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1681
    Cell Significance Index: 316.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1664
    Cell Significance Index: 9.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1650
    Cell Significance Index: 7.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1176
    Cell Significance Index: 181.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1163
    Cell Significance Index: 6.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0907
    Cell Significance Index: 57.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0732
    Cell Significance Index: 135.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0727
    Cell Significance Index: 1.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0655
    Cell Significance Index: 1.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0555
    Cell Significance Index: 9.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0006
    Cell Significance Index: 0.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0151
    Cell Significance Index: -11.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0159
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0260
    Cell Significance Index: -16.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0278
    Cell Significance Index: -0.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0327
    Cell Significance Index: -18.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0469
    Cell Significance Index: -4.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0585
    Cell Significance Index: -1.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0637
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0832
    Cell Significance Index: -17.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0901
    Cell Significance Index: -0.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1118
    Cell Significance Index: -16.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1177
    Cell Significance Index: -13.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1193
    Cell Significance Index: -2.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1212
    Cell Significance Index: -34.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1855
    Cell Significance Index: -4.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2004
    Cell Significance Index: -12.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3216
    Cell Significance Index: -33.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3252
    Cell Significance Index: -24.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3338
    Cell Significance Index: -38.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3651
    Cell Significance Index: -5.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3714
    Cell Significance Index: -16.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4266
    Cell Significance Index: -33.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4330
    Cell Significance Index: -7.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4435
    Cell Significance Index: -29.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4481
    Cell Significance Index: -16.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5602
    Cell Significance Index: -16.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5728
    Cell Significance Index: -16.4200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5759
    Cell Significance Index: -11.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6039
    Cell Significance Index: -21.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6197
    Cell Significance Index: -7.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7067
    Cell Significance Index: -43.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7254
    Cell Significance Index: -9.2900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7570
    Cell Significance Index: -27.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7637
    Cell Significance Index: -19.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7968
    Cell Significance Index: -25.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8214
    Cell Significance Index: -26.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8995
    Cell Significance Index: -29.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9030
    Cell Significance Index: -37.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9637
    Cell Significance Index: -33.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** IFT25 exhibits characteristics that are typical of intraflagellar transport proteins, including: 1. **Localization to cilia**: IFT25 is specifically localized to the cilia and flagella of various cell types, suggesting its role in ciliary assembly and maintenance. 2. **Association with IFT complex**: IFT25 is a component of the IFT complex, which is responsible for the movement of cargo along the axoneme of cilia. 3. **Regulation of ciliary function**: Alterations in IFT25 expression or function may impact ciliary function, leading to defects in cellular processes that rely on cilia. 4. **Expression in developmentally important cell types**: IFT25 is highly expressed in embryonic stem cells, hematopoietic progenitor cells, and other cell types involved in development and immune responses. **Pathways and Functions** IFT25 is involved in several key pathways, including: 1. **Intraflagellar transport (IFT)**: IFT25 is a component of the IFT complex, which is responsible for the movement of cargo along the axoneme of cilia. 2. **Ciliary tip assembly**: IFT25 plays a role in the assembly of the ciliary tip, which is critical for ciliary function and cellular processes that rely on cilia. 3. **Cell differentiation**: IFT25 is highly expressed in cells involved in development and immune responses, suggesting its role in regulating cell differentiation and cellular homeostasis. 4. **Smoothened signaling pathway**: IFT25 is involved in the Smoothened signaling pathway, which is critical for left/right axis specification and heart development. **Clinical Significance** Dysregulation of IFT25 has been implicated in various diseases and disorders, including: 1. **Ciliopathies**: Alterations in IFT25 expression or function may contribute to the development of ciliopathies, a group of disorders characterized by defects in ciliary function and structure. 2. **Immune disorders**: IFT25 is highly expressed in cells involved in immune responses, and alterations in its expression or function may impact immune function and contribute to the development of immune disorders. 3. **Developmental disorders**: IFT25 is highly expressed in embryonic stem cells and other cell types involved in development, and alterations in its expression or function may impact developmental processes and contribute to the development of developmental disorders. In conclusion, IFT25 is a critical gene that plays a key role in the assembly, maintenance, and function of cilia and flagella in various cell types. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the functions and clinical significance of IFT25.

Genular Protein ID: 3751287187

Symbol: IFT25_HUMAN

Name: Intraflagellar transport protein 25 homolog

UniProtKB Accession Codes:

Q9Y547 A6NG57 D3DQ45 Q9Y684

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 3 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2018407

Title: Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26).

PubMed ID: 2018407

DOI: 10.1007/bf02390087

PubMed ID: 19921466

Title: Why proteins without an alpha-crystallin domain should not be included in the human small heat shock protein family HSPB.

PubMed ID: 19921466

DOI: 10.1007/s12192-009-0155-4

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 18816799

Title: Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study.

PubMed ID: 18816799

DOI: 10.1002/prot.22229

Sequence Information:

  • Length: 144
  • Mass: 16297
  • Checksum: 43B7DBDD47A528C9
  • Sequence:
    • MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI ICFHKHVRIE 
RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL QNEEIVAHDG SATYLRFIIV 
SAFDHFASVH SVSAEGTVVS NLSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.