PDPK1 | ENSG00000140992 | NCBI 5170

Details for: PDPK1

Gene ID: 5170

Symbol: PDPK1

Ensembl ID: ENSG00000140992

Description: 3-phosphoinositide dependent protein kinase 1

Associated with

Activation of akt2
(R-HSA-165158)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Costimulation by the cd28 family
(R-HSA-388841)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream tcr signaling
(R-HSA-202424)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-stimulated signaling through prkcz
(R-HSA-9634635)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
G-protein beta:gamma signalling
(R-HSA-397795)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Integrin signaling
(R-HSA-354192)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Rsk activation
(R-HSA-444257)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Tcr signaling
(R-HSA-202403)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transmission across chemical synapses
(R-HSA-112315)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Viral infection pathways
(R-HSA-9824446)
3-phosphoinositide-dependent protein kinase activity
(GO:0004676)
Actin cytoskeleton organization
(GO:0030036)
Atp binding
(GO:0005524)
Calcium-mediated signaling
(GO:0019722)
Cell migration
(GO:0016477)
Chromatin remodeling
(GO:0006338)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Histone h2as1 kinase activity
(GO:0044024)
Hyperosmotic response
(GO:0006972)
Insulin receptor signaling pathway
(GO:0008286)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of protein kinase activity
(GO:0006469)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phospholipase activator activity
(GO:0016004)
Phospholipase binding
(GO:0043274)
Positive regulation of phospholipase activity
(GO:0010518)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Type b pancreatic cell development
(GO:0003323)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 233.2441
Cell Significance Index: -36.2800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 144.3759
Cell Significance Index: -36.6200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 86.7359
Cell Significance Index: -40.9500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 83.2970
Cell Significance Index: -33.8400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 75.3132
Cell Significance Index: -38.7400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.4546
Cell Significance Index: -33.8500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 31.3474
Cell Significance Index: -38.6500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.0620
Cell Significance Index: -37.6700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.8576
Cell Significance Index: -36.4200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 9.9074
Cell Significance Index: -39.1000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.9993
Cell Significance Index: -13.1300
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 4.9240
Cell Significance Index: 81.1400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9702
Cell Significance Index: 390.9900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.5119
Cell Significance Index: 40.3700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.4818
Cell Significance Index: 88.9600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.3837
Cell Significance Index: 398.1200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3406
Cell Significance Index: 145.8200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2395
Cell Significance Index: 248.6500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0635
Cell Significance Index: 14.5100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.0531
Cell Significance Index: 46.5800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.0349
Cell Significance Index: 39.1900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9397
Cell Significance Index: 152.8400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.8219
Cell Significance Index: 22.9700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6402
Cell Significance Index: 13.8700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5619
Cell Significance Index: 37.7800
Cell Name: decidual cell (CL2000002)
Fold Change: 0.5233
Cell Significance Index: 8.4000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5205
Cell Significance Index: 93.8300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4884
Cell Significance Index: 60.0500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4663
Cell Significance Index: 21.7400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4212
Cell Significance Index: 151.0900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3909
Cell Significance Index: 270.3800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3653
Cell Significance Index: 25.2600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3436
Cell Significance Index: 187.6500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3383
Cell Significance Index: 305.4300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3368
Cell Significance Index: 15.2700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3353
Cell Significance Index: 9.6600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3332
Cell Significance Index: 17.3100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.3018
Cell Significance Index: 19.0200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2809
Cell Significance Index: 38.5700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2588
Cell Significance Index: 49.2500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2531
Cell Significance Index: 19.4300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2243
Cell Significance Index: 6.4000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2161
Cell Significance Index: 13.9400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1944
Cell Significance Index: 33.1900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1917
Cell Significance Index: 84.7400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1813
Cell Significance Index: 17.9300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1006
Cell Significance Index: 5.2800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0563
Cell Significance Index: 7.2200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0498
Cell Significance Index: 93.8100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0474
Cell Significance Index: 5.5900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0212
Cell Significance Index: 13.4600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0171
Cell Significance Index: 26.3300
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0152
Cell Significance Index: 28.0100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0008
Cell Significance Index: 1.1000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0022
Cell Significance Index: -1.5900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0098
Cell Significance Index: -7.4300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0124
Cell Significance Index: -5.6200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0128
Cell Significance Index: -9.4600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0171
Cell Significance Index: -10.7000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0281
Cell Significance Index: -0.6000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0463
Cell Significance Index: -26.1400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0513
Cell Significance Index: -2.4100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0562
Cell Significance Index: -5.7400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0823
Cell Significance Index: -2.2400
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0844
Cell Significance Index: -5.1900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0890
Cell Significance Index: -11.5000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0960
Cell Significance Index: -3.3400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1191
Cell Significance Index: -25.0900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1273
Cell Significance Index: -14.8400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1352
Cell Significance Index: -2.8800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1393
Cell Significance Index: -9.8500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1550
Cell Significance Index: -22.5300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1908
Cell Significance Index: -14.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2038
Cell Significance Index: -23.3500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2108
Cell Significance Index: -11.8300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2367
Cell Significance Index: -7.5800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2463
Cell Significance Index: -5.1100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2505
Cell Significance Index: -6.4400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2724
Cell Significance Index: -31.0900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2939
Cell Significance Index: -15.3100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3240
Cell Significance Index: -11.3900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3297
Cell Significance Index: -34.3300
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3452
Cell Significance Index: -5.8200
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.3594
Cell Significance Index: -4.8500
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3715
Cell Significance Index: -29.4300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3849
Cell Significance Index: -10.1200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3976
Cell Significance Index: -9.9400
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4084
Cell Significance Index: -6.0300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4791
Cell Significance Index: -8.8600
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4892
Cell Significance Index: -7.3300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.5392
Cell Significance Index: -9.2400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.5408
Cell Significance Index: -14.4900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.5491
Cell Significance Index: -9.1900
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5515
Cell Significance Index: -8.1400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5715
Cell Significance Index: -35.0400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6504
Cell Significance Index: -32.8700
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.6530
Cell Significance Index: -9.8400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.6626
Cell Significance Index: -19.4600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7190
Cell Significance Index: -22.9000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7924
Cell Significance Index: -22.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** * PDPK1 is a serine/threonine kinase enzyme that phosphorylates a wide range of substrates, including proteins, lipids, and other kinases. * It is activated by phosphatidylinositol 3-phosphate (PI(3)P) and phosphatidylinositol 3,4,5-trisphosphate (PIP3), which are products of PI3K activity. * PDPK1 is involved in the regulation of multiple signaling pathways, including the PI3K/AKT pathway, MAPK/ERK pathway, and NF-κB pathway. * It is highly expressed in various cell types, including immune cells, neurons, and epithelial cells. * PDPK1 is implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. **Pathways and Functions:** * PI3K/AKT pathway: PDPK1 is a key downstream effector of PI3K and is involved in the regulation of cell survival, proliferation, and metabolism. * MAPK/ERK pathway: PDPK1 is involved in the regulation of cell proliferation, differentiation, and survival through the activation of MAPK/ERK. * NF-κB pathway: PDPK1 is involved in the regulation of inflammation and immune responses through the activation of NF-κB. * Cell signaling: PDPK1 is involved in the regulation of various cellular processes, including cell adhesion, migration, and differentiation. * Metabolism: PDPK1 is involved in the regulation of glucose and lipid metabolism through the activation of key enzymes and transcription factors. * Cancer: PDPK1 is implicated in the development and progression of various cancers, including breast, lung, and colon cancer. * Neurodegenerative disorders: PDPK1 is implicated in the development and progression of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. **Clinical Significance:** * PDPK1 is a potential therapeutic target for various diseases, including cancer, diabetes, and neurodegenerative disorders. * Abnormal expression or activity of PDPK1 has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. * PDPK1 is a key player in the regulation of cell signaling, metabolism, and survival, and its dysregulation can have significant clinical implications. * Further research is needed to fully understand the role of PDPK1 in human disease and to develop effective therapeutic strategies targeting this enzyme. In conclusion, PDPK1 is a critical enzyme that plays a key role in various cellular processes, including cell signaling, survival, and metabolism. Its dysregulation is implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders. Further research is needed to fully understand the role of PDPK1 in human disease and to develop effective therapeutic strategies targeting this enzyme.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

3-phosphoinositide-dependent protein kinase 1

Genular Protein ID: 2030207548

Symbol: PDPK1_HUMAN

Name: 3-phosphoinositide-dependent protein kinase 1

UniProtKB Accession Codes:

O15530 H0Y4Z0 Q59EH6 Q6FI20 Q8IV52 Q9BRD5

Database IDs:

Citations:

PubMed ID: 9094314

Title: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha.

PubMed ID: 9094314

DOI: 10.1016/s0960-9822(06)00122-9

PubMed ID: 9368760

Title: 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

PubMed ID: 9368760

DOI: 10.1016/s0960-9822(06)00336-8

PubMed ID: 9445477

Title: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

PubMed ID: 9445477

DOI: 10.1126/science.279.5351.710

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9637919

Title: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.

PubMed ID: 9637919

DOI: 10.1016/s0960-9822(98)70274-x

PubMed ID: 9768361

Title: Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.

PubMed ID: 9768361

DOI: 10.1016/s0960-9822(98)70444-0

PubMed ID: 9707564

Title: Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.

PubMed ID: 9707564

DOI: 10.1073/pnas.95.17.9849

PubMed ID: 9445476

Title: Phosphorylation and activation of p70s6k by PDK1.

PubMed ID: 9445476

DOI: 10.1126/science.279.5351.707

PubMed ID: 10455013

Title: Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.

PubMed ID: 10455013

DOI: 10.1042/bj3420287

PubMed ID: 10364160

Title: A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.

PubMed ID: 10364160

DOI: 10.1101/gad.13.11.1438

PubMed ID: 10480933

Title: 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

PubMed ID: 10480933

DOI: 10.1074/jbc.274.38.27168

PubMed ID: 10995762

Title: p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

PubMed ID: 10995762

DOI: 10.1074/jbc.m006553200

PubMed ID: 11481331

Title: Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 (PDK1) and their role in regulating kinase activity.

PubMed ID: 11481331

DOI: 10.1074/jbc.m105916200

PubMed ID: 12177059

Title: Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.

PubMed ID: 12177059

DOI: 10.1074/jbc.m205141200

PubMed ID: 12167717

Title: Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

PubMed ID: 12167717

DOI: 10.1128/mcb.22.17.6247-6260.2002

PubMed ID: 14585963

Title: Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.

PubMed ID: 14585963

DOI: 10.1128/mcb.23.22.8019-8029.2003

PubMed ID: 14604990

Title: Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner.

PubMed ID: 14604990

DOI: 10.1074/jbc.m309653200

PubMed ID: 15210700

Title: The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

PubMed ID: 15210700

DOI: 10.1074/jbc.m405340200

PubMed ID: 10226025

Title: PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

PubMed ID: 10226025

DOI: 10.1016/s0960-9822(99)80186-9

PubMed ID: 15209375

Title: PDK1, the master regulator of AGC kinase signal transduction.

PubMed ID: 15209375

DOI: 10.1016/j.semcdb.2003.12.022

PubMed ID: 16207722

Title: 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.

PubMed ID: 16207722

DOI: 10.1074/jbc.m506235200

PubMed ID: 16251192

Title: Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.

PubMed ID: 16251192

DOI: 10.1074/jbc.m507539200

PubMed ID: 15743829

Title: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.

PubMed ID: 15743829

DOI: 10.1128/mcb.25.6.2347-2363.2005

PubMed ID: 16314505

Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.

PubMed ID: 16314505

DOI: 10.1128/mcb.25.24.10803-10814.2005

PubMed ID: 16780920

Title: Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity.

PubMed ID: 16780920

DOI: 10.1016/j.bioorg.2006.05.002

PubMed ID: 17327236

Title: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.

PubMed ID: 17327236

DOI: 10.1074/jbc.m609279200

PubMed ID: 17371830

Title: Essential role of PDK1 in regulating endothelial cell migration.

PubMed ID: 17371830

DOI: 10.1083/jcb.200607053

PubMed ID: 18835241

Title: The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.

PubMed ID: 18835241

DOI: 10.1016/j.abb.2008.09.008

PubMed ID: 18616680

Title: TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.

PubMed ID: 18616680

DOI: 10.1111/j.1349-7006.2008.00874.x

PubMed ID: 18802401

Title: Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways.

PubMed ID: 18802401

DOI: 10.4161/cc.7.19.6810

PubMed ID: 18024423

Title: Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PubMed ID: 18024423

DOI: 10.1074/jbc.m706361200

PubMed ID: 19591923

Title: The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1.

PubMed ID: 19591923

DOI: 10.1016/j.cellsig.2009.06.010

PubMed ID: 19276999

Title: IGF-I regulated phosphorylation and translocation of PDK-1 in neurons.

PubMed ID: 19276999

DOI: 10.1097/wnr.0b013e328329a41a

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22544756

Title: PDK1 phosphorylation at Thr354 by murine protein serine/threonine kinase 38 contributes to the negative regulation of PDK1 activity.

PubMed ID: 22544756

DOI: 10.1074/jbc.m111.331827

PubMed ID: 22347420

Title: Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.

PubMed ID: 22347420

DOI: 10.1371/journal.pone.0031003

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12169624

Title: High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

PubMed ID: 12169624

DOI: 10.1093/emboj/cdf437

PubMed ID: 15741170

Title: Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

PubMed ID: 15741170

DOI: 10.1074/jbc.m500977200

PubMed ID: 15772071

Title: Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

PubMed ID: 15772071

DOI: 10.1074/jbc.m501367200

PubMed ID: 20978239

Title: Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells.

PubMed ID: 20978239

DOI: 10.1126/scisignal.2000738

PubMed ID: 22999883

Title: Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.

PubMed ID: 22999883

DOI: 10.1016/j.chembiol.2012.07.017

Sequence Information:

Length: 556
Mass: 63152
Checksum: ED8C0306DC4D0653
Sequence:

MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP 
GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK 
ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET 
CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN 
SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD 
FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA 
YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD 
SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE 
GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ 
EVWRQRYQSH PDAAVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PDPK1

Associated with

Cells (max top 100)

Other Information

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. PubMed ID: 9094314

3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. PubMed ID: 9368760

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. PubMed ID: 9445477

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. PubMed ID: 9637919

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. PubMed ID: 9768361

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. PubMed ID: 9707564

Phosphorylation and activation of p70s6k by PDK1. PubMed ID: 9445476

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. PubMed ID: 10455013

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. PubMed ID: 10364160

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. PubMed ID: 10480933

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). PubMed ID: 10995762

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 (PDK1) and their role in regulating kinase activity. PubMed ID: 11481331

Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. PubMed ID: 12177059

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. PubMed ID: 12167717

Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. PubMed ID: 14585963

Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. PubMed ID: 14604990

The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. PubMed ID: 15210700

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. PubMed ID: 10226025

PDK1, the master regulator of AGC kinase signal transduction. PubMed ID: 15209375

3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. PubMed ID: 16207722

Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. PubMed ID: 16251192

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. PubMed ID: 15743829

Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling. PubMed ID: 16314505

Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity. PubMed ID: 16780920

3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. PubMed ID: 17327236

Essential role of PDK1 in regulating endothelial cell migration. PubMed ID: 17371830

The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. PubMed ID: 18835241

TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. PubMed ID: 18616680

Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways. PubMed ID: 18802401

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. PubMed ID: 18024423

The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1. PubMed ID: 19591923

IGF-I regulated phosphorylation and translocation of PDK-1 in neurons. PubMed ID: 19276999

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

PDK1 phosphorylation at Thr354 by murine protein serine/threonine kinase 38 contributes to the negative regulation of PDK1 activity. PubMed ID: 22544756

Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1. PubMed ID: 22347420

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. PubMed ID: 12169624

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding. PubMed ID: 15741170

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. PubMed ID: 15772071

Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells. PubMed ID: 20978239

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. PubMed ID: 22999883