PDPK1 | ENSG00000140992 | NCBI 5170

Details for: PDPK1

Associated with

Activation of akt2
(R-HSA-165158)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd28 co-stimulation
(R-HSA-389356)
Cd28 dependent pi3k/akt signaling
(R-HSA-389357)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Costimulation by the cd28 family
(R-HSA-388841)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream tcr signaling
(R-HSA-202424)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-stimulated signaling through prkcz
(R-HSA-9634635)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
G-protein beta:gamma signalling
(R-HSA-397795)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Integrin signaling
(R-HSA-354192)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 degradation
(R-HSA-6804757)
Regulation of tp53 expression and degradation
(R-HSA-6806003)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Rsk activation
(R-HSA-444257)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by gpcr
(R-HSA-372790)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Tcr signaling
(R-HSA-202403)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transmission across chemical synapses
(R-HSA-112315)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
Vegfr2 mediated vascular permeability
(R-HSA-5218920)
Viral infection pathways
(R-HSA-9824446)
3-phosphoinositide-dependent protein kinase activity
(GO:0004676)
Actin cytoskeleton organization
(GO:0030036)
Activation of protein kinase b activity
(GO:0032148)
Atp binding
(GO:0005524)
Calcium-mediated signaling
(GO:0019722)
Cell migration
(GO:0016477)
Cell projection
(GO:0042995)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to insulin stimulus
(GO:0032869)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Focal adhesion
(GO:0005925)
Histone h2as1 kinase activity
(GO:0044024)
Hyperosmotic response
(GO:0006972)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Insulin receptor signaling pathway
(GO:0008286)
Intracellular signal transduction
(GO:0035556)
Membrane
(GO:0016020)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nucleus
(GO:0005634)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phospholipase activator activity
(GO:0016004)
Phospholipase binding
(GO:0043274)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phospholipase activity
(GO:0010518)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Positive regulation of sprouting angiogenesis
(GO:1903672)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Postsynaptic density
(GO:0014069)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of mast cell degranulation
(GO:0043304)
T cell costimulation
(GO:0031295)
Type b pancreatic cell development
(GO:0003323)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

choroid plexus epithelial cell CL0000706

CSI 6.64

rCSI 10.87%

PRS 41.26
hepatocyte CL0000182

CSI 5.68

rCSI 10.16%

PRS 49.99
near-projecting glutamatergic cortical neuron CL4023012

CSI 4.44

rCSI 16.76%

PRS 35.35
fallopian tube secretory epithelial cell CL4030006

CSI 4.3

rCSI 4.14%

PRS 51.65
intestinal tuft cell CL0019032

CSI 3.57

rCSI 5.46%

PRS 56.09
lung neuroendocrine cell CL1000223

CSI 3.54

rCSI 5.23%

PRS 56.76
double negative thymocyte CL0002489

CSI 3.32

rCSI 2.31%

PRS 61.42
lung macrophage CL1001603

CSI 3.28

rCSI 7.33%

PRS 58.54
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.19

rCSI 2.42%

PRS 63.74
blood vessel endothelial cell CL0000071

CSI 3.05

rCSI 6.34%

PRS 48.8
renal alpha-intercalated cell CL0005011

CSI 3.02

rCSI 4.04%

PRS 59.98
IgG plasma cell CL0000985

CSI 3

rCSI 3.6%

PRS 70.14
unswitched memory B cell CL0000970

CSI 2.9

rCSI 2.44%

PRS 69.13
enteric smooth muscle cell CL0002504

CSI 2.81

rCSI 4.01%

PRS 53.84
pancreatic D cell CL0000173

CSI 2.76

rCSI 2.71%

PRS 53.88
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 2.71

rCSI 13.59%

PRS 63.37
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 2.7

rCSI 1.6%

PRS 68.03
direct pathway medium spiny neuron CL4023026

CSI 2.69

rCSI 64.3%

PRS 33.97
indirect pathway medium spiny neuron CL4023029

CSI 2.64

rCSI 63.61%

PRS 34.93
renal beta-intercalated cell CL0002201

CSI 2.64

rCSI 6.28%

PRS 52.88
L6b glutamatergic cortical neuron CL4023038

CSI 2.59

rCSI 8.1%

PRS 35.9
brush cell of tracheobronchial tree CL0002075

CSI 2.59

rCSI 7.69%

PRS 61.89
melanocyte CL0000148

CSI 2.53

rCSI 1.87%

PRS 44.27
alveolar macrophage CL0000583

CSI 2.39

rCSI 3.93%

PRS 56.9
myeloid leukocyte CL0000766

CSI 2.38

rCSI 2.2%

PRS 52.4
Kupffer cell CL0000091

CSI 2.33

rCSI 5.32%

PRS 50.81
myoepithelial cell CL0000185

CSI 2.3

rCSI 5.81%

PRS 59.87
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.28

rCSI 2.06%

PRS 48.1
CD4-positive helper T cell CL0000492

CSI 2.27

rCSI 1.72%

PRS 64.95
medium spiny neuron CL1001474

CSI 2.27

rCSI 19.54%

PRS 38.47
fibroblast of cardiac tissue CL0002548

CSI 2.26

rCSI 10.82%

PRS 50.32
goblet cell CL0000160

CSI 2.22

rCSI 2.1%

PRS 51.74
squamous epithelial cell CL0000076

CSI 2.18

rCSI 5.17%

PRS 56.58
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.12

rCSI 5.53%

PRS 50.51
interneuron CL0000099

CSI 2.11

rCSI 4.24%

PRS 40.75
blood vessel smooth muscle cell CL0019018

CSI 2.11

rCSI 17.17%

PRS 44.94
secretory cell CL0000151

CSI 2.1

rCSI 2.19%

PRS 51.81
hepatic stellate cell CL0000632

CSI 2.1

rCSI 7.88%

PRS 43.79
mesodermal cell CL0000222

CSI 2.09

rCSI 2.51%

PRS 49.26
pro-B cell CL0000826

CSI 2.05

rCSI 1.69%

PRS 52.86
T-helper 17 cell CL0000899

CSI 2.04

rCSI 1.62%

PRS 73.95
luminal epithelial cell of mammary gland CL0002326

CSI 2.03

rCSI 3.69%

PRS 67.61
BEST4+ enteroycte CL4030026

CSI 2

rCSI 2.49%

PRS 53.66
pulmonary ionocyte CL0017000

CSI 2

rCSI 2.43%

PRS 59.25
duct epithelial cell CL0000068

CSI 1.98

rCSI 2.9%

PRS 54.79
T follicular helper cell CL0002038

CSI 1.97

rCSI 1.47%

PRS 66.59
perivascular cell CL4033054

CSI 1.95

rCSI 2.66%

PRS 56.59
intermediate monocyte CL0002393

CSI 1.93

rCSI 2.92%

PRS 54.15
interstitial cell of Cajal CL0002088

CSI 1.93

rCSI 2.46%

PRS 57.24
mature astrocyte CL0002627

CSI 1.91

rCSI 8.14%

PRS 46.51
inflammatory macrophage CL0000863

CSI 1.9

rCSI 3.25%

PRS 77.21
CD4-positive, alpha-beta memory T cell CL0000897

CSI 1.9

rCSI 1.36%

PRS 65.3
myofibroblast cell CL0000186

CSI 1.89

rCSI 2.61%

PRS 54.69
immature B cell CL0000816

CSI 1.85

rCSI 1.37%

PRS 65.23
transit amplifying cell of colon CL0009011

CSI 1.84

rCSI 2.17%

PRS 54.38
renal principal cell CL0005009

CSI 1.83

rCSI 4.76%

PRS 55.79
respiratory suprabasal cell CL4033048

CSI 1.83

rCSI 2.34%

PRS 56.2
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 1.8

rCSI 1.21%

PRS 63.29
VIP GABAergic cortical interneuron CL4023016

CSI 1.78

rCSI 2.13%

PRS 34.37
plasmacytoid dendritic cell, human CL0001058

CSI 1.76

rCSI 1.23%

PRS 53.77
rod bipolar cell CL0000751

CSI 1.73

rCSI 3.11%

PRS 44.61
epithelial cell of lung CL0000082

CSI 1.73

rCSI 1.43%

PRS 50.1
cardiac endothelial cell CL0010008

CSI 1.7

rCSI 6.87%

PRS 49.67
bronchus fibroblast of lung CL2000093

CSI 1.7

rCSI 1.38%

PRS 51.9
periportal region hepatocyte CL0019026

CSI 1.69

rCSI 6.58%

PRS 58.77
retinal cone cell CL0000573

CSI 1.68

rCSI 2.71%

PRS 41.54
pancreatic A cell CL0000171

CSI 1.67

rCSI 1.75%

PRS 54.56
colon epithelial cell CL0011108

CSI 1.67

rCSI 1.75%

PRS 48.28
neural crest cell CL0011012

CSI 1.66

rCSI 1.31%

PRS 38.58
colonocyte CL1000347

CSI 1.66

rCSI 2.37%

PRS 57.36
naive T cell CL0000898

CSI 1.64

rCSI 1.14%

PRS 65.39
precursor B cell CL0000817

CSI 1.63

rCSI 1.42%

PRS 61.51
CD14-positive monocyte CL0001054

CSI 1.62

rCSI 2.02%

PRS 62.69
retinal blood vessel endothelial cell CL0002585

CSI 1.61

rCSI 2.57%

PRS 55.34
chondrocyte CL0000138

CSI 1.6

rCSI 2.55%

PRS 43.91
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.59

rCSI 1.56%

PRS 67.43
common myeloid progenitor CL0000049

CSI 1.59

rCSI 1.29%

PRS 52.39
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.57

rCSI 2.05%

PRS 65.15
neuroblast (sensu Vertebrata) CL0000031

CSI 1.57

rCSI 2.01%

PRS 49.14
epithelial cell of lower respiratory tract CL0002632

CSI 1.57

rCSI 1.21%

PRS 52.14
intestinal epithelial cell CL0002563

CSI 1.56

rCSI 1.64%

PRS 50.24
double-positive, alpha-beta thymocyte CL0000809

CSI 1.55

rCSI 1.58%

PRS 65.04
lung pericyte CL0009089

CSI 1.54

rCSI 4.05%

PRS 59.54
ciliated cell CL0000064

CSI 1.52

rCSI 2.47%

PRS 49.07
pvalb GABAergic cortical interneuron CL4023018

CSI 1.52

rCSI 1.89%

PRS 32.81
elicited macrophage CL0000861

CSI 1.52

rCSI 1.39%

PRS 59.72
retina horizontal cell CL0000745

CSI 1.52

rCSI 2.31%

PRS 47.86
mature B cell CL0000785

CSI 1.49

rCSI 1.3%

PRS 61.75
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.49

rCSI 3.85%

PRS 46.95
ependymal cell CL0000065

CSI 1.47

rCSI 2.99%

PRS 32.48
regular atrial cardiac myocyte CL0002129

CSI 1.47

rCSI 4.72%

PRS 50.22
ciliated epithelial cell CL0000067

CSI 1.46

rCSI 1.28%

PRS 39.97
cerebral cortex neuron CL0010012

CSI 1.44

rCSI 5.89%

PRS 47.89
adventitial cell CL0002503

CSI 1.42

rCSI 3.38%

PRS 60.88
enterocyte CL0000584

CSI 1.41

rCSI 2.28%

PRS 58.17
hematopoietic stem cell CL0000037

CSI 1.39

rCSI 0.93%

PRS 55.12
CD14-low, CD16-positive monocyte CL0002396

CSI 1.38

rCSI 1.07%

PRS 50.7
stem cell CL0000034

CSI 1.38

rCSI 1.33%

PRS 41.89
multi-ciliated epithelial cell CL0005012

CSI 1.37

rCSI 1.37%

PRS 45.15
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.37

rCSI 2.34%

PRS 71.38

L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.5%

PRS 33.2%
deuterosomal cell CL4033044

CSI 0.5

rCSI 1.5%

PRS 58.6%
kidney connecting tubule epithelial cell CL1000768

CSI 0.5

rCSI 1.3%

PRS 41.3%
pancreatic ductal cell CL0002079

CSI 0.5

rCSI 1.0%

PRS 53.6%
podocyte CL0000653

CSI 0.6

rCSI 2.4%

PRS 50.4%
retinal ganglion cell CL0000740

CSI 0.6

rCSI 1.4%

PRS 38.7%
small intestine goblet cell CL1000495

CSI 0.7

rCSI 1.4%

PRS 60.7%
regular ventricular cardiac myocyte CL0002131

CSI 0.7

rCSI 4.2%

PRS 43.5%
parietal epithelial cell CL1000452

CSI 0.7

rCSI 1.8%

PRS 43.3%
promonocyte CL0000559

CSI 0.7

rCSI 1.2%

PRS 61.0%
glial cell CL0000125

CSI 0.8

rCSI 2.9%

PRS 43.5%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.8

rCSI 2.4%

PRS 38.3%
retinal bipolar neuron CL0000748

CSI 0.8

rCSI 1.5%

PRS 40.4%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.8

rCSI 2.2%

PRS 59.7%
astrocyte of the cerebral cortex CL0002605

CSI 0.8

rCSI 1.8%

PRS 35.3%
paneth cell CL0000510

CSI 0.8

rCSI 1.2%

PRS 68.5%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.9

rCSI 2.1%

PRS 33.4%
nasal mucosa goblet cell CL0002480

CSI 0.9

rCSI 1.0%

PRS 60.7%
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 0.9

rCSI 2.0%

PRS 49.0%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.9

rCSI 2.9%

PRS 39.4%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.9

rCSI 1.3%

PRS 47.9%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.9

rCSI 1.6%

PRS 34.5%
lung secretory cell CL1000272

CSI 1.0

rCSI 2.4%

PRS 49.2%
effector CD4-positive, alpha-beta T cell CL0001044

CSI 1.0

rCSI 2.8%

PRS 70.5%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.0

rCSI 1.9%

PRS 69.8%
extravillous trophoblast CL0008036

CSI 1.0

rCSI 1.3%

PRS 47.2%
pulmonary artery endothelial cell CL1001568

CSI 1.0

rCSI 1.4%

PRS 63.9%
Hofbauer cell CL3000001

CSI 1.0

rCSI 2.0%

PRS 62.0%
Schwann cell CL0002573

CSI 1.0

rCSI 2.9%

PRS 50.1%
peripheral nervous system neuron CL2000032

CSI 1.0

rCSI 1.4%

PRS 44.2%
lung ciliated cell CL1000271

CSI 1.0

rCSI 1.2%

PRS 41.3%
mucus secreting cell CL0000319

CSI 1.1

rCSI 1.7%

PRS 62.3%
renal interstitial pericyte CL1001318

CSI 1.1

rCSI 2.9%

PRS 47.5%
type B pancreatic cell CL0000169

CSI 1.1

rCSI 2.4%

PRS 48.9%
ionocyte CL0005006

CSI 1.1

rCSI 1.2%

PRS 49.7%
cardiac muscle cell CL0000746

CSI 1.1

rCSI 1.6%

PRS 41.8%
vascular associated smooth muscle cell CL0000359

CSI 1.1

rCSI 3.7%

PRS 53.4%
placental villous trophoblast CL2000060

CSI 1.2

rCSI 1.8%

PRS 49.2%
dendritic cell, human CL0001056

CSI 1.2

rCSI 1.8%

PRS 59.4%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.2

rCSI 6.9%

PRS 36.0%
granulocyte monocyte progenitor cell CL0000557

CSI 1.2

rCSI 1.0%

PRS 55.8%
sst GABAergic cortical interneuron CL4023017

CSI 1.2

rCSI 1.5%

PRS 35.5%
central nervous system neuron CL2000029

CSI 1.2

rCSI 8.7%

PRS 38.7%
Langerhans cell CL0000453

CSI 1.2

rCSI 1.8%

PRS 68.5%
inhibitory interneuron CL0000498

CSI 1.2

rCSI 2.8%

PRS 41.8%
enteroendocrine cell CL0000164

CSI 1.2

rCSI 1.7%

PRS 53.7%
pulmonary alveolar type 2 cell CL0002063

CSI 1.2

rCSI 1.9%

PRS 60.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.2

rCSI 2.2%

PRS 33.5%
cardiac neuron CL0010022

CSI 1.2

rCSI 4.0%

PRS 48.2%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.3

rCSI 1.5%

PRS 59.6%
sncg GABAergic cortical interneuron CL4023015

CSI 1.3

rCSI 2.0%

PRS 36.6%
basal cell CL0000646

CSI 1.3

rCSI 1.7%

PRS 52.5%
cerebral cortex endothelial cell CL1001602

CSI 1.3

rCSI 2.2%

PRS 41.7%
amacrine cell CL0000561

CSI 1.3

rCSI 3.7%

PRS 41.9%
intestine goblet cell CL0019031

CSI 1.3

rCSI 1.2%

PRS 49.8%
epithelial cell of proximal tubule CL0002306

CSI 1.3

rCSI 3.3%

PRS 46.1%
cerebral cortex GABAergic interneuron CL0010011

CSI 1.4

rCSI 4.0%

PRS 55.4%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.4

rCSI 3.3%

PRS 39.7%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI 1.4

rCSI 2.3%

PRS 71.4%
multi-ciliated epithelial cell CL0005012

CSI 1.4

rCSI 1.4%

PRS 45.2%
stem cell CL0000034

CSI 1.4

rCSI 1.3%

PRS 41.9%
CD14-low, CD16-positive monocyte CL0002396

CSI 1.4

rCSI 1.1%

PRS 50.7%
hematopoietic stem cell CL0000037

CSI 1.4

rCSI 0.9%

PRS 55.1%
enterocyte CL0000584

CSI 1.4

rCSI 2.3%

PRS 58.2%
adventitial cell CL0002503

CSI 1.4

rCSI 3.4%

PRS 60.9%
cerebral cortex neuron CL0010012

CSI 1.4

rCSI 5.9%

PRS 47.9%
ciliated epithelial cell CL0000067

CSI 1.5

rCSI 1.3%

PRS 40.0%
regular atrial cardiac myocyte CL0002129

CSI 1.5

rCSI 4.7%

PRS 50.2%
ependymal cell CL0000065

CSI 1.5

rCSI 3.0%

PRS 32.5%
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.5

rCSI 3.9%

PRS 47.0%
mature B cell CL0000785

CSI 1.5

rCSI 1.3%

PRS 61.8%
retina horizontal cell CL0000745

CSI 1.5

rCSI 2.3%

PRS 47.9%
elicited macrophage CL0000861

CSI 1.5

rCSI 1.4%

PRS 59.7%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.5

rCSI 1.9%

PRS 32.8%
ciliated cell CL0000064

CSI 1.5

rCSI 2.5%

PRS 49.1%
lung pericyte CL0009089

CSI 1.5

rCSI 4.1%

PRS 59.5%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.6

rCSI 1.6%

PRS 65.0%
intestinal epithelial cell CL0002563

CSI 1.6

rCSI 1.6%

PRS 50.2%
epithelial cell of lower respiratory tract CL0002632

CSI 1.6

rCSI 1.2%

PRS 52.1%
neuroblast (sensu Vertebrata) CL0000031

CSI 1.6

rCSI 2.0%

PRS 49.1%
CD14-positive, CD16-positive monocyte CL0002397

CSI 1.6

rCSI 2.1%

PRS 65.2%
common myeloid progenitor CL0000049

CSI 1.6

rCSI 1.3%

PRS 52.4%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.6

rCSI 1.6%

PRS 67.4%
chondrocyte CL0000138

CSI 1.6

rCSI 2.6%

PRS 43.9%
retinal blood vessel endothelial cell CL0002585

CSI 1.6

rCSI 2.6%

PRS 55.3%
CD14-positive monocyte CL0001054

CSI 1.6

rCSI 2.0%

PRS 62.7%
precursor B cell CL0000817

CSI 1.6

rCSI 1.4%

PRS 61.5%
naive T cell CL0000898

CSI 1.6

rCSI 1.1%

PRS 65.4%
colonocyte CL1000347

CSI 1.7

rCSI 2.4%

PRS 57.4%
neural crest cell CL0011012

CSI 1.7

rCSI 1.3%

PRS 38.6%
colon epithelial cell CL0011108

CSI 1.7

rCSI 1.8%

PRS 48.3%
pancreatic A cell CL0000171

CSI 1.7

rCSI 1.8%

PRS 54.6%
retinal cone cell CL0000573

CSI 1.7

rCSI 2.7%

PRS 41.5%
periportal region hepatocyte CL0019026

CSI 1.7

rCSI 6.6%

PRS 58.8%
bronchus fibroblast of lung CL2000093

CSI 1.7

rCSI 1.4%

PRS 51.9%
cardiac endothelial cell CL0010008

CSI 1.7

rCSI 6.9%

PRS 49.7%
epithelial cell of lung CL0000082

CSI 1.7

rCSI 1.4%

PRS 50.1%
rod bipolar cell CL0000751

CSI 1.7

rCSI 3.1%

PRS 44.6%
plasmacytoid dendritic cell, human CL0001058

CSI 1.8

rCSI 1.2%

PRS 53.8%
VIP GABAergic cortical interneuron CL4023016

CSI 1.8

rCSI 2.1%

PRS 34.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [PDPK1](/details-gene/5170) (3-phosphoinositide dependent protein kinase 1) encodes a master protein serine/threonine kinase that functions as a critical node in intracellular signaling. It is a key downstream effector of PI3-kinase (PI3K) and is essential for the activation of a wide range of AGC kinase family members, including AKT/PKB, p70 S6 kinase (S6K), and protein kinase C (PKC) ([Link](https://doi.org/10.1016/s0960-9822(06)00122-9)). This central role places [PDPK1](/details-gene/5170) at the heart of regulating fundamental cellular processes such as cell growth, proliferation, survival, and metabolism. **Overall**, its expression profile is broad, with notable significance in diverse cell types including [choroid plexus epithelial cell](/details-cell/CL0000706), [hepatocyte](/details-cell/CL0000182), various immune cells, and neurons, reflecting its ubiquitous importance in signal transduction across multiple organ systems. ## Cellular Roles and Expression Landscape The expression pattern of [PDPK1](/details-gene/5170) underscores its foundational role as a signaling integrator in a wide array of cell lineages. **Overall**, it exhibits high significance in specialized epithelial cells, such as [choroid plexus epithelial cell](/details-cell/CL0000706) and [fallopian tube secretory epithelial cell](/details-cell/CL4030006), suggesting a role in maintaining barrier function and secretory activities. Its high CSI score in [hepatocyte](/details-cell/CL0000182) is consistent with its established function in insulin signaling and metabolic regulation. Furthermore, [PDPK1](/details-gene/5170) appears to be a key player in the nervous system, as evidenced by its significance in [near-projecting glutamatergic cortical neuron](/details-cell/CL4023012). This aligns with its involvement in pathways like [Activation of nmda receptors and postsynaptic events](/details-reactome/R-HSA-442755). The gene also shows notable expression in various endocrine cells, including [lung neuroendocrine cell](/details-cell/CL1000223) and [pancreatic D cell](/details-cell/CL0000173). Within the immune system, [PDPK1](/details-gene/5170) demonstrates broad importance across both innate and adaptive lineages. It is significant in [lung macrophage](/details-cell/CL1001603) as well as in multiple lymphocyte subsets, including [double negative thymocyte](/details-cell/CL0002489), [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050), [IgG plasma cell](/details-cell/CL0000985), and [unswitched memory B cell](/details-cell/CL0000970). This widespread expression pattern in immune cells points to its central role in processes like T-cell activation, B-cell differentiation, and innate immune responses. ## Pathways and Molecular Function [PDPK1](/details-gene/5170) is a protein kinase with a primary molecular function of [3-phosphoinositide-dependent protein kinase activity](/details-go/GO:0004676), enabling it to phosphorylate and activate downstream targets upon recruitment to the plasma membrane by the lipid second messenger PIP3. Its function is central to the [Pip3 activates akt signaling](/details-reactome/R-HSA-1257604) pathway, a critical axis for cell survival and growth ([Link](https://doi.org/10.1016/s0960-9822(98)70274-x)). Seminal studies have demonstrated its direct role in phosphorylating and activating Protein Kinase B (AKT), p70S6K, and other AGC kinases ([Link](https://doi.org/10.1126/science.279.5351.710), [Link](https://doi.org/10.1126/science.279.5351.707)). The extensive list of associated biological processes highlights its pleiotropic nature. In metabolically active cells like [hepatocyte](/details-cell/CL0000182), its role is critical for the [Insulin receptor signaling pathway](/details-go/GO:0008286). In immune cells, such as [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050), it is integral to the [Adaptive immune system](/details-reactome/R-HSA-1280218), particularly through its involvement in [Tcr signaling](/details-reactome/R-HSA-202403) and [Cd28 co-stimulation](/details-reactome/R-HSA-389356). Furthermore, its function extends to regulating the [actin cytoskeleton organization](/details-go/GO:0030036) and [cell migration](/details-go/GO:0016477), which is consistent with its expression in endothelial cells and its role in processes like angiogenesis ([Link](https://www.ebi.ac.uk/QuickGO/term/GO:0045766)). The kinase also participates in signaling cascades initiated by growth factors ([Cellular response to epidermal growth factor stimulus](/details-go/GO:0071364)) and G-protein coupled receptors ([Gpcr downstream signalling](/details-reactome/R-HSA-388396)). ## Research Directions The ubiquitous and critical role of [PDPK1](/details-gene/5170) in cellular signaling makes it a central focus for research, particularly in understanding how a single kinase can regulate such diverse outcomes in different cell types. ### Proposed Hypotheses: 1. Given its high significance in [choroid plexus epithelial cell](/details-cell/CL0000706) and its established role in regulating the cytoskeleton, it is hypothesized that [PDPK1](/details-gene/5170) is a critical regulator of blood-cerebrospinal fluid barrier integrity. It may achieve this by controlling the phosphorylation status of proteins that govern tight junction assembly and dynamics. 2. The high significance of [PDPK1](/details-gene/5170) in both developing ([double negative thymocyte](/details-cell/CL0002489)) and mature ([effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050)) T cells suggests that its activity level is precisely tuned to control distinct stages of T cell life, from thymic selection to peripheral effector function. We hypothesize that distinct upstream signals in these cellular contexts dictate specific downstream [PDPK1](/details-gene/5170) substrate selection, leading to divergent functional outcomes. ### Experimental Approach: To test the first hypothesis regarding the role of [PDPK1](/details-gene/5170) in the blood-cerebrospinal fluid barrier, a conditional knockout mouse model could be generated to specifically delete [PDPK1](/details-gene/5170) in choroid plexus epithelial cells. In vivo barrier permeability could then be quantitatively assessed by measuring the extravasation of fluorescently labeled dextrans or other tracers into the brain parenchyma. Furthermore, primary cultures of choroid plexus epithelial cells from these mice could be used for in vitro analysis of transepithelial electrical resistance (TEER). The localization and expression levels of key tight junction proteins (e.g., Claudins, Occludin, ZO-1) would be examined via immunofluorescence microscopy and western blot to determine the molecular mechanism underlying any observed barrier defects. ### Therapeutic Potential: As a central kinase in the PI3K/AKT signaling pathway, which is one of the most frequently dysregulated pathways in human cancer ([Link](https://reactome.org/content/detail/R-HSA-2219528)), [PDPK1](/details-gene/5170) is a well-validated therapeutic target. Inhibition of [PDPK1](/details-gene/5170) is a promising strategy for cancer treatment, particularly in tumors with activating mutations in PI3K or loss of the PTEN tumor suppressor. However, its crucial role in normal physiology, especially in insulin signaling and immune function, presents a major challenge due to the high risk of on-target toxicities with systemic inhibitors. The development of next-generation therapies may focus on allosteric inhibitors, degraders (PROTACs), or delivery systems that achieve tumor-specific targeting to improve the therapeutic index.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

3-phosphoinositide-dependent protein kinase 1

Genular Protein ID: 2030207548

Symbol: PDPK1_HUMAN

Name: 3-phosphoinositide-dependent protein kinase 1

UniProtKB Accession Codes:

O15530 H0Y4Z0 Q59EH6 Q6FI20 Q8IV52 Q9BRD5

Database IDs:

Citations:

PubMed ID: 9094314

Title: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha.

PubMed ID: 9094314

DOI: 10.1016/s0960-9822(06)00122-9

PubMed ID: 9368760

Title: 3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

PubMed ID: 9368760

DOI: 10.1016/s0960-9822(06)00336-8

PubMed ID: 9445477

Title: Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

PubMed ID: 9445477

DOI: 10.1126/science.279.5351.710

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9637919

Title: Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.

PubMed ID: 9637919

DOI: 10.1016/s0960-9822(98)70274-x

PubMed ID: 9768361

Title: Regulation of protein kinase C zeta by PI 3-kinase and PDK-1.

PubMed ID: 9768361

DOI: 10.1016/s0960-9822(98)70444-0

PubMed ID: 9707564

Title: Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.

PubMed ID: 9707564

DOI: 10.1073/pnas.95.17.9849

PubMed ID: 9445476

Title: Phosphorylation and activation of p70s6k by PDK1.

PubMed ID: 9445476

DOI: 10.1126/science.279.5351.707

PubMed ID: 10455013

Title: Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.

PubMed ID: 10455013

DOI: 10.1042/bj3420287

PubMed ID: 10364160

Title: A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.

PubMed ID: 10364160

DOI: 10.1101/gad.13.11.1438

PubMed ID: 10480933

Title: 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1.

PubMed ID: 10480933

DOI: 10.1074/jbc.274.38.27168

PubMed ID: 10995762

Title: p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

PubMed ID: 10995762

DOI: 10.1074/jbc.m006553200

PubMed ID: 11481331

Title: Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 (PDK1) and their role in regulating kinase activity.

PubMed ID: 11481331

DOI: 10.1074/jbc.m105916200

PubMed ID: 12177059

Title: Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3.

PubMed ID: 12177059

DOI: 10.1074/jbc.m205141200

PubMed ID: 12167717

Title: Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

PubMed ID: 12167717

DOI: 10.1128/mcb.22.17.6247-6260.2002

PubMed ID: 14585963

Title: Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.

PubMed ID: 14585963

DOI: 10.1128/mcb.23.22.8019-8029.2003

PubMed ID: 14604990

Title: Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner.

PubMed ID: 14604990

DOI: 10.1074/jbc.m309653200

PubMed ID: 15210700

Title: The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1.

PubMed ID: 15210700

DOI: 10.1074/jbc.m405340200

PubMed ID: 10226025

Title: PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

PubMed ID: 10226025

DOI: 10.1016/s0960-9822(99)80186-9

PubMed ID: 15209375

Title: PDK1, the master regulator of AGC kinase signal transduction.

PubMed ID: 15209375

DOI: 10.1016/j.semcdb.2003.12.022

PubMed ID: 16207722

Title: 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling.

PubMed ID: 16207722

DOI: 10.1074/jbc.m506235200

PubMed ID: 16251192

Title: Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.

PubMed ID: 16251192

DOI: 10.1074/jbc.m507539200

PubMed ID: 15743829

Title: Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.

PubMed ID: 15743829

DOI: 10.1128/mcb.25.6.2347-2363.2005

PubMed ID: 16314505

Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.

PubMed ID: 16314505

DOI: 10.1128/mcb.25.24.10803-10814.2005

PubMed ID: 16780920

Title: Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity.

PubMed ID: 16780920

DOI: 10.1016/j.bioorg.2006.05.002

PubMed ID: 17327236

Title: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.

PubMed ID: 17327236

DOI: 10.1074/jbc.m609279200

PubMed ID: 17371830

Title: Essential role of PDK1 in regulating endothelial cell migration.

PubMed ID: 17371830

DOI: 10.1083/jcb.200607053

PubMed ID: 18835241

Title: The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.

PubMed ID: 18835241

DOI: 10.1016/j.abb.2008.09.008

PubMed ID: 18616680

Title: TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.

PubMed ID: 18616680

DOI: 10.1111/j.1349-7006.2008.00874.x

PubMed ID: 18802401

Title: Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways.

PubMed ID: 18802401

DOI: 10.4161/cc.7.19.6810

PubMed ID: 18024423

Title: Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PubMed ID: 18024423

DOI: 10.1074/jbc.m706361200

PubMed ID: 19591923

Title: The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1.

PubMed ID: 19591923

DOI: 10.1016/j.cellsig.2009.06.010

PubMed ID: 19276999

Title: IGF-I regulated phosphorylation and translocation of PDK-1 in neurons.

PubMed ID: 19276999

DOI: 10.1097/wnr.0b013e328329a41a

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22544756

Title: PDK1 phosphorylation at Thr354 by murine protein serine/threonine kinase 38 contributes to the negative regulation of PDK1 activity.

PubMed ID: 22544756

DOI: 10.1074/jbc.m111.331827

PubMed ID: 22347420

Title: Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1.

PubMed ID: 22347420

DOI: 10.1371/journal.pone.0031003

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12169624

Title: High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site.

PubMed ID: 12169624

DOI: 10.1093/emboj/cdf437

PubMed ID: 15741170

Title: Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

PubMed ID: 15741170

DOI: 10.1074/jbc.m500977200

PubMed ID: 15772071

Title: Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

PubMed ID: 15772071

DOI: 10.1074/jbc.m501367200

PubMed ID: 20978239

Title: Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells.

PubMed ID: 20978239

DOI: 10.1126/scisignal.2000738

PubMed ID: 22999883

Title: Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site.

PubMed ID: 22999883

DOI: 10.1016/j.chembiol.2012.07.017

Sequence Information:

Length: 556
Mass: 63152
Checksum: ED8C0306DC4D0653
Sequence:

MARTTSQLYD AVPIQSSVVL CSCPSPSMVR TQTESSTPPG IPGGSRQGPA MDGTAAEPRP 
GAGSLQHAQP PPQPRKKRPE DFKFGKILGE GSFSTVVLAR ELATSREYAI KILEKRHIIK 
ENKVPYVTRE RDVMSRLDHP FFVKLYFTFQ DDEKLYFGLS YAKNGELLKY IRKIGSFDET 
CTRFYTAEIV SALEYLHGKG IIHRDLKPEN ILLNEDMHIQ ITDFGTAKVL SPESKQARAN 
SFVGTAQYVS PELLTEKSAC KSSDLWALGC IIYQLVAGLP PFRAGNEYLI FQKIIKLEYD 
FPEKFFPKAR DLVEKLLVLD ATKRLGCEEM EGYGPLKAHP FFESVTWENL HQQTPPKLTA 
YLPAMSEDDE DCYGNYDNLL SQFGCMQVSS SSSSHSLSAS DTGLPQRSGS NIEQYIHDLD 
SNSFELDLQF SEDEKRLLLE KQAGGNPWHQ FVENNLILKM GPVDKRKGLF ARRRQLLLTE 
GPHLYYVDPV NKVLKGEIPW SQELRPEAKN FKTFFVHTPN RTYYLMDPSG NAHKWCRKIQ 
EVWRQRYQSH PDAAVQ

	Overall overall
	Acute kidney failure MONDO0002492
	Alzheimer disease MONDO0004975
	Basal cell carcinoma MONDO0020804
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Fovea centralis UBERON0001786
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	Interventricular septum UBERON0002094
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Parkinson disease MONDO0005180
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Skin of body UBERON0002097
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Vascular dementia MONDO0004648

Details for: PDPK1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. PubMed ID: 9094314

3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. PubMed ID: 9368760

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. PubMed ID: 9445477

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. PubMed ID: 9637919

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. PubMed ID: 9768361

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. PubMed ID: 9707564

Phosphorylation and activation of p70s6k by PDK1. PubMed ID: 9445476

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo. PubMed ID: 10455013

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. PubMed ID: 10364160

90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. PubMed ID: 10480933

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). PubMed ID: 10995762

Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 (PDK1) and their role in regulating kinase activity. PubMed ID: 11481331

Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. PubMed ID: 12177059

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. PubMed ID: 12167717

Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions. PubMed ID: 14585963

Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner. PubMed ID: 14604990

The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1. PubMed ID: 15210700

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. PubMed ID: 10226025

PDK1, the master regulator of AGC kinase signal transduction. PubMed ID: 15209375

3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. PubMed ID: 16207722

Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. PubMed ID: 16251192

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation. PubMed ID: 15743829

Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling. PubMed ID: 16314505

Role of the PH domain in regulating in vitro autophosphorylation events required for reconstitution of PDK1 catalytic activity. PubMed ID: 16780920

3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins. PubMed ID: 17327236

Essential role of PDK1 in regulating endothelial cell migration. PubMed ID: 17371830

The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. PubMed ID: 18835241

TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. PubMed ID: 18616680

Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways. PubMed ID: 18802401

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. PubMed ID: 18024423

The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1. PubMed ID: 19591923

IGF-I regulated phosphorylation and translocation of PDK-1 in neurons. PubMed ID: 19276999

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

PDK1 phosphorylation at Thr354 by murine protein serine/threonine kinase 38 contributes to the negative regulation of PDK1 activity. PubMed ID: 22544756

Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1. PubMed ID: 22347420

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site. PubMed ID: 12169624

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding. PubMed ID: 15741170

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. PubMed ID: 15772071

Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells. PubMed ID: 20978239

Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. PubMed ID: 22999883