Details for: FBXO40

Gene ID: 51725

Symbol: FBXO40

Ensembl ID: ENSG00000163833

Description: F-box protein 40

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3435
    Cell Significance Index: 179.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3603
    Cell Significance Index: 33.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3068
    Cell Significance Index: 33.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5310
    Cell Significance Index: 7.8400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.3991
    Cell Significance Index: 6.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2234
    Cell Significance Index: 44.8100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1302
    Cell Significance Index: 1.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0284
    Cell Significance Index: 19.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0258
    Cell Significance Index: 48.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0233
    Cell Significance Index: 0.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0207
    Cell Significance Index: 3.7300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0172
    Cell Significance Index: 0.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0148
    Cell Significance Index: 5.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -6.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0047
    Cell Significance Index: -1.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0077
    Cell Significance Index: -0.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0079
    Cell Significance Index: -5.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0122
    Cell Significance Index: -6.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0127
    Cell Significance Index: -6.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0223
    Cell Significance Index: -4.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0232
    Cell Significance Index: -3.3700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0281
    Cell Significance Index: -0.4200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0297
    Cell Significance Index: -0.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0318
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0330
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0330
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0380
    Cell Significance Index: -6.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0395
    Cell Significance Index: -1.8400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0423
    Cell Significance Index: -1.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0435
    Cell Significance Index: -1.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0438
    Cell Significance Index: -4.4700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0507
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0553
    Cell Significance Index: -7.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0554
    Cell Significance Index: -5.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0615
    Cell Significance Index: -7.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0638
    Cell Significance Index: -7.3100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0649
    Cell Significance Index: -0.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0650
    Cell Significance Index: -2.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0702
    Cell Significance Index: -3.5500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0801
    Cell Significance Index: -1.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1040
    Cell Significance Index: -2.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1066
    Cell Significance Index: -6.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1072
    Cell Significance Index: -7.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1121
    Cell Significance Index: -5.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1122
    Cell Significance Index: -0.7600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1124
    Cell Significance Index: -3.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1180
    Cell Significance Index: -1.3400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1206
    Cell Significance Index: -1.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1206
    Cell Significance Index: -1.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1207
    Cell Significance Index: -7.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1286
    Cell Significance Index: -4.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1333
    Cell Significance Index: -2.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1349
    Cell Significance Index: -6.3400
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1393
    Cell Significance Index: -1.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1447
    Cell Significance Index: -5.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1501
    Cell Significance Index: -2.9300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1526
    Cell Significance Index: -2.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1534
    Cell Significance Index: -4.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1570
    Cell Significance Index: -8.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1602
    Cell Significance Index: -4.7200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1610
    Cell Significance Index: -1.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1668
    Cell Significance Index: -8.7600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1671
    Cell Significance Index: -1.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1684
    Cell Significance Index: -7.4500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1698
    Cell Significance Index: -1.6100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1867
    Cell Significance Index: -2.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1900
    Cell Significance Index: -4.8400
  • Cell Name: lung perichondrial fibroblast (CL4033026)
    Fold Change: -0.1921
    Cell Significance Index: -1.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1964
    Cell Significance Index: -4.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1991
    Cell Significance Index: -7.5400
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2095
    Cell Significance Index: -2.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2125
    Cell Significance Index: -5.3000
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.2134
    Cell Significance Index: -2.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2198
    Cell Significance Index: -5.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2200
    Cell Significance Index: -3.7700
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2256
    Cell Significance Index: -2.2100
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2266
    Cell Significance Index: -2.9000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2274
    Cell Significance Index: -3.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2348
    Cell Significance Index: -6.2700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2359
    Cell Significance Index: -2.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2363
    Cell Significance Index: -6.9400
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.2430
    Cell Significance Index: -2.1600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2480
    Cell Significance Index: -5.3000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2483
    Cell Significance Index: -2.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2558
    Cell Significance Index: -7.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2570
    Cell Significance Index: -9.0300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2576
    Cell Significance Index: -2.8000
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.2593
    Cell Significance Index: -2.4000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2621
    Cell Significance Index: -4.2200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2638
    Cell Significance Index: -2.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2655
    Cell Significance Index: -5.2500
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.2674
    Cell Significance Index: -2.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2683
    Cell Significance Index: -4.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2717
    Cell Significance Index: -6.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2749
    Cell Significance Index: -6.6600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2774
    Cell Significance Index: -2.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FBXO40 is a 14-kDa protein belonging to the F-box protein family, which is characterized by a conserved F-box motif. The protein is primarily expressed in muscle cells, neurons, and immune cells, including helper T cells and GABAergic interneurons. FBXO40 is also found in cardiac muscle cells and various epithelial cells. Its expression is tightly regulated by post-translational modifications, including neddylation and ubiquitination, which are critical for its function. **Pathways and Functions:** FBXO40 is involved in several key pathways, including: 1. **Adaptive Immune System:** FBXO40 plays a crucial role in the regulation of immune responses by controlling the degradation of proteins involved in antigen processing and presentation. It interacts with other proteins, such as MHC class I and II molecules, to facilitate the presentation of antigens to T cells. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** FBXO40 is a ubiquitin protein ligase that targets proteins for degradation by the proteasome. This process is essential for the regulation of protein turnover and immune response. 3. **Class I MHC Mediated Antigen Processing & Presentation:** FBXO40 interacts with MHC class I molecules to facilitate the presentation of antigens to CD8+ T cells. 4. **Cytoplasmic and Cytosolic Pathways:** FBXO40 is also involved in the regulation of protein turnover in the cytoplasm and cytosol, where it interacts with other proteins to control protein degradation and immune response. **Clinical Significance:** Dysregulation of FBXO40 has been implicated in various immune-related disorders, including: 1. **Autoimmune Diseases:** FBXO40 dysfunction has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where the regulation of immune responses is impaired. 2. **Cancer:** FBXO40 is involved in the regulation of protein turnover and immune response in cancer cells, where its dysregulation can contribute to tumor progression and metastasis. 3. **Neurological Disorders:** FBXO40 is also involved in the regulation of protein turnover in neurons, where its dysregulation can contribute to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, FBXO40 is a critical protein involved in various cellular processes, including the adaptive immune system, antigen processing, and protein degradation. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of FBXO40 in maintaining immune homeostasis and preventing disease. Further research is needed to fully understand the role of FBXO40 in human health and disease.

Genular Protein ID: 970674994

Symbol: FBX40_HUMAN

Name: F-box only protein 40

UniProtKB Accession Codes:

Q9UH90 B2RAX7 Q32M70 Q9ULM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17928169

Title: FBXO40, a gene encoding a novel muscle-specific F-box protein, is upregulated in denervation-related muscle atrophy.

PubMed ID: 17928169

DOI: 10.1016/j.gene.2007.08.020

Sequence Information:

  • Length: 709
  • Mass: 79782
  • Checksum: 4B69F51EA78D78E3
  • Sequence:
    • MGKARRSPPG HHRHCEGCFN RHCHIPVEPN TSCLVISCHL LCGATFHMCK EAEHQLLCPL 
EQVPCLNSEY GCPLSMSRHK LAKHLQVCPA SVVCCSMEWN RWPNVDSETT LHENIMKETP 
SEECLDTALA LQDQKVLFRS LKMVELFPET REATEEEPTM NGETSVEEMG GAVGGVDIGL 
VPHGLSATNG EMAELSQEER EVLAKTKEGM DLVKFGQWEN IFSKEHAASA LTNSSASCES 
KNKNDSEKEQ ISSGHNMVEG EGAPKKKEPQ ENQKQQDVRT AMETTGLAPW QDGVLERLKT 
AVDAKDYNMY LVHNGRMLIH FGQMPACTPK ERDFVYGKLE AQEVKTVYTF KVPVSYCGKR 
ARLGDAMLSC KPSEHKAVDT SDLGITVEDL PKSDLIKTTL QCALERELKG HVISESRSID 
GLFMDFATQT YNFEPEQFSS GTVLADLTAA TPGGLHVELH SECVTRRHNK SSSAFTFTCN 
KFFRRDEFPL HFKNVHTDIQ SCLNGWFQHR CPLAYLGCTF VQNHFRPPGQ KAKVIYSQEL 
KTFAIKPEVA PELSEGRKNN HLLGHGGKSQ NSLTSLPLEI LKYIAGFLDS VSLAQLSQVS 
VLMRNICATL LQERGMVLLQ WKKKRYSHGG TSWRVHREIW QFSSLFSKIK SWEFNEVTSM 
SEHLKSCPFN IVEHKTDPIL LTSMCQPREQ ARESLVSTFR IRPRGRYVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.