Details for: RAPGEF6

Gene ID: 51735

Symbol: RAPGEF6

Ensembl ID: ENSG00000158987

Description: Rap guanine nucleotide exchange factor 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 199.2347
    Cell Significance Index: -30.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.4160
    Cell Significance Index: -31.0500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 56.4752
    Cell Significance Index: -29.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.8160
    Cell Significance Index: -31.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.5511
    Cell Significance Index: -28.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.1626
    Cell Significance Index: -32.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.0529
    Cell Significance Index: 135.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.0475
    Cell Significance Index: 115.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.0124
    Cell Significance Index: 169.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6355
    Cell Significance Index: 528.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3790
    Cell Significance Index: 853.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.3774
    Cell Significance Index: 52.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.3667
    Cell Significance Index: 56.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.8205
    Cell Significance Index: 22.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6657
    Cell Significance Index: 102.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5408
    Cell Significance Index: 118.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2125
    Cell Significance Index: 30.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1099
    Cell Significance Index: 23.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7630
    Cell Significance Index: 20.4500
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.6744
    Cell Significance Index: 7.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6297
    Cell Significance Index: 31.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6142
    Cell Significance Index: 99.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5110
    Cell Significance Index: 147.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5051
    Cell Significance Index: 456.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4638
    Cell Significance Index: 27.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3779
    Cell Significance Index: 41.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3692
    Cell Significance Index: 3.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3534
    Cell Significance Index: 43.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3289
    Cell Significance Index: 59.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2935
    Cell Significance Index: 8.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2697
    Cell Significance Index: 31.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2267
    Cell Significance Index: 10.2800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.2230
    Cell Significance Index: 2.2500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1933
    Cell Significance Index: 2.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1845
    Cell Significance Index: 8.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1259
    Cell Significance Index: 8.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0517
    Cell Significance Index: 9.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0478
    Cell Significance Index: 26.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0408
    Cell Significance Index: 4.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0178
    Cell Significance Index: 7.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0098
    Cell Significance Index: -18.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0164
    Cell Significance Index: -30.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0206
    Cell Significance Index: -31.7500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0243
    Cell Significance Index: -0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0253
    Cell Significance Index: -34.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0337
    Cell Significance Index: -24.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0360
    Cell Significance Index: -27.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0391
    Cell Significance Index: -24.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0456
    Cell Significance Index: -25.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0519
    Cell Significance Index: -23.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0542
    Cell Significance Index: -7.4500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0577
    Cell Significance Index: -36.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0641
    Cell Significance Index: -2.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0835
    Cell Significance Index: -16.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0912
    Cell Significance Index: -9.3200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1153
    Cell Significance Index: -1.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1184
    Cell Significance Index: -15.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1212
    Cell Significance Index: -3.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1254
    Cell Significance Index: -14.6200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1291
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1393
    Cell Significance Index: -29.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1475
    Cell Significance Index: -9.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1598
    Cell Significance Index: -20.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1637
    Cell Significance Index: -27.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1812
    Cell Significance Index: -26.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1998
    Cell Significance Index: -22.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2201
    Cell Significance Index: -6.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2363
    Cell Significance Index: -5.1200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2489
    Cell Significance Index: -3.5700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2591
    Cell Significance Index: -5.5000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2660
    Cell Significance Index: -4.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2869
    Cell Significance Index: -6.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2891
    Cell Significance Index: -15.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3108
    Cell Significance Index: -32.3600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3119
    Cell Significance Index: -7.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3142
    Cell Significance Index: -23.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3197
    Cell Significance Index: -21.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3471
    Cell Significance Index: -21.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3494
    Cell Significance Index: -22.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3503
    Cell Significance Index: -27.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3776
    Cell Significance Index: -12.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3845
    Cell Significance Index: -7.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4356
    Cell Significance Index: -20.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4556
    Cell Significance Index: -3.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4741
    Cell Significance Index: -33.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4846
    Cell Significance Index: -10.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4901
    Cell Significance Index: -25.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4964
    Cell Significance Index: -14.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5124
    Cell Significance Index: -17.9500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5242
    Cell Significance Index: -10.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5876
    Cell Significance Index: -25.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6383
    Cell Significance Index: -18.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6456
    Cell Significance Index: -16.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7134
    Cell Significance Index: -24.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7161
    Cell Significance Index: -16.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7222
    Cell Significance Index: -26.5100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.7330
    Cell Significance Index: -4.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAPGEF6 is a highly conserved protein that belongs to the Ras GEF family, which is characterized by its ability to facilitate the exchange of GDP for GTP on Ras proteins. This exchange is essential for the activation of Ras proteins, which, in turn, regulate a wide range of cellular processes. RAPGEF6 is specifically expressed in various cell types, including hematopoietic cells, endothelial cells, and neurons, highlighting its diverse roles in different tissues. **Pathways and Functions:** RAPGEF6 is involved in several key signaling pathways, including: 1. **Ras protein signal transduction:** RAPGEF6 regulates the activity of Ras proteins, which are essential for cell growth, differentiation, and survival. 2. **Microvillus assembly:** RAPGEF6 plays a crucial role in the assembly of microvilli, which are essential for the maintenance of cellular polarity and integrity. 3. **Endothelial intestinal barrier establishment:** RAPGEF6 is involved in the establishment of the endothelial intestinal barrier, which is critical for maintaining gut homeostasis and preventing inflammation. 4. **GTP-dependent protein binding:** RAPGEF6 interacts with various GTP-dependent proteins, including Ras proteins, to regulate their activity. **Clinical Significance:** Dysregulation of RAPGEF6 has been implicated in various disease states, including: 1. **Cancer:** Overexpression of RAPGEF6 has been observed in several types of cancer, including colon, breast, and lung cancer, suggesting its potential as a therapeutic target. 2. **Neurological disorders:** RAPGEF6 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, highlighting its potential as a therapeutic target. 3. **Inflammatory disorders:** RAPGEF6 has been shown to play a role in the regulation of inflammatory responses, suggesting its potential as a therapeutic target in inflammatory diseases. In conclusion, RAPGEF6 is a critical regulator of cellular signaling and endothelial integrity. Its dysregulation has been implicated in various disease states, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which RAPGEF6 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1681309820

Symbol: RPGF6_HUMAN

Name: Rap guanine nucleotide exchange factor 6

UniProtKB Accession Codes:

Q8TEU7 A3KN82 A5PLL6 B7ZML2 E9PDV7 Q8NI21 Q8TEU6 Q96PC1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 5 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 6 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12581858

Title: Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.

PubMed ID: 12581858

DOI: 10.1016/s0167-4889(02)00365-8

PubMed ID: 11524421

Title: Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras.

PubMed ID: 11524421

DOI: 10.1074/jbc.m105760200

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1601
  • Mass: 179423
  • Checksum: CF4C5407EB61EEE2
  • Sequence:
    • MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS ARARYERYSG 
NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN 
AKDNEDSILQ REIPARQSRR RFRKINYKGE RQTITDDVEV NSYLSLPADL TKMHLTENPH 
PQVTHVSSSQ SGCSIASDSG SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI 
DRTDPLQGRD LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV 
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL DKQYMHGIVR 
TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH EHRELDRSGT RKGHIVIKAT 
PERLIMHLIE EHSIVDPTYI EDFLLTYRTF LESPLDVGIK LLEWFKIDSL RDKVTRIVLL 
WVNNHFNDFE GDPAMTRFLE EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES 
PLQFSLNGGS EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN 
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG DIEQTSQEKG 
SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ SQDDSIVGTR HCRHSLAIMP 
IPGTLSSSSP DLLQPTTSML DFSNPSDIPD QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA 
VHEFGLTGAS DTYSLCEVSV TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC 
SDEDAQELVK ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL 
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM FAIISGLNLA 
SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL SSQSMQPPII PLFPVVKKDM 
TFLHEGNDSK VDGLVNFEKL RMISKEIRQV VRMTSANMDP AMMFRQRSLS QGSTNSNMLD 
VQGGAHKKRA RRSSLLNAKK LYEDAQMARK VKQYLSSLDV ETDEEKFQMM SLQWEPAYGT 
LTKNLSEKRS AKSSEMSPVP MRSAGQTTKA HLHQPHRVSQ VLQVPAVNLH PIRKKGQTKD 
PALNTSLPQK VLGTTEEISG KKHTEDTISV ASSLHSSPPA SPQGSPHKGY TLIPSAKSDN 
LSDSSHSEIS SRSSIVSNCS VDSMSAALQD ERCSSQALAV PESTGALEKT EHASGIGDHS 
QHGPGWTLLK PSLIKCLAVS SSVSNEEISQ EHIIIEAADS GRGSWTSCSS SSHDNFQSLP 
NPKSWDFLNS YRHTHLDDPI AEVEPTDSEP YSCSKSCSRT CGQCKGSLER KSWTSSSSLS 
DTYEPNYGTV KQRVLESTPA ESSEGLDPKD ATDPVYKTVT SSTEKGLIVY CVTSPKKDDR 
YREPPPTPPG YLGISLADLK EGPHTHLKPP DYSVAVQRSK MMHNSLSRLP PASLSSNLVA 
CVPSKIVTQP QRHNLQPFHP KLGDVTDADS EADENEQVSA V

Genular Protein ID: 347944003

Symbol: B2RTU6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RTU6

Database IDs:

ARBA 6 BioGRID-ORCS 1 CDD 5 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 4 Gene3D 4 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 10 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 SAM 1 SMART 5 SUPFAM 3

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1609
  • Mass: 180463
  • Checksum: 7647B91B3DD9226D
  • Sequence:
    • MNSPVDPGAR QALRKKPPER TPEDLNTIYS YLHGMEILSN LREHQLRLMS ARARYERYSG 
NQVLFCSETI ARCWYILLSG SVLVKGSMVL PPCSFGKQFG GKRGCDCLVL EPSEMIVVEN 
AKDNEDSILQ REIPARQSRR RFRKINYKGE RQTITDDVEV NSYLSLPADL TKMHLTENPH 
PQVTHVSSSQ SGCSIASDSG SSSLSDIYQA TESEVGDVDL TRLPEGPVDS EDDEEEDEEI 
DRTDPLQGRD LVRECLEKEP ADKTDDDIEQ LLEFMHQLPA FANMTMSVRR ELCSVMIFEV 
VEQAGAIILE DGQELDSWYV ILNGTVEISH PDGKVENLFM GNSFGITPTL DKQYMHGIVR 
TKVDDCQFVC IAQQDYWRIL NHVEKNTHKV EEEGEIVMVH EHRELDRSGT RKGHIVIKAT 
PERLIMHLIE EHSIVDPTYI EDFLLTYRTF LESPLDVGIK LLEWFKIDSL RDKVTRIVLL 
WVNNHFNDFE GDPAMTRFLE EFEKNLEDTK MNGHLRLLNI ACAAKAKWRQ VVLQKASRES 
PLQFSLNGGS EKGFGIFVEG VEPGSKAADS GLKRGDQIME VNGQNFENIT FMKAVEILRN 
NTHLALTVKT NIFVFKELLF RTEQEKSGVP HIPKIAEKKS NRHSIQHVPG DIEQTSQEKG 
SKKVKANTVS GGRNKIRKIL DKTRFSILPP KLFSDGGLSQ SQDDSIVGTR HCRHSLAIMP 
IPGTLSSSSP DLLQPTTSML DFSNPSDIPD QVIRVFKVDQ QSCYIIISKD TTAKEVVFHA 
VHEFGLTGAS DTYSLCEVSV TPEGVIKQRR LPDQFSKLAD RIQLNGRYYL KNNMETETLC 
SDEDAQELVK ESQLSMLQLS TIEVATQLSM RDFDLFRNIE PTEYIDDLFK LNSKTGNTHL 
KRFEDIVNQE TFWVASEILT EANQLKRMKI IKHFIKIALH CRECKNFNSM FAIISGLNLA 
SVARLRGTWE KLPSKYEKHL QDLQDIFDPS RNMAKYRNIL SSQSMQPPII PLFPVVKKDM 
TFLHEGNDSK VDGLVNFEKL RMISKEIRQV VRMTSANMDP AMMFRQRKKR WRSLGSLSQG 
STNSNMLDVQ GGAHKKRARR SSLLNAKKLY EDAQMARKVK QYLSSLDVET DEEKFQMMSL 
QWEPAYGTLT KNLSEKRSAK SSEMSPVPMR SAGQTTKAHL HQPHRVSQVL QVPAVNLHPI 
RKKGQTKDPA LNTSLPQKVL GTTEEISGKK HTEDTISVAS SLHSSPPASP QGSPHKGYTL 
IPSAKSDNLS DSSHSEISSR SSIVSNCSVD SMSAALQDER CSSQALAVPE STGALEKTEH 
ASGIGDHSQH GPGWTLLKPS LIKCLAVSSS VSNEEISQEH IIIEAADSGR GSWTSCSSSS 
HDNFQSLPNP KSWDFLNSYR HTHLDDPIAE VEPTDSEPYS CSKSCSRTCG QCKGSLERKS 
WTSSSSLSDT YEPNYGTVKR RVLESTPAES SEGLDPKDAT DPVYKTVTSS TEKGLIVYCV 
TSPKKDDRYR EPPPTPPGYL GISLADLKEG PHTHLKPPDY SVAVQRSKMM HNSLSRLPPA 
SLSSNLVACV PSKIVTQPQR HNLQPFHPKL GDVTDADSEA DENEQVSAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.