Details for: RAB8B

Gene ID: 51762

Symbol: RAB8B

Ensembl ID: ENSG00000166128

Description: RAB8B, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.3926
    Cell Significance Index: -41.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.3145
    Cell Significance Index: -41.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 102.5737
    Cell Significance Index: -42.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.0812
    Cell Significance Index: -44.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 94.7060
    Cell Significance Index: -38.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.1587
    Cell Significance Index: -43.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.7649
    Cell Significance Index: -38.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.1659
    Cell Significance Index: -42.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2262
    Cell Significance Index: -38.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8007
    Cell Significance Index: -42.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.3423
    Cell Significance Index: -22.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.7022
    Cell Significance Index: -29.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1987
    Cell Significance Index: 256.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.1416
    Cell Significance Index: 61.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6922
    Cell Significance Index: 104.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4449
    Cell Significance Index: 28.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3424
    Cell Significance Index: 481.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.3285
    Cell Significance Index: 31.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0640
    Cell Significance Index: 173.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0515
    Cell Significance Index: 104.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0325
    Cell Significance Index: 932.3000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.9737
    Cell Significance Index: 6.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8595
    Cell Significance Index: 172.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5795
    Cell Significance Index: 400.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5023
    Cell Significance Index: 54.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4841
    Cell Significance Index: 3.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4429
    Cell Significance Index: 87.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3875
    Cell Significance Index: 45.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3811
    Cell Significance Index: 68.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3618
    Cell Significance Index: 9.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3366
    Cell Significance Index: 46.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3349
    Cell Significance Index: 41.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3333
    Cell Significance Index: 6.1600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2958
    Cell Significance Index: 8.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2479
    Cell Significance Index: 16.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2311
    Cell Significance Index: 12.9700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2201
    Cell Significance Index: 3.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1263
    Cell Significance Index: 3.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1249
    Cell Significance Index: 55.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0993
    Cell Significance Index: 5.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0692
    Cell Significance Index: 130.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0668
    Cell Significance Index: 0.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0530
    Cell Significance Index: 10.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0413
    Cell Significance Index: 22.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0351
    Cell Significance Index: 53.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0232
    Cell Significance Index: 42.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0185
    Cell Significance Index: 2.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0014
    Cell Significance Index: 1.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0005
    Cell Significance Index: 0.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0023
    Cell Significance Index: -0.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0073
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0199
    Cell Significance Index: -12.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0231
    Cell Significance Index: -17.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0318
    Cell Significance Index: -0.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0439
    Cell Significance Index: -24.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0485
    Cell Significance Index: -35.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0510
    Cell Significance Index: -38.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0781
    Cell Significance Index: -2.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0926
    Cell Significance Index: -4.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1015
    Cell Significance Index: -2.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1030
    Cell Significance Index: -21.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1031
    Cell Significance Index: -17.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1204
    Cell Significance Index: -7.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1266
    Cell Significance Index: -5.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1297
    Cell Significance Index: -37.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1429
    Cell Significance Index: -20.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1782
    Cell Significance Index: -18.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1867
    Cell Significance Index: -6.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1892
    Cell Significance Index: -4.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1941
    Cell Significance Index: -14.9000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2492
    Cell Significance Index: -6.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2565
    Cell Significance Index: -33.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2629
    Cell Significance Index: -11.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2788
    Cell Significance Index: -31.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3132
    Cell Significance Index: -32.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3133
    Cell Significance Index: -22.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3458
    Cell Significance Index: -16.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3700
    Cell Significance Index: -6.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3721
    Cell Significance Index: -24.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3753
    Cell Significance Index: -14.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3841
    Cell Significance Index: -43.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3858
    Cell Significance Index: -28.7500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3923
    Cell Significance Index: -2.3700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4346
    Cell Significance Index: -6.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4750
    Cell Significance Index: -7.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4763
    Cell Significance Index: -13.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4989
    Cell Significance Index: -39.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5055
    Cell Significance Index: -10.5800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5793
    Cell Significance Index: -15.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6563
    Cell Significance Index: -21.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7173
    Cell Significance Index: -43.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7314
    Cell Significance Index: -38.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7396
    Cell Significance Index: -37.3800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7442
    Cell Significance Index: -24.3700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7991
    Cell Significance Index: -16.9600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8271
    Cell Significance Index: -18.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8525
    Cell Significance Index: -14.3600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8576
    Cell Significance Index: -22.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8658
    Cell Significance Index: -17.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAB8B is a small GTPase that belongs to the RAS superfamily, characterized by its ability to bind GTP and GDP. The gene is highly conserved across species, with high sequence identity to other RAB family members. RAB8B's expression is widespread, with significant levels found in hematopoietic cells, smooth muscle fibers, and epithelial cells. The protein is localized to various cellular compartments, including the plasma membrane, endosomes, and peroxisomes. **Pathways and Functions:** RAB8B is involved in multiple cellular pathways, including: 1. **Antigen Processing and Presentation:** RAB8B regulates the trafficking of antigen-presenting cells, influencing the presentation of antigens to T-cells. 2. **Cell-Substrate Junction Organization:** RAB8B is essential for maintaining the structure and function of cell-substrate junctions, which are critical for cell adhesion and migration. 3. **Cilium Assembly:** RAB8B is involved in the assembly and maintenance of cilia, which are essential for sensory perception and motility. 4. **Endocytic Recycling:** RAB8B regulates the endocytic recycling of proteins, influencing cellular homeostasis and maintaining protein quality control. 5. **Extracellular Exosome Secretion:** RAB8B is involved in the regulation of exosome secretion, which is essential for intercellular communication and signaling. **Clinical Significance:** RAB8B's involvement in various cellular processes makes it an essential gene for maintaining cellular homeostasis and regulating various physiological and pathological conditions. Mutations or dysregulation of RAB8B have been implicated in: 1. **Hematological Disorders:** RAB8B mutations have been associated with hematological disorders, such as anemia and leukopenia. 2. **Neurological Disorders:** RAB8B dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** RAB8B is involved in cancer progression and metastasis, particularly in epithelial cancers. 4. **Immunological Disorders:** RAB8B is essential for immune cell function, and dysregulation of RAB8B has been implicated in immunological disorders, such as autoimmune diseases. In conclusion, RAB8B is a multifaceted gene that plays a crucial role in regulating membrane trafficking, cellular functions, and various physiological and pathological conditions. Further studies are necessary to elucidate the mechanisms underlying RAB8B's functions and to explore its therapeutic potential in various diseases.

Genular Protein ID: 4041552852

Symbol: RAB8B_HUMAN

Name: Ras-related protein Rab-8B

UniProtKB Accession Codes:

Q92930 Q5JPC4 Q9P293

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMART 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9030196

Title: RAB GTPases expressed in human melanoma cells.

PubMed ID: 9030196

DOI: 10.1016/s0167-4889(96)00169-3

PubMed ID: 12221131

Title: A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.

PubMed ID: 12221131

DOI: 10.1091/mbc.e02-03-0143

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21255211

Title: Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes.

PubMed ID: 21255211

DOI: 10.1111/j.1600-0854.2011.01165.x

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 32344433

Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.

PubMed ID: 32344433

DOI: 10.1083/jcb.201811014

Sequence Information:

  • Length: 207
  • Mass: 23584
  • Checksum: 5960993C0F87F944
  • Sequence:
    • MAKTYDYLFK LLLIGDSGVG KTCLLFRFSE DAFNTTFIST IGIDFKIRTI ELDGKKIKLQ 
IWDTAGQERF RTITTAYYRG AMGIMLVYDI TNEKSFDNIK NWIRNIEEHA SSDVERMILG 
NKCDMNDKRQ VSKERGEKLA IDYGIKFLET SAKSSANVEE AFFTLARDIM TKLNRKMNDS 
NSAGAGGPVK ITENRSKKTS FFRCSLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.