Details for: PFKFB4

Gene ID: 5210

Symbol: PFKFB4

Ensembl ID: ENSG00000114268

Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.8195
    Cell Significance Index: -12.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.4144
    Cell Significance Index: -12.2800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 27.9380
    Cell Significance Index: -11.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.9404
    Cell Significance Index: -11.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9760
    Cell Significance Index: -12.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.8997
    Cell Significance Index: 551.8200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.8752
    Cell Significance Index: 30.9000
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.6540
    Cell Significance Index: 2.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3842
    Cell Significance Index: 36.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1727
    Cell Significance Index: 1058.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8200
    Cell Significance Index: 89.2000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.8144
    Cell Significance Index: 5.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7719
    Cell Significance Index: 46.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7296
    Cell Significance Index: 118.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6627
    Cell Significance Index: 14.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6354
    Cell Significance Index: 9.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5694
    Cell Significance Index: 16.4100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5607
    Cell Significance Index: 6.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4323
    Cell Significance Index: 29.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4083
    Cell Significance Index: 11.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3782
    Cell Significance Index: 37.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3623
    Cell Significance Index: 71.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2831
    Cell Significance Index: 56.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2738
    Cell Significance Index: 98.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2554
    Cell Significance Index: 8.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2484
    Cell Significance Index: 2.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2484
    Cell Significance Index: 382.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2365
    Cell Significance Index: 163.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1731
    Cell Significance Index: 319.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1573
    Cell Significance Index: 3.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1202
    Cell Significance Index: 163.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1056
    Cell Significance Index: 6.4900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1010
    Cell Significance Index: 1.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0922
    Cell Significance Index: 13.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0745
    Cell Significance Index: 40.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0734
    Cell Significance Index: 138.2600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0671
    Cell Significance Index: 0.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0436
    Cell Significance Index: 7.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0398
    Cell Significance Index: 2.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0322
    Cell Significance Index: 1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0312
    Cell Significance Index: 14.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0307
    Cell Significance Index: 1.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0304
    Cell Significance Index: 0.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0236
    Cell Significance Index: 10.4400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0072
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0047
    Cell Significance Index: 0.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0039
    Cell Significance Index: 2.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0135
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0161
    Cell Significance Index: -12.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0165
    Cell Significance Index: -9.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0186
    Cell Significance Index: -2.2900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0269
    Cell Significance Index: -0.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0303
    Cell Significance Index: -3.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0346
    Cell Significance Index: -9.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0359
    Cell Significance Index: -3.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0373
    Cell Significance Index: -4.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0379
    Cell Significance Index: -0.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0419
    Cell Significance Index: -5.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0544
    Cell Significance Index: -1.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0608
    Cell Significance Index: -4.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0613
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0614
    Cell Significance Index: -12.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0665
    Cell Significance Index: -8.5200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0713
    Cell Significance Index: -1.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0804
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0889
    Cell Significance Index: -10.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0891
    Cell Significance Index: -4.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0918
    Cell Significance Index: -6.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0944
    Cell Significance Index: -0.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0978
    Cell Significance Index: -12.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0978
    Cell Significance Index: -2.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1008
    Cell Significance Index: -6.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1030
    Cell Significance Index: -12.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1048
    Cell Significance Index: -7.4100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1204
    Cell Significance Index: -1.4600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1263
    Cell Significance Index: -1.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1410
    Cell Significance Index: -4.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1453
    Cell Significance Index: -3.8200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1478
    Cell Significance Index: -1.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1536
    Cell Significance Index: -7.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1561
    Cell Significance Index: -12.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1575
    Cell Significance Index: -11.7400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1576
    Cell Significance Index: -3.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1640
    Cell Significance Index: -3.4800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1699
    Cell Significance Index: -2.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1725
    Cell Significance Index: -11.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1870
    Cell Significance Index: -3.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1881
    Cell Significance Index: -8.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1913
    Cell Significance Index: -4.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2057
    Cell Significance Index: -7.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2134
    Cell Significance Index: -10.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2145
    Cell Significance Index: -6.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2184
    Cell Significance Index: -7.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2422
    Cell Significance Index: -2.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2472
    Cell Significance Index: -8.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2522
    Cell Significance Index: -4.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bifunctional enzyme**: PFKFB4 possesses two catalytic domains, allowing it to produce and degrade F2,6BP. 2. **Regulation of glycolysis**: PFKFB4 plays a pivotal role in controlling glycolytic flux by modulating F2,6BP levels. 3. **Significant expression**: PFKFB4 is expressed in various cell types, including corneal endothelial cells, lens epithelial cells, and mononuclear cells. 4. **Metabolic significance**: PFKFB4 is involved in glucose metabolism, glycolysis, and the regulation of glycolytic enzymes. **Pathways and Functions:** 1. **Glycolysis**: PFKFB4 is a key enzyme in the glycolytic pathway, regulating the production of F2,6BP, which in turn modulates glycolytic flux. 2. **Fructose-2,6-bisphosphate metabolism**: PFKFB4 catalyzes the production and degradation of F2,6BP, influencing glycolytic activity. 3. **Regulation of glycolysis by F2,6BP**: PFKFB4's activity is modulated by F2,6BP, which in turn regulates glycolytic enzymes, such as phosphofructokinase-1 (PFK-1) and hexokinase (HK). 4. **Carbohydrate phosphorylation**: PFKFB4 is involved in the phosphorylation of fructose-6-phosphate, which is a critical step in glycolysis. **Clinical Significance:** 1. **Cancer**: PFKFB4 overexpression has been linked to various cancers, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. 2. **Metabolic disorders**: PFKFB4 dysregulation has been implicated in metabolic disorders, such as type 2 diabetes and obesity, highlighting its importance in glucose metabolism. 3. **Neurological disorders**: PFKFB4's role in glycolysis and F2,6BP metabolism makes it a potential target for neurological disorders, such as Alzheimer's disease. 4. **Ophthalmic diseases**: PFKFB4's expression in corneal endothelial cells and lens epithelial cells makes it a potential target for ophthalmic diseases, such as glaucoma and cataracts. In conclusion, PFKFB4 is a multifaceted enzyme that plays a critical role in regulating glycolysis and metabolism. Its dysregulation has been implicated in various disease states, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which PFKFB4 regulates glycolysis and its role in disease states.

Genular Protein ID: 856626079

Symbol: F264_HUMAN

Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

UniProtKB Accession Codes:

Q16877 Q5S3G5 Q5XLC2 Q64EX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 31 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 4 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15474002

Title: Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation.

PubMed ID: 15474002

DOI: 10.1016/j.febslet.2004.08.053

PubMed ID: 10095107

Title: Cloning, expression and chromosomal localization of a human testis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

PubMed ID: 10095107

DOI: 10.1016/s0378-1119(99)00037-2

PubMed ID: 15642344

Title: Specific expression of pfkfb4 gene in spermatogonia germ cells and analysis of its 5'-flanking region.

PubMed ID: 15642344

DOI: 10.1016/j.febslet.2004.11.096

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8830046

Title: Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta.

PubMed ID: 8830046

DOI: 10.1093/oxfordjournals.jbchem.a021270

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 469
  • Mass: 54040
  • Checksum: 7E190C3C0A197D9F
  • Sequence:
    • MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR GKTYISKKLT 
RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL KIRKQCALAA LRDVRRFLSE 
EGGHVAVFDA TNTTRERRAT IFNFGEQNGY KTFFVESICV DPEVIAANIV QVKLGSPDYV 
NRDSDEATED FMRRIECYEN SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY 
YLMNIHVTPR SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW 
TSQMKRTIQT AEALGVPYEQ WKVLNEIDAG VCEEMTYEEI QDNYPLEFAL RDQDKYRYRY 
PKGESYEDLV QRLEPVIMEL ERQENVLVIC HQAVMRCLLA YFLDKAAEQL PYLKCPLHTV 
LKLTPVAYGC KVESIFLNVA AVNTHRDRPQ NVDISRPPEE ALVTVPAHQ

Genular Protein ID: 1889660135

Symbol: Q66S35_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q66S35

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 5 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15474002

Title: Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation.

PubMed ID: 15474002

DOI: 10.1016/j.febslet.2004.08.053

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 462
  • Mass: 53285
  • Checksum: 28F3B97F9C8911F1
  • Sequence:
    • MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR GKTYISKKLT 
RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL KIRKQCALAA LRDVRRFLSE 
EGGHVAVFDA TNTTRERRAT IFNFGEQNGY KTFFVESICV DPEVIAANIV QVKLGSPDYV 
NRDSDEATED FMRRIECYEN SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY 
YLMNIHVTPR SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW 
TSQMKRTIQT AEALGVPYEQ WKGVCEEMTY EEIQDNYPLE FALRDQDKYR YRYPKGESYE 
DLVQRLEPVI MELERQENVL VICHQAVMRC LLAYFLDKAA EQLPYLKCPL HTVLKLTPVA 
YGCKVESIFL NVAAVNTHRD RPQNVDISRP PEEALVTVPA HQ

Genular Protein ID: 157687731

Symbol: B7Z5C3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z5C3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 458
  • Mass: 52494
  • Checksum: 119BBD79D4364123
  • Sequence:
    • MDRGSLGGSS LTDLGPGSSR RVCMTNCPTL IVMVGLPARG KTYISKKLTR YLNWIGVPTR 
EFNVGQYRRD VVKTYKSFEF FLPDNEEGLK IRKQCALAAL RDVRRFLSEE GGHVAVFDAT 
NTTRERRATI FNFGEQNGYK TFFVESICVD PEVIAANIVQ VKLGSPDYVN RDSDEATEDF 
MRRIECYENS YESLDEDLDR DLSYIKIMDV GQSYVVNRVA DHIQSRIVYY LMNIHVTPRS 
IYLCRHGESE LNLKGRIGGD PGLSPRGREF AKSLAQFISD QNIKDLKVWT SQMKRTIQTA 
EALGVPYEQW KVLNEIDAGV CEEMTYEEIQ DNYPLEFALR DQDKYRYRYP KGESYEDLVQ 
RLEPVIMELE RQENVLVICH QAVMRCLLAY FLDKAAEQLP YLKCPLHTVL KLTPVAYGCK 
VESIFLNVAA VNTHRDRPQN VDISRPPEEA LVTVPAHQ

Genular Protein ID: 915296942

Symbol: Q5XLC3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5XLC3

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 15474002

Title: Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation.

PubMed ID: 15474002

DOI: 10.1016/j.febslet.2004.08.053

Sequence Information:

  • Length: 278
  • Mass: 32278
  • Checksum: D82CE1C319B2642C
  • Sequence:
    • MRRIECYENS YESLDEDLDR DLSYIKIMDV GQSYVVNRVA DHIQSRIVYY LMNIHVTPRS 
IYLCRHGESE LNLKGRIGGD PGLSPRGREF AKSLAQFISD QNIKDLKVWT SQMKRTIQTA 
EALGVPYEQW KVLNEIDAGV CEEMTYEEIQ DNYPLEFALR DQDKYRYRYP KGESYEDLVQ 
RLEPVIMELE RQENVLVICH QAVMRCLLAY FLDKAAEQLP YLKCPLHTVL KLTPVAYGCK 
VESIFLNVAA VNTHRDRPQN VDISRPPEEA LVTVPAHQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.