Details for: PGM1
Gene ID: 5236
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PGM1
Ensembl ID: ENSG00000079739
Description: phosphoglucomutase 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 28.83rCSI 35.67%PRS 46.44
-
CSI 23.22rCSI 47.67%PRS 71.42
-
CSI 16.13rCSI 63.04%PRS 58.19
-
CSI 13.96rCSI 18.55%PRS 55.97
-
CSI 10.17rCSI 7.89%PRS 51.37
-
CSI 7.84rCSI 7.54%PRS 50.94
-
CSI 7.15rCSI 18.09%PRS 58.97
-
CSI 5.97rCSI 4.83%PRS 51.56
-
CSI 5.38rCSI 9.63%PRS 49.2
-
CSI 5.11rCSI 5.48%PRS 48.9
-
CSI 4.52rCSI 4.17%PRS 51.57
-
CSI 4.49rCSI 10.55%PRS 57.9
-
CSI 4.25rCSI 6.5%PRS 60.02
-
CSI 4.13rCSI 6.14%PRS 52.83
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CSI 4.03rCSI 3.49%PRS 55
-
CSI 3.62rCSI 5.21%PRS 60.55
-
CSI 3.47rCSI 10.04%PRS 41.3
-
CSI 3.45rCSI 5.69%PRS 56.14
-
CSI 3.41rCSI 29.38%PRS 37.77
-
CSI 3.4rCSI 3.34%PRS 53.25
-
CSI 3.35rCSI 2.55%PRS 62.95
-
CSI 3.24rCSI 6.69%PRS 54.96
-
CSI 3.22rCSI 2.14%PRS 54.37
-
CSI 3.2rCSI 3.03%PRS 51.06
-
CSI 3.1rCSI 4.29%PRS 54.17
-
CSI 3.08rCSI 2.97%PRS 74.41
-
CSI 3rCSI 2.37%PRS 37.94
-
CSI 2.93rCSI 3.65%PRS 32.22
-
CSI 2.86rCSI 7.26%PRS 45.86
-
CSI 2.79rCSI 12.47%PRS 35.72
-
CSI 2.78rCSI 5.64%PRS 32
-
CSI 2.76rCSI 1.93%PRS 52.91
-
CSI 2.73rCSI 3.51%PRS 48.51
-
CSI 2.71rCSI 2.52%PRS 50.26
-
CSI 2.59rCSI 3.8%PRS 45.28
-
CSI 2.56rCSI 2.12%PRS 52.06
-
CSI 2.52rCSI 2.27%PRS 47.36
-
CSI 2.47rCSI 3.15%PRS 56.45
-
CSI 2.46rCSI 3.52%PRS 41.17
-
CSI 2.43rCSI 3.24%PRS 59.19
-
CSI 2.39rCSI 1.94%PRS 51.12
-
CSI 2.38rCSI 1.79%PRS 54.83
-
CSI 2.38rCSI 5.44%PRS 49.99
-
CSI 2.38rCSI 1.87%PRS 57.23
-
CSI 2.37rCSI 2.48%PRS 47.56
-
CSI 2.37rCSI 2.48%PRS 53.9
-
CSI 2.35rCSI 1.76%PRS 65.83
-
CSI 2.32rCSI 3.8%PRS 40.6
-
CSI 2.3rCSI 30.68%PRS 70.59
-
CSI 2.29rCSI 5.23%PRS 43.41
-
CSI 2.26rCSI 1.53%PRS 62.34
-
CSI 2.25rCSI 13.27%PRS 35.32
-
CSI 2.25rCSI 3.08%PRS 45.84
-
CSI 2.22rCSI 3.09%PRS 50
-
CSI 2.19rCSI 3.36%PRS 58.42
-
CSI 2.17rCSI 2.79%PRS 45.01
-
CSI 2.13rCSI 2.55%PRS 48.55
-
CSI 2.08rCSI 2.01%PRS 41.2
-
CSI 2.08rCSI 5.08%PRS 45.46
-
CSI 2.06rCSI 13.5%PRS 81.25
-
CSI 2.05rCSI 2.3%PRS 67.45
-
CSI 2.01rCSI 2.69%PRS 51.81
-
CSI 1.97rCSI 7.4%PRS 43.11
-
CSI 1.96rCSI 3.39%PRS 41.01
-
CSI 1.93rCSI 3.11%PRS 57.61
-
CSI 1.91rCSI 2.94%PRS 50.42
-
CSI 1.91rCSI 1.6%PRS 55.63
-
CSI 1.9rCSI 3.33%PRS 42.71
-
CSI 1.9rCSI 1.57%PRS 49.36
-
CSI 1.9rCSI 2.31%PRS 58.5
-
CSI 1.89rCSI 2.77%PRS 54.04
-
CSI 1.88rCSI 7.31%PRS 58.13
-
CSI 1.82rCSI 6.89%PRS 34.74
-
CSI 1.77rCSI 4.62%PRS 57.38
-
CSI 1.77rCSI 2.55%PRS 63.44
-
CSI 1.75rCSI 2.06%PRS 53.82
-
CSI 1.74rCSI 1.82%PRS 49.55
-
CSI 1.7rCSI 5.52%PRS 52
-
CSI 1.67rCSI 2.99%PRS 43.86
-
CSI 1.66rCSI 2.63%PRS 61.55
-
CSI 1.61rCSI 2.57%PRS 44.14
-
CSI 1.59rCSI 2.98%PRS 39.76
-
CSI 1.58rCSI 2.27%PRS 56.73
-
CSI 1.56rCSI 2.62%PRS 33.87
-
CSI 1.56rCSI 2.28%PRS 62.09
-
CSI 1.56rCSI 2.4%PRS 48.45
-
CSI 1.5rCSI 2.14%PRS 53.08
-
CSI 1.49rCSI 2.28%PRS 66.35
-
CSI 1.46rCSI 5.02%PRS 79.58
-
CSI 1.44rCSI 4.64%PRS 49.46
-
CSI 1.42rCSI 1.65%PRS 40.6
-
CSI 1.39rCSI 3.75%PRS 59.01
-
CSI 1.37rCSI 3.06%PRS 34.68
-
CSI 1.37rCSI 2.02%PRS 55.99
-
CSI 1.36rCSI 2.4%PRS 32.96
-
CSI 1.34rCSI 1.42%PRS 64.11
-
CSI 1.33rCSI 2.12%PRS 43.19
-
CSI 1.33rCSI 1.18%PRS 49.12
-
CSI 1.31rCSI 6.57%PRS 62.5
-
CSI 1.3rCSI 1.56%PRS 33.77
-
CSI 0.3rCSI 4.2%PRS 73.4%
-
CSI 0.3rCSI 3.0%PRS 65.9%
-
CSI 0.3rCSI 5.0%PRS 73.0%
-
CSI 0.4rCSI 9.9%PRS 34.3%
-
CSI 0.4rCSI 1.3%PRS 35.3%
-
CSI 0.5rCSI 3.5%PRS 69.5%
-
CSI 0.6rCSI 1.5%PRS 32.8%
-
CSI 0.7rCSI 3.7%PRS 36.4%
-
CSI 0.7rCSI 3.4%PRS 63.5%
-
CSI 0.7rCSI 1.1%PRS 40.9%
-
CSI 0.7rCSI 2.0%PRS 64.3%
-
CSI 0.7rCSI 2.7%PRS 32.6%
-
CSI 0.8rCSI 1.7%PRS 38.1%
-
CSI 0.8rCSI 5.2%PRS 42.8%
-
CSI 0.8rCSI 2.1%PRS 40.5%
-
CSI 0.9rCSI 2.7%PRS 37.6%
-
CSI 0.9rCSI 2.5%PRS 67.2%
-
CSI 0.9rCSI 2.1%PRS 64.6%
-
CSI 0.9rCSI 3.8%PRS 68.1%
-
CSI 0.9rCSI 3.1%PRS 65.3%
-
CSI 1.0rCSI 2.1%PRS 48.2%
-
CSI 1.0rCSI 1.9%PRS 69.1%
-
CSI 1.0rCSI 5.7%PRS 61.1%
-
CSI 1.1rCSI 4.0%PRS 42.8%
-
CSI 1.1rCSI 1.9%PRS 60.2%
-
CSI 1.1rCSI 2.5%PRS 59.9%
-
CSI 1.1rCSI 2.7%PRS 61.7%
-
CSI 1.2rCSI 1.8%PRS 47.1%
-
CSI 1.2rCSI 1.5%PRS 34.9%
-
CSI 1.2rCSI 4.0%PRS 57.6%
-
CSI 1.3rCSI 1.7%PRS 53.0%
-
CSI 1.3rCSI 2.0%PRS 36.0%
-
CSI 1.3rCSI 3.4%PRS 49.2%
-
CSI 1.3rCSI 1.6%PRS 33.8%
-
CSI 1.3rCSI 6.6%PRS 62.5%
-
CSI 1.3rCSI 1.2%PRS 49.1%
-
CSI 1.3rCSI 2.1%PRS 43.2%
-
CSI 1.3rCSI 1.4%PRS 64.1%
-
CSI 1.4rCSI 2.4%PRS 33.0%
-
CSI 1.4rCSI 2.0%PRS 56.0%
-
CSI 1.4rCSI 3.1%PRS 34.7%
-
CSI 1.4rCSI 3.8%PRS 59.0%
-
CSI 1.4rCSI 1.7%PRS 40.6%
-
CSI 1.4rCSI 4.6%PRS 49.5%
-
CSI 1.5rCSI 5.0%PRS 79.6%
-
CSI 1.5rCSI 2.3%PRS 66.4%
-
CSI 1.5rCSI 2.1%PRS 53.1%
-
CSI 1.6rCSI 2.4%PRS 48.5%
-
CSI 1.6rCSI 2.3%PRS 62.1%
-
CSI 1.6rCSI 2.6%PRS 33.9%
-
CSI 1.6rCSI 2.3%PRS 56.7%
-
CSI 1.6rCSI 3.0%PRS 39.8%
-
CSI 1.6rCSI 2.6%PRS 44.1%
-
CSI 1.7rCSI 2.6%PRS 61.6%
-
CSI 1.7rCSI 3.0%PRS 43.9%
-
CSI 1.7rCSI 5.5%PRS 52.0%
-
CSI 1.7rCSI 1.8%PRS 49.6%
-
CSI 1.8rCSI 2.1%PRS 53.8%
-
CSI 1.8rCSI 2.6%PRS 63.4%
-
CSI 1.8rCSI 4.6%PRS 57.4%
-
CSI 1.8rCSI 6.9%PRS 34.7%
-
CSI 1.9rCSI 7.3%PRS 58.1%
-
CSI 1.9rCSI 2.8%PRS 54.0%
-
CSI 1.9rCSI 2.3%PRS 58.5%
-
CSI 1.9rCSI 1.6%PRS 49.4%
-
CSI 1.9rCSI 3.3%PRS 42.7%
-
CSI 1.9rCSI 1.6%PRS 55.6%
-
CSI 1.9rCSI 2.9%PRS 50.4%
-
CSI 1.9rCSI 3.1%PRS 57.6%
-
CSI 2.0rCSI 3.4%PRS 41.0%
-
CSI 2.0rCSI 7.4%PRS 43.1%
-
CSI 2.0rCSI 2.7%PRS 51.8%
-
CSI 2.1rCSI 2.3%PRS 67.5%
-
CSI 2.1rCSI 13.5%PRS 81.3%
-
CSI 2.1rCSI 5.1%PRS 45.5%
-
CSI 2.1rCSI 2.0%PRS 41.2%
-
CSI 2.1rCSI 2.6%PRS 48.6%
-
CSI 2.2rCSI 2.8%PRS 45.0%
-
CSI 2.2rCSI 3.4%PRS 58.4%
-
CSI 2.2rCSI 3.1%PRS 50.0%
-
CSI 2.3rCSI 3.1%PRS 45.8%
-
CSI 2.3rCSI 13.3%PRS 35.3%
-
CSI 2.3rCSI 1.5%PRS 62.3%
-
CSI 2.3rCSI 5.2%PRS 43.4%
-
CSI 2.3rCSI 30.7%PRS 70.6%
-
CSI 2.3rCSI 3.8%PRS 40.6%
-
CSI 2.4rCSI 1.8%PRS 65.8%
-
CSI 2.4rCSI 2.5%PRS 53.9%
-
CSI 2.4rCSI 2.5%PRS 47.6%
-
CSI 2.4rCSI 1.9%PRS 57.2%
-
CSI 2.4rCSI 5.4%PRS 50.0%
-
CSI 2.4rCSI 1.8%PRS 54.8%
-
CSI 2.4rCSI 1.9%PRS 51.1%
-
CSI 2.4rCSI 3.2%PRS 59.2%
-
CSI 2.5rCSI 3.5%PRS 41.2%
-
CSI 2.5rCSI 3.2%PRS 56.5%
-
CSI 2.5rCSI 2.3%PRS 47.4%
-
CSI 2.6rCSI 2.1%PRS 52.1%
-
CSI 2.6rCSI 3.8%PRS 45.3%
-
CSI 2.7rCSI 2.5%PRS 50.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2879835140
Symbol: PGM1_HUMAN
Name: Phosphoglucomutase-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1530890
Title: Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1.
PubMed ID: 1530890
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8257433
Title: Phosphoglucomutase 1: a gene with two promoters and a duplicated first exon.
PubMed ID: 8257433
DOI: 10.1042/bj2960417
PubMed ID: 15378030
Title: Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase.
PubMed ID: 15378030
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26972339
Title: Induced structural disorder as a molecular mechanism for enzyme dysfunction in phosphoglucomutase 1 deficiency.
PubMed ID: 26972339
PubMed ID: 7902567
Title: Intragenic recombination at the human phosphoglucomutase 1 locus: predictions fulfilled.
PubMed ID: 7902567
PubMed ID: 7902568
Title: The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination.
PubMed ID: 7902568
PubMed ID: 19625727
Title: Muscle glycogenosis due to phosphoglucomutase 1 deficiency.
PubMed ID: 19625727
DOI: 10.1056/nejmc0901158
PubMed ID: 22492991
Title: Gene identification in the congenital disorders of glycosylation type I by whole-exome sequencing.
PubMed ID: 22492991
DOI: 10.1093/hmg/dds123
PubMed ID: 22976764
Title: A novel congenital disorder of glycosylation type without central nervous system involvement caused by mutations in the phosphoglucomutase 1 gene.
PubMed ID: 22976764
PubMed ID: 24499211
Title: Multiple phenotypes in phosphoglucomutase 1 deficiency.
PubMed ID: 24499211
PubMed ID: 25288802
Title: Compromised catalysis and potential folding defects in in vitro studies of missense mutants associated with hereditary phosphoglucomutase 1 deficiency.
PubMed ID: 25288802
Sequence Information:
- Length: 562
- Mass: 61449
- Checksum: 61A26C19107D467A
- Sequence:
MVKIVTVKTQ AYQDQKPGTS GLRKRVKVFQ SSANYAENFI QSIISTVEPA QRQEATLVVG GDGRFYMKEA IQLIARIAAA NGIGRLVIGQ NGILSTPAVS CIIRKIKAIG GIILTASHNP GGPNGDFGIK FNISNGGPAP EAITDKIFQI SKTIEEYAVC PDLKVDLGVL GKQQFDLENK FKPFTVEIVD SVEAYATMLR SIFDFSALKE LLSGPNRLKI RIDAMHGVVG PYVKKILCEE LGAPANSAVN CVPLEDFGGH HPDPNLTYAA DLVETMKSGE HDFGAAFDGD GDRNMILGKH GFFVNPSDSV AVIAANIFSI PYFQQTGVRG FARSMPTSGA LDRVASATKI ALYETPTGWK FFGNLMDASK LSLCGEESFG TGSDHIREKD GLWAVLAWLS ILATRKQSVE DILKDHWQKY GRNFFTRYDY EEVEAEGANK MMKDLEALMF DRSFVGKQFS ANDKVYTVEK ADNFEYSDPV DGSISRNQGL RLIFTDGSRI VFRLSGTGSA GATIRLYIDS YEKDVAKINQ DPQVMLAPLI SIALKVSQLQ ERTGRTAPTV IT
Genular Protein ID: 3473471788
Symbol: B7Z6C2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 580
- Mass: 63751
- Checksum: CB288911B786EF4B
- Sequence:
MSDFEEWISG TYRKMEEGPL PLLTFATAPY HDQKPGTSGL RKKTYYFEEK PCYLENFIQS IFFSIDLKDR QGSSLVVGGD GRYFNKSAIE TIVQMAAANG IGRLVIGQNG ILSTPAVSCI IRKIKAIGGI ILTASHNPGG PNGDFGIKFN ISNGGPAPEA ITDKIFQISK TIEEYAVCPD LKVDLGVLGK QQFDLENKFK PFTVEIVDSV EAYATMLRSI FDFSALKELL SGPNRLKIRI DAMHGVVGPY VKKILCEELG APANSAVNCV PLEDFGGHHP DPNLTYAADL VETMKSGEHD FGAAFDGDGD RNMILGKHGF FVNPSDSVAV IAANIFSIPY FQQTGVRGFA RSMPTSGALD RVASATKIAL YETPTGWKFF GNLMDASKLS LCGEESFGTG SDHVREKDGL WAVLAWLSIL ATRKQSVEDI LKDHWQKHGR NFFTRYDYEE VEAEGANKMM KDLEALMFDR SFVGKQFSAN DKVYTVEKAD NFEYSDPVDG SISRNQGLRL IFTDGSRIVF RLSGTGSAGA TIRLYIDSYE KDVAKINQDP QVMLAPLISI ALKVSQLQER TGRTAPTVIT
Genular Protein ID: 1350177900
Symbol: B4DDQ8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 365
- Mass: 40230
- Checksum: 51772F8499A0C7D5
- Sequence:
MLRSIFDFSA LKELLSGPNR LKICIDAMHG VVGPYVKKIL CEELGAPANS AVNCVPLEDF GGHHPDPNLT YAADLVETMK SGEHDFGAAF DGDGDRNMIL GKHGFFVNPS DSVAVIAANI FSIPYFQQTG VRGFARSMPT SGALDRVASA TKIALYETPT GWKFFGNLMD ASKLSLCGEE SFGTGSDHIR EKDGLWAVLA WLSILATRKQ SVEDILKDHW QKYGRNFFTR YDYEEVEAEG ANKMMKDLEA LMFDRSFVGK QFSANDKVYT VEKADNFEYS DPVDGSISRN QGLRLIFTDG SRIVFRLSGT GSAGATIRLY IDSYEKDVAK INQDPQVMLA PLISIALKVS QLQERTGRTA PTVIT