Details for: PGM3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 7.76rCSI 17.39%PRS 62.96
-
CSI 6.35rCSI 23.79%PRS 72.48
-
CSI 4.82rCSI 3.74%PRS 83.7
-
CSI 4.45rCSI 8.94%PRS 70.28
-
CSI 4.26rCSI 3.53%PRS 80.74
-
CSI 4.2rCSI 10.86%PRS 75.47
-
CSI 4.06rCSI 6.45%PRS 73.06
-
CSI 3.27rCSI 5.35%PRS 69.63
-
CSI 3.24rCSI 7.71%PRS 85.27
-
CSI 3.11rCSI 3%PRS 73.34
-
CSI 3.02rCSI 7.09%PRS 80.15
-
CSI 2.96rCSI 2.63%PRS 77.77
-
CSI 2.88rCSI 2.83%PRS 82.7
-
CSI 2.88rCSI 3.82%PRS 85.52
-
CSI 2.81rCSI 4.47%PRS 88.52
-
CSI 2.76rCSI 2.89%PRS 83.32
-
CSI 2.73rCSI 2.15%PRS 84.89
-
CSI 2.72rCSI 11.77%PRS 87.02
-
CSI 2.68rCSI 1.99%PRS 73.61
-
CSI 2.64rCSI 2.09%PRS 68.84
-
CSI 2.63rCSI 6.86%PRS 78.76
-
CSI 2.61rCSI 3.37%PRS 63.25
-
CSI 2.51rCSI 3.61%PRS 86.81
-
CSI 2.5rCSI 2.33%PRS 80.9
-
CSI 2.47rCSI 7.34%PRS 88.39
-
CSI 2.46rCSI 3.05%PRS 77.94
-
CSI 2.46rCSI 2.32%PRS 78.71
-
CSI 2.45rCSI 4.31%PRS 75.58
-
CSI 2.44rCSI 2.49%PRS 87.3
-
CSI 2.41rCSI 3.3%PRS 84.44
-
CSI 2.38rCSI 2.75%PRS 72.43
-
CSI 2.1rCSI 3.1%PRS 83.93
-
CSI 2.03rCSI 14.93%PRS 67.52
-
CSI 2.02rCSI 4.61%PRS 71.57
-
CSI 2.01rCSI 4.96%PRS 79.83
-
CSI 1.99rCSI 2.38%PRS 89.57
-
CSI 1.98rCSI 2.9%PRS 84.8
-
CSI 1.98rCSI 9.46%PRS 79.95
-
CSI 1.96rCSI 2.1%PRS 81.36
-
CSI 1.95rCSI 2.98%PRS 76.9
-
CSI 1.92rCSI 3.48%PRS 71.57
-
CSI 1.91rCSI 2.37%PRS 60.06
-
CSI 1.9rCSI 1.75%PRS 81.53
-
CSI 1.89rCSI 1.66%PRS 69.35
-
CSI 1.88rCSI 2.42%PRS 70.28
-
CSI 1.83rCSI 1.92%PRS 77.52
-
CSI 1.79rCSI 2.15%PRS 77.82
-
CSI 1.72rCSI 1.98%PRS 72.16
-
CSI 1.71rCSI 4.35%PRS 70.55
-
CSI 1.68rCSI 2.29%PRS 79.86
-
CSI 1.68rCSI 1.75%PRS 77.73
-
CSI 1.66rCSI 2.88%PRS 71.69
-
CSI 1.66rCSI 1.82%PRS 81.89
-
CSI 1.62rCSI 2.9%PRS 73.46
-
CSI 1.61rCSI 2.24%PRS 78.53
-
CSI 1.61rCSI 3.53%PRS 85.52
-
CSI 1.61rCSI 2.46%PRS 80.28
-
CSI 1.59rCSI 2.57%PRS 79.29
-
CSI 1.58rCSI 1.52%PRS 79.41
-
CSI 1.57rCSI 4.54%PRS 86.63
-
CSI 1.55rCSI 2%PRS 76.11
-
CSI 1.55rCSI 6.04%PRS 79.67
-
CSI 1.52rCSI 1.78%PRS 81.64
-
CSI 1.51rCSI 2.34%PRS 79.15
-
CSI 1.5rCSI 2.4%PRS 71.66
-
CSI 1.5rCSI 3.9%PRS 87.08
-
CSI 1.48rCSI 4.79%PRS 78.23
-
CSI 1.48rCSI 2.64%PRS 79.21
-
CSI 1.45rCSI 1.73%PRS 62.24
-
CSI 1.44rCSI 2.28%PRS 81.55
-
CSI 1.4rCSI 5.02%PRS 60.03
-
CSI 1.39rCSI 2.46%PRS 61.48
-
CSI 1.38rCSI 1.98%PRS 80.75
-
CSI 1.37rCSI 2.49%PRS 89.88
-
CSI 1.31rCSI 1.92%PRS 89
-
CSI 1.29rCSI 2.17%PRS 62.12
-
CSI 1.28rCSI 1.83%PRS 69.84
-
CSI 1.24rCSI 1.83%PRS 89.81
-
CSI 1.2rCSI 1.93%PRS 70.12
-
CSI 1.19rCSI 3.72%PRS 63.79
-
CSI 1.15rCSI 3.74%PRS 77.73
-
CSI 1.08rCSI 1.74%PRS 63.71
-
CSI 1.08rCSI 3.02%PRS 86.96
-
CSI 1.01rCSI 8.23%PRS 74.2
-
CSI 0.99rCSI 2.19%PRS 65.86
-
CSI 0.98rCSI 2.48%PRS 73.39
-
CSI 0.92rCSI 2.66%PRS 86.19
-
CSI 0.91rCSI 3.44%PRS 62.6
-
CSI 0.88rCSI 2.82%PRS 82.06
-
CSI 0.85rCSI 1.66%PRS 82.99
-
CSI 0.82rCSI 2.38%PRS 69.62
-
CSI 0.79rCSI 1.75%PRS 79.48
-
CSI 0.77rCSI 1.88%PRS 60.11
-
CSI 0.64rCSI 3.44%PRS 87.73
-
CSI 0.61rCSI 2.32%PRS 71.07
-
CSI 0.59rCSI 13.82%PRS 91.52
-
CSI 0.56rCSI 3.23%PRS 83.96
-
CSI 0.52rCSI 1.61%PRS 66.13
-
CSI 0.5rCSI 2.94%PRS 62.83
-
CSI 0.22rCSI 5.21%PRS 61.02
-
CSI 0.2rCSI 4.9%PRS 60.5%
-
CSI 0.2rCSI 5.2%PRS 61.0%
-
CSI 0.5rCSI 2.9%PRS 62.8%
-
CSI 0.5rCSI 1.6%PRS 66.1%
-
CSI 0.6rCSI 3.2%PRS 84.0%
-
CSI 0.6rCSI 13.8%PRS 91.5%
-
CSI 0.6rCSI 2.3%PRS 71.1%
-
CSI 0.6rCSI 3.4%PRS 87.7%
-
CSI 0.8rCSI 1.9%PRS 60.1%
-
CSI 0.8rCSI 1.8%PRS 79.5%
-
CSI 0.8rCSI 2.4%PRS 69.6%
-
CSI 0.9rCSI 1.7%PRS 83.0%
-
CSI 0.9rCSI 2.8%PRS 82.1%
-
CSI 0.9rCSI 3.4%PRS 62.6%
-
CSI 0.9rCSI 2.7%PRS 86.2%
-
CSI 1.0rCSI 2.5%PRS 73.4%
-
CSI 1.0rCSI 2.2%PRS 65.9%
-
CSI 1.0rCSI 8.2%PRS 74.2%
-
CSI 1.1rCSI 3.0%PRS 87.0%
-
CSI 1.1rCSI 1.7%PRS 63.7%
-
CSI 1.2rCSI 3.7%PRS 77.7%
-
CSI 1.2rCSI 3.7%PRS 63.8%
-
CSI 1.2rCSI 1.9%PRS 70.1%
-
CSI 1.2rCSI 1.8%PRS 89.8%
-
CSI 1.3rCSI 1.8%PRS 69.8%
-
CSI 1.3rCSI 2.2%PRS 62.1%
-
CSI 1.3rCSI 1.9%PRS 89.0%
-
CSI 1.4rCSI 2.5%PRS 89.9%
-
CSI 1.4rCSI 2.0%PRS 80.8%
-
CSI 1.4rCSI 2.5%PRS 61.5%
-
CSI 1.4rCSI 5.0%PRS 60.0%
-
CSI 1.4rCSI 2.3%PRS 81.6%
-
CSI 1.5rCSI 1.7%PRS 62.2%
-
CSI 1.5rCSI 2.6%PRS 79.2%
-
CSI 1.5rCSI 4.8%PRS 78.2%
-
CSI 1.5rCSI 3.9%PRS 87.1%
-
CSI 1.5rCSI 2.4%PRS 71.7%
-
CSI 1.5rCSI 2.3%PRS 79.2%
-
CSI 1.5rCSI 1.8%PRS 81.6%
-
CSI 1.6rCSI 6.0%PRS 79.7%
-
CSI 1.6rCSI 2.0%PRS 76.1%
-
CSI 1.6rCSI 4.5%PRS 86.6%
-
CSI 1.6rCSI 1.5%PRS 79.4%
-
CSI 1.6rCSI 2.6%PRS 79.3%
-
CSI 1.6rCSI 2.5%PRS 80.3%
-
CSI 1.6rCSI 3.5%PRS 85.5%
-
CSI 1.6rCSI 2.2%PRS 78.5%
-
CSI 1.6rCSI 2.9%PRS 73.5%
-
CSI 1.7rCSI 1.8%PRS 81.9%
-
CSI 1.7rCSI 2.9%PRS 71.7%
-
CSI 1.7rCSI 1.8%PRS 77.7%
-
CSI 1.7rCSI 2.3%PRS 79.9%
-
CSI 1.7rCSI 4.4%PRS 70.6%
-
CSI 1.7rCSI 2.0%PRS 72.2%
-
CSI 1.8rCSI 2.2%PRS 77.8%
-
CSI 1.8rCSI 1.9%PRS 77.5%
-
CSI 1.9rCSI 2.4%PRS 70.3%
-
CSI 1.9rCSI 1.7%PRS 69.4%
-
CSI 1.9rCSI 1.8%PRS 81.5%
-
CSI 1.9rCSI 2.4%PRS 60.1%
-
CSI 1.9rCSI 3.5%PRS 71.6%
-
CSI 2.0rCSI 3.0%PRS 76.9%
-
CSI 2.0rCSI 2.1%PRS 81.4%
-
CSI 2.0rCSI 9.5%PRS 80.0%
-
CSI 2.0rCSI 2.9%PRS 84.8%
-
CSI 2.0rCSI 2.4%PRS 89.6%
-
CSI 2.0rCSI 5.0%PRS 79.8%
-
CSI 2.0rCSI 4.6%PRS 71.6%
-
CSI 2.0rCSI 14.9%PRS 67.5%
-
CSI 2.1rCSI 3.1%PRS 83.9%
-
CSI 2.4rCSI 2.8%PRS 72.4%
-
CSI 2.4rCSI 3.3%PRS 84.4%
-
CSI 2.4rCSI 2.5%PRS 87.3%
-
CSI 2.5rCSI 4.3%PRS 75.6%
-
CSI 2.5rCSI 2.3%PRS 78.7%
-
CSI 2.5rCSI 3.1%PRS 77.9%
-
CSI 2.5rCSI 7.3%PRS 88.4%
-
CSI 2.5rCSI 2.3%PRS 80.9%
-
CSI 2.5rCSI 3.6%PRS 86.8%
-
CSI 2.6rCSI 3.4%PRS 63.3%
-
CSI 2.6rCSI 6.9%PRS 78.8%
-
CSI 2.6rCSI 2.1%PRS 68.8%
-
CSI 2.7rCSI 2.0%PRS 73.6%
-
CSI 2.7rCSI 11.8%PRS 87.0%
-
CSI 2.7rCSI 2.2%PRS 84.9%
-
CSI 2.8rCSI 2.9%PRS 83.3%
-
CSI 2.8rCSI 4.5%PRS 88.5%
-
CSI 2.9rCSI 3.8%PRS 85.5%
-
CSI 2.9rCSI 2.8%PRS 82.7%
-
CSI 3.0rCSI 2.6%PRS 77.8%
-
CSI 3.0rCSI 7.1%PRS 80.2%
-
CSI 3.1rCSI 3.0%PRS 73.3%
-
CSI 3.2rCSI 7.7%PRS 85.3%
-
CSI 3.3rCSI 5.4%PRS 69.6%
-
CSI 4.1rCSI 6.5%PRS 73.1%
-
CSI 4.2rCSI 10.9%PRS 75.5%
-
CSI 4.3rCSI 3.5%PRS 80.7%
-
CSI 4.5rCSI 8.9%PRS 70.3%
-
CSI 4.8rCSI 3.7%PRS 83.7%
-
CSI 6.4rCSI 23.8%PRS 72.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2262051024
Symbol: AGM1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10721701
Title: Cloning and characterization of complementary DNA encoding human N-acetylglucosamine-phosphate mutase protein.
PubMed ID: 10721701
PubMed ID: 11004509
Title: Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis.
PubMed ID: 11004509
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24931394
Title: PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia.
PubMed ID: 24931394
PubMed ID: 24589341
Title: Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment.
PubMed ID: 24589341
PubMed ID: 24698316
Title: Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.
PubMed ID: 24698316
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 12174217
Title: Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1).
PubMed ID: 12174217
Sequence Information:
- Length: 542
- Mass: 59852
- Checksum: 6A4FBCD99A2154A9
- Sequence:
MDLGAITKYS ALHAKPNGLI LQYGTAGFRT KAEHLDHVMF RMGLLAVLRS KQTKSTIGVM VTASHNPEED NGVKLVDPLG EMLAPSWEEH ATCLANAEEQ DMQRVLIDIS EKEAVNLQQD AFVVIGRDTR PSSEKLSQSV IDGVTVLGGQ FHDYGLLTTP QLHYMVYCRN TGGRYGKATI EGYYQKLSKA FVELTKQASC SGDEYRSLKV DCANGIGALK LREMEHYFSQ GLSVQLFNDG SKGKLNHLCG ADFVKSHQKP PQGMEIKSNE RCCSFDGDAD RIVYYYHDAD GHFHLIDGDK IATLISSFLK ELLVEIGESL NIGVVQTAYA NGSSTRYLEE VMKVPVYCTK TGVKHLHHKA QEFDIGVYFE ANGHGTALFS TAVEMKIKQS AEQLEDKKRK AAKMLENIID LFNQAAGDAI SDMLVIEAIL ALKGLTVQQW DALYTDLPNR QLKVQVADRR VISTTDAERQ AVTPPGLQEA INDLVKKYKL SRAFVRPSGT EDVVRVYAEA DSQESADHLA HEVSLAVFQL AGGIGERPQP GF
Genular Protein ID: 2317761499
Symbol: J3KN95_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 441
- Mass: 49095
- Checksum: 42EF02D2BFEC7289
- Sequence:
MLAPSWEEHA TCLANAEEQD MQRVLIDISE KEAVNLQQDA FVVIGRDTRP SSEKLSQSVI DGVTVLGGQF HDYGLLTTPQ LHYMVYCRNT GGRYGKATIE GYYQKLSKAF VELTKQASCS GDEYRSLKVD CANGIGALKL REMEHYFSQG LSVQLFNDGS KGKLNHLCGA DFVKSHQKPP QGMEIKSNER CCSFDGDADR IVYYYHDADG HFHLIDGDKI ATLISSFLKE LLVEIGESLN IGVVQTAYAN GSSTRYLEEV MKVPVYCTKT GVKHLHHKAQ EFDIGVYFEA NGHGTALFST AVEMKIKQSA EQLEDKKRKA AKMLENIIDL FNQAAGDAIS DMLVIEAILA LKGLTVQQWD ALYTDLPNRQ LKVQVADRRV ISTTDAERQA VTPPGLQEAI NDLVKKYKLS RAFVRPSGTE DVVRVYAEAD SQVRKCRSPC T