Details for: ABCB1

Gene ID: 5243

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ABCB1

Ensembl ID: ENSG00000085563

Description: ATP binding cassette subfamily B member 1

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cerebral cortex endothelial cell CL1001602
    CSI 47.41
    rCSI 82.01%
    PRS 63.46
  • retinal blood vessel endothelial cell CL0002585
    CSI 15.98
    rCSI 25.52%
    PRS 76.68
  • goblet cell CL0000160
    CSI 14.17
    rCSI 13.39%
    PRS 72.15
  • enterocyte CL0000584
    CSI 10.04
    rCSI 16.19%
    PRS 73.57
  • colon epithelial cell CL0011108
    CSI 9.99
    rCSI 10.46%
    PRS 70.01
  • amacrine cell CL0000561
    CSI 9.47
    rCSI 27.46%
    PRS 62.08
  • cardiac endothelial cell CL0010008
    CSI 7.95
    rCSI 32.06%
    PRS 72.21
  • enterocyte of epithelium of large intestine CL0002071
    CSI 7.51
    rCSI 39.43%
    PRS 80.37
  • endothelial cell of vascular tree CL0002139
    CSI 6.6
    rCSI 36.07%
    PRS 70.25
  • OFF-bipolar cell CL0000750
    CSI 6.08
    rCSI 8.31%
    PRS 76.75
  • naive B cell CL0000788
    CSI 5.89
    rCSI 5.06%
    PRS 80.12
  • mucosal invariant T cell CL0000940
    CSI 5.69
    rCSI 4.59%
    PRS 82.96
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 5.6
    rCSI 5.1%
    PRS 85.96
  • stem cell CL0000034
    CSI 5.27
    rCSI 5.08%
    PRS 65.04
  • pancreatic A cell CL0000171
    CSI 5.06
    rCSI 5.3%
    PRS 76.35
  • retinal bipolar neuron CL0000748
    CSI 5.01
    rCSI 9.39%
    PRS 60.84
  • mature T cell CL0002419
    CSI 4.83
    rCSI 3.76%
    PRS 88.5
  • alpha-beta T cell CL0000789
    CSI 4.79
    rCSI 5.62%
    PRS 87.38
  • vascular leptomeningeal cell CL4023051
    CSI 4.53
    rCSI 7.95%
    PRS 65.63
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.52
    rCSI 6.4%
    PRS 69.24
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 4.44
    rCSI 13.9%
    PRS 58.47
  • kidney connecting tubule epithelial cell CL1000768
    CSI 4.44
    rCSI 11.26%
    PRS 62.76
  • hepatocyte CL0000182
    CSI 4.39
    rCSI 7.85%
    PRS 72.24
  • group 3 innate lymphoid cell CL0001071
    CSI 4.23
    rCSI 3.18%
    PRS 78.84
  • interneuron CL0000099
    CSI 4.2
    rCSI 8.44%
    PRS 62.37
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 3.95
    rCSI 14.22%
    PRS 52.33
  • inhibitory interneuron CL0000498
    CSI 3.85
    rCSI 8.88%
    PRS 60.89
  • enteroendocrine cell of small intestine CL0009006
    CSI 3.58
    rCSI 7.89%
    PRS 83.04
  • endothelial cell of arteriole CL1000412
    CSI 3.22
    rCSI 17.84%
    PRS 84.36
  • periportal region hepatocyte CL0019026
    CSI 3.08
    rCSI 11.98%
    PRS 74.56
  • cerebellar granule cell CL0001031
    CSI 2.96
    rCSI 4.36%
    PRS 65.78
  • colonocyte CL1000347
    CSI 2.92
    rCSI 4.18%
    PRS 74.91
  • epithelial cell of proximal tubule CL0002306
    CSI 2.88
    rCSI 7.03%
    PRS 65.9
  • enteroendocrine cell CL0000164
    CSI 2.86
    rCSI 3.9%
    PRS 73.63
  • cholangiocyte CL1000488
    CSI 2.79
    rCSI 16.7%
    PRS 76.68
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 2.76
    rCSI 6.64%
    PRS 87.58
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.71
    rCSI 6.59%
    PRS 52.47
  • blood vessel endothelial cell CL0000071
    CSI 2.69
    rCSI 5.58%
    PRS 69.89
  • hematopoietic stem cell CL0000037
    CSI 2.68
    rCSI 1.78%
    PRS 75.71
  • peripheral nervous system neuron CL2000032
    CSI 2.61
    rCSI 3.55%
    PRS 64.15
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.49
    rCSI 2.25%
    PRS 70.4
  • L6b glutamatergic cortical neuron CL4023038
    CSI 2.48
    rCSI 7.74%
    PRS 56.02
  • podocyte CL0000653
    CSI 2.44
    rCSI 10.84%
    PRS 73.24
  • intrahepatic cholangiocyte CL0002538
    CSI 2.29
    rCSI 5.49%
    PRS 79.25
  • adipocyte CL0000136
    CSI 2.23
    rCSI 2.87%
    PRS 63.68
  • ON midget ganglion cell CL4033046
    CSI 2.17
    rCSI 44.28%
    PRS 62.86
  • BEST4+ enteroycte CL4030026
    CSI 2.17
    rCSI 2.7%
    PRS 74.39
  • follicular B cell CL0000843
    CSI 2.11
    rCSI 7.67%
    PRS 90.25
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.09
    rCSI 50.37%
    PRS 53.66
  • activated type II NK T cell CL0000931
    CSI 2.02
    rCSI 2.27%
    PRS 87.31
  • neural cell CL0002319
    CSI 1.93
    rCSI 7.3%
    PRS 56.17
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.91
    rCSI 4.94%
    PRS 67.92
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 1.9
    rCSI 2.36%
    PRS 52.22
  • renal principal cell CL0005009
    CSI 1.88
    rCSI 4.89%
    PRS 74.97
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.86
    rCSI 2.22%
    PRS 54.11
  • pancreatic ductal cell CL0002079
    CSI 1.73
    rCSI 3.36%
    PRS 76.16
  • cardiac blood vessel endothelial cell CL0010006
    CSI 1.7
    rCSI 12.03%
    PRS 65.62
  • OFF midget ganglion cell CL4033047
    CSI 1.67
    rCSI 34.02%
    PRS 64.27
  • ON parasol ganglion cell CL4033052
    CSI 1.67
    rCSI 23.68%
    PRS 63.73
  • sst GABAergic cortical interneuron CL4023017
    CSI 1.62
    rCSI 2.08%
    PRS 55.56
  • M cell of gut CL0000682
    CSI 1.52
    rCSI 1.62%
    PRS 79.86
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.52
    rCSI 5.73%
    PRS 54.69
  • intraepithelial lymphocyte CL0002496
    CSI 1.5
    rCSI 4.09%
    PRS 93.35
  • type L enteroendocrine cell CL0002279
    CSI 1.5
    rCSI 2.81%
    PRS 83.26
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.49
    rCSI 2.63%
    PRS 53.34
  • parietal epithelial cell CL1000452
    CSI 1.46
    rCSI 3.91%
    PRS 63.93
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.34
    rCSI 2.15%
    PRS 56.04
  • small intestine goblet cell CL1000495
    CSI 1.32
    rCSI 2.88%
    PRS 79.4
  • endothelial cell of uterus CL0009095
    CSI 1.28
    rCSI 9.36%
    PRS 84.17
  • smooth muscle cell CL0000192
    CSI 1.24
    rCSI 2.95%
    PRS 72
  • direct pathway medium spiny neuron CL4023026
    CSI 1.22
    rCSI 29.29%
    PRS 53.01
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 0.93
    rCSI 2.51%
    PRS 79.03
  • pancreatic PP cell CL0002275
    CSI 0.9
    rCSI 3.58%
    PRS 82.51
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.85
    rCSI 2.38%
    PRS 81.99
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.82
    rCSI 4.85%
    PRS 55.21
  • H2 horizontal cell CL0004218
    CSI 0.75
    rCSI 3.72%
    PRS 68.61
  • central nervous system neuron CL2000029
    CSI 0.73
    rCSI 5.36%
    PRS 59.75
  • endothelial cell of venule CL1000414
    CSI 0.69
    rCSI 6.16%
    PRS 84.14
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.68
    rCSI 10.49%
    PRS 84.3
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 0.68
    rCSI 1.13%
    PRS 54.25
  • retinal ganglion cell CL0000740
    CSI 0.68
    rCSI 1.49%
    PRS 58.6
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.5
    rCSI 3.41%
    PRS 82.15
  • paneth cell of colon CL0009009
    CSI 0.34
    rCSI 3.38%
    PRS 84.99

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ABCB1](/details-gene/5243), also known as Multidrug Resistance Protein 1 (MDR1), is an ATP-dependent efflux pump belonging to the ATP-binding cassette (ABC) superfamily of transporters. It functions as a broad-spectrum transporter, extruding a wide variety of xenobiotics, drugs, and lipids across the cell membrane, thereby playing a critical role in cellular detoxification and the development of multidrug resistance in cancer. The protein is clinically significant, with its function being linked to variations in drug metabolism and response ([171050](https://omim.org/entry/171050)). **Overall**, the expression profile of [ABCB1](/details-gene/5243) is highest in cells that form physiological barriers, most notably in `[cerebral cortex endothelial cell](/details-cell/CL1001602)`, `[goblet cell](/details-cell/CL0000160)`, and `[enterocyte](/details-cell/CL0000584)`, underscoring its role in protecting sensitive tissues like the brain and regulating substance absorption and excretion in the gut. ## Cellular Roles and Expression Landscape The expression landscape of [ABCB1](/details-gene/5243) highlights its specialized function as a gatekeeper in barrier tissues. Its most significant expression is found in endothelial and epithelial lineages, which interface with the external or internal environment. * **Physiological Barriers:** The gene's highest significance index is observed in `[cerebral cortex endothelial cell](/details-cell/CL1001602)` (CSI: 47.41), a key component of the blood-brain barrier. This is consistent with its established role in limiting the entry of toxins and therapeutic agents into the central nervous system. Significant expression is also seen in `[retinal blood vessel endothelial cell](/details-cell/CL0002585)`, suggesting a similar protective function in the blood-retina barrier. * **Gastrointestinal Tract:** High significance in intestinal epithelial cells, including `[goblet cell](/details-cell/CL0000160)`, `[enterocyte](/details-cell/CL0000584)`, and `[colon epithelial cell](/details-cell/CL0011108)`, points to a crucial role in regulating the absorption of nutrients and drugs while actively exporting toxins from the body. * **Stem and Immune Cells:** Moderate but notable expression in `[stem cell](/details-cell/CL0000034)` is consistent with the "pump" function that protects these vital cells from cytotoxic compounds. Its expression in immune populations such as `[naive B cell](/details-cell/CL0000788)` and `[effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913)` may suggest a role in regulating immune cell survival or function in xenobiotic-rich environments. ## Pathways and Molecular Function The functional annotations for [ABCB1](/details-gene/5243) align closely with its cellular expression profile, cementing its identity as a versatile transmembrane transporter. Its primary molecular function is described by terms such as `[GO:0042910](https://www.ebi.ac.uk/QuickGO/term/GO:0042910)` (xenobiotic transmembrane transporter activity) and `[GO:0042626](https://www.ebi.ac.uk/QuickGO/term/GO:0042626)` (ATPase-coupled transmembrane transporter activity). The biological processes involving [ABCB1](/details-gene/5243) are dominated by transport-related activities. Its critical role in pharmacology is highlighted by its involvement in `[R-HSA-9748784](https://reactome.org/content/detail/R-HSA-9748784)` (Drug ADME) and pathways for specific drugs like abacavir ([R-HSA-2161522](https://reactome.org/content/detail/R-HSA-2161522)). Its high expression in cerebral endothelial cells directly correlates with its annotated function in `[GO:0150104](https://www.ebi.ac.uk/QuickGO/term/GO:0150104)` (Transport across blood-brain barrier). Beyond xenobiotics, [ABCB1](/details-gene/5243) also functions as a lipid translocase, or floppase, participating in `[GO:0045332](https://www.ebi.ac.uk/QuickGO/term/GO:0045332)` (phospholipid translocation). Studies indicate it has broad specificity for lipids, in contrast to the more specific MDR3 P-glycoprotein ([Link](https://doi.org/10.1016/s0092-8674(00)81370-7)). At the subcellular level, it is primarily localized to the `[GO:0016324](https://www.ebi.ac.uk/QuickGO/term/GO:0016324)` (apical plasma membrane) of polarized cells, a position that is essential for its efflux function. ## Research Directions The well-established role of [ABCB1](/details-gene/5243) in multidrug resistance makes it a subject of intense research, particularly in oncology and pharmacology. Its expression pattern suggests clear avenues for further investigation. **Proposed Hypotheses:** 1. Given its high significance in `[cerebral cortex endothelial cell](/details-cell/CL1001602)`, transient and targeted inhibition of [ABCB1](/details-gene/5243) activity at the blood-brain barrier could be a viable strategy to significantly increase the bioavailability of neurotherapeutics for treating conditions like brain tumors or neurodegenerative diseases. 2. The expression of [ABCB1](/details-gene/5243) in `[stem cell](/details-cell/CL0000034)` populations suggests that its activity is a key mechanism protecting cancer stem cells from chemotherapy. Therefore, co-administering an [ABCB1](/details-gene/5243) inhibitor with standard cytotoxic agents may preferentially target cancer stem cells, reducing the likelihood of tumor relapse. **Experimental Approach:** To test the first hypothesis, an *in vivo* study using a rodent model of glioblastoma could be performed. A cohort of tumor-bearing mice would be treated with a known chemotherapeutic agent that is a substrate of [ABCB1](/details-gene/5243) (e.g., doxorubicin). An experimental group would receive the same chemotherapy in combination with a brain-penetrant [ABCB1](/details-gene/5243) inhibitor (e.g., a third-generation inhibitor like tariquidar). The primary outcomes would be tumor volume, measured by magnetic resonance imaging (MRI), and overall survival. Drug concentration in brain tissue and tumor tissue could be quantified via mass spectrometry to directly confirm that inhibition of [ABCB1](/details-gene/5243) increases drug delivery across the blood-brain barrier. **Therapeutic Potential:** [ABCB1](/details-gene/5243) is not a therapeutic target for activation but is a critical target for **inhibition**. Its overexpression is a primary mechanism of acquired resistance to a wide range of anticancer drugs, and its function at physiological barriers limits the efficacy of many pharmaceuticals. Consequently, the development of specific, potent, and non-toxic inhibitors of [ABCB1](/details-gene/5243) remains a major goal in clinical oncology and neuropharmacology. An effective inhibitor could resensitize resistant tumors to chemotherapy or unlock the potential of numerous CNS drugs that currently cannot cross the blood-brain barrier in therapeutic concentrations.

Genular Protein ID: 2737481444

Symbol: MDR1_HUMAN

Name: Multidrug resistance protein 1

UniProtKB Accession Codes:

P08183 A8K294 B5AK60 Q12755 Q14812

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTC 1 CTD 1 ChEBI 26 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 588 DrugCentral 1 EC 2 EMBL 34 EMDB 20 Ensembl 3 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2876781

Title: Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

PubMed ID: 2876781

DOI: 10.1016/0092-8674(86)90595-7

PubMed ID: 1967175

Title: Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

PubMed ID: 1967175

DOI: 10.1016/s0021-9258(19)40260-3

PubMed ID: 9038218

Title: Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

PubMed ID: 9038218

DOI: 10.1074/jbc.272.9.5974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 1972623

Title: mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles.

PubMed ID: 1972623

DOI: 10.1016/0006-291x(90)90401-8

PubMed ID: 2568832

Title: P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

PubMed ID: 2568832

DOI: 10.1016/0006-291x(89)91985-2

PubMed ID: 8898203

Title: MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

PubMed ID: 8898203

DOI: 10.1016/s0092-8674(00)81370-7

PubMed ID: 11258197

Title: ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

PubMed ID: 11258197

DOI: 10.1517/14622416.2.1.51

PubMed ID: 15488952

Title: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

PubMed ID: 15488952

DOI: 10.1016/j.molimm.2004.07.005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24333728

Title: Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.

PubMed ID: 24333728

DOI: 10.1016/j.canlet.2013.12.007

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 35970996

Title: Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.

PubMed ID: 35970996

DOI: 10.1038/s41589-022-01109-0

PubMed ID: 2897240

Title: An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.

PubMed ID: 2897240

DOI: 10.1016/0092-8674(88)90568-5

PubMed ID: 9473242

Title: Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.

PubMed ID: 9473242

PubMed ID: 10790226

Title: A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein.

PubMed ID: 10790226

DOI: 10.1002/(sici)1098-1004(200005)15:5<486::aid-humu26>3.0.co;2-p

PubMed ID: 10716719

Title: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.

PubMed ID: 10716719

DOI: 10.1073/pnas.97.7.3473

PubMed ID: 11240981

Title: Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

PubMed ID: 11240981

DOI: 10.1067/mcp.2001.114164

PubMed ID: 15618700

Title: Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys).

PubMed ID: 15618700

DOI: 10.2133/dmpk.17.479

PubMed ID: 15618713

Title: Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone.

PubMed ID: 15618713

DOI: 10.2133/dmpk.17.566

PubMed ID: 11829140

Title: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.

PubMed ID: 11829140

DOI: 10.1007/s10038-002-8653-6

PubMed ID: 14610718

Title: MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.

PubMed ID: 14610718

DOI: 10.1086/379927

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1280
  • Mass: 141479
  • Checksum: F0230744AB288C73
  • Sequence:
    • MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 
HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG 
IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS 
KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT 
DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP SIEAFANARG 
AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS YPSRKEVKIL KGLNLKVQSG 
QTVALVGNSG CGKSTTVQLM QRLYDPTEGM VSVDGQDIRT INVRFLREII GVVSQEPVLF 
ATTIAENIRY GRENVTMDEI EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA 
IARALVRNPK ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA LEMSSNDSRS 
SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI MKLNLTEWPY FVVGVFCAII 
NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ NSNLFSLLFL ALGIISFITF FLQGFTFGKA 
GEILTKRLRY MVFRSMLRQD VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI 
ANLGTGIIIS FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY FSYAGCFRFG 
AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK AKISAAHIIM IIEKTPLIDS 
YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI PVLQGLSLEV KKGQTLALVG SSGCGKSTVV 
QLLERFYDPL AGKVLLDGKE IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV 
SQEEIVRAAK EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR VKEHGTHQQL 
LAQKGIYFSM VSVQAGTKRQ