Details for: ABCB1

Gene ID: 5243

Symbol: ABCB1

Ensembl ID: ENSG00000085563

Description: ATP binding cassette subfamily B member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.7494
    Cell Significance Index: -15.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.3713
    Cell Significance Index: -13.0300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 28.0436
    Cell Significance Index: -13.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4660
    Cell Significance Index: -15.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7519
    Cell Significance Index: -10.4000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.1193
    Cell Significance Index: 11.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5538
    Cell Significance Index: -9.5200
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.0285
    Cell Significance Index: 7.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6391
    Cell Significance Index: 266.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4060
    Cell Significance Index: 40.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2755
    Cell Significance Index: 36.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1725
    Cell Significance Index: 13.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1308
    Cell Significance Index: 1021.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1084
    Cell Significance Index: 120.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0590
    Cell Significance Index: 28.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.0139
    Cell Significance Index: 17.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0077
    Cell Significance Index: 16.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9265
    Cell Significance Index: 62.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8811
    Cell Significance Index: 21.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8211
    Cell Significance Index: 50.4700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.7830
    Cell Significance Index: 5.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7501
    Cell Significance Index: 33.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7495
    Cell Significance Index: 215.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.7408
    Cell Significance Index: 462.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7209
    Cell Significance Index: 27.3000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6950
    Cell Significance Index: 14.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6758
    Cell Significance Index: 135.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5646
    Cell Significance Index: 39.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5461
    Cell Significance Index: 13.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5200
    Cell Significance Index: 51.4400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4864
    Cell Significance Index: 12.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3042
    Cell Significance Index: 6.5900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.3034
    Cell Significance Index: 1.9000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2553
    Cell Significance Index: 2.1700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2524
    Cell Significance Index: 3.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2181
    Cell Significance Index: 41.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1955
    Cell Significance Index: 6.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1838
    Cell Significance Index: 65.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1707
    Cell Significance Index: 7.7400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1128
    Cell Significance Index: 0.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0906
    Cell Significance Index: 1.1300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0654
    Cell Significance Index: 0.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0582
    Cell Significance Index: 40.2300
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.0573
    Cell Significance Index: 0.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0563
    Cell Significance Index: 1.2000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0547
    Cell Significance Index: 0.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0414
    Cell Significance Index: 8.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0098
    Cell Significance Index: 4.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0027
    Cell Significance Index: -0.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0047
    Cell Significance Index: -0.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0076
    Cell Significance Index: -5.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0170
    Cell Significance Index: -10.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0205
    Cell Significance Index: -15.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0245
    Cell Significance Index: -10.8200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0268
    Cell Significance Index: -5.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0273
    Cell Significance Index: -14.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0306
    Cell Significance Index: -5.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0385
    Cell Significance Index: -5.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0398
    Cell Significance Index: -7.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0555
    Cell Significance Index: -0.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0633
    Cell Significance Index: -8.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0634
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0680
    Cell Significance Index: -7.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0709
    Cell Significance Index: -2.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0765
    Cell Significance Index: -2.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0899
    Cell Significance Index: -9.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0924
    Cell Significance Index: -11.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0997
    Cell Significance Index: -13.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1050
    Cell Significance Index: -13.5600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1092
    Cell Significance Index: -1.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1114
    Cell Significance Index: -13.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1147
    Cell Significance Index: -1.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1194
    Cell Significance Index: -13.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1329
    Cell Significance Index: -5.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1351
    Cell Significance Index: -8.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1430
    Cell Significance Index: -10.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1437
    Cell Significance Index: -14.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1475
    Cell Significance Index: -4.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1529
    Cell Significance Index: -8.5800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1556
    Cell Significance Index: -2.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1667
    Cell Significance Index: -13.2000
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.1687
    Cell Significance Index: -1.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1772
    Cell Significance Index: -3.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1777
    Cell Significance Index: -8.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1799
    Cell Significance Index: -13.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1843
    Cell Significance Index: -3.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1897
    Cell Significance Index: -6.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1906
    Cell Significance Index: -5.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1952
    Cell Significance Index: -3.8600
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.1990
    Cell Significance Index: -2.2300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2177
    Cell Significance Index: -4.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2277
    Cell Significance Index: -14.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ABCB1 is a transmembrane protein that spans the plasma membrane, with two nucleotide-binding domains (NBDs) and two transmembrane domains (TMDs). The NBDs are responsible for ATP hydrolysis, which drives the transport of substrates across the membrane. The TMDs anchor the protein to the membrane and facilitate the interaction with substrates. ABCB1 has a broad substrate specificity, transporting a wide range of compounds, including xenobiotics, endogenous substances, and drugs. **Pathways and Functions** ABCB1 is involved in various cellular processes, including: 1. **Xenobiotic Detoxification**: ABCB1 plays a critical role in the efflux of xenobiotics, such as drugs and environmental toxins, out of cells, reducing their toxicity and promoting cellular homeostasis. 2. **Drug Transport**: ABCB1 is responsible for the transport of various drugs, including anticancer agents, across cell membranes, influencing their efficacy and toxicity. 3. **Endogenous Substance Transport**: ABCB1 transports endogenous substances, such as steroids and bile salts, across cell membranes, regulating their concentration and activity. 4. **Cellular Homeostasis**: ABCB1 helps maintain cellular homeostasis by regulating the concentration of substances that can disrupt cellular processes, such as calcium and phospholipid homeostasis. **Clinical Significance** Dysregulation of ABCB1 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of ABCB1 has been observed in various types of cancer, including breast, lung, and colon cancer, contributing to resistance to chemotherapy and radiation therapy. 2. **Neurological Disorders**: ABCB1 has been implicated in neurological disorders, such as epilepsy, schizophrenia, and multiple sclerosis, where its dysregulation can lead to abnormal substance transport and neuronal dysfunction. 3. **Infectious Diseases**: ABCB1 plays a role in the transport of antibiotics and other antimicrobial agents, influencing their efficacy and resistance development in pathogens. 4. **Pharmacokinetics**: ABCB1 influences the pharmacokinetics of various drugs, affecting their absorption, distribution, metabolism, and excretion. In conclusion, ABCB1 is a critical gene involved in the transport of various substances across cell membranes, playing a vital role in maintaining cellular homeostasis and protecting against toxic substances. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and clinical significance in the development of novel therapeutic strategies.

Genular Protein ID: 2737481444

Symbol: MDR1_HUMAN

Name: Multidrug resistance protein 1

UniProtKB Accession Codes:

P08183 A8K294 B5AK60 Q12755 Q14812

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTC 1 CTD 1 ChEBI 26 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 100 DrugCentral 1 EC 2 EMBL 34 EMDB 20 Ensembl 3 ExpressionAtlas 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2876781

Title: Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

PubMed ID: 2876781

DOI: 10.1016/0092-8674(86)90595-7

PubMed ID: 1967175

Title: Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins.

PubMed ID: 1967175

DOI: 10.1016/s0021-9258(19)40260-3

PubMed ID: 9038218

Title: Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

PubMed ID: 9038218

DOI: 10.1074/jbc.272.9.5974

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 1972623

Title: mdr1/P-glycoprotein gene segments analyzed from various human leukemic cell lines exhibiting different multidrug resistance profiles.

PubMed ID: 1972623

DOI: 10.1016/0006-291x(90)90401-8

PubMed ID: 2568832

Title: P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

PubMed ID: 2568832

DOI: 10.1016/0006-291x(89)91985-2

PubMed ID: 8898203

Title: MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine.

PubMed ID: 8898203

DOI: 10.1016/s0092-8674(00)81370-7

PubMed ID: 11258197

Title: ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

PubMed ID: 11258197

DOI: 10.1517/14622416.2.1.51

PubMed ID: 15488952

Title: Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

PubMed ID: 15488952

DOI: 10.1016/j.molimm.2004.07.005

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24333728

Title: Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function.

PubMed ID: 24333728

DOI: 10.1016/j.canlet.2013.12.007

PubMed ID: 28408210

Title: The Organic Anion-Transporting Peptide 2B1 Is Localized in the Basolateral Membrane of the Human Jejunum and Caco-2 Monolayers.

PubMed ID: 28408210

DOI: 10.1016/j.xphs.2017.04.001

PubMed ID: 35970996

Title: Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux.

PubMed ID: 35970996

DOI: 10.1038/s41589-022-01109-0

PubMed ID: 2897240

Title: An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.

PubMed ID: 2897240

DOI: 10.1016/0092-8674(88)90568-5

PubMed ID: 9473242

Title: Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors.

PubMed ID: 9473242

PubMed ID: 10790226

Title: A new polymorphism (N21D) in the exon 2 of the human MDR1 gene encoding the P-glycoprotein.

PubMed ID: 10790226

DOI: 10.1002/(sici)1098-1004(200005)15:5<486::aid-humu26>3.0.co;2-p

PubMed ID: 10716719

Title: Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.

PubMed ID: 10716719

DOI: 10.1073/pnas.97.7.3473

PubMed ID: 11240981

Title: Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

PubMed ID: 11240981

DOI: 10.1067/mcp.2001.114164

PubMed ID: 15618700

Title: Polymorphism of MDR1 gene in healthy Japanese subjects: a novel SNP with an amino acid substitution (Glu108Lys).

PubMed ID: 15618700

DOI: 10.2133/dmpk.17.479

PubMed ID: 15618713

Title: Twelve novel single nucleotide polymorphisms in ABCB1/MDR1 among Japanese patients with ventricular tachycardia who were administered amiodarone.

PubMed ID: 15618713

DOI: 10.2133/dmpk.17.566

PubMed ID: 11829140

Title: Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.

PubMed ID: 11829140

DOI: 10.1007/s10038-002-8653-6

PubMed ID: 14610718

Title: MDR1 Ala893 polymorphism is associated with inflammatory bowel disease.

PubMed ID: 14610718

DOI: 10.1086/379927

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1280
  • Mass: 141479
  • Checksum: F0230744AB288C73
  • Sequence:
    • MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 
HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG 
IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS 
KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT 
DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP SIEAFANARG 
AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS YPSRKEVKIL KGLNLKVQSG 
QTVALVGNSG CGKSTTVQLM QRLYDPTEGM VSVDGQDIRT INVRFLREII GVVSQEPVLF 
ATTIAENIRY GRENVTMDEI EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA 
IARALVRNPK ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA LEMSSNDSRS 
SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI MKLNLTEWPY FVVGVFCAII 
NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ NSNLFSLLFL ALGIISFITF FLQGFTFGKA 
GEILTKRLRY MVFRSMLRQD VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI 
ANLGTGIIIS FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY FSYAGCFRFG 
AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK AKISAAHIIM IIEKTPLIDS 
YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI PVLQGLSLEV KKGQTLALVG SSGCGKSTVV 
QLLERFYDPL AGKVLLDGKE IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV 
SQEEIVRAAK EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR VKEHGTHQQL 
LAQKGIYFSM VSVQAGTKRQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.