Details for: PHF2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 156.3854
Cell Significance Index: -24.3300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 97.7356
Cell Significance Index: -24.7900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.1314
Cell Significance Index: -19.9600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 20.9271
Cell Significance Index: -19.9800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 20.3576
Cell Significance Index: -25.1000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.0449
Cell Significance Index: -24.2300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.4064
Cell Significance Index: -25.2800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.7062
Cell Significance Index: -10.3000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.8460
Cell Significance Index: 30.4200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.0833
Cell Significance Index: 14.7800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0517
Cell Significance Index: 949.6200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7139
Cell Significance Index: 143.2100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7052
Cell Significance Index: 76.7100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7015
Cell Significance Index: 114.1000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.5960
Cell Significance Index: 15.3200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5833
Cell Significance Index: 35.0200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5832
Cell Significance Index: 30.3800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5715
Cell Significance Index: 113.4100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5555
Cell Significance Index: 199.2500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4318
Cell Significance Index: 10.8000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3950
Cell Significance Index: 30.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3631
Cell Significance Index: 16.4600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3628
Cell Significance Index: 7.8600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3438
Cell Significance Index: 23.7800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3378
Cell Significance Index: 60.9000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3141
Cell Significance Index: 217.2400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3082
Cell Significance Index: 58.6600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2818
Cell Significance Index: 34.6500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2462
Cell Significance Index: 24.3500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1994
Cell Significance Index: 10.3600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1935
Cell Significance Index: 10.8600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1846
Cell Significance Index: 5.3200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1673
Cell Significance Index: 22.9800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1444
Cell Significance Index: 63.8600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1375
Cell Significance Index: 8.4500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1158
Cell Significance Index: 5.4000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1032
Cell Significance Index: 2.2600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0840
Cell Significance Index: 45.8600 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0838
Cell Significance Index: 1.2100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0630
Cell Significance Index: 3.9700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0592
Cell Significance Index: 2.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0412
Cell Significance Index: 77.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0331
Cell Significance Index: 21.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0326
Cell Significance Index: 50.2500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0269
Cell Significance Index: 12.2200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0243
Cell Significance Index: 0.6800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0239
Cell Significance Index: 3.0700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0188
Cell Significance Index: 0.8300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0170
Cell Significance Index: 2.9000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0065
Cell Significance Index: 12.0000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0049
Cell Significance Index: 6.6900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0006
Cell Significance Index: 0.0100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0094
Cell Significance Index: -1.3700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0095
Cell Significance Index: -7.0600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0153
Cell Significance Index: -9.5500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0215
Cell Significance Index: -15.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0217
Cell Significance Index: -12.2500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0262
Cell Significance Index: -19.8200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0290
Cell Significance Index: -2.0500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0396
Cell Significance Index: -1.5000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0614
Cell Significance Index: -12.9400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0637
Cell Significance Index: -1.7000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0646
Cell Significance Index: -18.5900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0683
Cell Significance Index: -7.8300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0939
Cell Significance Index: -9.5900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1188
Cell Significance Index: -14.0100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1216
Cell Significance Index: -2.5900 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1220
Cell Significance Index: -8.2000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1235
Cell Significance Index: -7.9700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1274
Cell Significance Index: -16.4600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1327
Cell Significance Index: -15.4600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1363
Cell Significance Index: -2.6600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1400
Cell Significance Index: -3.8100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1424
Cell Significance Index: -6.7000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1914
Cell Significance Index: -3.9700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1969
Cell Significance Index: -20.5000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2109
Cell Significance Index: -24.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2152
Cell Significance Index: -16.0400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2396
Cell Significance Index: -6.4200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2551
Cell Significance Index: -8.1700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2612
Cell Significance Index: -20.6900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2681
Cell Significance Index: -7.6900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2785
Cell Significance Index: -6.6800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3038
Cell Significance Index: -15.9500 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3577
Cell Significance Index: -5.3600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3618
Cell Significance Index: -6.0600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3948
Cell Significance Index: -8.4400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4096
Cell Significance Index: -25.1100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.4406
Cell Significance Index: -6.6400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4440
Cell Significance Index: -15.4300 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.4522
Cell Significance Index: -7.2600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4668
Cell Significance Index: -6.6900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4755
Cell Significance Index: -7.0200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4875
Cell Significance Index: -12.8200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.5043
Cell Significance Index: -25.4900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5131
Cell Significance Index: -10.7400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5334
Cell Significance Index: -17.4700 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5421
Cell Significance Index: -19.9000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.5454
Cell Significance Index: -14.5900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5670
Cell Significance Index: -16.1800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 923696306
Symbol: PHF2_HUMAN
Name: Lysine-specific demethylase PHF2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10051327
Title: PHF2, a novel PHD finger gene located on human chromosome 9q22.
PubMed ID: 10051327
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20813266
Title: The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.
PubMed ID: 20813266
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21532585
Title: PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.
PubMed ID: 21532585
DOI: 10.1038/ncb2228
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 20129925
Title: Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation.
PubMed ID: 20129925
PubMed ID: 21167174
Title: Structural basis for human PHF2 Jumonji domain interaction with metal ions.
PubMed ID: 21167174
Sequence Information:
- Length: 1096
- Mass: 120775
- Checksum: DD088363DB76674D
- Sequence:
MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS TLKKKRTWHK HGPGQAPDVK PVQNGSQLFI KELRSRTFPS AEDVVARVPG SQLTLGYMEE HGFTEPILVP KKDGLGLAVP APTFYVSDVE NYVGPERSVD VTDVTKQKDC KMKLKEFVDY YYSTNRKRVL NVTNLEFSDT RMSSFVEPPD IVKKLSWVEN YWPDDALLAK PKVTKYCLIC VKDSYTDFHI DSGGASAWYH VLKGEKTFYL IRPASANISL YERWRSASNH SEMFFADQVD KCYKCIVKQG QTLFIPSGWI YATLTPVDCL AFAGHFLHSL SVEMQMRAYE VERRLKLGSL TQFPNFETAC WYMGKHLLEA FKGSHKSGKQ LPPHLVQGAK ILNGAFRSWT KKQALAEHED ELPEHFKPSQ LIKDLAKEIR LSENASKAVR PEVNTVASSD EVCDGDREKE EPPSPIEATP PQSLLEKVSK KKTPKTVKMP KPSKIPKPPK PPKPPRPPKT LKLKDGGKKK GKKSRESASP TIPNLDLLEA HTKEALTKME PPKKGKATKS VLSVPNKDVV HMQNDVERLE IREQTKSKSE AKWKYKNSKP DSLLKMEEEQ KLEKSPLAGN KDNKFSFSFS NKKLLGSKAL RPPTSPGVFG ALQNFKEDKP KPVRDEYEYV SDDGELKIDE FPIRRKKNAP KRDLSFLLDK KAVLPTPVTK PKLDSAAYKS DDSSDEGSLH IDTDTKPGRN ARVKKESGSS AAGILDLLQA SEEVGALEYN PSSQPPASPS TQEAIQGMLS MANLQASDSC LQTTWGAGQA KGSSLAAHGA RKNGGGSGKS AGKRLLKRAA KNSVDLDDYE EEQDHLDACF KDSDYVYPSL ESDEDNPIFK SRSKKRKGSD DAPYSPTARV GPSVPRQDRP VREGTRVASI ETGLAAAAAK LSQQEEQKSK KKKSAKRKLT PNTTSPSTST SISAGTTSTS TTPASTTPAS TTPASTSTAS SQASQEGSSP EPPPESHSSS LADHEYTAAG TFTGAQAGRT SQPMAPGVFL TQRRPSASSP NNNTAAKGKR TKKGMATAKQ RLGKILKIHR NGKLLL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.