Details for: PHF2

Gene ID: 5253

Symbol: PHF2

Ensembl ID: ENSG00000197724

Description: PHD finger protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 156.3854
    Cell Significance Index: -24.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.7356
    Cell Significance Index: -24.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.1314
    Cell Significance Index: -19.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.9271
    Cell Significance Index: -19.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.3576
    Cell Significance Index: -25.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0449
    Cell Significance Index: -24.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4064
    Cell Significance Index: -25.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.7062
    Cell Significance Index: -10.3000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.8460
    Cell Significance Index: 30.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0833
    Cell Significance Index: 14.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0517
    Cell Significance Index: 949.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7139
    Cell Significance Index: 143.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7052
    Cell Significance Index: 76.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7015
    Cell Significance Index: 114.1000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5960
    Cell Significance Index: 15.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5833
    Cell Significance Index: 35.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5832
    Cell Significance Index: 30.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5715
    Cell Significance Index: 113.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5555
    Cell Significance Index: 199.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4318
    Cell Significance Index: 10.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3950
    Cell Significance Index: 30.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3631
    Cell Significance Index: 16.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3628
    Cell Significance Index: 7.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3438
    Cell Significance Index: 23.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3378
    Cell Significance Index: 60.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3141
    Cell Significance Index: 217.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3082
    Cell Significance Index: 58.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2818
    Cell Significance Index: 34.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2462
    Cell Significance Index: 24.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1994
    Cell Significance Index: 10.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1935
    Cell Significance Index: 10.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1846
    Cell Significance Index: 5.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1673
    Cell Significance Index: 22.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1444
    Cell Significance Index: 63.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1375
    Cell Significance Index: 8.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1158
    Cell Significance Index: 5.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1032
    Cell Significance Index: 2.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0840
    Cell Significance Index: 45.8600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0838
    Cell Significance Index: 1.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0630
    Cell Significance Index: 3.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0592
    Cell Significance Index: 2.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0412
    Cell Significance Index: 77.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0331
    Cell Significance Index: 21.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0326
    Cell Significance Index: 50.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0269
    Cell Significance Index: 12.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0243
    Cell Significance Index: 0.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0239
    Cell Significance Index: 3.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0188
    Cell Significance Index: 0.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0170
    Cell Significance Index: 2.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0065
    Cell Significance Index: 12.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0049
    Cell Significance Index: 6.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0094
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0095
    Cell Significance Index: -7.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0153
    Cell Significance Index: -9.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0215
    Cell Significance Index: -15.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0262
    Cell Significance Index: -19.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0290
    Cell Significance Index: -2.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0396
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0614
    Cell Significance Index: -12.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0637
    Cell Significance Index: -1.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0646
    Cell Significance Index: -18.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0683
    Cell Significance Index: -7.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0939
    Cell Significance Index: -9.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1188
    Cell Significance Index: -14.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1216
    Cell Significance Index: -2.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1220
    Cell Significance Index: -8.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1235
    Cell Significance Index: -7.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1274
    Cell Significance Index: -16.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1327
    Cell Significance Index: -15.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1363
    Cell Significance Index: -2.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1400
    Cell Significance Index: -3.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1424
    Cell Significance Index: -6.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1914
    Cell Significance Index: -3.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1969
    Cell Significance Index: -20.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2109
    Cell Significance Index: -24.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2152
    Cell Significance Index: -16.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2396
    Cell Significance Index: -6.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2551
    Cell Significance Index: -8.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2612
    Cell Significance Index: -20.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2681
    Cell Significance Index: -7.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2785
    Cell Significance Index: -6.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3038
    Cell Significance Index: -15.9500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3577
    Cell Significance Index: -5.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3618
    Cell Significance Index: -6.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3948
    Cell Significance Index: -8.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4096
    Cell Significance Index: -25.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4406
    Cell Significance Index: -6.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4440
    Cell Significance Index: -15.4300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4522
    Cell Significance Index: -7.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4668
    Cell Significance Index: -6.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4755
    Cell Significance Index: -7.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4875
    Cell Significance Index: -12.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5043
    Cell Significance Index: -25.4900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5131
    Cell Significance Index: -10.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5334
    Cell Significance Index: -17.4700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5421
    Cell Significance Index: -19.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5454
    Cell Significance Index: -14.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5670
    Cell Significance Index: -16.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHF2 is a member of the PHD (proline-histidine-aspartate) finger protein family, which is characterized by the presence of a PHD domain. This domain is responsible for the recognition and binding of specific histone modifications, such as H3K9 and H4K20 trimethylation. PHF2 is a lysine-specific demethylase, which means it removes methyl groups from lysine residues on histones, thereby regulating chromatin structure and gene expression. **Pathways and Functions:** PHF2 is involved in several key pathways, including: 1. **Chromatin modifying enzymes**: PHF2 is a histone demethylase that regulates chromatin structure by removing methyl groups from histones. 2. **Chromatin organization**: PHF2 plays a crucial role in maintaining the structure and organization of chromatin, which is essential for gene expression. 3. **Histone demethylase activity**: PHF2 is a histone demethylase that regulates histone H3K9 and H4K20 trimethylation. 4. **Histone h3k9 demethylase activity**: PHF2 is involved in the demethylation of histone H3K9, which is a key regulator of gene expression. 5. **Histone h4k20 demethylase activity**: PHF2 is involved in the demethylation of histone H4K20, which is a regulator of chromatin organization. 6. **Iron ion binding**: PHF2 contains an iron-binding domain, which is essential for its enzymatic activity. 7. **Protein binding**: PHF2 interacts with various proteins, including transcription factors and chromatin-modifying enzymes, to regulate gene expression. **Clinical Significance:** Dysregulation of PHF2 has been implicated in several diseases, including: 1. **Neurological disorders**: PHF2 has been associated with neurological disorders, such as Parkinson's disease and Huntington's disease. 2. **Cancer**: PHF2 is often downregulated in cancer, leading to the silencing of tumor suppressor genes. 3. **Liver development**: PHF2 plays a crucial role in liver development, and its dysregulation can lead to liver dysfunction. 4. **Cardiac muscle myoblasts**: PHF2 is involved in the regulation of cardiac muscle development, and its dysregulation can lead to cardiac dysfunction. In conclusion, PHF2 is a critical gene that plays a key role in epigenetic regulation and transcriptional control. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the mechanisms of PHF2 and its potential therapeutic applications.

Genular Protein ID: 923696306

Symbol: PHF2_HUMAN

Name: Lysine-specific demethylase PHF2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10051327

Title: PHF2, a novel PHD finger gene located on human chromosome 9q22.

PubMed ID: 10051327

DOI: 10.1007/s003359900989

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20813266

Title: The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics.

PubMed ID: 20813266

DOI: 10.1016/j.cell.2010.07.047

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21532585

Title: PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B.

PubMed ID: 21532585

DOI: 10.1038/ncb2228

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20129925

Title: Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation.

PubMed ID: 20129925

DOI: 10.1074/jbc.c109.097667

PubMed ID: 21167174

Title: Structural basis for human PHF2 Jumonji domain interaction with metal ions.

PubMed ID: 21167174

DOI: 10.1016/j.jmb.2010.12.013

Sequence Information:

  • Length: 1096
  • Mass: 120775
  • Checksum: DD088363DB76674D
  • Sequence:
  • MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS 
    TLKKKRTWHK HGPGQAPDVK PVQNGSQLFI KELRSRTFPS AEDVVARVPG SQLTLGYMEE 
    HGFTEPILVP KKDGLGLAVP APTFYVSDVE NYVGPERSVD VTDVTKQKDC KMKLKEFVDY 
    YYSTNRKRVL NVTNLEFSDT RMSSFVEPPD IVKKLSWVEN YWPDDALLAK PKVTKYCLIC 
    VKDSYTDFHI DSGGASAWYH VLKGEKTFYL IRPASANISL YERWRSASNH SEMFFADQVD 
    KCYKCIVKQG QTLFIPSGWI YATLTPVDCL AFAGHFLHSL SVEMQMRAYE VERRLKLGSL 
    TQFPNFETAC WYMGKHLLEA FKGSHKSGKQ LPPHLVQGAK ILNGAFRSWT KKQALAEHED 
    ELPEHFKPSQ LIKDLAKEIR LSENASKAVR PEVNTVASSD EVCDGDREKE EPPSPIEATP 
    PQSLLEKVSK KKTPKTVKMP KPSKIPKPPK PPKPPRPPKT LKLKDGGKKK GKKSRESASP 
    TIPNLDLLEA HTKEALTKME PPKKGKATKS VLSVPNKDVV HMQNDVERLE IREQTKSKSE 
    AKWKYKNSKP DSLLKMEEEQ KLEKSPLAGN KDNKFSFSFS NKKLLGSKAL RPPTSPGVFG 
    ALQNFKEDKP KPVRDEYEYV SDDGELKIDE FPIRRKKNAP KRDLSFLLDK KAVLPTPVTK 
    PKLDSAAYKS DDSSDEGSLH IDTDTKPGRN ARVKKESGSS AAGILDLLQA SEEVGALEYN 
    PSSQPPASPS TQEAIQGMLS MANLQASDSC LQTTWGAGQA KGSSLAAHGA RKNGGGSGKS 
    AGKRLLKRAA KNSVDLDDYE EEQDHLDACF KDSDYVYPSL ESDEDNPIFK SRSKKRKGSD 
    DAPYSPTARV GPSVPRQDRP VREGTRVASI ETGLAAAAAK LSQQEEQKSK KKKSAKRKLT 
    PNTTSPSTST SISAGTTSTS TTPASTTPAS TTPASTSTAS SQASQEGSSP EPPPESHSSS 
    LADHEYTAAG TFTGAQAGRT SQPMAPGVFL TQRRPSASSP NNNTAAKGKR TKKGMATAKQ 
    RLGKILKIHR NGKLLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.