Details for: PIGF

Gene ID: 5281

Symbol: PIGF

Ensembl ID: ENSG00000151665

Description: phosphatidylinositol glycan anchor biosynthesis class F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.4603
    Cell Significance Index: -32.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.9502
    Cell Significance Index: -29.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.9465
    Cell Significance Index: -28.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.4264
    Cell Significance Index: -33.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.5629
    Cell Significance Index: -28.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.7828
    Cell Significance Index: -34.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3966
    Cell Significance Index: -30.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7961
    Cell Significance Index: -34.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1009
    Cell Significance Index: -21.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5652
    Cell Significance Index: 298.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6642
    Cell Significance Index: 86.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6433
    Cell Significance Index: 1483.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4801
    Cell Significance Index: 13.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1578
    Cell Significance Index: 208.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1173
    Cell Significance Index: 181.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9811
    Cell Significance Index: 120.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8084
    Cell Significance Index: 22.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8066
    Cell Significance Index: 440.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7472
    Cell Significance Index: 148.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6930
    Cell Significance Index: 9.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6785
    Cell Significance Index: 46.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6430
    Cell Significance Index: 29.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5849
    Cell Significance Index: 117.3300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4530
    Cell Significance Index: 44.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4395
    Cell Significance Index: 303.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4290
    Cell Significance Index: 27.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3520
    Cell Significance Index: 126.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3420
    Cell Significance Index: 43.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3252
    Cell Significance Index: 44.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2645
    Cell Significance Index: 14.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2254
    Cell Significance Index: 99.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2182
    Cell Significance Index: 13.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2166
    Cell Significance Index: 11.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1768
    Cell Significance Index: 5.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1764
    Cell Significance Index: 4.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1756
    Cell Significance Index: 7.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1572
    Cell Significance Index: 6.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1475
    Cell Significance Index: 17.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1419
    Cell Significance Index: 5.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1358
    Cell Significance Index: 3.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1237
    Cell Significance Index: 5.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1136
    Cell Significance Index: 8.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1125
    Cell Significance Index: 7.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0612
    Cell Significance Index: 115.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0605
    Cell Significance Index: 1.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0532
    Cell Significance Index: 3.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0429
    Cell Significance Index: 66.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0392
    Cell Significance Index: 2.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0317
    Cell Significance Index: 58.4400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0281
    Cell Significance Index: 0.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0216
    Cell Significance Index: 0.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0149
    Cell Significance Index: 0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0114
    Cell Significance Index: 7.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0099
    Cell Significance Index: 0.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0075
    Cell Significance Index: 10.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0061
    Cell Significance Index: -1.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0098
    Cell Significance Index: -7.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0198
    Cell Significance Index: -8.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0339
    Cell Significance Index: -4.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0339
    Cell Significance Index: -2.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0344
    Cell Significance Index: -1.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0352
    Cell Significance Index: -2.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0413
    Cell Significance Index: -30.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0491
    Cell Significance Index: -5.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0502
    Cell Significance Index: -6.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0506
    Cell Significance Index: -28.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0621
    Cell Significance Index: -10.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0636
    Cell Significance Index: -39.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0669
    Cell Significance Index: -1.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0814
    Cell Significance Index: -0.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0938
    Cell Significance Index: -27.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1246
    Cell Significance Index: -4.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1805
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1817
    Cell Significance Index: -38.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2023
    Cell Significance Index: -23.1800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2120
    Cell Significance Index: -3.2200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2379
    Cell Significance Index: -1.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2777
    Cell Significance Index: -28.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2964
    Cell Significance Index: -5.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3312
    Cell Significance Index: -8.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3527
    Cell Significance Index: -11.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3640
    Cell Significance Index: -7.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3721
    Cell Significance Index: -29.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3955
    Cell Significance Index: -9.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4545
    Cell Significance Index: -11.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4585
    Cell Significance Index: -12.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4825
    Cell Significance Index: -5.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4977
    Cell Significance Index: -14.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5398
    Cell Significance Index: -14.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5751
    Cell Significance Index: -35.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5891
    Cell Significance Index: -12.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5979
    Cell Significance Index: -12.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6133
    Cell Significance Index: -9.1900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6231
    Cell Significance Index: -6.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6323
    Cell Significance Index: -31.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6518
    Cell Significance Index: -18.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7122
    Cell Significance Index: -10.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7426
    Cell Significance Index: -27.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **GPI-anchored protein biosynthesis**: PIGF is essential for the synthesis of GPI-anchored proteins, which are critical for various cellular functions. 2. **High expression in immune cells**: PIGF is significantly expressed in immune cells, such as plasmablasts, preosteoblasts, and respiratory goblet cells, suggesting its involvement in immune regulation. 3. **Tissue-specific expression**: PIGF is expressed in various tissues, including bladder urothelial cells, skeletal muscle fibers, and kidney collecting duct intercalated cells. 4. **Involvement in multiple signaling pathways**: PIGF is involved in several signaling pathways, including the endoplasmic reticulum membrane, ethanolaminephosphotransferase activity, and the synthesis of GPI-anchored proteins. **Pathways and Functions:** 1. **GPI anchor biosynthetic process**: PIGF is involved in the biosynthesis of GPI-anchored proteins, which are essential for various cellular functions. 2. **Endoplasmic reticulum membrane**: PIGF is involved in the synthesis of GPI-anchored proteins, which are anchored to the endoplasmic reticulum membrane. 3. **Ethanolaminephosphotransferase activity**: PIGF is involved in the transfer of ethanolamine to phosphatidylglycerol, a precursor to GPI-anchored proteins. 4. **Mannose-ethanolamine phosphotransferase activity**: PIGF is involved in the transfer of mannose to ethanolamine, another precursor to GPI-anchored proteins. 5. **Metabolism of proteins**: PIGF is involved in the synthesis and modification of GPI-anchored proteins, which are essential for various cellular functions. **Clinical Significance:** The PIGF gene has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: Mutations in the PIGF gene have been associated with immunodeficiency disorders, such as Bruton's agammaglobulinemia. 2. **Cancer**: GPI-anchored proteins, which are synthesized by PIGF, are involved in the modulation of cell signaling and adhesion, which can contribute to cancer progression. 3. **Infectious diseases**: PIGF is involved in the regulation of immune responses, and its dysregulation can contribute to the pathogenesis of infectious diseases. In conclusion, the PIGF gene plays a critical role in the biosynthesis of GPI-anchored proteins, which are essential for various cellular functions and immune regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of PIGF in human health and disease.

Genular Protein ID: 499929265

Symbol: PIGF_HUMAN

Name: Phosphatidylinositol-glycan biosynthesis class F protein

UniProtKB Accession Codes:

Q07326 Q8WW20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8463218

Title: Cloning of a human gene, PIG-F, a component of glycosylphosphatidylinositol anchor biosynthesis, by a novel expression cloning strategy.

PubMed ID: 8463218

DOI: 10.1016/s0021-9258(18)53122-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632136

Title: GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol.

PubMed ID: 15632136

DOI: 10.1074/jbc.m413755200

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 33386993

Title: PIGF deficiency causes a phenotype overlapping with DOORS syndrome.

PubMed ID: 33386993

DOI: 10.1007/s00439-020-02251-2

Sequence Information:

  • Length: 219
  • Mass: 24890
  • Checksum: 313F97A55B781EBF
  • Sequence:
    • MKDNDIKRLL YTHLLCIFSI ILSVFIPSLF LENFSILETH LTWLCICSGF VTAVNLVLYL 
VVKPNTSSKR SSLSHKVTGF LKCCIYFLMS CFSFHVIFVL YGAPLIELAL ETFLFAVILS 
TFTTVPCLCL LGPNLKAWLR VFSRNGVTSI WENSLQITTI SSFVGAWLGA LPIPLDWERP 
WQVWPISCTL GATFGYVAGL VISPLWIYWN RKQLTYKNN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.