Details for: PKNOX1
Gene ID: 5316
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PKNOX1
Ensembl ID: ENSG00000160199
Description: PBX/knotted 1 homeobox 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 10.02rCSI 21.31%PRS 73.79
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CSI 6.89rCSI 26.96%PRS 58.01
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CSI 6.41rCSI 24.23%PRS 61.82
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CSI 5.14rCSI 16.07%PRS 62.96
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CSI 5.13rCSI 9.32%PRS 70.85
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CSI 5.07rCSI 14.27%PRS 74.43
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CSI 4.24rCSI 10.36%PRS 71.77
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CSI 4.22rCSI 4.88%PRS 71.59
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CSI 3.7rCSI 21.79%PRS 62.05
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CSI 3.69rCSI 8.97%PRS 59.37
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CSI 3.42rCSI 29.51%PRS 67.61
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CSI 3.4rCSI 13.72%PRS 78.97
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CSI 3.39rCSI 10.61%PRS 65.36
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CSI 3.15rCSI 4.04%PRS 82.68
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CSI 3.15rCSI 3.45%PRS 81.36
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CSI 3.02rCSI 2.23%PRS 72.88
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CSI 3rCSI 4.92%PRS 68.85
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CSI 2.99rCSI 3.72%PRS 80.41
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CSI 2.99rCSI 2.63%PRS 68.5
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CSI 2.93rCSI 3.52%PRS 77.03
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CSI 2.93rCSI 5.07%PRS 70.9
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CSI 2.93rCSI 4.3%PRS 72.35
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CSI 2.92rCSI 2.04%PRS 82.6
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CSI 2.8rCSI 2.45%PRS 86.48
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CSI 2.68rCSI 6.12%PRS 70.86
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CSI 2.68rCSI 2.12%PRS 67.99
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CSI 2.67rCSI 2.8%PRS 82.68
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CSI 2.6rCSI 3.33%PRS 75.4
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CSI 2.56rCSI 7.56%PRS 80.3
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CSI 2.55rCSI 5.65%PRS 78.65
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CSI 2.5rCSI 3.22%PRS 62.44
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CSI 2.49rCSI 8.95%PRS 59.23
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CSI 2.47rCSI 5.64%PRS 80.04
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CSI 2.46rCSI 3.51%PRS 80.24
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CSI 2.45rCSI 2.28%PRS 80.11
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CSI 2.44rCSI 2.92%PRS 61.43
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CSI 2.41rCSI 2.99%PRS 59.23
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CSI 2.41rCSI 4.22%PRS 73.02
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CSI 2.4rCSI 3.28%PRS 83.71
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CSI 2.36rCSI 6.16%PRS 80.39
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CSI 2.33rCSI 4.67%PRS 69.48
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CSI 2.32rCSI 2.29%PRS 81.93
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CSI 2.31rCSI 3.09%PRS 78.12
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CSI 2.3rCSI 2.22%PRS 72.52
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CSI 2.25rCSI 3.48%PRS 78.41
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CSI 2.21rCSI 1.49%PRS 91.16
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CSI 2.08rCSI 2.4%PRS 71.5
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CSI 2.06rCSI 3.29%PRS 83.06
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CSI 1.96rCSI 3.12%PRS 72.32
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CSI 1.95rCSI 2.98%PRS 76.27
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CSI 1.95rCSI 1.71%PRS 84.24
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CSI 1.93rCSI 3.92%PRS 57.9
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CSI 1.9rCSI 9.1%PRS 79.34
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CSI 1.89rCSI 1.54%PRS 78.77
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CSI 1.87rCSI 4.33%PRS 67.43
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CSI 1.87rCSI 4.47%PRS 79.58
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CSI 1.86rCSI 44.56%PRS 59.68
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CSI 1.86rCSI 1.79%PRS 78.65
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CSI 1.85rCSI 1.39%PRS 84.95
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CSI 1.79rCSI 43.15%PRS 60.25
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CSI 1.78rCSI 2.72%PRS 86.48
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CSI 1.77rCSI 2.42%PRS 71.16
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CSI 1.74rCSI 5.64%PRS 77.5
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CSI 1.71rCSI 1.31%PRS 82.09
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CSI 1.7rCSI 5.71%PRS 63.41
-
CSI 1.67rCSI 2.07%PRS 77.18
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CSI 1.63rCSI 3.23%PRS 75.13
-
CSI 1.62rCSI 4.19%PRS 74.72
-
CSI 1.58rCSI 2.55%PRS 69.35
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CSI 1.52rCSI 2.45%PRS 63.01
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CSI 1.51rCSI 3.73%PRS 78.94
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CSI 1.5rCSI 2.12%PRS 76
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CSI 1.48rCSI 4%PRS 84.24
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CSI 1.45rCSI 2.62%PRS 93.69
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CSI 1.4rCSI 3.13%PRS 62.11
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CSI 1.34rCSI 2.37%PRS 60.65
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CSI 1.32rCSI 1.81%PRS 70.95
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CSI 1.3rCSI 3.77%PRS 68.87
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CSI 1.3rCSI 3.47%PRS 71.07
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CSI 1.18rCSI 2.42%PRS 67.06
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CSI 1.17rCSI 2.55%PRS 67.21
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CSI 1.17rCSI 2.19%PRS 67.73
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CSI 1.14rCSI 2.52%PRS 65.16
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CSI 1.1rCSI 2.63%PRS 66.46
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CSI 1.08rCSI 2.98%PRS 74.4
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CSI 1.01rCSI 1.59%PRS 81
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CSI 0.98rCSI 4.29%PRS 67.86
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CSI 0.96rCSI 2.43%PRS 69.7
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CSI 0.92rCSI 3.03%PRS 65.74
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CSI 0.88rCSI 6.46%PRS 66.79
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CSI 0.84rCSI 2.35%PRS 86.46
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CSI 0.81rCSI 1.35%PRS 61.32
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CSI 0.69rCSI 1.88%PRS 86.24
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CSI 0.65rCSI 5.25%PRS 73.44
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CSI 0.62rCSI 3.48%PRS 65.45
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CSI 0.61rCSI 2.71%PRS 79.88
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CSI 0.4rCSI 5.72%PRS 70.45
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1203806922
Symbol: PKNX1_HUMAN
Name: Homeobox protein PKNOX1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9143494
Title: Cloning of a novel homeobox-containing gene, PKNOX1, and mapping to human chromosome 21q22.3.
PubMed ID: 9143494
PubMed ID: 9479508
Title: PKNOX1, a gene encoding PREP1, a new regulator of Pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17B/C.
PubMed ID: 9479508
PubMed ID: 15468914
Title: Molecular cloning for an alternatively splicing cDNA of human PKNOX1 gene and it's expression analysis.
PubMed ID: 15468914
PubMed ID: 10830953
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 31839203
Title: Gain-of-function MN1 truncation variants cause a recognizable syndrome with craniofacial and brain abnormalities.
PubMed ID: 31839203
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 436
- Mass: 47607
- Checksum: 381E901F435AC5F2
- Sequence:
MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI ASGVAQPPPS ELTMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM AGQSEDESVD STEEDAGALA PAHISGLVLE NSDSLQ
Genular Protein ID: 3255815686
Symbol: E7EPN6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10830953
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 319
- Mass: 34519
- Checksum: D0D47039D1B45670
- Sequence:
MVKAIQVLRI HLLELEKVNE LCKDFCSRYI ACLKTKMNSE TLLSGEPGSP YSPVQSQQIQ SAITGTISPQ GIVVPASALQ QGNVAMATVA GGTVYQPVTV VTPQGQVVTQ TLSPGTIRIQ NSQLQLQLNQ DLSILHQDDG SSKNKRGVLP KHATNVMRSW LFQHIGHPYP TEDEKKQIAA QTNLTLLQVN NWFINARRRI LQPMLDSSCS ETPKTKKKTA QNRPVQRFWP DSIASGVAQP PPSELTMSEG AVVTITTPVN MNVDSLQSLS SDGATLAVQQ VMMAGQSEDE SVDSTEEDAG ALAPAHISGL VLENSDSLQ
Genular Protein ID: 1512031010
Symbol: B4DGV5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 319
- Mass: 34547
- Checksum: 54463854676F3B36
- Sequence:
MVKAIQVLRI HLLELEKVNE LCKDFCSRYI ACLKTKMNSE TLLSGEPGSP YSPVQSQQIQ SAITGTISPQ GIVVPASALQ RGNVAMATVA GGTVYQPVTV VTPQGQVVTQ TLSPGTIRIQ NSQLQLQLNQ DLSILHQDDG SSKNKRGVLP KHATNVMRSW LFQHIGHPYP TEDEKKQIAA QTNLTLLQVN NWFINARRRI LQPMLDSSCS ETPKTKKKTA QNRPVQRFWP DSIASGVAQP PPSELTMSEG AVVTITTPVN MNVDSLQSLS SDGATLAVQQ VMMAGQSEDE SVDSTEEDAG ALAPAHISGL VLENSDSLQ
Genular Protein ID: 2663857688
Symbol: Q6PKH2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 336
- Mass: 37296
- Checksum: 7CDB474D4C3A455B
- Sequence:
MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN LTLLQVNNWF INARRRILQP MLDSSCSETP KKKKKK