Details for: NUDT9

Gene ID: 53343

Symbol: NUDT9

Ensembl ID: ENSG00000170502

Description: nudix hydrolase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 200.1347
    Cell Significance Index: -31.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 117.6258
    Cell Significance Index: -29.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.7065
    Cell Significance Index: -32.9100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.2296
    Cell Significance Index: -27.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.7145
    Cell Significance Index: -27.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0593
    Cell Significance Index: -32.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1876
    Cell Significance Index: -29.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2260
    Cell Significance Index: -32.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1997
    Cell Significance Index: -11.3800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.1786
    Cell Significance Index: 51.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4168
    Cell Significance Index: 19.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9891
    Cell Significance Index: 160.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8223
    Cell Significance Index: 22.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8196
    Cell Significance Index: 42.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8070
    Cell Significance Index: 161.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7986
    Cell Significance Index: 36.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7702
    Cell Significance Index: 20.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7074
    Cell Significance Index: 32.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6647
    Cell Significance Index: 19.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5873
    Cell Significance Index: 116.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5688
    Cell Significance Index: 102.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5223
    Cell Significance Index: 36.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5202
    Cell Significance Index: 284.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5140
    Cell Significance Index: 70.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5021
    Cell Significance Index: 12.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.4994
    Cell Significance Index: 311.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4510
    Cell Significance Index: 55.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4481
    Cell Significance Index: 404.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4301
    Cell Significance Index: 73.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4058
    Cell Significance Index: 145.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3594
    Cell Significance Index: 22.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2998
    Cell Significance Index: 6.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2936
    Cell Significance Index: 37.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2220
    Cell Significance Index: 98.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2056
    Cell Significance Index: 3.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1880
    Cell Significance Index: 10.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1710
    Cell Significance Index: 32.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1415
    Cell Significance Index: 10.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1396
    Cell Significance Index: 96.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1347
    Cell Significance Index: 7.0700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0739
    Cell Significance Index: 0.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0693
    Cell Significance Index: 1.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0566
    Cell Significance Index: 4.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0519
    Cell Significance Index: 2.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0468
    Cell Significance Index: 4.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0449
    Cell Significance Index: 2.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0387
    Cell Significance Index: 72.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0306
    Cell Significance Index: 3.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0252
    Cell Significance Index: 11.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0222
    Cell Significance Index: 14.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0188
    Cell Significance Index: 0.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0139
    Cell Significance Index: 0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0121
    Cell Significance Index: 0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0102
    Cell Significance Index: 15.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0082
    Cell Significance Index: 15.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0058
    Cell Significance Index: 7.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0036
    Cell Significance Index: -2.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0226
    Cell Significance Index: -12.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0279
    Cell Significance Index: -0.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0390
    Cell Significance Index: -0.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0440
    Cell Significance Index: -5.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0449
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0511
    Cell Significance Index: -10.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0537
    Cell Significance Index: -5.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0586
    Cell Significance Index: -0.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0669
    Cell Significance Index: -1.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0673
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0704
    Cell Significance Index: -8.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0924
    Cell Significance Index: -26.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1054
    Cell Significance Index: -12.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1083
    Cell Significance Index: -15.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1247
    Cell Significance Index: -14.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1343
    Cell Significance Index: -1.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1363
    Cell Significance Index: -1.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1535
    Cell Significance Index: -2.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1544
    Cell Significance Index: -3.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1852
    Cell Significance Index: -12.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1968
    Cell Significance Index: -10.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2115
    Cell Significance Index: -13.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2288
    Cell Significance Index: -10.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2485
    Cell Significance Index: -7.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2697
    Cell Significance Index: -7.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2723
    Cell Significance Index: -28.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2865
    Cell Significance Index: -10.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3328
    Cell Significance Index: -26.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3371
    Cell Significance Index: -6.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3624
    Cell Significance Index: -4.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3918
    Cell Significance Index: -24.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5136
    Cell Significance Index: -13.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5339
    Cell Significance Index: -14.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5383
    Cell Significance Index: -15.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5408
    Cell Significance Index: -27.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5461
    Cell Significance Index: -11.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5920
    Cell Significance Index: -8.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6121
    Cell Significance Index: -14.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6189
    Cell Significance Index: -19.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6200
    Cell Significance Index: -5.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUDT9 is a mitochondrial enzyme that exhibits high specificity for ADP-ribose pyrophosphate, a substrate that is crucial for various cellular processes. The enzyme is characterized by its ability to hydrolyze ADP-ribose pyrophosphate, resulting in the production of ADP-ribose and pyrophosphate. NUDT9 is also known to interact with various proteins, including those involved in cell signaling and mitochondrial function, suggesting its potential role in regulating cellular processes. **Pathways and Functions:** NUDT9 is involved in several key metabolic pathways, including: 1. **Nucleotide metabolism:** NUDT9 plays a critical role in the regulation of nucleotide metabolism, including the hydrolysis of ADP-ribose pyrophosphate, a key intermediate in the metabolic pathways of nucleotides. 2. **Cell signaling:** NUDT9 interacts with various proteins involved in cell signaling, including those involved in the regulation of cell proliferation, differentiation, and survival. 3. **Mitochondrial function:** NUDT9 is localized to the mitochondrial matrix and is involved in the regulation of mitochondrial function, including the regulation of ATP production and mitochondrial dynamics. 4. **Exosome-mediated transport:** NUDT9 is also involved in the regulation of exosome-mediated transport, which is crucial for the removal of waste products from cells. **Clinical Significance:** Dysregulation of NUDT9 has been implicated in various human diseases, including: 1. **Metabolic disorders:** Mutations in NUDT9 have been associated with metabolic disorders, including obesity and type 2 diabetes. 2. **Cancer:** NUDT9 has been shown to be overexpressed in various types of cancer, including breast and lung cancer, suggesting its potential role in cancer development and progression. 3. **Neurological disorders:** NUDT9 has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, NUDT9 is a critical enzyme involved in the regulation of various cellular processes, including nucleotide metabolism, cell signaling, and mitochondrial function. Its dysregulation has been implicated in various human diseases, highlighting the importance of NUDT9 in maintaining cellular homeostasis. Further research is needed to fully understand the functions of NUDT9 and its role in human diseases. **References:** 1. [Insert references to studies on NUDT9] 2. [Insert references to studies on the role of NUDT9 in metabolic disorders] 3. [Insert references to studies on the role of NUDT9 in cancer] 4. [Insert references to studies on the role of NUDT9 in neurological disorders] **Note:** The references provided are fictional and for demonstration purposes only. In a real-world article, you would need to include actual references to studies on NUDT9.

Genular Protein ID: 2600771930

Symbol: NUDT9_HUMAN

Name: ADP-ribose pyrophosphatase, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11385575

Title: ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology.

PubMed ID: 11385575

DOI: 10.1038/35079100

PubMed ID: 11825615

Title: Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose).

PubMed ID: 11825615

DOI: 10.1016/s0167-4838(01)00296-5

PubMed ID: 12427752

Title: NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.

PubMed ID: 12427752

DOI: 10.1074/jbc.m205601200

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12897971

Title: Interaction of C17orf25 with ADP-ribose pyrophosphatase NUDT9 detected via yeast two-hybrid method.

PubMed ID: 12897971

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 12948489

Title: The crystal structure and mutational analysis of human NUDT9.

PubMed ID: 12948489

DOI: 10.1016/s0022-2836(03)00954-9

Sequence Information:

  • Length: 350
  • Mass: 39125
  • Checksum: 2EA5B24B88FB3420
  • Sequence:
  • MAGRLLGKAL AAVSLSLALA SVTIRSSRCR GIQAFRNSFS SSWFHLNTNV MSGSNGSKEN 
    SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYKPVEYT AVSVLAGPRW ADPQISESNF 
    SPKFNEKDGH VERKSKNGLY EIENGRPRNP AGRTGLVGRG LLGRWGPNHA ADPIITRWKR 
    DSSGNKIMHP VSGKHILQFV AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ 
    KTSAEKREIE EKLHKLFSQD HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE TGEIMDNLML 
    EAGDDAGKVK WVDINDKLKL YASHSQFIKL VAEKRDAHWS EDSEADCHAL

Genular Protein ID: 800164729

Symbol: Q8NG26_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 300
  • Mass: 33746
  • Checksum: 9C35210C703657AE
  • Sequence:
  • MSGSNGSKEN SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYKPVEYT AVSVLAGPRW 
    ADPQISEGNF SPKFNEKDGH VERKSKNGLY EIENGRPRNP AGRTGLVGRG LLGRWGPNHA 
    ADPIITRWKR DSSGNKIMHP VSGKHILQFV AIKRKDCGEW AIPGGMVDPG EKISATLKRE 
    FGEEALNSLQ KTSAEKREIE EKLHKLFSQD HLVIYKGYVD DPRNTDNAWM ETEAVNYHDE 
    TGEIMDNLML EAGDDAGKVK WVDINDKLKL YASHSQFIKL VAEKRDAHWS EDSEADCHAL

Genular Protein ID: 2930235092

Symbol: Q96KB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 350
  • Mass: 39042
  • Checksum: 8BE1A31ECCFB343D
  • Sequence:
  • MAGRLLGKAL AAVSLSLALA SVTIRSSRCR GIQAFRNSFS SSWFHLNTNV MSGSNGSKEN 
    SHNKARTSPY PGSKVERSQV PNEKVGWLVE WQDYKPVEYT AVSVLAGPRW ADPQISESNF 
    SPKFNEKDGH VERKSKNGLY EIENGRPRNP AGRTGLVGRG LLGRWGPNHA ADPIITRWKR 
    DSSGNKIMHP VSGKHILQFV AIKRKDCGEW AIPGGMVDPG EKISATLKRE FGEEALNSLQ 
    KTSAEKREIE EKLHKLFSQD HLVIYKGYVD DPRNTDNACM ETEAVNYHDE TGEIMDNLML 
    EAGDDAGKVK WVDINDKLKL YASHSQFIKL VAEKRDAHWS EDSEADCHAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.