PLCG1 | ENSG00000124181 | NCBI 5335

Details for: PLCG1

Gene ID: 5335

Symbol: PLCG1

Ensembl ID: ENSG00000124181

Description: phospholipase C gamma 1

Associated with

Activated ntrk2 signals through plcg1
(R-HSA-9026527)
Activated ntrk3 signals through plcg1
(R-HSA-9034793)
Adaptive immune system
(R-HSA-1280218)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Axon guidance
(R-HSA-422475)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Constitutive signaling by egfrviii
(R-HSA-5637810)
Constitutive signaling by ligand-responsive egfr cancer variants
(R-HSA-1236382)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Downstream signal transduction
(R-HSA-186763)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Erythropoietin activates phospholipase c gamma (plcg)
(R-HSA-9027277)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated ca+2 mobilization
(R-HSA-2871809)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
Generation of second messenger molecules
(R-HSA-202433)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Inositol phosphate metabolism
(R-HSA-1483249)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Isg15 antiviral mechanism
(R-HSA-1169408)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Nervous system development
(R-HSA-9675108)
Netrin-1 signaling
(R-HSA-373752)
Parasitic infection pathways
(R-HSA-9824443)
Pecam1 interactions
(R-HSA-210990)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Plc-gamma1 signalling
(R-HSA-167021)
Plcg1 events in erbb2 signaling
(R-HSA-1251932)
Ret signaling
(R-HSA-8853659)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Role of second messengers in netrin-1 signaling
(R-HSA-418890)
Signaling by alk
(R-HSA-201556)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrk3 (trkc)
(R-HSA-9034015)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Synthesis of ip3 and ip4 in the cytosol
(R-HSA-1855204)
Tcr signaling
(R-HSA-202403)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
Calcium ion binding
(GO:0005509)
Glutamate receptor binding
(GO:0035254)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Neurotrophin trka receptor binding
(GO:0005168)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase c activity
(GO:0004629)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Receptor tyrosine kinase binding
(GO:0030971)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 133.1446
Cell Significance Index: -20.7100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 82.5569
Cell Significance Index: -20.9400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 45.8823
Cell Significance Index: -18.6400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.9755
Cell Significance Index: -20.9300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.2083
Cell Significance Index: -19.3100
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.3218
Cell Significance Index: -21.0000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4784
Cell Significance Index: 281.3500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9516
Cell Significance Index: 188.8600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8656
Cell Significance Index: 85.6300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6598
Cell Significance Index: 595.7500
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.6424
Cell Significance Index: 9.2400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6258
Cell Significance Index: 125.5400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6140
Cell Significance Index: 31.9800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5452
Cell Significance Index: 377.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4602
Cell Significance Index: 13.2600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4409
Cell Significance Index: 71.7100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4099
Cell Significance Index: 23.0000
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.3890
Cell Significance Index: 5.4400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3626
Cell Significance Index: 130.0700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3622
Cell Significance Index: 39.4000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2857
Cell Significance Index: 17.5600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2309
Cell Significance Index: 6.7800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2240
Cell Significance Index: 6.2600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2232
Cell Significance Index: 17.1300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2197
Cell Significance Index: 13.1900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2103
Cell Significance Index: 9.5300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1800
Cell Significance Index: 24.7200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1468
Cell Significance Index: 10.1500
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1029
Cell Significance Index: 4.5500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0864
Cell Significance Index: 3.2700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0810
Cell Significance Index: 14.6100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0804
Cell Significance Index: 1.5700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0574
Cell Significance Index: 0.7300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0521
Cell Significance Index: 23.0400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0479
Cell Significance Index: 90.1600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0477
Cell Significance Index: 26.0300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0381
Cell Significance Index: 24.1800
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0379
Cell Significance Index: 1.0200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0190
Cell Significance Index: 29.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0175
Cell Significance Index: 0.4600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0168
Cell Significance Index: 31.0400
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0098
Cell Significance Index: 1.2500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0084
Cell Significance Index: 0.9900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0082
Cell Significance Index: 0.1400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0019
Cell Significance Index: 2.6300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0139
Cell Significance Index: -6.3300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0196
Cell Significance Index: -2.8500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0231
Cell Significance Index: -16.9100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0256
Cell Significance Index: -18.9700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0261
Cell Significance Index: -19.7500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0268
Cell Significance Index: -3.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0372
Cell Significance Index: -20.9900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0382
Cell Significance Index: -23.8500
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0404
Cell Significance Index: -0.9700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0459
Cell Significance Index: -0.9600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0475
Cell Significance Index: -1.6700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0581
Cell Significance Index: -16.7100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0790
Cell Significance Index: -5.3100
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.0915
Cell Significance Index: -0.6200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0940
Cell Significance Index: -10.9500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0984
Cell Significance Index: -3.4200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0984
Cell Significance Index: -10.0500
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1035
Cell Significance Index: -17.6700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1128
Cell Significance Index: -23.7700
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1384
Cell Significance Index: -3.0300
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1425
Cell Significance Index: -2.3900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1437
Cell Significance Index: -18.5600
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1440
Cell Significance Index: -2.4900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1456
Cell Significance Index: -3.0200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1460
Cell Significance Index: -3.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1517
Cell Significance Index: -17.3900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1602
Cell Significance Index: -2.3000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1642
Cell Significance Index: -11.6100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1661
Cell Significance Index: -17.2900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1809
Cell Significance Index: -4.6500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1830
Cell Significance Index: -8.5300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1831
Cell Significance Index: -8.6100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1987
Cell Significance Index: -10.3200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.2211
Cell Significance Index: -4.7300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2300
Cell Significance Index: -14.1000
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2400
Cell Significance Index: -3.2800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2402
Cell Significance Index: -17.9000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2559
Cell Significance Index: -20.2700
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2577
Cell Significance Index: -3.6900
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2833
Cell Significance Index: -18.2800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2878
Cell Significance Index: -15.1100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3327
Cell Significance Index: -20.9700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3443
Cell Significance Index: -9.8700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3681
Cell Significance Index: -12.0500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3759
Cell Significance Index: -10.2300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3964
Cell Significance Index: -9.9100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3981
Cell Significance Index: -12.6800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.4022
Cell Significance Index: -2.4300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4190
Cell Significance Index: -13.4200
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4339
Cell Significance Index: -9.2100
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4422
Cell Significance Index: -15.4900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4695
Cell Significance Index: -13.8300
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4818
Cell Significance Index: -13.7500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4978
Cell Significance Index: -7.3500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5125
Cell Significance Index: -10.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PLCG1 is a member of the PLC family, characterized by its ability to hydrolyze phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These second messengers play critical roles in various cellular processes, including calcium signaling, cell proliferation, and differentiation. PLCG1 is specifically activated by the binding of ligands to its associated receptors, such as EGFR, NTRKs, and FcεRI. This activation leads to the generation of IP3 and DAG, which in turn activate downstream signaling pathways. **Pathways and Functions:** PLCG1 is involved in various signaling pathways that regulate immune responses, cell growth, and development. Some of the key pathways and functions of PLCG1 include: * Cell surface interactions at the vascular wall: PLCG1 plays a role in the regulation of vascular smooth muscle cell proliferation and migration. * Cytokine signaling in the immune system: PLCG1 is involved in the regulation of cytokine production and signaling in immune cells. * Developmental biology: PLCG1 is essential for the development of the nervous system and the regulation of cell growth and differentiation. * Infectious disease: PLCG1 is involved in the regulation of immune responses to parasitic infections, such as Leishmania. * Metabolism: PLCG1 plays a role in the regulation of glucose metabolism and insulin signaling. **Clinical Significance:** The dysregulation of PLCG1 has been implicated in several diseases, including: * Cancer: PLCG1 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer. * Inflammatory disorders: PLCG1 plays a role in the regulation of inflammatory responses, and its dysregulation has been implicated in conditions such as rheumatoid arthritis and asthma. * Parasitic infections: PLCG1 is involved in the regulation of immune responses to parasitic infections, such as Leishmania. * Neurological disorders: PLCG1 is involved in the regulation of neuronal function and plasticity, and its dysregulation has been implicated in conditions such as Alzheimer's disease and Parkinson's disease. In conclusion, PLCG1 is a multifaceted enzyme involved in various signaling pathways that regulate immune responses, cell growth, and development. Its dysregulation has been implicated in several diseases, including cancer, inflammatory disorders, and parasitic infections. Further research is needed to fully understand the mechanisms by which PLCG1 regulates these processes and to develop therapeutic strategies to target this enzyme in disease contexts.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 740687735

Symbol: PLCG1_HUMAN

Name: PLC-148

UniProtKB Accession Codes:

P19174 B7ZLY7 B9EGH4 E1P5W4 Q2V575

Database IDs:

Citations:

PubMed ID: 2167438

Title: Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

PubMed ID: 2167438

DOI: 10.1128/mcb.10.9.4770-4777.1990

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1656221

Title: A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

PubMed ID: 1656221

DOI: 10.1128/mcb.11.10.5068-5078.1991

PubMed ID: 1370476

Title: Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1.

PubMed ID: 1370476

DOI: 10.1016/s0021-9258(18)45973-x

PubMed ID: 7518429

Title: Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.

PubMed ID: 7518429

DOI: 10.1016/s0021-9258(17)32309-8

PubMed ID: 8657103

Title: Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk.

PubMed ID: 8657103

DOI: 10.1128/mcb.16.4.1305

PubMed ID: 9038210

Title: Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes.

PubMed ID: 9038210

DOI: 10.1074/jbc.272.9.5915

PubMed ID: 9178760

Title: Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

PubMed ID: 9178760

DOI: 10.1038/sj.onc.1201123

PubMed ID: 9489702

Title: LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.

PubMed ID: 9489702

DOI: 10.1016/s0092-8674(00)80901-0

PubMed ID: 10488157

Title: Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.

PubMed ID: 10488157

DOI: 10.1074/jbc.274.39.28050

PubMed ID: 10102632

Title: Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.

PubMed ID: 10102632

DOI: 10.1038/sj.onc.1202478

PubMed ID: 10873601

Title: Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1.

PubMed ID: 10873601

DOI: 10.1006/bbrc.2000.2887

PubMed ID: 11518702

Title: The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.

PubMed ID: 11518702

DOI: 10.1074/jbc.m101546200

PubMed ID: 10747847

Title: Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.

PubMed ID: 10747847

DOI: 10.1074/jbc.c000085200

PubMed ID: 11259588

Title: Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation.

PubMed ID: 11259588

DOI: 10.1128/mcb.21.7.2393-2403.2001

PubMed ID: 11564877

Title: Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.

PubMed ID: 11564877

DOI: 10.1128/mcb.21.20.6939-6950.2001

PubMed ID: 12913111

Title: The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling.

PubMed ID: 12913111

DOI: 10.1083/jcb.200303040

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15488758

Title: TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.

PubMed ID: 15488758

DOI: 10.1016/j.ccr.2004.09.011

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15270728

Title: Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells.

PubMed ID: 15270728

DOI: 10.1111/j.1365-2567.2004.01918.x

PubMed ID: 15102829

Title: Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.

PubMed ID: 15102829

DOI: 10.1074/jbc.m314015200

PubMed ID: 15215251

Title: Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells.

PubMed ID: 15215251

DOI: 10.1074/jbc.m401538200

PubMed ID: 16081816

Title: Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.

PubMed ID: 16081816

DOI: 10.4049/jimmunol.175.4.2449

PubMed ID: 16844695

Title: Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F.

PubMed ID: 16844695

DOI: 10.1074/jbc.m600448200

PubMed ID: 17229814

Title: Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.

PubMed ID: 17229814

DOI: 10.1152/ajpcell.00420.2006

PubMed ID: 17561467

Title: Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1.

PubMed ID: 17561467

DOI: 10.1016/j.bone.2006.11.030

PubMed ID: 17620338

Title: Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation.

PubMed ID: 17620338

DOI: 10.1074/jbc.m701797200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19286672

Title: A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.

PubMed ID: 19286672

DOI: 10.1093/hmg/ddp116

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20494825

Title: Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.

PubMed ID: 20494825

DOI: 10.1016/j.cellsig.2010.05.004

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21765395

Title: Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.

PubMed ID: 21765395

DOI: 10.1038/emboj.2011.234

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22561606

Title: Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.

PubMed ID: 22561606

DOI: 10.1038/ni.2301

PubMed ID: 15863030

Title: Cellular signaling by fibroblast growth factor receptors.

PubMed ID: 15863030

DOI: 10.1016/j.cytogfr.2005.01.001

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 37422272

Title: A gain-of-function variation in PLCG1 causes a new immune dysregulation disease.

PubMed ID: 37422272

DOI: 10.1016/j.jaci.2023.06.020

PubMed ID: 7681365

Title: Solution structure of the SH3 domain of phospholipase C-gamma.

PubMed ID: 7681365

DOI: 10.1016/0092-8674(93)90583-c

Sequence Information:

Length: 1290
Mass: 148532
Checksum: AE05ABE2A18EDDAC
Sequence:

MAGAASPCAN GCGPGAPSDA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 
TWSRGADKIE GAIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 
SLQATSEDEV NMWIKGLTWL MEDTLQAPTP LQIERWLRKQ FYSVDRNRED RISAKDLKNM 
LSQVNYRVPN MRFLRERLTD LEQRSGDITY GQFAQLYRSL MYSAQKTMDL PFLEASTLRA 
GERPELCRVS LPEFQQFLLD YQGELWAVDR LQVQEFMLSF LRDPLREIEE PYFFLDEFVT 
FLFSKENSVW NSQLDAVCPD TMNNPLSHYW ISSSHNTYLT GDQFSSESSL EAYARCLRMG 
CRCIELDCWD GPDGMPVIYH GHTLTTKIKF SDVLHTIKEH AFVASEYPVI LSIEDHCSIA 
QQRNMAQYFK KVLGDTLLTK PVEISADGLP SPNQLKRKIL IKHKKLAEGS AYEEVPTSMM 
YSENDISNSI KNGILYLEDP VNHEWYPHYF VLTSSKIYYS EETSSDQGNE DEEEPKEVSS 
STELHSNEKW FHGKLGAGRD GRHIAERLLT EYCIETGAPD GSFLVRESET FVGDYTLSFW 
RNGKVQHCRI HSRQDAGTPK FFLTDNLVFD SLYDLITHYQ QVPLRCNEFE MRLSEPVPQT 
NAHESKEWYH ASLTRAQAEH MLMRVPRDGA FLVRKRNEPN SYAISFRAEG KIKHCRVQQE 
GQTVMLGNSE FDSLVDLISY YEKHPLYRKM KLRYPINEEA LEKIGTAEPD YGALYEGRNP 
GFYVEANPMP TFKCAVKALF DYKAQREDEL TFIKSAIIQN VEKQEGGWWR GDYGGKKQLW 
FPSNYVEEMV NPVALEPERE HLDENSPLGD LLRGVLDVPA CQIAIRPEGK NNRLFVFSIS 
MASVAHWSLD VAADSQEELQ DWVKKIREVA QTADARLTEG KIMERRKKIA LELSELVVYC 
RPVPFDEEKI GTERACYRDM SSFPETKAEK YVNKAKGKKF LQYNRLQLSR IYPKGQRLDS 
SNYDPLPMWI CGSQLVALNF QTPDKPMQMN QALFMTGRHC GYVLQPSTMR DEAFDPFDKS 
SLRGLEPCAI SIEVLGARHL PKNGRGIVCP FVEIEVAGAE YDSTKQKTEF VVDNGLNPVW 
PAKPFHFQIS NPEFAFLRFV VYEEDMFSDQ NFLAQATFPV KGLKTGYRAV PLKNNYSEDL 
ELASLLIKID IFPAKENGDL SPFSGTSLRE RGSDASGQLF HGRAREGSFE SRYQQPFEDF 
RISQEHLADH FDSRERRAPR RTRVNGDNRL

Genular Protein ID: 1586169236

Symbol: Q4LE43_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4LE43

Database IDs:

Sequence Information:

Length: 1412
Mass: 161303
Checksum: 6B3233E8A77FAD3D
Sequence:

ESSAGLRAGW VDRERRALPP PSRLRPRLRP VWGSRGAGAA GRRAGVLPTG ARAPLFPAPK 
RGGASGQPRP AALRPRPVSA CRSRRRVPLV CRLSLSPNLS RRRCACSRAV LACAAAAPSV 
GAMAGAASPC ANGCGPGAPS DAEVLHLCRS LEVGTVMTLF YSKKSQRPER KTFQVKLETR 
QITWSRGADK IEGAIDIREI KEIRPGKTSR DFDRYQEDPA FRPDQSHCFV ILYGMEFRLK 
TLSLQATSED EVNMWIKGLT WLMEDTLQAP TPLQIERWLR KQFYSVDRNR EDRISAKDLK 
NMLSQVNYRV PNMRFLRERL TDLEQRSGDI TYGQFAQLYR SLMYSAQKTM DLPFLEASTL 
RAGERPELCR VSLPEFQQFL LDYQGELWAV DRLQVQEFML SFLRDPLREI EEPYFFLDEF 
VTFLFSKENS VWNSQLDAVC PDTMNNPLSH YWISSSHNTY LTGDQFSSES SLEAYARCLR 
MGCRCIELDC WDGPDGMPVI YHGHTLTTKI KFSDVLHTIK EHAFVASEYP VILSIEDHCS 
IAQQRNMAQY FKKVLGDTLL TKPVEISADG LPSPNQLKRK ILIKHKKLAE GSAYEEVPTS 
MMYSENDISN SIKNGILYLE DPVNHEWYPH YFVLTSSKIY YSEETSSDQG NEDEEEPKEV 
SSSTELHSNE KWFHGKLGAG RDGRHIAERL LTEYCIETGA PDGSFLVRES ETFVGDYTLS 
FWRNGKVQHC RIHSRQDAGT PKFFLTDNLV FDSLYDLITH YQQVPLRCNE FEMRLSEPVP 
QTNAHESKEW YHASLTRAQA EHMLMRVPRD GAFLVRKRNE PNSYAISFRA EGKIKHCRVQ 
QEGQTVMLGN SEFDSLVDLI SYYEKHPLYR KMKLRYPINE EALEKIGTAE PDYGALYEGR 
NPGFYVEANP MPTFKCAVKA LFDYKAQRED ELTFTKSAII QNVEKQEGGW WRGDYGGKKQ 
LWFPSNYVEE MVNPVALEPE REHLDENSPL GDLLRGVLDV PACQIAIRPE GKNNRLFVFS 
ISMASVAHWS LDVAADSQEE LQDWVKKIRE VAQTADARLT EGKIMERRKK IALELSELVV 
YCRPVPFDEE KIGTERACYR DMSSFPETKA EKYVNKAKGK KFLQYNRLQL SRIYPKGQRL 
DSSNYDPLPM WICGSQLVAL NFQTPDKPMQ MNQALFMTGR HCGYVLQPST MRDEAFDPFD 
KSSLRGLEPC AISIEVLGAR HLPKNGRGIV CPFVEIEVAG AEYDSTKQKT EFVVDNGLNP 
VWPAKPFHFQ ISNPEFAFLR FVVYEEDMFS DQNFLAQATF PVKGLKTGYR AVPLKNNYSE 
DLELASLLIK IDIFPAKENG DLSPFSGTSL RERGSDASGQ LFHGRAREGS FESRYQQPFE 
DFRISQEHLA DHFDSRERRA PRRTRVNGDN RL

Genular Protein ID: 3282748543

Symbol: Q9UFY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UFY1

Database IDs:

Sequence Information:

Length: 629
Mass: 71370
Checksum: 0DC47D69895BD95F
Sequence:

RVQQEGQTVM LGNSEFDSLV DLISYYEKHP LYRKMKLRYP INEEALEKIG TAEPDYGALY 
EGRNPGFYVE ANPMPTFKCA VKALFDYKAQ REDELTFTKS AIIQNVEKQE GGWWRGDYGG 
KKQLWFPSNY VEEMVNPVAL EPEREHLDEN SPLGDLLRGV LDVPACQIAI RPEGKNNRLF 
VFSISMASVA HWSLDVAADS QEELQDWVKK IREVAQTADA RLTEGKIMER RKKIALELSE 
LVVYCRPVPF DEEKIGTERA CYRDMSSFPE TKAEKYVNKA KGKKFLQYNR LQLSRIYPKG 
QRLDSSNYDP LPMWICGSQL VALNFQTPDK PMQMNQALFM TGRHCGYVLQ PSTMRDEAFD 
PFDKSSLRGL EPCAISIEVL GARHLPKNGR GIVCPFVEIE VAGAEYDSTK QKTEFVVDNG 
LNPVWPAKPF HFQISNPEFA FLRFVVYEED MFSDQNFLAQ ATFPVKGLKT GYRAVPLKNN 
YSEDLELASL LIKIDIFPAK QENGDLSPFS GTSLRERGSD ASGQLFHGRA REGSFESRYQ 
QPFEDFRISQ EHLADHFDSR ERSKDTLPFC PGPQEGLGSM ETTASSCTPA SLESSRCCAP 
CRMPRTGFFG SSPLWRPSGS RSLKPGFQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PLCG1

Associated with

Cells (max top 100)

Other Information

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. PubMed ID: 2167438

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. PubMed ID: 1656221

Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1. PubMed ID: 1370476

Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1. PubMed ID: 7518429

Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. PubMed ID: 8657103

Direct association of Csk homologous kinase (CHK) with the diphosphorylated site Tyr568/570 of the activated c-KIT in megakaryocytes. PubMed ID: 9038210

Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site. PubMed ID: 9178760

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. PubMed ID: 9489702

Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. PubMed ID: 10488157

Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. PubMed ID: 10102632

Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. PubMed ID: 10873601

The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK. PubMed ID: 11518702

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. PubMed ID: 10747847

Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. PubMed ID: 11259588

Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes. PubMed ID: 11564877

The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling. PubMed ID: 12913111

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. PubMed ID: 15144186

TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma. PubMed ID: 15488758

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. PubMed ID: 15270728

Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress. PubMed ID: 15102829

Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells. PubMed ID: 15215251

Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. PubMed ID: 16081816

Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. PubMed ID: 16844695

Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration. PubMed ID: 17229814

Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1. PubMed ID: 17561467

Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation. PubMed ID: 17620338

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells. PubMed ID: 19286672

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration. PubMed ID: 20494825

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function. PubMed ID: 21765395

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. PubMed ID: 22561606

Cellular signaling by fibroblast growth factor receptors. PubMed ID: 15863030

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A gain-of-function variation in PLCG1 causes a new immune dysregulation disease. PubMed ID: 37422272

Solution structure of the SH3 domain of phospholipase C-gamma. PubMed ID: 7681365

Database document:

PubMed ID: 2167438

PubMed ID: 11780052

PubMed ID: 15489334

PubMed ID: 1656221

PubMed ID: 1370476

PubMed ID: 7518429

PubMed ID: 8657103

PubMed ID: 9038210

PubMed ID: 9178760

PubMed ID: 9489702

PubMed ID: 10488157

PubMed ID: 10102632

PubMed ID: 10873601

PubMed ID: 11518702

PubMed ID: 10747847

PubMed ID: 11259588

PubMed ID: 11564877

PubMed ID: 12913111

PubMed ID: 15144186

PubMed ID: 15488758

PubMed ID: 15526160

PubMed ID: 15270728

PubMed ID: 15102829

PubMed ID: 15215251

PubMed ID: 16081816

PubMed ID: 16844695

PubMed ID: 17229814

PubMed ID: 17561467

PubMed ID: 17620338

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19286672

PubMed ID: 19690332

PubMed ID: 20494825

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 21765395

PubMed ID: 21406692

PubMed ID: 22561606

PubMed ID: 15863030

PubMed ID: 23186163

PubMed ID: 37422272

PubMed ID: 7681365