Details for: PLD2

Gene ID: 5338

Symbol: PLD2

Ensembl ID: ENSG00000129219

Description: phospholipase D2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 71.6190
    Cell Significance Index: -11.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.6440
    Cell Significance Index: -11.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 24.3687
    Cell Significance Index: -11.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.4519
    Cell Significance Index: -9.5300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.9346
    Cell Significance Index: -9.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.0352
    Cell Significance Index: -11.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1883
    Cell Significance Index: -11.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1710
    Cell Significance Index: -6.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8231
    Cell Significance Index: -11.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5663
    Cell Significance Index: 21.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8324
    Cell Significance Index: 82.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7164
    Cell Significance Index: 646.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6020
    Cell Significance Index: 31.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5621
    Cell Significance Index: 15.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5047
    Cell Significance Index: 54.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4809
    Cell Significance Index: 28.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4762
    Cell Significance Index: 94.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4560
    Cell Significance Index: 53.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4460
    Cell Significance Index: 72.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3920
    Cell Significance Index: 10.6700
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2817
    Cell Significance Index: 1.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2698
    Cell Significance Index: 18.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2603
    Cell Significance Index: 5.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2475
    Cell Significance Index: 11.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2416
    Cell Significance Index: 6.9600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2176
    Cell Significance Index: 1.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1874
    Cell Significance Index: 8.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1526
    Cell Significance Index: 18.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1503
    Cell Significance Index: 19.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1332
    Cell Significance Index: 17.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1193
    Cell Significance Index: 5.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1171
    Cell Significance Index: 8.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1122
    Cell Significance Index: 15.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1122
    Cell Significance Index: 49.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1108
    Cell Significance Index: 3.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1093
    Cell Significance Index: 19.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1081
    Cell Significance Index: 74.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1064
    Cell Significance Index: 2.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0952
    Cell Significance Index: 18.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0840
    Cell Significance Index: 2.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0796
    Cell Significance Index: 4.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0765
    Cell Significance Index: 41.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0714
    Cell Significance Index: 1.5200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0707
    Cell Significance Index: 1.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0572
    Cell Significance Index: 11.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0553
    Cell Significance Index: 1.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0343
    Cell Significance Index: 2.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0343
    Cell Significance Index: 12.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0288
    Cell Significance Index: 2.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0064
    Cell Significance Index: 11.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0051
    Cell Significance Index: 7.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0145
    Cell Significance Index: -2.4800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0157
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0203
    Cell Significance Index: -11.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0233
    Cell Significance Index: -14.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0235
    Cell Significance Index: -6.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0289
    Cell Significance Index: -4.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0308
    Cell Significance Index: -0.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0567
    Cell Significance Index: -6.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0634
    Cell Significance Index: -13.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0670
    Cell Significance Index: -4.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0698
    Cell Significance Index: -8.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0724
    Cell Significance Index: -4.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0762
    Cell Significance Index: -1.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0897
    Cell Significance Index: -5.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1027
    Cell Significance Index: -10.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1230
    Cell Significance Index: -7.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1256
    Cell Significance Index: -7.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1268
    Cell Significance Index: -2.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1282
    Cell Significance Index: -6.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1302
    Cell Significance Index: -10.3100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1341
    Cell Significance Index: -1.1400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1358
    Cell Significance Index: -3.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1388
    Cell Significance Index: -3.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1546
    Cell Significance Index: -10.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1576
    Cell Significance Index: -2.7000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1595
    Cell Significance Index: -5.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1667
    Cell Significance Index: -8.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1953
    Cell Significance Index: -3.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2046
    Cell Significance Index: -9.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2143
    Cell Significance Index: -3.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2198
    Cell Significance Index: -3.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2217
    Cell Significance Index: -5.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2309
    Cell Significance Index: -6.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2336
    Cell Significance Index: -4.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2340
    Cell Significance Index: -8.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2346
    Cell Significance Index: -2.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2409
    Cell Significance Index: -6.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2446
    Cell Significance Index: -3.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2459
    Cell Significance Index: -4.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2477
    Cell Significance Index: -9.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2530
    Cell Significance Index: -3.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** PLD2 is widely expressed in various tissues, including the brain, immune cells, and epithelial cells. Its expression is also observed in abnormal cells and transit amplifying cells, suggesting its potential role in cancer and stem cell maintenance. 2. **Subcellular Localization:** PLD2 is primarily localized to the plasma membrane, where it is involved in phospholipid metabolism and cell signaling. 3. **Enzymatic Activity:** PLD2 exhibits N-acylphosphatidylethanolamine-specific phospholipase D activity, which is distinct from other PLD isoforms. 4. **Regulatory Mechanisms:** PLD2 is subject to post-translational modifications, including phosphorylation and ubiquitination, which modulate its activity and localization. **Pathways and Functions:** 1. **Phospholipid Metabolism:** PLD2 is involved in the hydrolysis of phosphatidylcholine to produce phosphatidic acid, which is further metabolized to produce various signaling molecules, including phosphatidylinositol and phosphatidylglycerol. 2. **Cytoskeleton Organization:** PLD2 regulates cytoskeleton dynamics by modulating the activity of small GTPases, such as Rac1 and Rac2, which are involved in cell migration, adhesion, and morphology. 3. **Immune Response:** PLD2 is involved in the regulation of phagocytosis and the Fc-gamma receptor signaling pathway, which is critical for the removal of pathogens and the presentation of antigens to immune cells. 4. **Cell Signaling:** PLD2 is a key regulator of cell signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, which are involved in cell growth, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** PLD2 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. Its expression is often upregulated in cancer cells, and its activity is correlated with tumor aggressiveness and metastasis. 2. **Neurological Disorders:** PLD2 has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Its expression is altered in these disorders, and its activity is correlated with disease progression. 3. **Immunological Disorders:** PLD2 plays a critical role in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Stem Cell Maintenance:** PLD2 is involved in the regulation of stem cell maintenance and differentiation, and its expression is altered in stem cell disorders, such as leukemia and lymphoma. In conclusion, PLD2 is a complex enzyme that plays a multifaceted role in phospholipid metabolism, cytoskeleton organization, and immune response. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and immunological disorders. Further research is needed to fully elucidate the mechanisms by which PLD2 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1868330218

Symbol: PLD2_HUMAN

Name: Choline phosphatase 2

UniProtKB Accession Codes:

O14939 I3L2C9 O43540 O43579 O43580 Q6PGR0 Q96BY3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 4 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9761774

Title: Characterization of human PLD2 and the analysis of PLD isoform splice variants.

PubMed ID: 9761774

DOI: 10.1096/fasebj.12.13.1309

PubMed ID: 9582313

Title: Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.

PubMed ID: 9582313

DOI: 10.1074/jbc.273.21.12846

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11032811

Title: Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity.

PubMed ID: 11032811

DOI: 10.1093/emboj/19.20.5440

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 933
  • Mass: 105987
  • Checksum: F25F6B73B45F57ED
  • Sequence:
    • MTATPESLFP TGDELDSSQL QMESDEVDTL KEGEDPADRM HPFLAIYELQ SLKVHPLVFA 
PGVPVTAQVV GTERYTSGSK VGTCTLYSVR LTHGDFSWTT KKKYRHFQEL HRDLLRHKVL 
MSLLPLARFA VAYSPARDAG NREMPSLPRA GPEGSTRHAA SKQKYLENYL NRLLTMSFYR 
NYHAMTEFLE VSQLSFIPDL GRKGLEGMIR KRSGGHRVPG LTCCGRDQVC YRWSKRWLVV 
KDSFLLYMCL ETGAISFVQL FDPGFEVQVG KRSTEARHGV RIDTSHRSLI LKCSSYRQAR 
WWAQEITELA QGPGRDFLQL HRHDSYAPPR PGTLARWFVN GAGYFAAVAD AILRAQEEIF 
ITDWWLSPEV YLKRPAHSDD WRLDIMLKRK AEEGVRVSIL LFKEVELALG INSGYSKRAL 
MLLHPNIKVM RHPDQVTLWA HHEKLLVVDQ VVAFLGGLDL AYGRWDDLHY RLTDLGDSSE 
SAASQPPTPR PDSPATPDLS HNQFFWLGKD YSNLITKDWV QLDRPFEDFI DRETTPRMPW 
RDVGVVVHGL PARDLARHFI QRWNFTKTTK AKYKTPTYPY LLPKSTSTAN QLPFTLPGGQ 
CTTVQVLRSV DRWSAGTLEN SILNAYLHTI RESQHFLYIE NQFFISCSDG RTVLNKVGDE 
IVDRILKAHK QGWCYRVYVL LPLLPGFEGD ISTGGGNSIQ AILHFTYRTL CRGEYSILHR 
LKAAMGTAWR DYISICGLRT HGELGGHPVS ELIYIHSKVL IADDRTVIIG SANINDRSLL 
GKRDSELAVL IEDTETEPSL MNGAEYQAGR FALSLRKHCF GVILGANTRP DLDLRDPICD 
DFFQLWQDMA ESNANIYEQI FRCLPSNATR SLRTLREYVA VEPLATVSPP LARSELTQVQ 
GHLVHFPLKF LEDESLLPPL GSKEGMIPLE VWT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.