Details for: FXYD1

Gene ID: 5348

Symbol: FXYD1

Ensembl ID: ENSG00000266964

Description: FXYD domain containing ion transport regulator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 45.7720
    Cell Significance Index: -21.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 12.1360
    Cell Significance Index: 101.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2684
    Cell Significance Index: -22.1500
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.9334
    Cell Significance Index: 42.9000
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 4.2625
    Cell Significance Index: 24.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6660
    Cell Significance Index: -11.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.8909
    Cell Significance Index: 82.8700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 2.8071
    Cell Significance Index: 32.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6623
    Cell Significance Index: 34.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5450
    Cell Significance Index: -5.5700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.3099
    Cell Significance Index: 37.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.2160
    Cell Significance Index: 54.0700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.7821
    Cell Significance Index: 10.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2375
    Cell Significance Index: 169.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0161
    Cell Significance Index: 17.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6638
    Cell Significance Index: 77.3600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.5038
    Cell Significance Index: 5.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3704
    Cell Significance Index: 5.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3514
    Cell Significance Index: 70.5000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3397
    Cell Significance Index: 7.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2094
    Cell Significance Index: 9.4900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1015
    Cell Significance Index: 1.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0757
    Cell Significance Index: 33.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0656
    Cell Significance Index: 5.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0598
    Cell Significance Index: 1.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0195
    Cell Significance Index: 0.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0020
    Cell Significance Index: 0.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0077
    Cell Significance Index: -2.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0108
    Cell Significance Index: -20.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0153
    Cell Significance Index: -28.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0185
    Cell Significance Index: -28.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0270
    Cell Significance Index: -19.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0283
    Cell Significance Index: -21.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0310
    Cell Significance Index: -19.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0322
    Cell Significance Index: -17.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0341
    Cell Significance Index: -25.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0407
    Cell Significance Index: -7.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0434
    Cell Significance Index: -24.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0465
    Cell Significance Index: -21.0900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0603
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0710
    Cell Significance Index: -12.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0713
    Cell Significance Index: -14.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0738
    Cell Significance Index: -1.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0768
    Cell Significance Index: -22.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0898
    Cell Significance Index: -14.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0973
    Cell Significance Index: -5.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1050
    Cell Significance Index: -12.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1199
    Cell Significance Index: -25.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1288
    Cell Significance Index: -5.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1402
    Cell Significance Index: -14.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1406
    Cell Significance Index: -18.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1517
    Cell Significance Index: -22.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1523
    Cell Significance Index: -10.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1639
    Cell Significance Index: -7.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1649
    Cell Significance Index: -3.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1724
    Cell Significance Index: -3.3700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1805
    Cell Significance Index: -3.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1990
    Cell Significance Index: -5.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2014
    Cell Significance Index: -4.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2180
    Cell Significance Index: -25.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2198
    Cell Significance Index: -25.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2300
    Cell Significance Index: -2.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2320
    Cell Significance Index: -17.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2321
    Cell Significance Index: -24.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2353
    Cell Significance Index: -14.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2523
    Cell Significance Index: -19.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2540
    Cell Significance Index: -6.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2579
    Cell Significance Index: -15.4800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2587
    Cell Significance Index: -1.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2654
    Cell Significance Index: -16.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2735
    Cell Significance Index: -18.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2996
    Cell Significance Index: -15.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3305
    Cell Significance Index: -21.3200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3336
    Cell Significance Index: -2.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3366
    Cell Significance Index: -22.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3561
    Cell Significance Index: -12.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3642
    Cell Significance Index: -22.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3757
    Cell Significance Index: -8.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3882
    Cell Significance Index: -4.4100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3965
    Cell Significance Index: -6.8600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3995
    Cell Significance Index: -6.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4256
    Cell Significance Index: -12.5000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.4369
    Cell Significance Index: -2.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4505
    Cell Significance Index: -23.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4719
    Cell Significance Index: -22.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5103
    Cell Significance Index: -15.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.5197
    Cell Significance Index: -7.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5198
    Cell Significance Index: -18.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5327
    Cell Significance Index: -16.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5460
    Cell Significance Index: -24.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5530
    Cell Significance Index: -4.4200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.5790
    Cell Significance Index: -6.3200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5859
    Cell Significance Index: -4.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6032
    Cell Significance Index: -19.7500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6282
    Cell Significance Index: -7.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6417
    Cell Significance Index: -24.3000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.6438
    Cell Significance Index: -8.2600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.6482
    Cell Significance Index: -5.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6501
    Cell Significance Index: -18.7300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.6559
    Cell Significance Index: -3.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The FXYD1 gene is characterized by its unique FXYD domain, which is a conserved motif found in various ion transport regulators. This domain is responsible for the regulation of chloride and sodium ion transport across cell membranes. The FXYD1 protein is also known to interact with various ion channels and transporters, including the sodium-potassium-exchange ATPase complex, and regulates their activity. Additionally, FXYD1 has been shown to be involved in the regulation of cardiac muscle cell membrane potential and heart contraction, making it a potential target for the treatment of cardiac arrhythmias. **Pathways and Functions** The FXYD1 gene is involved in various physiological and pathological processes, including: 1. **Ion Homeostasis**: FXYD1 regulates chloride, sodium, and potassium ion transport across cell membranes, maintaining ion homeostasis and preventing various diseases associated with ion imbalances. 2. **Cardiac Conduction**: FXYD1 regulates cardiac muscle cell membrane potential and heart contraction, making it a potential target for the treatment of cardiac arrhythmias. 3. **Sodium-Potassium-Exchange ATPase Complex**: FXYD1 interacts with the sodium-potassium-exchange ATPase complex, regulating its activity and ion transport across cell membranes. 4. **Chloride Transport**: FXYD1 regulates chloride transport across cell membranes, including the apical plasma membrane and the sarcolemma. 5. **Regulation of Protein Glutathionylation**: FXYD1 has been shown to regulate the negative regulation of protein glutathionylation, a process involved in the regulation of protein function and stability. **Clinical Significance** The FXYD1 gene has significant clinical implications, particularly in the treatment of various diseases associated with ion imbalances and cardiac arrhythmias. Some potential therapeutic applications of FXYD1 include: 1. **Cardiac Arrhythmias**: FXYD1 may be a potential target for the treatment of cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. 2. **Hypokalemic Periodic Paralysis**: FXYD1 has been implicated in hypokalemic periodic paralysis, a disease characterized by recurrent episodes of muscle weakness and paralysis. 3. **SARS-CoV Infections**: FXYD1 has been shown to be involved in the regulation of sodium ion transport and may be a potential target for the treatment of SARS-CoV infections. In conclusion, the FXYD1 gene plays a crucial role in regulating ion transport across various cell membranes and has significant clinical implications in the treatment of various diseases associated with ion imbalances and cardiac arrhythmias. Further research is needed to fully understand the function and therapeutic potential of FXYD1.

Genular Protein ID: 1152504902

Symbol: PLM_HUMAN

Name: N/A

UniProtKB Accession Codes:

O00168 A8K196

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9169143

Title: Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1.

PubMed ID: 9169143

DOI: 10.1006/geno.1997.4665

PubMed ID: 10950925

Title: The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression.

PubMed ID: 10950925

DOI: 10.1006/geno.2000.6274

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10811636

Title: Phospholemman is a substrate for myotonic dystrophy protein kinase.

PubMed ID: 10811636

DOI: 10.1074/jbc.m000899200

PubMed ID: 16597826

Title: Secondary structure, orientation, and oligomerization of phospholemman, a cardiac transmembrane protein.

PubMed ID: 16597826

DOI: 10.1110/ps.051899406

PubMed ID: 21868384

Title: The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation.

PubMed ID: 21868384

DOI: 10.1074/jbc.m111.282145

PubMed ID: 17511473

Title: Structure of the Na,K-ATPase regulatory protein FXYD1 in micelles.

PubMed ID: 17511473

DOI: 10.1021/bi700391b

Sequence Information:

  • Length: 92
  • Mass: 10441
  • Checksum: 11602EFEAFFD8BD8
  • Sequence:
    • MASLGHILVF CVGLLTMAKA ESPKEHDPFT YDYQSLQIGG LVIAGILFIL GILIVLSRRC 
RCKFNQQQRT GEPDEEEGTF RSSIRRLSTR RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.