Details for: PLOD1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 146.7097
Cell Significance Index: -22.8200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 90.9150
Cell Significance Index: -23.0600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 56.7548
Cell Significance Index: -23.3800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 53.4501
Cell Significance Index: -25.2400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 51.9376
Cell Significance Index: -21.1000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 46.6188
Cell Significance Index: -23.9800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 22.1107
Cell Significance Index: -21.1100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.0437
Cell Significance Index: -23.4800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.4367
Cell Significance Index: -19.7700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 5.9832
Cell Significance Index: -23.6100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.5985
Cell Significance Index: 46.0900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.5641
Cell Significance Index: 81.4700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.4801
Cell Significance Index: 30.9800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2361
Cell Significance Index: 122.2800 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.0892
Cell Significance Index: 7.3800 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.0678
Cell Significance Index: 6.6400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9962
Cell Significance Index: 899.5300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7044
Cell Significance Index: 18.8800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6207
Cell Significance Index: 67.5200 - Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.5916
Cell Significance Index: 3.6600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.5324
Cell Significance Index: 73.1200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.5271
Cell Significance Index: 5.7300 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.4646
Cell Significance Index: 4.8500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4519
Cell Significance Index: 246.8200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.4197
Cell Significance Index: 19.5700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3623
Cell Significance Index: 46.4500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3461
Cell Significance Index: 68.6800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3267
Cell Significance Index: 22.5900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2267
Cell Significance Index: 45.4800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1936
Cell Significance Index: 36.8500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1838
Cell Significance Index: 8.3300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1819
Cell Significance Index: 5.2400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1364
Cell Significance Index: 94.3500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.1165
Cell Significance Index: 0.9500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1152
Cell Significance Index: 6.0500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1124
Cell Significance Index: 20.2700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1095
Cell Significance Index: 39.2800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1033
Cell Significance Index: 17.6400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0992
Cell Significance Index: 1.6600 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0957
Cell Significance Index: 12.3600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0737
Cell Significance Index: 113.3900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0444
Cell Significance Index: 19.6100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0426
Cell Significance Index: 57.9000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0360
Cell Significance Index: 67.6900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0264
Cell Significance Index: 48.6300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0225
Cell Significance Index: 10.2000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0116
Cell Significance Index: 0.3100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0085
Cell Significance Index: 0.1800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.0035
Cell Significance Index: 0.0500 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0008
Cell Significance Index: 0.0200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0002
Cell Significance Index: -0.0100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0017
Cell Significance Index: -0.0100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0100
Cell Significance Index: -6.3700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0132
Cell Significance Index: -9.8100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0135
Cell Significance Index: -10.2200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0172
Cell Significance Index: -10.7600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0236
Cell Significance Index: -2.9000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0250
Cell Significance Index: -2.5500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0279
Cell Significance Index: -20.4200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0281
Cell Significance Index: -0.5200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0300
Cell Significance Index: -16.9200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0617
Cell Significance Index: -17.7400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0676
Cell Significance Index: -14.2500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0755
Cell Significance Index: -2.1100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0758
Cell Significance Index: -8.8300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0843
Cell Significance Index: -3.9600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0845
Cell Significance Index: -0.7100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0894
Cell Significance Index: -10.2400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0952
Cell Significance Index: -2.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0961
Cell Significance Index: -13.9700 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.1038
Cell Significance Index: -0.6500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1185
Cell Significance Index: -13.9700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1237
Cell Significance Index: -4.3000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1347
Cell Significance Index: -8.2600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1558
Cell Significance Index: -17.7800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1585
Cell Significance Index: -11.8100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1588
Cell Significance Index: -8.2500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1624
Cell Significance Index: -16.9100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1700
Cell Significance Index: -12.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1870
Cell Significance Index: -5.9900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2018
Cell Significance Index: -13.0200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2617
Cell Significance Index: -5.6700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2673
Cell Significance Index: -17.9700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2852
Cell Significance Index: -17.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2874
Cell Significance Index: -16.1300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2883
Cell Significance Index: -22.8300 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2883
Cell Significance Index: -14.5700 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: -0.3516
Cell Significance Index: -1.7100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3578
Cell Significance Index: -9.7400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3776
Cell Significance Index: -16.7000 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.3873
Cell Significance Index: -5.5500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3974
Cell Significance Index: -10.6300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4031
Cell Significance Index: -25.4100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4512
Cell Significance Index: -17.0900 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.5458
Cell Significance Index: -7.6500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5567
Cell Significance Index: -19.5000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.5596
Cell Significance Index: -17.7000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.5597
Cell Significance Index: -11.6100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5665
Cell Significance Index: -16.2400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5668
Cell Significance Index: -14.5700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1466045069
Symbol: PLOD1_HUMAN
Name: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1577494
Title: Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3-p36.2.
PubMed ID: 1577494
PubMed ID: 7713497
Title: Structure and expression of the human lysyl hydroxylase gene (PLOD): introns 9 and 16 contain Alu sequences at the sites of recombination in Ehlers-Danlos syndrome type VI patients.
PubMed ID: 7713497
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8621606
Title: Site-directed mutagenesis of human lysyl hydroxylase expressed in insect cells. Identification of histidine residues and an aspartic acid residue critical for catalytic activity.
PubMed ID: 8621606
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 8163671
Title: A patient with Ehlers-Danlos syndrome type VI is a compound heterozygote for mutations in the lysyl hydroxylase gene.
PubMed ID: 8163671
DOI: 10.1172/jci117155
PubMed ID: 9617436
Title: Ehlers-Danlos syndrome type VI: lysyl hydroxylase deficiency due to a novel point mutation (W612C).
PubMed ID: 9617436
PubMed ID: 10686424
Title: Deletion of cysteine 369 in lysyl hydroxylase 1 eliminates enzyme activity and causes Ehlers-Danlos syndrome type VI.
PubMed ID: 10686424
PubMed ID: 15666309
Title: Nevo syndrome is allelic to the kyphoscoliotic type of the Ehlers-Danlos syndrome (EDS VIA).
PubMed ID: 15666309
DOI: 10.1002/ajmg.a.30529
PubMed ID: 15854030
Title: A novel mutation in the lysyl hydroxylase 1 gene causes decreased lysyl hydroxylase activity in an Ehlers-Danlos VIA patient.
PubMed ID: 15854030
PubMed ID: 15979919
Title: Mutation analysis of the PLOD1 gene: an efficient multistep approach to the molecular diagnosis of the kyphoscoliotic type of Ehlers-Danlos syndrome (EDS VIA).
PubMed ID: 15979919
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 727
- Mass: 83550
- Checksum: 6C3E0C11B15D598C
- Sequence:
MRPLLLLALL GWLLLAEAKG DAKPEDNLLV LTVATKETEG FRRFKRSAQF FNYKIQALGL GEDWNVEKGT SAGGGQKVRL LKKALEKHAD KEDLVILFAD SYDVLFASGP RELLKKFRQA RSQVVFSAEE LIYPDRRLET KYPVVSDGKR FLGSGGFIGY APNLSKLVAE WEGQDSDSDQ LFYTKIFLDP EKREQINITL DHRCRIFQNL DGALDEVVLK FEMGHVRARN LAYDTLPVLI HGNGPTKLQL NYLGNYIPRF WTFETGCTVC DEGLRSLKGI GDEALPTVLV GVFIEQPTPF VSLFFQRLLR LHYPQKHMRL FIHNHEQHHK AQVEEFLAQH GSEYQSVKLV GPEVRMANAD ARNMGADLCR QDRSCTYYFS VDADVALTEP NSLRLLIQQN KNVIAPLMTR HGRLWSNFWG ALSADGYYAR SEDYVDIVQG RRVGVWNVPY ISNIYLIKGS ALRGELQSSD LFHHSKLDPD MAFCANIRQQ DVFMFLTNRH TLGHLLSLDS YRTTHLHNDL WEVFSNPEDW KEKYIHQNYT KALAGKLVET PCPDVYWFPI FTEVACDELV EEMEHFGQWS LGNNKDNRIQ GGYENVPTID IHMNQIGFER EWHKFLLEYI APMTEKLYPG YYTRAQFDLA FVVRYKPDEQ PSLMPHHDAS TFTINIALNR VGVDYEGGGC RFLRYNCSIR APRKGWTLMH PGRLTHYHEG LPTTRGTRYI AVSFVDP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.