Details for: PLOD2

Gene ID: 5352

Symbol: PLOD2

Ensembl ID: ENSG00000152952

Description: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 281.3330
    Cell Significance Index: -43.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.6119
    Cell Significance Index: -42.2600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 112.9877
    Cell Significance Index: -46.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 101.4628
    Cell Significance Index: -41.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.3598
    Cell Significance Index: -46.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.1111
    Cell Significance Index: -41.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.5812
    Cell Significance Index: -43.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.4332
    Cell Significance Index: -49.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1580
    Cell Significance Index: -44.0300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.8337
    Cell Significance Index: 22.6300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.3426
    Cell Significance Index: 24.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9006
    Cell Significance Index: 377.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8208
    Cell Significance Index: 82.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7863
    Cell Significance Index: 30.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4390
    Cell Significance Index: 110.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3401
    Cell Significance Index: 75.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.2088
    Cell Significance Index: 548.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1785
    Cell Significance Index: 33.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0449
    Cell Significance Index: 62.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9314
    Cell Significance Index: 151.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.9155
    Cell Significance Index: 1409.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9112
    Cell Significance Index: 19.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7688
    Cell Significance Index: 11.5200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7574
    Cell Significance Index: 9.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6789
    Cell Significance Index: 46.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6541
    Cell Significance Index: 16.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5959
    Cell Significance Index: 76.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5925
    Cell Significance Index: 15.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5295
    Cell Significance Index: 289.1700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4679
    Cell Significance Index: 6.7300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4619
    Cell Significance Index: 2.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4443
    Cell Significance Index: 159.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4058
    Cell Significance Index: 81.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3951
    Cell Significance Index: 39.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3363
    Cell Significance Index: 620.1800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3297
    Cell Significance Index: 4.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3182
    Cell Significance Index: 432.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3129
    Cell Significance Index: 198.7500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3062
    Cell Significance Index: 4.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3057
    Cell Significance Index: 15.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3028
    Cell Significance Index: 3.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2865
    Cell Significance Index: 539.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2394
    Cell Significance Index: 6.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2102
    Cell Significance Index: 4.4000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1953
    Cell Significance Index: 1.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1923
    Cell Significance Index: 36.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1553
    Cell Significance Index: 140.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1431
    Cell Significance Index: 98.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1345
    Cell Significance Index: 6.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1326
    Cell Significance Index: 2.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1197
    Cell Significance Index: 7.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1155
    Cell Significance Index: 4.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1028
    Cell Significance Index: 18.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0838
    Cell Significance Index: 14.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0384
    Cell Significance Index: 5.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0226
    Cell Significance Index: 0.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0046
    Cell Significance Index: 2.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0159
    Cell Significance Index: -11.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0242
    Cell Significance Index: -15.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0354
    Cell Significance Index: -2.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0450
    Cell Significance Index: -34.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0455
    Cell Significance Index: -25.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0590
    Cell Significance Index: -6.7400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0606
    Cell Significance Index: -0.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0703
    Cell Significance Index: -7.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0821
    Cell Significance Index: -0.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0840
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0990
    Cell Significance Index: -20.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1006
    Cell Significance Index: -14.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1262
    Cell Significance Index: -36.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1409
    Cell Significance Index: -14.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1576
    Cell Significance Index: -10.6000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1707
    Cell Significance Index: -2.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1719
    Cell Significance Index: -5.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2110
    Cell Significance Index: -24.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2447
    Cell Significance Index: -31.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2750
    Cell Significance Index: -32.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3123
    Cell Significance Index: -9.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3408
    Cell Significance Index: -5.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3865
    Cell Significance Index: -6.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4209
    Cell Significance Index: -49.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4290
    Cell Significance Index: -30.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4401
    Cell Significance Index: -23.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4419
    Cell Significance Index: -10.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4505
    Cell Significance Index: -21.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4840
    Cell Significance Index: -29.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5605
    Cell Significance Index: -44.3900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5989
    Cell Significance Index: -5.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6287
    Cell Significance Index: -12.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6299
    Cell Significance Index: -13.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6316
    Cell Significance Index: -38.7200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6570
    Cell Significance Index: -9.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6689
    Cell Significance Index: -34.8400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.7029
    Cell Significance Index: -3.0600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7467
    Cell Significance Index: -11.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7570
    Cell Significance Index: -48.8400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8028
    Cell Significance Index: -40.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLOD2 is a member of the peptidyl-lysine hydroxylase family, which is responsible for the post-translational modification of lysine residues in collagen. Specifically, PLOD2 catalyzes the conversion of lysine to hydroxylysine, a critical step in collagen cross-linking and stability. This enzyme is highly expressed in various cell types, including lens epithelial cells, ciliary muscle cells, and preosteoblasts, highlighting its importance in maintaining tissue homeostasis. **Pathways and Functions:** PLOD2 is involved in several key pathways, including collagen biosynthesis and modification, protein modification, and response to hypoxia. The enzyme's primary function is to hydroxylate lysine residues in procollagen, which is then converted into mature collagen. This process is essential for the formation of stable collagen fibers, which provide structural support to tissues such as skin, bones, and cartilage. Additionally, PLOD2 has been implicated in the regulation of cellular responses to hypoxia, a condition characterized by low oxygen levels, which is often associated with tissue injury or disease. **Clinical Significance:** Dysregulation of PLOD2 has been linked to various diseases and disorders, including osteogenesis imperfecta (OI), a genetic disorder characterized by fragile bones and connective tissue defects. Mutations in the PLOD2 gene have been identified as a primary cause of OI, highlighting the enzyme's critical role in collagen biosynthesis and tissue integrity. Furthermore, PLOD2 has been implicated in the pathogenesis of other diseases, such as atherosclerosis, where aberrant collagen deposition and remodeling contribute to vascular disease progression. In conclusion, PLOD2 is a vital enzyme that plays a central role in collagen biosynthesis and modification. Its dysregulation has significant implications for tissue health and disease, underscoring the importance of PLOD2 in immunology and clinical applications. Further research is needed to fully elucidate the mechanisms by which PLOD2 regulates collagen homeostasis and to explore its potential as a therapeutic target for diseases associated with collagen dysfunction.

Genular Protein ID: 1162888705

Symbol: PLOD2_HUMAN

Name: Lysyl hydroxylase 2

UniProtKB Accession Codes:

O00469 B3KWS3 Q59ED2 Q8N170

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 6 Ensembl 7 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9054364

Title: Cloning and characterization of a novel human lysyl hydroxylase isoform highly expressed in pancreas and muscle.

PubMed ID: 9054364

DOI: 10.1074/jbc.272.11.6831

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 10372558

Title: Tissue specificity of a new splice form of the human lysyl hydroxylase 2 gene.

PubMed ID: 10372558

DOI: 10.1016/s0945-053x(99)00013-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 12881513

Title: Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.

PubMed ID: 12881513

DOI: 10.1074/jbc.m307380200

PubMed ID: 15523624

Title: Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2.

PubMed ID: 15523624

DOI: 10.1002/ajmg.a.30231

PubMed ID: 22689593

Title: Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome--osteogenesis imperfecta phenotypic spectrum.

PubMed ID: 22689593

DOI: 10.1002/humu.22133

PubMed ID: 29983323

Title: De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus.

PubMed ID: 29983323

DOI: 10.1016/j.neuron.2018.06.019

Sequence Information:

  • Length: 737
  • Mass: 84686
  • Checksum: C9AEA79A574D6B66
  • Sequence:
    • MGGCTVKPQL LLLALVLHPW NPCLGADSEK PSSIPTDKLL VITVATKESD GFHRFMQSAK 
YFNYTVKVLG QGEEWRGGDG INSIGGGQKV RLMKEVMEHY ADQDDLVVMF TECFDVIFAG 
GPEEVLKKFQ KANHKVVFAA DGILWPDKRL ADKYPVVHIG KRYLNSGGFI GYAPYVNRIV 
QQWNLQDNDD DQLFYTKVYI DPLKREAINI TLDHKCKIFQ TLNGAVDEVV LKFENGKARA 
KNTFYETLPV AINGNGPTKI LLNYFGNYVP NSWTQDNGCT LCEFDTVDLS AVDVHPNVSI 
GVFIEQPTPF LPRFLDILLT LDYPKEALKL FIHNKEVYHE KDIKVFFDKA KHEIKTIKIV 
GPEENLSQAE ARNMGMDFCR QDEKCDYYFS VDADVVLTNP RTLKILIEQN RKIIAPLVTR 
HGKLWSNFWG ALSPDGYYAR SEDYVDIVQG NRVGVWNVPY MANVYLIKGK TLRSEMNERN 
YFVRDKLDPD MALCRNAREM GVFMYISNRH EFGRLLSTAN YNTSHYNNDL WQIFENPVDW 
KEKYINRDYS KIFTENIVEQ PCPDVFWFPI FSEKACDELV EEMEHYGKWS GGKHHDSRIS 
GGYENVPTDD IHMKQVDLEN VWLHFIREFI APVTLKVFAG YYTKGFALLN FVVKYSPERQ 
RSLRPHHDAS TFTINIALNN VGEDFQGGGC KFLRYNCSIE SPRKGWSFMH PGRLTHLHEG 
LPVKNGTRYI AVSFIDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.