Details for: PMCH

Gene ID: 5367

Symbol: PMCH

Ensembl ID: ENSG00000183395

Description: pro-melanin concentrating hormone

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.6241
    Cell Significance Index: 39.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7317
    Cell Significance Index: 11.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.1433
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1210
    Cell Significance Index: 3.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0306
    Cell Significance Index: 0.9000
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0279
    Cell Significance Index: 0.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0086
    Cell Significance Index: 0.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0018
    Cell Significance Index: 0.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0016
    Cell Significance Index: -0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0018
    Cell Significance Index: -3.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0022
    Cell Significance Index: -3.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0049
    Cell Significance Index: -2.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0050
    Cell Significance Index: -1.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0084
    Cell Significance Index: -1.6600
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: -0.0111
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0145
    Cell Significance Index: -2.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0151
    Cell Significance Index: -0.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0157
    Cell Significance Index: -2.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0165
    Cell Significance Index: -2.8100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0173
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0221
    Cell Significance Index: -2.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0224
    Cell Significance Index: -2.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0229
    Cell Significance Index: -0.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0387
    Cell Significance Index: -2.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0397
    Cell Significance Index: -2.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0407
    Cell Significance Index: -2.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0428
    Cell Significance Index: -1.0700
  • Cell Name: immature alpha-beta T cell (CL0000790)
    Fold Change: -0.0434
    Cell Significance Index: -0.3200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0440
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0445
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0451
    Cell Significance Index: -0.4900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0453
    Cell Significance Index: -0.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0467
    Cell Significance Index: -2.6200
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0515
    Cell Significance Index: -0.5000
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0516
    Cell Significance Index: -0.5200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0537
    Cell Significance Index: -0.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0556
    Cell Significance Index: -1.4900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0580
    Cell Significance Index: -0.4700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0611
    Cell Significance Index: -0.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0649
    Cell Significance Index: -3.3700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0654
    Cell Significance Index: -0.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0654
    Cell Significance Index: -2.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0712
    Cell Significance Index: -3.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0775
    Cell Significance Index: -3.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0777
    Cell Significance Index: -2.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0798
    Cell Significance Index: -3.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0811
    Cell Significance Index: -3.0700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0816
    Cell Significance Index: -0.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0824
    Cell Significance Index: -2.2100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0839
    Cell Significance Index: -1.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0845
    Cell Significance Index: -2.9600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0852
    Cell Significance Index: -0.5000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0864
    Cell Significance Index: -1.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0867
    Cell Significance Index: -2.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0899
    Cell Significance Index: -2.5900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0909
    Cell Significance Index: -0.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0910
    Cell Significance Index: -2.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0918
    Cell Significance Index: -2.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0923
    Cell Significance Index: -2.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0966
    Cell Significance Index: -1.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0986
    Cell Significance Index: -2.1600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0998
    Cell Significance Index: -1.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0999
    Cell Significance Index: -1.3700
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1031
    Cell Significance Index: -1.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1033
    Cell Significance Index: -1.5000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1041
    Cell Significance Index: -1.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1050
    Cell Significance Index: -2.7600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1055
    Cell Significance Index: -1.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1080
    Cell Significance Index: -2.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1088
    Cell Significance Index: -3.1200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1168
    Cell Significance Index: -2.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1176
    Cell Significance Index: -2.4400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1190
    Cell Significance Index: -1.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1203
    Cell Significance Index: -3.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1223
    Cell Significance Index: -1.5500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.1228
    Cell Significance Index: -0.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1230
    Cell Significance Index: -2.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1231
    Cell Significance Index: -1.6800
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.1255
    Cell Significance Index: -1.3000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.1260
    Cell Significance Index: -1.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1263
    Cell Significance Index: -2.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1340
    Cell Significance Index: -2.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1353
    Cell Significance Index: -2.5000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1359
    Cell Significance Index: -1.7200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.1366
    Cell Significance Index: -1.6200
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1375
    Cell Significance Index: -1.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1388
    Cell Significance Index: -2.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1395
    Cell Significance Index: -3.4800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1403
    Cell Significance Index: -1.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1437
    Cell Significance Index: -2.4100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1447
    Cell Significance Index: -1.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1462
    Cell Significance Index: -2.8900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1467
    Cell Significance Index: -3.1700
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.1487
    Cell Significance Index: -1.7300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1525
    Cell Significance Index: -2.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PMCH is a 36-amino acid peptide that is produced by neurons in the arcuate nucleus of the hypothalamus. It is primarily expressed in the brain, but its expression is also detected in peripheral tissues, including the immune system. PMCH is a ligand for the type 1 MCH receptor, which is widely expressed in the brain and peripheral tissues. **Pathways and Functions:** PMCH signaling is mediated through the Gq-coupled type 1 MCH receptor, which activates phospholipase C and leads to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). These secondary messengers regulate various cellular processes, including: 1. **Behavioral regulation**: PMCH has been implicated in the regulation of feeding behavior, energy homeostasis, and anxiety-like behaviors. 2. **Cell differentiation**: PMCH promotes the differentiation of neural progenitor cells and the development of the cerebral cortex. 3. **Immune regulation**: PMCH has been shown to modulate the activity of immune cells, including T cells and macrophages, and regulate the production of cytokines. 4. **Spermatogenesis**: PMCH is involved in the regulation of spermatogenesis, a critical process in male reproductive biology. **Clinical Significance:** Dysregulation of PMCH signaling has been implicated in various diseases, including: 1. **Obesity and metabolic disorders**: PMCH has been shown to play a role in energy homeostasis and glucose metabolism, making it a potential target for the treatment of obesity and related metabolic disorders. 2. **Anxiety and depression**: PMCH has been implicated in the regulation of anxiety-like behaviors and may be a potential therapeutic target for the treatment of anxiety disorders. 3. **Immune-related disorders**: PMCH has been shown to modulate the activity of immune cells, making it a potential target for the treatment of immune-related disorders, such as autoimmune diseases. 4. **Neurodegenerative diseases**: PMCH has been implicated in the regulation of neuronal function and may be a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's disease. In conclusion, PMCH is a multifunctional neuropeptide that plays a critical role in various physiological processes, including behavior, cell differentiation, and immune regulation. Further research is needed to fully elucidate the mechanisms of PMCH signaling and its clinical significance in disease states.

Genular Protein ID: 841694244

Symbol: MCH_HUMAN

Name: Pro-MCH

UniProtKB Accession Codes:

P20382 Q16044 Q8WVG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 2149166

Title: Structure of the human melanin concentrating hormone mRNA.

PubMed ID: 2149166

DOI: 10.1210/mend-4-4-632

PubMed ID: 8326825

Title: Isolation and characterization of the human melanin-concentrating hormone gene and a variant gene.

PubMed ID: 8326825

DOI: 10.1016/0169-328x(93)90093-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10037747

Title: Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.

PubMed ID: 10037747

DOI: 10.1074/jbc.274.10.6536

PubMed ID: 9191099

Title: The melanin-concentrating hormone gene in human: flanking region analysis, fine chromosome mapping, and tissue-specific expression.

PubMed ID: 9191099

DOI: 10.1016/s0169-328x(97)00018-1

Sequence Information:

  • Length: 165
  • Mass: 18679
  • Checksum: 2339E8938EBEC499
  • Sequence:
    • MAKMNLSSYI LILTFSLFSQ GILLSASKSI RNLDDDMVFN TFRLGKGFQK EDTAEKSVIA 
PSLEQYKNDE SSFMNEEENK VSKNTGSKHN FLNHGLPLNL AIKPYLALKG SVAFPAENGV 
QNTESTQEKR EIGDEENSAK FPIGRRDFDM LRCMLGRVYR PCWQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.