Details for: POLR2J

Gene ID: 5439

Symbol: POLR2J

Ensembl ID: ENSG00000005075

Description: RNA polymerase II subunit J

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 216.5287
    Cell Significance Index: -33.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.5764
    Cell Significance Index: -38.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.4076
    Cell Significance Index: -54.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.3177
    Cell Significance Index: -50.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.8231
    Cell Significance Index: -49.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.3254
    Cell Significance Index: -50.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.3955
    Cell Significance Index: -47.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.3552
    Cell Significance Index: -41.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.3222
    Cell Significance Index: -52.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7550
    Cell Significance Index: -31.4900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6001
    Cell Significance Index: 20.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2825
    Cell Significance Index: 106.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8233
    Cell Significance Index: 49.6300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.7931
    Cell Significance Index: 11.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7501
    Cell Significance Index: 240.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7122
    Cell Significance Index: 35.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7085
    Cell Significance Index: 933.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6796
    Cell Significance Index: 38.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6787
    Cell Significance Index: 302.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6468
    Cell Significance Index: 202.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6053
    Cell Significance Index: 189.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4923
    Cell Significance Index: 77.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4775
    Cell Significance Index: 69.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3954
    Cell Significance Index: 15.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3854
    Cell Significance Index: 36.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3728
    Cell Significance Index: 88.5700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2819
    Cell Significance Index: 11.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2688
    Cell Significance Index: 57.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2469
    Cell Significance Index: 92.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2046
    Cell Significance Index: 131.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1282
    Cell Significance Index: 79.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1252
    Cell Significance Index: 33.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1104
    Cell Significance Index: 490.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0746
    Cell Significance Index: 74.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0596
    Cell Significance Index: 36.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0185
    Cell Significance Index: 100.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9884
    Cell Significance Index: 126.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8633
    Cell Significance Index: 111.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8633
    Cell Significance Index: 140.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7949
    Cell Significance Index: 9.0300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7388
    Cell Significance Index: 7.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7100
    Cell Significance Index: 37.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6319
    Cell Significance Index: 11.6800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3167
    Cell Significance Index: 4.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2682
    Cell Significance Index: 77.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2580
    Cell Significance Index: 6.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2042
    Cell Significance Index: 12.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1690
    Cell Significance Index: 32.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1121
    Cell Significance Index: 22.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0904
    Cell Significance Index: 68.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0860
    Cell Significance Index: 17.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0541
    Cell Significance Index: 0.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0504
    Cell Significance Index: 36.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0212
    Cell Significance Index: 7.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0014
    Cell Significance Index: -0.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0096
    Cell Significance Index: -8.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0191
    Cell Significance Index: -35.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0321
    Cell Significance Index: -59.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0383
    Cell Significance Index: -58.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0426
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0453
    Cell Significance Index: -33.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0453
    Cell Significance Index: -61.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0618
    Cell Significance Index: -2.1700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0635
    Cell Significance Index: -1.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0654
    Cell Significance Index: -41.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0741
    Cell Significance Index: -41.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0898
    Cell Significance Index: -56.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0968
    Cell Significance Index: -43.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1895
    Cell Significance Index: -6.0700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2149
    Cell Significance Index: -5.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2178
    Cell Significance Index: -24.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2213
    Cell Significance Index: -25.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2244
    Cell Significance Index: -3.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2543
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2622
    Cell Significance Index: -55.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3120
    Cell Significance Index: -45.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3150
    Cell Significance Index: -24.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3274
    Cell Significance Index: -9.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3295
    Cell Significance Index: -20.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4163
    Cell Significance Index: -5.6800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4656
    Cell Significance Index: -2.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4975
    Cell Significance Index: -5.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5054
    Cell Significance Index: -10.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5056
    Cell Significance Index: -52.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6023
    Cell Significance Index: -17.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6037
    Cell Significance Index: -33.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6297
    Cell Significance Index: -48.3200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7018
    Cell Significance Index: -47.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7346
    Cell Significance Index: -7.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7703
    Cell Significance Index: -6.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7913
    Cell Significance Index: -19.7800
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.7925
    Cell Significance Index: -9.4300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8110
    Cell Significance Index: -4.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8193
    Cell Significance Index: -50.2300
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.8300
    Cell Significance Index: -9.0100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8690
    Cell Significance Index: -14.9800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -1.0111
    Cell Significance Index: -5.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0217
    Cell Significance Index: -27.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0859
    Cell Significance Index: -18.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** POLR2J is a conserved protein that belongs to the family of RNA polymerase II subunits. It is a large protein with a molecular weight of approximately 300 kDa and is composed of a central domain and two C-terminal domains. The central domain is thought to be involved in the interaction with other RNAPII subunits, while the C-terminal domains are involved in the recognition of specific DNA sequences and the recruitment of transcription factors. POLR2J is also known to interact with various proteins, including the transcription factor TBP (TATA-binding protein) and the RNA-binding protein CTD (carboxy-terminal domain) kinase. **Pathways and Functions** POLR2J is involved in several key pathways, including: 1. **Transcription elongation**: POLR2J plays a crucial role in the process of transcription elongation, where the RNA polymerase moves along the DNA template and adds nucleotides to the growing RNA chain. 2. **Gene expression**: POLR2J is involved in the regulation of gene expression, where it interacts with transcription factors and other proteins to control the transcription of specific genes. 3. **DNA repair**: POLR2J has been implicated in the process of DNA repair, where it interacts with proteins involved in the repair of DNA damage. 4. **Cell cycle regulation**: POLR2J has been shown to play a role in the regulation of the cell cycle, where it interacts with proteins involved in the progression of the cell cycle. **Clinical Significance** Dysregulation of the POLR2J gene has been implicated in several diseases, including: 1. **Cancer**: Mutations in the POLR2J gene have been associated with various types of cancer, including breast cancer and lung cancer. 2. **Neurological disorders**: POLR2J has been implicated in the regulation of gene expression in the brain, and mutations in the gene have been associated with neurological disorders such as Alzheimer's disease and Parkinson's disease. 3. **Autoimmune diseases**: POLR2J has been implicated in the regulation of immune responses, and mutations in the gene have been associated with autoimmune diseases such as rheumatoid arthritis and lupus. In conclusion, the POLR2J gene is a critical component of the RNA polymerase II complex and plays a key role in the regulation of gene expression, DNA repair, and cell cycle regulation. Dysregulation of the gene has been implicated in several diseases, highlighting the importance of understanding the function of POLR2J in normal cellular processes.

Genular Protein ID: 3103409598

Symbol: RPB11_HUMAN

Name: DNA-directed RNA polymerase II subunit RPB11-a

UniProtKB Accession Codes:

P52435 A5D6V8 O43375

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 10 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 41 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8797801

Title: Cloning of a novel human RNA polymerase II subunit downregulated by doxorubicin: new potential mechanisms of drug related toxicity.

PubMed ID: 8797801

DOI: 10.1016/0014-5793(96)00277-3

PubMed ID: 9201987

Title: Interactions between the human RNA polymerase II subunits.

PubMed ID: 9201987

DOI: 10.1074/jbc.272.27.16815

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 10783144

Title: Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb.

PubMed ID: 10783144

DOI: 10.1096/fasebj.14.7.904

PubMed ID: 11747469

Title: A human RNA polymerase II subunit is encoded by a recently generated multigene family.

PubMed ID: 11747469

DOI: 10.1186/1471-2199-2-14

PubMed ID: 37595871

Title: SHP-1 phosphatase acts as a coactivator of PCK1 transcription to control gluconeogenesis.

PubMed ID: 37595871

DOI: 10.1016/j.jbc.2023.105164

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

PubMed ID: 30190596

Title: Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

PubMed ID: 30190596

DOI: 10.1038/s41594-018-0118-5

Sequence Information:

  • Length: 117
  • Mass: 13293
  • Checksum: 6F78AB256EF8F647
  • Sequence:
    • MNAPPAFESF LLFEGEKKIT INKDTKVPNA CLFTINKEDH TLGNIIKSQL LKDPQVLFAG 
YKVPHPLEHK IIIRVQTTPD YSPQEAFTNA ITDLISELSL LEERFRVAIK DKQEGIE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.