Details for: POU3F1

Gene ID: 5453

Symbol: POU3F1

Ensembl ID: ENSG00000185668

Description: POU class 3 homeobox 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.0398
    Cell Significance Index: -9.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.0455
    Cell Significance Index: -9.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.0335
    Cell Significance Index: -6.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4888
    Cell Significance Index: 112.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6432
    Cell Significance Index: 85.3600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.5303
    Cell Significance Index: 3.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2372
    Cell Significance Index: -3.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7415
    Cell Significance Index: 11.1100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.5610
    Cell Significance Index: 6.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3886
    Cell Significance Index: 11.0900
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.3683
    Cell Significance Index: 3.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3546
    Cell Significance Index: 156.7600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3217
    Cell Significance Index: 2.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2459
    Cell Significance Index: 13.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2345
    Cell Significance Index: 3.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2016
    Cell Significance Index: 24.7900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1978
    Cell Significance Index: 1.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1879
    Cell Significance Index: 8.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1801
    Cell Significance Index: 5.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1655
    Cell Significance Index: 21.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1076
    Cell Significance Index: 19.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0773
    Cell Significance Index: 2.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0681
    Cell Significance Index: 2.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0589
    Cell Significance Index: 36.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0381
    Cell Significance Index: 2.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0372
    Cell Significance Index: 4.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0274
    Cell Significance Index: 5.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0201
    Cell Significance Index: 1.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0034
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0069
    Cell Significance Index: -3.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0088
    Cell Significance Index: -13.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0094
    Cell Significance Index: -1.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0098
    Cell Significance Index: -2.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0100
    Cell Significance Index: -13.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0101
    Cell Significance Index: -5.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0119
    Cell Significance Index: -7.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0122
    Cell Significance Index: -4.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0125
    Cell Significance Index: -9.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0159
    Cell Significance Index: -0.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0206
    Cell Significance Index: -9.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0278
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0295
    Cell Significance Index: -5.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0339
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0380
    Cell Significance Index: -4.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0414
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0489
    Cell Significance Index: -5.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0535
    Cell Significance Index: -7.7800
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.0556
    Cell Significance Index: -0.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0584
    Cell Significance Index: -1.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0598
    Cell Significance Index: -6.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0746
    Cell Significance Index: -9.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0755
    Cell Significance Index: -3.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0858
    Cell Significance Index: -5.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0871
    Cell Significance Index: -0.9900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0873
    Cell Significance Index: -1.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0911
    Cell Significance Index: -9.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0941
    Cell Significance Index: -2.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1000
    Cell Significance Index: -5.2500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1056
    Cell Significance Index: -4.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1085
    Cell Significance Index: -2.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1209
    Cell Significance Index: -7.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1214
    Cell Significance Index: -4.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1269
    Cell Significance Index: -6.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1355
    Cell Significance Index: -4.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1395
    Cell Significance Index: -2.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1409
    Cell Significance Index: -10.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1452
    Cell Significance Index: -8.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1559
    Cell Significance Index: -11.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1561
    Cell Significance Index: -5.4700
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.1576
    Cell Significance Index: -1.5000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1609
    Cell Significance Index: -0.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1763
    Cell Significance Index: -3.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1911
    Cell Significance Index: -6.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1988
    Cell Significance Index: -5.7000
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1998
    Cell Significance Index: -1.3000
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: -0.1998
    Cell Significance Index: -0.2300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2010
    Cell Significance Index: -7.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2172
    Cell Significance Index: -5.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2257
    Cell Significance Index: -2.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2368
    Cell Significance Index: -11.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2392
    Cell Significance Index: -6.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2578
    Cell Significance Index: -4.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2623
    Cell Significance Index: -2.4200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2760
    Cell Significance Index: -3.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2770
    Cell Significance Index: -8.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2779
    Cell Significance Index: -3.9800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2831
    Cell Significance Index: -7.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2881
    Cell Significance Index: -8.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2896
    Cell Significance Index: -9.4800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2898
    Cell Significance Index: -2.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2931
    Cell Significance Index: -7.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3027
    Cell Significance Index: -9.6400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3032
    Cell Significance Index: -7.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3069
    Cell Significance Index: -8.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3092
    Cell Significance Index: -6.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3128
    Cell Significance Index: -7.9900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.3138
    Cell Significance Index: -3.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** POU3F1 is a member of the POU domain-containing transcription factor family, which is characterized by the presence of a highly conserved POU domain. This domain is essential for the recognition of specific DNA sequences and the regulation of gene expression. POU3F1 is primarily expressed in neural cells, including neurons, glial cells, and progenitor cells, and is involved in various developmental processes, such as axon ensheathment, myelination, and the formation of the anterior and posterior neural plates. **Pathways and Functions:** POU3F1 is involved in several key pathways, including: 1. **Axon ensheathment**: POU3F1 regulates the expression of genes involved in axon ensheathment, a critical process for the formation of the myelin sheath. 2. **Myelination in peripheral nervous system**: POU3F1 is essential for the regulation of myelination in the peripheral nervous system, ensuring the proper formation of the myelin sheath around axons. 3. **Developmental biology**: POU3F1 is involved in the formation of the anterior and posterior neural plates, which are critical for the development of the nervous system. 4. **Chromatin regulation**: POU3F1 regulates chromatin structure and function, influencing gene expression and transcriptional activity. **Functions:** POU3F1 functions as a transcription factor, regulating the expression of target genes involved in neural development and myelination. It interacts with other transcription factors, such as Egr2 and Sox10, to regulate the expression of specific genes involved in these processes. POU3F1 also regulates the activity of RNA polymerase II, a key enzyme involved in transcriptional activity. **Clinical Significance:** Dysregulation of POU3F1 has been implicated in various neurological disorders, including: 1. **Neurodevelopmental disorders**: Mutations in POU3F1 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Myelin disorders**: POU3F1 mutations have been linked to myelin disorders, such as Charcot-Marie-Tooth disease and Leber's hereditary optic neuropathy. 3. **Cancer**: POU3F1 has been implicated in the development of certain types of cancer, including glioblastoma and medulloblastoma. In conclusion, POU3F1 is a critical gene involved in various developmental processes, including neural development, myelination, and differentiation of specific cell types. Its dysregulation has been implicated in various neurological disorders, highlighting its importance in understanding the underlying mechanisms of these diseases. Further research is needed to fully elucidate the functions of POU3F1 and its role in human disease.

Genular Protein ID: 1750142413

Symbol: PO3F1_HUMAN

Name: POU domain, class 3, transcription factor 1

UniProtKB Accession Codes:

Q03052 Q5TAG2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7909356

Title: Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.

PubMed ID: 7909356

DOI: 10.1128/mcb.14.5.3263-3275.1994

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8451175

Title: The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart.

PubMed ID: 8451175

DOI: 10.1093/nar/21.4.1043

Sequence Information:

  • Length: 451
  • Mass: 45496
  • Checksum: 563217BD6A3D00CD
  • Sequence:
    • MATTAQYLPR GPGGGAGGTG PLMHPDAAAA AAAAAAAERL HAGAAYREVQ KLMHHEWLGA 
GAGHPVGLAH PQWLPTGGGG GGDWAGGPHL EHGKAGGGGT GRADDGGGGG GFHARLVHQG 
AAHAGAAWAQ GSTAHHLGPA MSPSPGASGG HQPQPLGLYA QAAYPGGGGG GLAGMLAAGG 
GGAGPGLHHA LHEDGHEAQL EPSPPPHLGA HGHAHGHAHA GGLHAAAAHL HPGAGGGGSS 
VGEHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ 
LSFKNMCKLK PLLNKWLEET DSSSGSPTNL DKIAAQGRKR KKRTSIEVGV KGALESHFLK 
CPKPSAHEIT GLADSLQLEK EVVRVWFCNR RQKEKRMTPA AGAGHPPMDD VYAPGELGPG 
GGGASPPSAP PPPPPAALHH HHHHTLPGSV Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.