MED1 | ENSG00000125686 | NCBI 5469

Details for: MED1

Gene ID: 5469

Symbol: MED1

Ensembl ID: ENSG00000125686

Description: mediator complex subunit 1

Associated with

Activation of gene expression by srebf (srebp)
(R-HSA-2426168)
Adipogenesis
(R-HSA-9843745)
Bmal1:clock,npas2 activates circadian gene expression
(R-HSA-1368108)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Circadian clock
(R-HSA-400253)
Cytoprotection by hmox1
(R-HSA-9707564)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Epigenetic regulation by wdr5-containing histone modifying complexes
(R-HSA-9917777)
Epigenetic regulation of adipogenesis genes by mll3 and mll4 complexes
(R-HSA-9851695)
Epigenetic regulation of gene expression
(R-HSA-212165)
Epigenetic regulation of gene expression by mll3 and mll4 complexes
(R-HSA-9818564)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Heme signaling
(R-HSA-9707616)
Infectious disease
(R-HSA-5663205)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroids
(R-HSA-8957322)
Mitochondrial biogenesis
(R-HSA-1592230)
Mll4 and mll3 complexes regulate expression of pparg target genes in adipogenesis and hepatic steatosis
(R-HSA-9841922)
Nuclear receptor transcription pathway
(R-HSA-383280)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-HSA-1655829)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii transcription
(R-HSA-73857)
Rora activates gene expression
(R-HSA-1368082)
Rsv-host interactions
(R-HSA-9833110)
Signaling by nuclear receptors
(R-HSA-9006931)
Signal transduction
(R-HSA-162582)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation of white adipocyte differentiation
(R-HSA-381340)
Viral infection pathways
(R-HSA-9824446)
Androgen biosynthetic process
(GO:0006702)
Angiogenesis
(GO:0001525)
Animal organ regeneration
(GO:0031100)
Brain development
(GO:0007420)
Cell morphogenesis
(GO:0000902)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription factor binding
(GO:0140297)
Embryonic heart tube development
(GO:0035050)
Embryonic hemopoiesis
(GO:0035162)
Embryonic hindlimb morphogenesis
(GO:0035116)
Embryonic placenta development
(GO:0001892)
General transcription initiation factor binding
(GO:0140296)
Histone acetyltransferase binding
(GO:0035035)
Keratinocyte differentiation
(GO:0030216)
Lactation
(GO:0007595)
Lbd domain binding
(GO:0050693)
Lens development in camera-type eye
(GO:0002088)
Liver development
(GO:0001889)
Monocyte differentiation
(GO:0030224)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor-mediated steroid hormone signaling pathway
(GO:0030518)
Nuclear receptor binding
(GO:0016922)
Nuclear receptor coactivator activity
(GO:0030374)
Nuclear retinoic acid receptor binding
(GO:0042974)
Nuclear thyroid hormone receptor binding
(GO:0046966)
Nuclear vitamin d receptor binding
(GO:0042809)
Peroxisome proliferator activated receptor binding
(GO:0042975)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Promoter-specific chromatin binding
(GO:1990841)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein ubiquitination
(GO:0016567)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Retinal pigment epithelium development
(GO:0003406)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Thyroid hormone generation
(GO:0006590)
Thyroid hormone receptor signaling pathway
(GO:0002154)
Transcription coactivator activity
(GO:0003713)
Transcription coactivator binding
(GO:0001223)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Ubiquitin protein ligase activity
(GO:0061630)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 146.2597
Cell Significance Index: -22.7500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 91.7036
Cell Significance Index: -23.2600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 56.7649
Cell Significance Index: -26.8000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 54.2760
Cell Significance Index: -22.0500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 48.1935
Cell Significance Index: -24.7900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 23.2209
Cell Significance Index: -22.1700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 20.4955
Cell Significance Index: -25.2700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.3771
Cell Significance Index: -25.1200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.5610
Cell Significance Index: -25.8900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.8409
Cell Significance Index: -17.9400
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 5.0489
Cell Significance Index: -11.0500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.7713
Cell Significance Index: 206.4300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3177
Cell Significance Index: 261.5100
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3134
Cell Significance Index: 17.9200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2827
Cell Significance Index: 208.6200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1097
Cell Significance Index: 66.6200
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.9776
Cell Significance Index: 50.9200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9556
Cell Significance Index: 103.9400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.8099
Cell Significance Index: 560.1500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.8067
Cell Significance Index: 21.5400
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7076
Cell Significance Index: 87.0100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6332
Cell Significance Index: 127.0200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5943
Cell Significance Index: 107.1400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5860
Cell Significance Index: 529.1400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4745
Cell Significance Index: 32.8200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4335
Cell Significance Index: 11.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4052
Cell Significance Index: 21.0500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3445
Cell Significance Index: 19.3300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3125
Cell Significance Index: 112.1000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2912
Cell Significance Index: 22.3500
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2768
Cell Significance Index: 151.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2698
Cell Significance Index: 37.0500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2569
Cell Significance Index: 113.6000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2476
Cell Significance Index: 7.1400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2458
Cell Significance Index: 6.8700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2080
Cell Significance Index: 4.4500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2078
Cell Significance Index: 20.5600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1741
Cell Significance Index: 11.2400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1642
Cell Significance Index: 19.3600
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.1635
Cell Significance Index: 16.7100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1562
Cell Significance Index: 7.0800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1263
Cell Significance Index: 5.8900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1159
Cell Significance Index: 8.2000
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1117
Cell Significance Index: 2.1800
Cell Name: decidual cell (CL2000002)
Fold Change: 0.1044
Cell Significance Index: 1.6800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0757
Cell Significance Index: 12.9300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0642
Cell Significance Index: 3.9500
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0622
Cell Significance Index: 7.9800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0601
Cell Significance Index: 11.4400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0273
Cell Significance Index: 0.9600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0239
Cell Significance Index: 0.6400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0163
Cell Significance Index: 30.6500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0080
Cell Significance Index: 0.3800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0027
Cell Significance Index: 4.9100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0012
Cell Significance Index: 0.7400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0009
Cell Significance Index: 1.4500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0008
Cell Significance Index: 1.0400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0075
Cell Significance Index: -4.7100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0089
Cell Significance Index: -6.5500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0098
Cell Significance Index: -4.4600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0134
Cell Significance Index: -9.9500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0187
Cell Significance Index: -14.1600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0241
Cell Significance Index: -0.6500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0339
Cell Significance Index: -2.5300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0346
Cell Significance Index: -0.7500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0347
Cell Significance Index: -19.5800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0467
Cell Significance Index: -0.8000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0529
Cell Significance Index: -6.8400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0610
Cell Significance Index: -1.3000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0634
Cell Significance Index: -4.0000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0640
Cell Significance Index: -13.4800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0760
Cell Significance Index: -21.8700
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0905
Cell Significance Index: -10.3300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0922
Cell Significance Index: -10.5600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1056
Cell Significance Index: -7.1000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1067
Cell Significance Index: -15.5100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1174
Cell Significance Index: -3.7600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1381
Cell Significance Index: -6.1100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1399
Cell Significance Index: -3.6000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1730
Cell Significance Index: -2.9000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1770
Cell Significance Index: -3.8800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1773
Cell Significance Index: -6.1600
Cell Name: peg cell (CL4033014)
Fold Change: -0.2058
Cell Significance Index: -4.7600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2116
Cell Significance Index: -4.3900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2150
Cell Significance Index: -8.1400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.2198
Cell Significance Index: -4.6000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2274
Cell Significance Index: -6.5200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2297
Cell Significance Index: -6.0400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2298
Cell Significance Index: -23.9300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.2322
Cell Significance Index: -6.8200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2492
Cell Significance Index: -6.2300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2726
Cell Significance Index: -21.5900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3112
Cell Significance Index: -1.8800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3125
Cell Significance Index: -16.4100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3216
Cell Significance Index: -8.2200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3619
Cell Significance Index: -22.1900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4007
Cell Significance Index: -3.6900
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.4128
Cell Significance Index: -6.2200
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4136
Cell Significance Index: -9.9200
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4139
Cell Significance Index: -7.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** MED1 is a transcriptional coactivator that plays a central role in regulating gene expression by facilitating the recruitment of RNA polymerase II to specific DNA sequences. It is a component of the mediator complex, which is a large protein complex that interacts with transcription factors and RNA polymerase II to regulate gene expression. MED1 possesses a unique structure, consisting of multiple domains that interact with various proteins and DNA sequences. These domains enable MED1 to bind to transcription factors, RNA polymerase II, and histones, facilitating the recruitment of RNA polymerase II to specific DNA sequences and promoting the transcription of target genes. **Pathways and Functions** MED1 is involved in various cellular pathways, including: 1. **Transcriptional regulation**: MED1 regulates the expression of genes by facilitating the recruitment of RNA polymerase II to specific DNA sequences. 2. **Cellular differentiation**: MED1 plays a role in the differentiation of cells, including neuronal and hematopoietic cells. 3. **Embryonic development**: MED1 is involved in the development of embryonic tissues, including the heart, brain, and liver. 4. **Metabolism**: MED1 regulates the expression of genes involved in lipid and steroid metabolism. 5. **Stress response**: MED1 is involved in the regulation of cellular responses to stress, including DNA damage and oxidative stress. **Clinical Significance** Dysregulation of MED1 has been implicated in various diseases, including: 1. **Cancer**: MED1 is overexpressed in certain types of cancer, including breast and lung cancer. 2. **Neurological disorders**: MED1 mutations have been associated with neurological disorders, including epilepsy and schizophrenia. 3. **Metabolic disorders**: MED1 is involved in lipid and steroid metabolism, and dysregulation of MED1 has been implicated in metabolic disorders, including obesity and diabetes. 4. **Cardiovascular disease**: MED1 is involved in the regulation of cardiac development and function, and dysregulation of MED1 has been implicated in cardiovascular disease. In conclusion, MED1 is a crucial regulator of gene expression that plays a central role in various cellular processes, including transcriptional regulation, cellular differentiation, and metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of MED1 in maintaining tissue homeostasis and preventing disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Mediator of RNA polymerase II transcription subunit 1

Genular Protein ID: 305185906

Symbol: MED1_HUMAN

Name: Mediator of RNA polymerase II transcription subunit 1

UniProtKB Accession Codes:

Q15648 A2RRQ6 O43810 O75447 Q6P9H7 Q6PK58 Q9HD39

Database IDs:

Citations:

PubMed ID: 9444950

Title: Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53.

PubMed ID: 9444950

DOI: 10.1038/sj.onc.1201492

PubMed ID: 9653119

Title: The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.

PubMed ID: 9653119

DOI: 10.1073/pnas.95.14.7939

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10235267

Title: Composite co-activator ARC mediates chromatin-directed transcriptional activation.

PubMed ID: 10235267

DOI: 10.1038/19789

PubMed ID: 10733574

Title: The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes.

PubMed ID: 10733574

DOI: 10.1128/mcb.20.8.2718-2726.2000

PubMed ID: 10235266

Title: Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.

PubMed ID: 10235266

DOI: 10.1038/19783

PubMed ID: 7776974

Title: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor.

PubMed ID: 7776974

DOI: 10.1210/mend.9.2.7776974

PubMed ID: 10024883

Title: A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation.

PubMed ID: 10024883

DOI: 10.1016/s1097-2765(00)80178-1

PubMed ID: 10406464

Title: Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors.

PubMed ID: 10406464

DOI: 10.1210/mend.13.7.0295

PubMed ID: 10478845

Title: Coactivators for the orphan nuclear receptor RORalpha.

PubMed ID: 10478845

DOI: 10.1210/mend.13.9.0343

PubMed ID: 10770935

Title: Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex.

PubMed ID: 10770935

DOI: 10.1074/jbc.m002013200

PubMed ID: 11303023

Title: Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta.

PubMed ID: 11303023

DOI: 10.1074/jbc.m011651200

PubMed ID: 12218053

Title: A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.

PubMed ID: 12218053

DOI: 10.1074/jbc.m206061200

PubMed ID: 12037571

Title: Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis.

PubMed ID: 12037571

DOI: 10.1038/417563a

PubMed ID: 11867769

Title: The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro.

PubMed ID: 11867769

DOI: 10.1073/pnas.261715899

PubMed ID: 12034878

Title: Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo.

PubMed ID: 12034878

DOI: 10.1073/pnas.122004799

PubMed ID: 12556447

Title: An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220.

PubMed ID: 12556447

DOI: 10.1074/jbc.m212950200

PubMed ID: 14636573

Title: Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.

PubMed ID: 14636573

DOI: 10.1016/s1097-2765(03)00391-5

PubMed ID: 15471764

Title: Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins.

PubMed ID: 15471764

DOI: 10.1074/jbc.m409778200

PubMed ID: 15175163

Title: A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.

PubMed ID: 15175163

DOI: 10.1016/j.molcel.2004.05.006

PubMed ID: 15340084

Title: Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors.

PubMed ID: 15340084

DOI: 10.1128/mcb.24.18.8244-8254.2004

PubMed ID: 15989967

Title: MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription.

PubMed ID: 15989967

DOI: 10.1016/j.molcel.2005.05.015

PubMed ID: 16314496

Title: Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation.

PubMed ID: 16314496

DOI: 10.1128/mcb.25.24.10695-10710.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16574658

Title: Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1.

PubMed ID: 16574658

DOI: 10.1074/jbc.m600163200

PubMed ID: 17000779

Title: Mediator modulates Gli3-dependent Sonic hedgehog signaling.

PubMed ID: 17000779

DOI: 10.1128/mcb.00443-06

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19786558

Title: The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors.

PubMed ID: 19786558

DOI: 10.1124/mol.109.057000

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24245781

Title: CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function.

PubMed ID: 24245781

DOI: 10.1111/gtc.12104

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29997176

Title: Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

PubMed ID: 29997176

DOI: 10.1073/pnas.1803909115

Sequence Information:

Length: 1581
Mass: 168478
Checksum: FCE0FE87EF08B887
Sequence:

MKAQGETEES EKLSKMSSLL ERLHAKFNQN RPWSETIKLV RQVMEKRVVM SSGGHQHLVS 
CLETLQKALK VTSLPAMTDR LESIARQNGL GSHLSASGTE CYITSDMFYV EVQLDPAGQL 
CDVKVAHHGE NPVSCPELVQ QLREKNFDEF SKHLKGLVNL YNLPGDNKLK TKMYLALQSL 
EQDLSKMAIM YWKATNAGPL DKILHGSVGY LTPRSGGHLM NLKYYVSPSD LLDDKTASPI 
ILHENNVSRS LGMNASVTIE GTSAVYKLPI APLIMGSHPV DNKWTPSFSS ITSANSVDLP 
ACFFLKFPQP IPVSRAFVQK LQNCTGIPLF ETQPTYAPLY ELITQFELSK DPDPIPLNHN 
MRFYAALPGQ QHCYFLNKDA PLPDGRSLQG TLVSKITFQH PGRVPLILNL IRHQVAYNTL 
IGSCVKRTIL KEDSPGLLQF EVCPLSESRF SVSFQHPVND SLVCVVMDVQ DSTHVSCKLY 
KGLSDALICT DDFIAKVVQR CMSIPVTMRA IRRKAETIQA DTPALSLIAE TVEDMVKKNL 
PPASSPGYGM TTGNNPMSGT TTPTNTFPGG PITTLFNMSM SIKDRHESVG HGEDFSKVSQ 
NPILTSLLQI TGNGGSTIGS SPTPPHHTPP PVSSMAGNTK NHPMLMNLLK DNPAQDFSTL 
YGSSPLERQN SSSGSPRMEI CSGSNKTKKK KSSRLPPEKP KHQTEDDFQR ELFSMDVDSQ 
NPIFDVNMTA DTLDTPHITP APSQCSTPPT TYPQPVPHPQ PSIQRMVRLS SSDSIGPDVT 
DILSDIAEEA SKLPSTSDDC PAIGTPLRDS SSSGHSQSTL FDSDVFQTNN NENPYTDPAD 
LIADAAGSPS SDSPTNHFFH DGVDFNPDLL NSQSQSGFGE EYFDESSQSG DNDDFKGFAS 
QALNTLGVPM LGGDNGETKF KGNNQADTVD FSIISVAGKA LAPADLMEHH SGSQGPLLTT 
GDLGKEKTQK RVKEGNGTSN STLSGPGLDS KPGKRSRTPS NDGKSKDKPP KRKKADTEGK 
SPSHSSSNRP FTPPTSTGGS KSPGSAGRSQ TPPGVATPPI PKITIQIPKG TVMVGKPSSH 
SQYTSSGSVS SSGSKSHHSH SSSSSSSAST SGKMKSSKSE GSSSSKLSSS MYSSQGSSGS 
SQSKNSSQSG GKPGSSPITK HGLSSGSSST KMKPQGKPSS LMNPSLSKPN ISPSHSRPPG 
GSDKLASPMK PVPGTPPSSK AKSPISSGSG GSHMSGTSSS SGMKSSSGLG SSGSLSQKTP 
PSSNSCTASS SSFSSSGSSM SSSQNQHGSS KGKSPSRNKK PSLTAVIDKL KHGVVTSGPG 
GEDPLDGQMG VSTNSSSHPM SSKHNMSGGE FQGKREKSDK DKSKVSTSGS SVDSSKKTSE 
SKNVGSTGVA KIIISKHDGG SPSIKAKVTL QKPGESSGEG LRPQMASSKN YGSPLISGST 
PKHERGSPSH SKSPAYTPQN LDSESESGSS IAEKSYQNSP SSDDGIRPLP EYSTEKHKKH 
KKEKKKVKDK DRDRDRDKDR DKKKSHSIKP ESWSKSPISS DQSLSMTSNT ILSADRPSRL 
SPDFMIGEED DDLMDVALIG N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MED1

Associated with

Cells (max top 100)

Other Information

Identification of RB18A, a 205 kDa new p53 regulatory protein which shares antigenic and functional properties with p53. PubMed ID: 9444950

The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. PubMed ID: 9653119

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Composite co-activator ARC mediates chromatin-directed transcriptional activation. PubMed ID: 10235267

The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. PubMed ID: 10733574

Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. PubMed ID: 10235266

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. PubMed ID: 7776974

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. PubMed ID: 10024883

Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors. PubMed ID: 10406464

Coactivators for the orphan nuclear receptor RORalpha. PubMed ID: 10478845

Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. PubMed ID: 10770935

Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta. PubMed ID: 11303023

A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression. PubMed ID: 12218053

Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. PubMed ID: 12037571

The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. PubMed ID: 11867769

Ordered recruitment of histone acetyltransferases and the TRAP/Mediator complex to thyroid hormone-responsive promoters in vivo. PubMed ID: 12034878

An extended LXXLL motif sequence determines the nuclear receptor binding specificity of TRAP220. PubMed ID: 12556447

Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. PubMed ID: 14636573

Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. PubMed ID: 15471764

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. PubMed ID: 15175163

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. PubMed ID: 15340084

MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. PubMed ID: 15989967

Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. PubMed ID: 16314496

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. PubMed ID: 16574658

Mediator modulates Gli3-dependent Sonic hedgehog signaling. PubMed ID: 17000779

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors. PubMed ID: 19786558

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. PubMed ID: 24245781

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. PubMed ID: 29997176