Details for: PPP1R7

Gene ID: 5510

Symbol: PPP1R7

Ensembl ID: ENSG00000115685

Description: protein phosphatase 1 regulatory subunit 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 249.8309
    Cell Significance Index: -38.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.5798
    Cell Significance Index: -40.7300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 119.6026
    Cell Significance Index: -49.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.0016
    Cell Significance Index: -50.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 93.1792
    Cell Significance Index: -47.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.2568
    Cell Significance Index: -51.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.2009
    Cell Significance Index: -47.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.4251
    Cell Significance Index: -49.0300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.1913
    Cell Significance Index: -29.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.1288
    Cell Significance Index: -31.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6390
    Cell Significance Index: -14.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0638
    Cell Significance Index: 123.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9818
    Cell Significance Index: 215.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.6203
    Cell Significance Index: 466.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3109
    Cell Significance Index: 61.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2898
    Cell Significance Index: 258.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1720
    Cell Significance Index: 15.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1318
    Cell Significance Index: 33.2400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1288
    Cell Significance Index: 10.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1166
    Cell Significance Index: 609.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0383
    Cell Significance Index: 71.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0166
    Cell Significance Index: 52.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9597
    Cell Significance Index: 173.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9266
    Cell Significance Index: 109.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9163
    Cell Significance Index: 48.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8937
    Cell Significance Index: 109.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8277
    Cell Significance Index: 36.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7742
    Cell Significance Index: 49.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7163
    Cell Significance Index: 98.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.7022
    Cell Significance Index: 26.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6595
    Cell Significance Index: 291.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6102
    Cell Significance Index: 38.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5775
    Cell Significance Index: 40.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5703
    Cell Significance Index: 113.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5630
    Cell Significance Index: 26.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5519
    Cell Significance Index: 54.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4735
    Cell Significance Index: 10.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4339
    Cell Significance Index: 9.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3810
    Cell Significance Index: 136.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3782
    Cell Significance Index: 64.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3314
    Cell Significance Index: 42.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3286
    Cell Significance Index: 42.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2376
    Cell Significance Index: 10.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2100
    Cell Significance Index: 6.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2081
    Cell Significance Index: 15.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1757
    Cell Significance Index: 4.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1580
    Cell Significance Index: 30.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0886
    Cell Significance Index: 61.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0285
    Cell Significance Index: 21.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0240
    Cell Significance Index: 0.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0213
    Cell Significance Index: 0.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0093
    Cell Significance Index: 17.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0059
    Cell Significance Index: 4.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0168
    Cell Significance Index: -31.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0214
    Cell Significance Index: -32.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0286
    Cell Significance Index: -38.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0329
    Cell Significance Index: -20.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0441
    Cell Significance Index: -4.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0460
    Cell Significance Index: -20.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0461
    Cell Significance Index: -28.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0474
    Cell Significance Index: -26.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1075
    Cell Significance Index: -22.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1102
    Cell Significance Index: -3.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1247
    Cell Significance Index: -2.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1308
    Cell Significance Index: -3.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1320
    Cell Significance Index: -15.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1411
    Cell Significance Index: -3.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1422
    Cell Significance Index: -20.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1666
    Cell Significance Index: -5.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1745
    Cell Significance Index: -2.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2082
    Cell Significance Index: -23.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2258
    Cell Significance Index: -13.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2629
    Cell Significance Index: -3.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2670
    Cell Significance Index: -17.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2824
    Cell Significance Index: -21.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2910
    Cell Significance Index: -7.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2939
    Cell Significance Index: -6.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3010
    Cell Significance Index: -48.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3653
    Cell Significance Index: -4.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4101
    Cell Significance Index: -14.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4146
    Cell Significance Index: -32.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4225
    Cell Significance Index: -7.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4569
    Cell Significance Index: -52.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4637
    Cell Significance Index: -26.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4658
    Cell Significance Index: -48.5000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.5654
    Cell Significance Index: -7.6300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6023
    Cell Significance Index: -6.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6106
    Cell Significance Index: -11.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6893
    Cell Significance Index: -19.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7792
    Cell Significance Index: -20.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8147
    Cell Significance Index: -49.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8771
    Cell Significance Index: -10.4600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9110
    Cell Significance Index: -9.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9412
    Cell Significance Index: -25.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9476
    Cell Significance Index: -30.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9642
    Cell Significance Index: -28.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9757
    Cell Significance Index: -27.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9788
    Cell Significance Index: -34.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9921
    Cell Significance Index: -32.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Regulation of PP1 activity:** PPP1R7 interacts with PP1, modulating its activity and substrate specificity. This interaction is crucial for regulating PP1's dephosphorylation activity, which in turn affects various cellular processes. 2. **Widespread expression:** PPP1R7 is expressed in multiple cell types, including germ cells, epithelial cells, immune cells, and neural cells, suggesting its involvement in diverse cellular functions. 3. **Cell type-specific expression:** The expression of PPP1R7 varies across different cell types, with some cells expressing high levels of PPP1R7, while others express low levels. This cell type-specific expression may reflect the specific roles of PPP1R7 in different cellular contexts. 4. **Regulation of signaling pathways:** PPP1R7 has been implicated in regulating various signaling pathways, including those involved in cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Positive regulation of protein dephosphorylation:** PPP1R7 enhances PP1's dephosphorylation activity, which is essential for regulating protein function and cellular processes. 2. **Protein binding:** PPP1R7 interacts with various proteins, including PP1, GSK3, and CDK5, modulating their activity and regulating cellular processes. 3. **Chromatin remodeling:** PPP1R7 has been implicated in regulating chromatin remodeling, which is essential for gene expression and cellular differentiation. 4. **Cell growth and differentiation:** PPP1R7 regulates cell growth and differentiation by modulating PP1's activity on key regulatory proteins. **Clinical Significance:** 1. **Cancer therapy:** PPP1R7 has been identified as a potential therapeutic target in cancer therapy due to its role in regulating cell growth and differentiation. 2. **Neurological disorders:** PPP1R7 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), due to its role in regulating protein phosphatase 1 activity. 3. **Immune system disorders:** PPP1R7 has been implicated in immune system disorders, including autoimmune diseases and immunodeficiency disorders, due to its role in regulating immune cell function. 4. **Regenerative medicine:** PPP1R7 has been identified as a potential therapeutic target in regenerative medicine due to its role in regulating cellular differentiation and survival. In conclusion, PPP1R7 is a critical regulator of protein phosphatase 1 activity, with implications for various cellular processes, including cell growth, differentiation, and survival. Further studies are needed to fully elucidate the role of PPP1R7 in different diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 3497008147

Symbol: PP1R7_HUMAN

Name: Protein phosphatase 1 regulatory subunit 7

UniProtKB Accession Codes:

Q15435 B4DFD4 B5MCY6 Q9UQE5 Q9UQE6 Q9Y6K4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 31 EMDB 5 Ensembl 6 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 7 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7498485

Title: Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1.

PubMed ID: 7498485

DOI: 10.1016/0014-5793(95)01180-m

PubMed ID: 10231361

Title: Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1.

PubMed ID: 10231361

DOI: 10.1046/j.1432-1327.1999.00344.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12226088

Title: Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PubMed ID: 12226088

DOI: 10.1074/jbc.m206838200

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 360
  • Mass: 41564
  • Checksum: 49BCCF675EAA94D1
  • Sequence:
    • MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHSSGIV ADLSEQSLKD GEERGEEDPE 
EEHELPVDME TINLDRDAED VDLNHYRIGK IEGFEVLKKV KTLCLRQNLI KCIENLEELQ 
SLRELDLYDN QIKKIENLEA LTELEILDIS FNLLRNIEGV DKLTRLKKLF LVNNKISKIE 
NLSNLHQLQM LELGSNRIRA IENIDTLTNL ESLFLGKNKI TKLQNLDALT NLTVLSMQSN 
RLTKIEGLQN LVNLRELYLS HNGIEVIEGL ENNNKLTMLD IASNRIKKIE NISHLTELQE 
FWMNDNLLES WSDLDELKGA RSLETVYLER NPLQKDPQYR RKVMLALPSV RQIDATFVRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.