Details for: PPP1R10

Gene ID: 5514

Symbol: PPP1R10

Ensembl ID: ENSG00000204569

Description: protein phosphatase 1 regulatory subunit 10

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.61
    Marker Score: 34738
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.34
    Marker Score: 1989
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.19
    Marker Score: 3824
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.01
    Marker Score: 975
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.99
    Marker Score: 20140
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8
    Marker Score: 2653
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.79
    Marker Score: 1879
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.74
    Marker Score: 751
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.73
    Marker Score: 1723
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.68
    Marker Score: 57010
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.65
    Marker Score: 513
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.59
    Marker Score: 1760
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.59
    Marker Score: 1694
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.57
    Marker Score: 17689.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.55
    Marker Score: 4342
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.48
    Marker Score: 1535
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.47
    Marker Score: 442
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.47
    Marker Score: 727
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.42
    Marker Score: 353
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.42
    Marker Score: 530
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.41
    Marker Score: 935
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.41
    Marker Score: 48669
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.39
    Marker Score: 3159.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.39
    Marker Score: 331
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.38
    Marker Score: 404
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.38
    Marker Score: 1583
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.37
    Marker Score: 314.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.36
    Marker Score: 1031
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.35
    Marker Score: 82967
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.34
    Marker Score: 815
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.34
    Marker Score: 1196
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.34
    Marker Score: 783
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.34
    Marker Score: 330
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.33
    Marker Score: 657
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.33
    Marker Score: 11400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.32
    Marker Score: 12563
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.32
    Marker Score: 1397.5
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.3
    Marker Score: 343
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.3
    Marker Score: 651
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.29
    Marker Score: 370
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.29
    Marker Score: 538
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.28
    Marker Score: 1091
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.27
    Marker Score: 5326.5
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.26
    Marker Score: 414
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.25
    Marker Score: 511.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.25
    Marker Score: 437
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.25
    Marker Score: 1922.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.24
    Marker Score: 2039
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.24
    Marker Score: 2808
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.23
    Marker Score: 5114
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.23
    Marker Score: 4554
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.22
    Marker Score: 629
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.22
    Marker Score: 1477
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.22
    Marker Score: 323
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.21
    Marker Score: 845
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.21
    Marker Score: 457
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.2
    Marker Score: 588
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.2
    Marker Score: 1025
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.2
    Marker Score: 2403
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.2
    Marker Score: 1100.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.19
    Marker Score: 241
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.19
    Marker Score: 25465
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.19
    Marker Score: 261
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.19
    Marker Score: 684
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.18
    Marker Score: 721
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.18
    Marker Score: 10266
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.18
    Marker Score: 4561
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.18
    Marker Score: 538.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.17
    Marker Score: 701
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.17
    Marker Score: 583
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.17
    Marker Score: 3140
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.17
    Marker Score: 11020.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.17
    Marker Score: 531
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.17
    Marker Score: 287
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.17
    Marker Score: 1263
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.16
    Marker Score: 1124
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.16
    Marker Score: 253
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.16
    Marker Score: 744
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.16
    Marker Score: 44059
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.16
    Marker Score: 11647.5
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.16
    Marker Score: 288
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.16
    Marker Score: 17295.5
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.16
    Marker Score: 317
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.15
    Marker Score: 596
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.15
    Marker Score: 466
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.15
    Marker Score: 3129
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.15
    Marker Score: 267
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.15
    Marker Score: 535.5
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 1.15
    Marker Score: 320
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.14
    Marker Score: 290
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.14
    Marker Score: 320
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.14
    Marker Score: 1090
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.14
    Marker Score: 645
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.13
    Marker Score: 888
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.13
    Marker Score: 475
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 1.13
    Marker Score: 334
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.13
    Marker Score: 439
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.13
    Marker Score: 1226
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 471

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Other Information

**Key Characteristics:** 1. **Regulatory Subunit of PP1:** PPP1R10 is a regulatory subunit of PP1, a serine/threonine phosphatase that plays a critical role in regulating cellular processes. 2. **Cellular Expression:** PPP1R10 is expressed in a wide range of cell types, including cardiac muscle cells, immune cells, and epithelial cells. 3. **Enzymatic Activity:** PPP1R10 modulates the enzymatic activity of PP1, which is involved in various cellular processes. 4. **Cellular Processes:** PPP1R10 is involved in regulating cell cycle, apoptosis, telomere maintenance, and protein binding. **Pathways and Functions:** 1. **Cell Cycle Regulation:** PPP1R10 modulates the activity of PP1, which is involved in regulating the cell cycle. Specifically, PP1 regulates the phosphorylation and dephosphorylation of key cell cycle regulators, such as cyclin-dependent kinases and cyclin-dependent phosphatases. 2. **Apoptosis Regulation:** PPP1R10 has been shown to regulate apoptosis by modulating the activity of PP1. PP1 dephosphorylates and activates pro-apoptotic proteins, such as Bax, while dephosphorylating and inactivating anti-apoptotic proteins, such as Bcl-2. 3. **Telomere Maintenance:** PPP1R10 has been implicated in telomere maintenance by regulating the activity of PP1. PP1 regulates the phosphorylation and dephosphorylation of telomerase, which is involved in telomere length maintenance. 4. **Protein Binding:** PPP1R10 regulates the binding of PP1 to target proteins, which is critical for its enzymatic activity. **Clinical Significance:** 1. **Cancer:** Dysregulation of PPP1R10 has been implicated in various cancers, including breast cancer and colorectal cancer. Overexpression or mutation of PPP1R10 can lead to uncontrolled cell growth and tumorigenesis. 2. **Cardiovascular Disorders:** PPP1R10 has been implicated in cardiovascular disorders, including atherosclerosis and cardiac hypertrophy. Dysregulation of PPP1R10 can lead to impaired cardiac function and increased risk of cardiovascular events. 3. **Immune Disorders:** PPP1R10 has been implicated in immune disorders, including autoimmune diseases and immunodeficiency disorders. Dysregulation of PPP1R10 can lead to impaired immune function and increased risk of infections. In conclusion, PPP1R10 is a critical regulatory subunit of PP1 that plays a pivotal role in regulating various cellular processes. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and immune disorders. Further research is needed to fully understand the role of PPP1R10 in regulating cellular processes and its clinical significance.

Genular Protein ID: 1703463680

Symbol: PP1RA_HUMAN

Name: Serine/threonine-protein phosphatase 1 regulatory subunit 10

UniProtKB Accession Codes:

Q96QC0 O00405

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9784381

Title: Cloning of a new gene (FB19) within HLA class I region.

PubMed ID: 9784381

DOI: 10.1006/bbrc.1998.9354

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9450550

Title: Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity.

PubMed ID: 9450550

DOI: 10.1016/s0014-5793(97)01485-3

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 940
  • Mass: 99058
  • Checksum: 49EE42961D734121
  • Sequence:
    • MGSGPIDPKE LLKGLDSFLN RDGEVKSVDG ISKIFSLMKE ARKMVSRCTY LNILLQTRSP 
EILVKFIDVG GYKLLNNWLT YSKTTNNIPL LQQILLTLQH LPLTVDHLKQ NNTAKLVKQL 
SKSSEDEELR KLASVLVSDW MAVIRSQSST QPAEKDKKKR KDEGKSRTTL PERPLTEVKA 
ETRAEEAPEK KREKPKSLRT TAPSHAKFRS TGLELETPSL VPVKKNASTV VVSDKYNLKP 
IPLKRQSNVA APGDATPPAE KKYKPLNTTP NATKEIKVKI IPPQPMEGLG FLDALNSAPV 
PGIKIKKKKK VLSPTAAKPS PFEGKTSTEP STAKPSSPEP APPSEAMDAD RPGTPVPPVE 
VPELMDTASL EPGALDAKPV ESPGDPNQLT RKGRKRKSVT WPEEGKLREY FYFELDETER 
VNVNKIKDFG EAAKREILSD RHAFETARRL SHDNMEEKVP WVCPRPLVLP SPLVTPGSNS 
QERYIQAERE KGILQELFLN KESPHEPDPE PYEPIPPKLI PLDEECSMDE TPYVETLEPG 
GSGGSPDGAG GSKLPPVLAN LMGSMGAGKG PQGPGGGGIN VQEILTSIMG SPNSHPSEEL 
LKQPDYSDKI KQMLVPHGLL GPGPIANGFP PGGPGGPKGM QHFPPGPGGP MPGPHGGPGG 
PVGPRLLGPP PPPRGGDPFW DGPGDPMRGG PMRGGPGPGP GPYHRGRGGR GGNEPPPPPP 
PFRGARGGRS GGGPPNGRGG PGGGMVGGGG HRPHEGPGGG MGNSSGHRPH EGPGGGMGSG 
HRPHEGPGGS MGGGGGHRPH EGPGGGISGG SGHRPHEGPG GGMGAGGGHR PHEGPGGSMG 
GSGGHRPHEG PGHGGPHGHR PHDVPGHRGH DHRGPPPHEH RGHDGPGHGG GGHRGHDGGH 
SHGGDMSNRP VCRHFMMKGN CRYENNCAFY HPGVNGPPLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.