Details for: PPP1R10

Gene ID: 5514

Symbol: PPP1R10

Ensembl ID: ENSG00000204569

Description: protein phosphatase 1 regulatory subunit 10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 357.9345
    Cell Significance Index: -55.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 207.9692
    Cell Significance Index: -52.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 142.4842
    Cell Significance Index: -67.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 129.6223
    Cell Significance Index: -52.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 119.9879
    Cell Significance Index: -61.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 100.3842
    Cell Significance Index: -67.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.6275
    Cell Significance Index: -53.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.4777
    Cell Significance Index: -57.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.7522
    Cell Significance Index: -60.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.8275
    Cell Significance Index: -58.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.8734
    Cell Significance Index: -39.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9512
    Cell Significance Index: 133.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8262
    Cell Significance Index: 38.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1226
    Cell Significance Index: 136.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.9318
    Cell Significance Index: 55.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4969
    Cell Significance Index: 191.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3203
    Cell Significance Index: 181.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3057
    Cell Significance Index: 160.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2469
    Cell Significance Index: 250.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2258
    Cell Significance Index: 220.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9973
    Cell Significance Index: 900.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9712
    Cell Significance Index: 429.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9434
    Cell Significance Index: 44.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9080
    Cell Significance Index: 180.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9034
    Cell Significance Index: 24.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8986
    Cell Significance Index: 146.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8894
    Cell Significance Index: 46.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8886
    Cell Significance Index: 20.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8573
    Cell Significance Index: 468.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7762
    Cell Significance Index: 36.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6381
    Cell Significance Index: 63.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6335
    Cell Significance Index: 35.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6031
    Cell Significance Index: 216.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5478
    Cell Significance Index: 38.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4765
    Cell Significance Index: 13.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4538
    Cell Significance Index: 313.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3775
    Cell Significance Index: 28.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.3395
    Cell Significance Index: 17.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3254
    Cell Significance Index: 16.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1528
    Cell Significance Index: 19.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0971
    Cell Significance Index: 6.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0952
    Cell Significance Index: 179.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0819
    Cell Significance Index: 15.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0731
    Cell Significance Index: 12.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0567
    Cell Significance Index: 87.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0371
    Cell Significance Index: 50.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0218
    Cell Significance Index: 40.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0136
    Cell Significance Index: 8.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0083
    Cell Significance Index: 6.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0104
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0230
    Cell Significance Index: -17.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0274
    Cell Significance Index: -12.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0497
    Cell Significance Index: -37.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0537
    Cell Significance Index: -33.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0681
    Cell Significance Index: -8.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0708
    Cell Significance Index: -39.9100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0998
    Cell Significance Index: -1.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1009
    Cell Significance Index: -10.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1424
    Cell Significance Index: -3.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1541
    Cell Significance Index: -22.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1610
    Cell Significance Index: -33.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1849
    Cell Significance Index: -13.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2121
    Cell Significance Index: -61.0400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2433
    Cell Significance Index: -5.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2509
    Cell Significance Index: -28.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2524
    Cell Significance Index: -29.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2616
    Cell Significance Index: -29.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2658
    Cell Significance Index: -6.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2808
    Cell Significance Index: -14.7500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3944
    Cell Significance Index: -3.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4275
    Cell Significance Index: -7.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4558
    Cell Significance Index: -20.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4694
    Cell Significance Index: -48.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4912
    Cell Significance Index: -17.0700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.5002
    Cell Significance Index: -3.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5188
    Cell Significance Index: -10.8600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5616
    Cell Significance Index: -9.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6095
    Cell Significance Index: -23.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6181
    Cell Significance Index: -48.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6396
    Cell Significance Index: -16.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6453
    Cell Significance Index: -5.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6915
    Cell Significance Index: -24.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7125
    Cell Significance Index: -22.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7201
    Cell Significance Index: -15.6000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7332
    Cell Significance Index: -7.5900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8271
    Cell Significance Index: -26.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8819
    Cell Significance Index: -13.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8937
    Cell Significance Index: -22.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9118
    Cell Significance Index: -55.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9742
    Cell Significance Index: -26.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9847
    Cell Significance Index: -28.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9912
    Cell Significance Index: -11.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0360
    Cell Significance Index: -20.2200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0658
    Cell Significance Index: -9.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0660
    Cell Significance Index: -34.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0727
    Cell Significance Index: -34.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1050
    Cell Significance Index: -38.7100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1338
    Cell Significance Index: -16.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1471
    Cell Significance Index: -28.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Regulatory Subunit of PP1:** PPP1R10 is a regulatory subunit of PP1, a serine/threonine phosphatase that plays a critical role in regulating cellular processes. 2. **Cellular Expression:** PPP1R10 is expressed in a wide range of cell types, including cardiac muscle cells, immune cells, and epithelial cells. 3. **Enzymatic Activity:** PPP1R10 modulates the enzymatic activity of PP1, which is involved in various cellular processes. 4. **Cellular Processes:** PPP1R10 is involved in regulating cell cycle, apoptosis, telomere maintenance, and protein binding. **Pathways and Functions:** 1. **Cell Cycle Regulation:** PPP1R10 modulates the activity of PP1, which is involved in regulating the cell cycle. Specifically, PP1 regulates the phosphorylation and dephosphorylation of key cell cycle regulators, such as cyclin-dependent kinases and cyclin-dependent phosphatases. 2. **Apoptosis Regulation:** PPP1R10 has been shown to regulate apoptosis by modulating the activity of PP1. PP1 dephosphorylates and activates pro-apoptotic proteins, such as Bax, while dephosphorylating and inactivating anti-apoptotic proteins, such as Bcl-2. 3. **Telomere Maintenance:** PPP1R10 has been implicated in telomere maintenance by regulating the activity of PP1. PP1 regulates the phosphorylation and dephosphorylation of telomerase, which is involved in telomere length maintenance. 4. **Protein Binding:** PPP1R10 regulates the binding of PP1 to target proteins, which is critical for its enzymatic activity. **Clinical Significance:** 1. **Cancer:** Dysregulation of PPP1R10 has been implicated in various cancers, including breast cancer and colorectal cancer. Overexpression or mutation of PPP1R10 can lead to uncontrolled cell growth and tumorigenesis. 2. **Cardiovascular Disorders:** PPP1R10 has been implicated in cardiovascular disorders, including atherosclerosis and cardiac hypertrophy. Dysregulation of PPP1R10 can lead to impaired cardiac function and increased risk of cardiovascular events. 3. **Immune Disorders:** PPP1R10 has been implicated in immune disorders, including autoimmune diseases and immunodeficiency disorders. Dysregulation of PPP1R10 can lead to impaired immune function and increased risk of infections. In conclusion, PPP1R10 is a critical regulatory subunit of PP1 that plays a pivotal role in regulating various cellular processes. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and immune disorders. Further research is needed to fully understand the role of PPP1R10 in regulating cellular processes and its clinical significance.

Genular Protein ID: 1703463680

Symbol: PP1RA_HUMAN

Name: Serine/threonine-protein phosphatase 1 regulatory subunit 10

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9784381

Title: Cloning of a new gene (FB19) within HLA class I region.

PubMed ID: 9784381

DOI: 10.1006/bbrc.1998.9354

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 9450550

Title: Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity.

PubMed ID: 9450550

DOI: 10.1016/s0014-5793(97)01485-3

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 940
  • Mass: 99058
  • Checksum: 49EE42961D734121
  • Sequence:
  • MGSGPIDPKE LLKGLDSFLN RDGEVKSVDG ISKIFSLMKE ARKMVSRCTY LNILLQTRSP 
    EILVKFIDVG GYKLLNNWLT YSKTTNNIPL LQQILLTLQH LPLTVDHLKQ NNTAKLVKQL 
    SKSSEDEELR KLASVLVSDW MAVIRSQSST QPAEKDKKKR KDEGKSRTTL PERPLTEVKA 
    ETRAEEAPEK KREKPKSLRT TAPSHAKFRS TGLELETPSL VPVKKNASTV VVSDKYNLKP 
    IPLKRQSNVA APGDATPPAE KKYKPLNTTP NATKEIKVKI IPPQPMEGLG FLDALNSAPV 
    PGIKIKKKKK VLSPTAAKPS PFEGKTSTEP STAKPSSPEP APPSEAMDAD RPGTPVPPVE 
    VPELMDTASL EPGALDAKPV ESPGDPNQLT RKGRKRKSVT WPEEGKLREY FYFELDETER 
    VNVNKIKDFG EAAKREILSD RHAFETARRL SHDNMEEKVP WVCPRPLVLP SPLVTPGSNS 
    QERYIQAERE KGILQELFLN KESPHEPDPE PYEPIPPKLI PLDEECSMDE TPYVETLEPG 
    GSGGSPDGAG GSKLPPVLAN LMGSMGAGKG PQGPGGGGIN VQEILTSIMG SPNSHPSEEL 
    LKQPDYSDKI KQMLVPHGLL GPGPIANGFP PGGPGGPKGM QHFPPGPGGP MPGPHGGPGG 
    PVGPRLLGPP PPPRGGDPFW DGPGDPMRGG PMRGGPGPGP GPYHRGRGGR GGNEPPPPPP 
    PFRGARGGRS GGGPPNGRGG PGGGMVGGGG HRPHEGPGGG MGNSSGHRPH EGPGGGMGSG 
    HRPHEGPGGS MGGGGGHRPH EGPGGGISGG SGHRPHEGPG GGMGAGGGHR PHEGPGGSMG 
    GSGGHRPHEG PGHGGPHGHR PHDVPGHRGH DHRGPPPHEH RGHDGPGHGG GGHRGHDGGH 
    SHGGDMSNRP VCRHFMMKGN CRYENNCAFY HPGVNGPPLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.