PPP2R1B | ENSG00000137713 | NCBI 5519

Details for: PPP2R1B

Gene ID: 5519

Symbol: PPP2R1B

Ensembl ID: ENSG00000137713

Description: protein phosphatase 2 scaffold subunit Abeta

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Cytokine signaling in immune system
(R-HSA-1280215)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
E2f mediated regulation of dna replication
(R-HSA-113510)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
G alpha (i) signalling events
(R-HSA-418594)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interferon signaling
(R-HSA-913531)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Mastl facilitates mitotic progression
(R-HSA-2465910)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Mitotic anaphase
(R-HSA-68882)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic prophase
(R-HSA-68875)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Negative regulation of mapk pathway
(R-HSA-5675221)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet homeostasis
(R-HSA-418346)
Platelet sensitization by ldl
(R-HSA-432142)
Pp2a-mediated dephosphorylation of key metabolic factors
(R-HSA-163767)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Regulation of tp53 activity
(R-HSA-5633007)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by gpcr
(R-HSA-372790)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Transcriptional regulation by tp53
(R-HSA-3700989)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by piezo1 and integrins in endothelial cells
(R-HSA-9860927)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 121.6366
Cell Significance Index: -18.9200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 91.7430
Cell Significance Index: -23.2700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 54.4729
Cell Significance Index: -22.4400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 51.2790
Cell Significance Index: -24.2100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 49.8453
Cell Significance Index: -20.2500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.2413
Cell Significance Index: -20.2800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.8733
Cell Significance Index: -23.2700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 8.2087
Cell Significance Index: -21.9900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.0770
Cell Significance Index: -23.9800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 3.2057
Cell Significance Index: 54.0000
Cell Name: adipocyte of breast (CL0002617)
Fold Change: 2.7573
Cell Significance Index: 34.7200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.5524
Cell Significance Index: 21.1800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.4042
Cell Significance Index: 138.9100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3805
Cell Significance Index: 273.9600
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.2989
Cell Significance Index: 27.7700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.2409
Cell Significance Index: 144.6100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8803
Cell Significance Index: 95.7500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8730
Cell Significance Index: 52.4100
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8229
Cell Significance Index: 16.0600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7443
Cell Significance Index: 121.0600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5797
Cell Significance Index: 400.9300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.4761
Cell Significance Index: 95.5100
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.4525
Cell Significance Index: 1.9700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4414
Cell Significance Index: 30.5300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3478
Cell Significance Index: 220.8900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3185
Cell Significance Index: 173.9500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2996
Cell Significance Index: 6.4900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2975
Cell Significance Index: 22.8300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2893
Cell Significance Index: 8.3400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2762
Cell Significance Index: 49.7900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2709
Cell Significance Index: 97.1700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2620
Cell Significance Index: 49.8600
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2466
Cell Significance Index: 3.6400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2043
Cell Significance Index: 9.2600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1813
Cell Significance Index: 80.1400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1714
Cell Significance Index: 4.7900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1694
Cell Significance Index: 20.8400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1672
Cell Significance Index: 150.9300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1618
Cell Significance Index: 249.0100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1557
Cell Significance Index: 8.0900
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1511
Cell Significance Index: 9.2900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1477
Cell Significance Index: 272.3200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1324
Cell Significance Index: 7.4300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1214
Cell Significance Index: 5.6600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1199
Cell Significance Index: 20.4700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1014
Cell Significance Index: 190.9700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0963
Cell Significance Index: 13.2300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0927
Cell Significance Index: 2.4900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0572
Cell Significance Index: 25.9700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0395
Cell Significance Index: 53.6600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0327
Cell Significance Index: 4.1900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0002
Cell Significance Index: -0.0200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0051
Cell Significance Index: -0.1400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0060
Cell Significance Index: -0.3800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0135
Cell Significance Index: -1.7500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0137
Cell Significance Index: -10.0500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0184
Cell Significance Index: -0.8700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0224
Cell Significance Index: -16.6000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0274
Cell Significance Index: -20.7600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0291
Cell Significance Index: -0.6200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0393
Cell Significance Index: -1.0500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0398
Cell Significance Index: -22.4700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0445
Cell Significance Index: -27.7800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0607
Cell Significance Index: -1.0400
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0631
Cell Significance Index: -2.3900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0649
Cell Significance Index: -4.8400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0718
Cell Significance Index: -5.0800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0784
Cell Significance Index: -8.0100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0805
Cell Significance Index: -11.7000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0837
Cell Significance Index: -24.0800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0883
Cell Significance Index: -2.5300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0926
Cell Significance Index: -4.1000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0945
Cell Significance Index: -2.4300
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0976
Cell Significance Index: -3.4300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1268
Cell Significance Index: -26.7000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1402
Cell Significance Index: -9.4300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1492
Cell Significance Index: -4.7800
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.1588
Cell Significance Index: -2.2200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1637
Cell Significance Index: -18.7500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1745
Cell Significance Index: -11.2600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1891
Cell Significance Index: -19.6900
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1945
Cell Significance Index: -4.0400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2031
Cell Significance Index: -10.5800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2128
Cell Significance Index: -5.3200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2548
Cell Significance Index: -20.1800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2805
Cell Significance Index: -7.3800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2920
Cell Significance Index: -4.2000
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2981
Cell Significance Index: -7.1500
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3053
Cell Significance Index: -3.1600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3174
Cell Significance Index: -11.0300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3370
Cell Significance Index: -20.6600
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3428
Cell Significance Index: -5.7700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3732
Cell Significance Index: -19.6000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4032
Cell Significance Index: -11.8400
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.4072
Cell Significance Index: -7.0400
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4327
Cell Significance Index: -13.7800
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.4542
Cell Significance Index: -6.9100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4713
Cell Significance Index: -6.7500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4799
Cell Significance Index: -8.4800
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.5030
Cell Significance Index: -7.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Scaffold Protein Function:** PPP2R1B acts as a scaffold protein, facilitating the assembly and regulation of the PP2A complex. 2. **Regulation of PP2A Activity:** PPP2R1B modulates the activity of PP2A by interacting with its regulatory subunits, thereby influencing the complex's substrate specificity and activity. 3. **Cellular Expression:** PPP2R1B is widely expressed in various cell types, including immune cells, epithelial cells, and fibroblasts. 4. **Pathway Involvement:** PPP2R1B is implicated in multiple signaling pathways, including those involved in immune response, cell cycle regulation, and signal transduction. **Pathways and Functions:** 1. **Adaptive Immune System:** PPP2R1B is involved in regulating T-cell activation and proliferation through the CD28 co-stimulation pathway. 2. **Antiviral Mechanisms:** PPP2R1B modulates the activity of interferon-stimulated genes, which are crucial for antiviral defense. 3. **Cell Cycle Regulation:** PPP2R1B regulates cell cycle progression by phosphorylating and dephosphorylating key proteins, such as cyclin-dependent kinases and cyclin-dependent phosphatases. 4. **Signal Transduction:** PPP2R1B interacts with various signaling proteins, including Akt, MAPK, and NF-κB, to regulate their activity and downstream effects. **Clinical Significance:** Dysregulation of PPP2R1B has been implicated in various diseases, including cancer, autoimmune disorders, and metabolic disorders. For example: 1. **Cancer:** Alterations in PPP2R1B expression have been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune Disorders:** PPP2R1B is involved in regulating T-cell activation and proliferation, which is dysregulated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Metabolic Disorders:** PPP2R1B regulates glucose metabolism and insulin signaling, which is impaired in metabolic disorders, such as type 2 diabetes. In conclusion, PPP2R1B is a multifunctional protein that plays a crucial role in regulating various cellular processes, including immune response, cell cycle progression, and signal transduction pathways. Its dysregulation has been implicated in various diseases, highlighting the importance of PPP2R1B in maintaining cellular homeostasis and promoting overall health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Genular Protein ID: 2924028128

Symbol: 2AAB_HUMAN

Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

UniProtKB Accession Codes:

P30154 A8MY67 B0YJ69 B4DGQ6 B4DK91 B4DWW5 F8W8G1 O75620 Q8NHV8

Database IDs:

Citations:

PubMed ID: 9795170

Title: Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23.

PubMed ID: 9795170

DOI: 10.1016/s0378-1119(98)00350-3

PubMed ID: 9765152

Title: Alterations of the PPP2R1B gene in human lung and colon cancer.

PubMed ID: 9765152

DOI: 10.1126/science.282.5387.284

PubMed ID: 11313745

Title: A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region.

PubMed ID: 11313745

DOI: 10.1038/sj.ejhg.5200585

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2159327

Title: Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure.

PubMed ID: 2159327

DOI: 10.1021/bi00465a002

PubMed ID: 10801873

Title: Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation.

PubMed ID: 10801873

DOI: 10.1074/jbc.m003259200

PubMed ID: 12670497

Title: Interaction between protein phosphatase 2A and members of the importin beta superfamily.

PubMed ID: 12670497

DOI: 10.1016/s0006-291x(03)00434-0

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10597236

Title: Absence of PPP2R1B gene alterations in primary ovarian cancers.

PubMed ID: 10597236

DOI: 10.1038/sj.onc.1203070

PubMed ID: 10896920

Title: Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers.

PubMed ID: 10896920

DOI: 10.1136/gut.47.2.268

PubMed ID: 11996789

Title: Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas.

PubMed ID: 11996789

DOI: 10.1016/s0165-4608(01)00597-0

Sequence Information:

Length: 601
Mass: 66214
Checksum: 86AB20D7505210B0
Sequence:

MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR 
SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA 
VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ 
QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC 
VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ 
NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV 
IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI 
VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK 
LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM 
AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL 
A

Database document:

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Details for: PPP2R1B

Associated with

Cells (max top 100)

Other Information

Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. PubMed ID: 9795170

Alterations of the PPP2R1B gene in human lung and colon cancer. PubMed ID: 9765152

A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. PubMed ID: 11313745

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure. PubMed ID: 2159327

Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation. PubMed ID: 10801873

Interaction between protein phosphatase 2A and members of the importin beta superfamily. PubMed ID: 12670497

Shugoshin collaborates with protein phosphatase 2A to protect cohesin. PubMed ID: 16541025

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Absence of PPP2R1B gene alterations in primary ovarian cancers. PubMed ID: 10597236

Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers. PubMed ID: 10896920

Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. PubMed ID: 11996789