PPP2R5D | ENSG00000112640 | NCBI 5528

Details for: PPP2R5D

Gene ID: 5528

Symbol: PPP2R5D

Ensembl ID: ENSG00000112640

Description: protein phosphatase 2 regulatory subunit B'delta

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Apc truncation mutants have impaired axin binding
(R-HSA-5467337)
Axin missense mutants destabilize the destruction complex
(R-HSA-5467340)
Beta-catenin phosphorylation cascade
(R-HSA-196299)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Costimulation by the cd28 family
(R-HSA-388841)
Ctla4 inhibitory signaling
(R-HSA-389513)
Ctnnb1 s33 mutants aren't phosphorylated
(R-HSA-5358747)
Ctnnb1 s37 mutants aren't phosphorylated
(R-HSA-5358749)
Ctnnb1 s45 mutants aren't phosphorylated
(R-HSA-5358751)
Ctnnb1 t41 mutants aren't phosphorylated
(R-HSA-5358752)
Cytokine signaling in immune system
(R-HSA-1280215)
Darpp-32 events
(R-HSA-180024)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-HSA-4641262)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Erk/mapk targets
(R-HSA-198753)
Erks are inactivated
(R-HSA-202670)
G alpha (i) signalling events
(R-HSA-418594)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Negative regulation of mapk pathway
(R-HSA-5675221)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet homeostasis
(R-HSA-418346)
Platelet sensitization by ldl
(R-HSA-432142)
Pp2a-mediated dephosphorylation of key metabolic factors
(R-HSA-163767)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
(R-HSA-9634600)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by amer1 mutants
(R-HSA-4839748)
Signaling by apc mutants
(R-HSA-4839744)
Signaling by axin mutants
(R-HSA-4839735)
Signaling by ctnnb1 phospho-site mutants
(R-HSA-4839743)
Signaling by gpcr
(R-HSA-372790)
Signaling by gsk3beta mutants
(R-HSA-5339716)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by wnt
(R-HSA-195721)
Signaling by wnt in cancer
(R-HSA-4791275)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Truncations of amer1 destabilize the destruction complex
(R-HSA-5467348)
Phosphoprotein phosphatase activity
(GO:0004721)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein phosphatase activator activity
(GO:0072542)
Protein phosphatase regulator activity
(GO:0019888)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 98.1065
Cell Significance Index: -15.2600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 62.2133
Cell Significance Index: -15.7800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 38.9855
Cell Significance Index: -16.0600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 35.8640
Cell Significance Index: -14.5700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.2711
Cell Significance Index: -14.5800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 13.4879
Cell Significance Index: -16.6300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.8196
Cell Significance Index: -15.5900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.0530
Cell Significance Index: -15.5200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.2828
Cell Significance Index: -16.9000
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 2.2593
Cell Significance Index: 37.2300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1685
Cell Significance Index: 115.6000
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.7936
Cell Significance Index: 4.9100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7742
Cell Significance Index: 84.2100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7599
Cell Significance Index: 45.6200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6740
Cell Significance Index: 135.2100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6690
Cell Significance Index: 108.8000
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.6012
Cell Significance Index: 12.8500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5814
Cell Significance Index: 16.7500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5705
Cell Significance Index: 66.4900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4942
Cell Significance Index: 446.1800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4366
Cell Significance Index: 30.1900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.4148
Cell Significance Index: 5.6600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4108
Cell Significance Index: 81.5300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.3962
Cell Significance Index: 20.6400
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3327
Cell Significance Index: 119.3400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3323
Cell Significance Index: 7.2000
Cell Name: decidual cell (CL2000002)
Fold Change: 0.3297
Cell Significance Index: 5.2900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2431
Cell Significance Index: 11.0200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2336
Cell Significance Index: 5.8400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2146
Cell Significance Index: 38.6800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1996
Cell Significance Index: 27.4100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1971
Cell Significance Index: 5.7900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.1860
Cell Significance Index: 11.7200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1777
Cell Significance Index: 9.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1766
Cell Significance Index: 7.8100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1717
Cell Significance Index: 6.5000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1676
Cell Significance Index: 31.9000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1672
Cell Significance Index: 12.8300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1408
Cell Significance Index: 17.3100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1390
Cell Significance Index: 2.9600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1378
Cell Significance Index: 3.8500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1326
Cell Significance Index: 15.6400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.1299
Cell Significance Index: 1.3500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1215
Cell Significance Index: 53.7300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1084
Cell Significance Index: 59.1900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0871
Cell Significance Index: 4.0600
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0870
Cell Significance Index: 1.9100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0744
Cell Significance Index: 4.5700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0470
Cell Significance Index: 32.5200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0396
Cell Significance Index: 1.3900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0389
Cell Significance Index: 2.0400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0114
Cell Significance Index: 0.7400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0091
Cell Significance Index: 17.1400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0054
Cell Significance Index: 7.3000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0048
Cell Significance Index: 7.3800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0047
Cell Significance Index: 0.6000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0020
Cell Significance Index: 0.1100
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0019
Cell Significance Index: 3.5100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0053
Cell Significance Index: -2.3900
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0056
Cell Significance Index: -3.5800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0131
Cell Significance Index: -9.5800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0176
Cell Significance Index: -2.5700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0183
Cell Significance Index: -13.8400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0213
Cell Significance Index: -15.7900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0251
Cell Significance Index: -0.4300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0256
Cell Significance Index: -1.7200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0279
Cell Significance Index: -15.7300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0291
Cell Significance Index: -18.2000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0371
Cell Significance Index: -6.3400
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0379
Cell Significance Index: -0.7400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0441
Cell Significance Index: -3.1200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0482
Cell Significance Index: -13.8800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0510
Cell Significance Index: -5.2100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0711
Cell Significance Index: -1.1900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0718
Cell Significance Index: -9.2800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0757
Cell Significance Index: -2.6300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0865
Cell Significance Index: -18.2100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0951
Cell Significance Index: -10.9000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1015
Cell Significance Index: -3.2500
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1059
Cell Significance Index: -2.7900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1088
Cell Significance Index: -2.9200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1288
Cell Significance Index: -3.3100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1294
Cell Significance Index: -6.0800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1341
Cell Significance Index: -3.5800
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.1359
Cell Significance Index: -1.7400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1424
Cell Significance Index: -2.9800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1438
Cell Significance Index: -14.9700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1492
Cell Significance Index: -11.1200
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1796
Cell Significance Index: -5.1300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1817
Cell Significance Index: -14.3900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1876
Cell Significance Index: -4.5000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1892
Cell Significance Index: -5.1500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1949
Cell Significance Index: -11.9500
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2191
Cell Significance Index: -4.6500
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2790
Cell Significance Index: -4.0000
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2994
Cell Significance Index: -4.4200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3009
Cell Significance Index: -8.0500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3045
Cell Significance Index: -9.9700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3064
Cell Significance Index: -9.7600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3143
Cell Significance Index: -9.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Regulatory Subunit of PP2A:** PPP2R5D is a regulatory subunit of PP2A, a serine/threonine phosphatase that plays a central role in dephosphorylating and regulating various proteins. 2. **Multi-Faceted Signaling:** PPP2R5D is involved in numerous signaling pathways, including those related to immune responses, cell cycle regulation, and metabolism. 3. **High Expression Levels:** PPP2R5D is highly expressed in various cell types, including immune cells, neural cells, and epithelial cells, suggesting its widespread importance in cellular function. 4. **Subcellular Localization:** PPP2R5D is primarily localized to the cytoplasm, although it may also be found in the nucleus and mitochondria. **Pathways and Functions:** 1. **Adaptive Immune Response:** PPP2R5D is involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. 2. **Cell Cycle Regulation:** PPP2R5D plays a role in regulating the cell cycle, particularly in the G2/M phase, by dephosphorylating and activating key proteins. 3. **Metabolism:** PPP2R5D is involved in the regulation of metabolic pathways, including glycolysis and glucose metabolism. 4. **Cytokine Signaling:** PPP2R5D is a key regulator of cytokine signaling, including the activation of NF-κB and the production of pro-inflammatory cytokines. 5. **Wnt Signaling:** PPP2R5D is involved in the regulation of Wnt signaling, which plays a critical role in cell proliferation, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** Alterations in PPP2R5D expression have been associated with various types of cancer, including colorectal, breast, and lung cancer. 2. **Neurological Disorders:** PPP2R5D has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Immune-Mediated Diseases:** PPP2R5D is involved in the regulation of immune-mediated diseases, including rheumatoid arthritis and lupus. 4. **Metabolic Disorders:** PPP2R5D has been linked to metabolic disorders, including diabetes and obesity. In conclusion, PPP2R5D is a multifunctional regulatory subunit of PP2A that plays a critical role in regulating various cellular processes, including immune responses, cell cycle regulation, and metabolism. Its involvement in multiple signaling pathways underscores its importance in maintaining cellular homeostasis and responding to environmental cues. Further research is necessary to fully elucidate the functions of PPP2R5D and its role in various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

Genular Protein ID: 692994211

Symbol: 2A5D_HUMAN

Name: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

UniProtKB Accession Codes:

Q14738 A8K3I9 B5BUA6 O00494 O00696 Q15171 Q5TC39

Database IDs:

Citations:

PubMed ID: 8703017

Title: The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.

PubMed ID: 8703017

DOI: 10.1074/jbc.271.36.22081

PubMed ID: 9180267

Title: Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A.

PubMed ID: 9180267

DOI: 10.1016/s0014-5793(97)00392-x

PubMed ID: 8566219

Title: Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A.

PubMed ID: 8566219

DOI: 10.1016/0014-5793(95)01500-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16541025

Title: Shugoshin collaborates with protein phosphatase 2A to protect cohesin.

PubMed ID: 16541025

DOI: 10.1038/nature04663

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22976297

Title: A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

PubMed ID: 22976297

DOI: 10.1242/jcs.111427

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 37761890

Title: Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients.

PubMed ID: 37761890

DOI: 10.3390/genes14091750

PubMed ID: 25533962

Title: Large-scale discovery of novel genetic causes of developmental disorders.

PubMed ID: 25533962

DOI: 10.1038/nature14135

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 26168268

Title: B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability.

PubMed ID: 26168268

DOI: 10.1172/jci79860

Sequence Information:

Length: 602
Mass: 69992
Checksum: F15F71AF4E565387
Sequence:

MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEAQPQP QPQPQPQAQS QPPSSNKRPS 
NSTPPPTQLS KIKYSGGPQI VKKERRQSSS RFNLSKNREL QKLPALKDSP TQEREELFIQ 
KLRQCCVLFD FVSDPLSDLK FKEVKRAGLN EMVEYITHSR DVVTEAIYPE AVTMFSVNLF 
RTLPPSSNPT GAEFDPEEDE PTLEAAWPHL QLVYEFFLRF LESPDFQPNI AKKYIDQKFV 
LALLDLFDSE DPRERDFLKT ILHRIYGKFL GLRAYIRRQI NHIFYRFIYE TEHHNGIAEL 
LEILGSIING FALPLKEEHK MFLIRVLLPL HKVKSLSVYH PQLAYCVVQF LEKESSLTEP 
VIVGLLKFWP KTHSPKEVMF LNELEEILDV IEPSEFSKVM EPLFRQLAKC VSSPHFQVAE 
RALYYWNNEY IMSLISDNAA RVLPIMFPAL YRNSKSHWNK TIHGLIYNAL KLFMEMNQKL 
FDDCTQQYKA EKQKGRFRMK EREEMWQKIE ELARLNPQYP MFRAPPPLPP VYSMETETPT 
AEDIQLLKRT VETEAVQMLK DIKKEKVLLR RKSELPQDVY TIKALEAHKR AEEFLTASQE 
AL

Database document:

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Details for: PPP2R5D

Associated with

Cells (max top 100)

Other Information

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. PubMed ID: 8703017

Molecular heterogeneity of the cDNA encoding a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A. PubMed ID: 9180267

Molecular cloning of a 74-kDa regulatory subunit (B'' or delta) of human protein phosphatase 2A. PubMed ID: 8566219

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Shugoshin collaborates with protein phosphatase 2A to protect cohesin. PubMed ID: 16541025

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex. PubMed ID: 22976297

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients. PubMed ID: 37761890

Large-scale discovery of novel genetic causes of developmental disorders. PubMed ID: 25533962

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978

B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability. PubMed ID: 26168268