Details for: PPP5C

Gene ID: 5536

Symbol: PPP5C

Ensembl ID: ENSG00000011485

Description: protein phosphatase 5 catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.3761
    Cell Significance Index: -27.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.1583
    Cell Significance Index: -27.1800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.6353
    Cell Significance Index: -29.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.9651
    Cell Significance Index: -25.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 26.9706
    Cell Significance Index: -25.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.6667
    Cell Significance Index: -29.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.9889
    Cell Significance Index: -24.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4961
    Cell Significance Index: -29.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.3744
    Cell Significance Index: -22.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7430
    Cell Significance Index: 172.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6777
    Cell Significance Index: 22.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1664
    Cell Significance Index: 233.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0340
    Cell Significance Index: 46.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9363
    Cell Significance Index: 152.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9078
    Cell Significance Index: 325.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8956
    Cell Significance Index: 177.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8883
    Cell Significance Index: 53.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7388
    Cell Significance Index: 19.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5900
    Cell Significance Index: 45.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5282
    Cell Significance Index: 476.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5063
    Cell Significance Index: 26.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4781
    Cell Significance Index: 13.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4657
    Cell Significance Index: 10.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4277
    Cell Significance Index: 233.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3564
    Cell Significance Index: 64.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3146
    Cell Significance Index: 38.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2925
    Cell Significance Index: 34.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2543
    Cell Significance Index: 14.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2537
    Cell Significance Index: 7.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2510
    Cell Significance Index: 173.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2373
    Cell Significance Index: 32.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2338
    Cell Significance Index: 16.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2200
    Cell Significance Index: 97.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2102
    Cell Significance Index: 12.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1770
    Cell Significance Index: 11.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1655
    Cell Significance Index: 8.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1582
    Cell Significance Index: 8.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1562
    Cell Significance Index: 3.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1508
    Cell Significance Index: 7.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1352
    Cell Significance Index: 3.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1296
    Cell Significance Index: 4.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1041
    Cell Significance Index: 13.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0998
    Cell Significance Index: 6.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0594
    Cell Significance Index: 11.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0548
    Cell Significance Index: 1.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0308
    Cell Significance Index: 1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0299
    Cell Significance Index: 13.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0207
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0202
    Cell Significance Index: 38.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0139
    Cell Significance Index: 8.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0048
    Cell Significance Index: 8.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0017
    Cell Significance Index: -2.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0046
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0111
    Cell Significance Index: -15.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0144
    Cell Significance Index: -1.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0154
    Cell Significance Index: -1.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0185
    Cell Significance Index: -14.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0273
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0319
    Cell Significance Index: -23.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0495
    Cell Significance Index: -27.9300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0521
    Cell Significance Index: -32.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0593
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0681
    Cell Significance Index: -11.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0716
    Cell Significance Index: -1.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0798
    Cell Significance Index: -3.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0871
    Cell Significance Index: -25.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0927
    Cell Significance Index: -4.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0928
    Cell Significance Index: -1.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0979
    Cell Significance Index: -7.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0998
    Cell Significance Index: -11.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1090
    Cell Significance Index: -15.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1123
    Cell Significance Index: -1.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1159
    Cell Significance Index: -2.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1363
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1520
    Cell Significance Index: -32.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1614
    Cell Significance Index: -6.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1746
    Cell Significance Index: -20.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1783
    Cell Significance Index: -5.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1828
    Cell Significance Index: -4.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1859
    Cell Significance Index: -2.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2072
    Cell Significance Index: -4.9700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2079
    Cell Significance Index: -3.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2235
    Cell Significance Index: -2.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2335
    Cell Significance Index: -6.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2436
    Cell Significance Index: -25.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2933
    Cell Significance Index: -23.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3350
    Cell Significance Index: -7.1100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3380
    Cell Significance Index: -7.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3548
    Cell Significance Index: -21.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4704
    Cell Significance Index: -9.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5110
    Cell Significance Index: -16.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5262
    Cell Significance Index: -16.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5540
    Cell Significance Index: -7.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5920
    Cell Significance Index: -15.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5963
    Cell Significance Index: -11.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6124
    Cell Significance Index: -14.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6149
    Cell Significance Index: -7.3300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6154
    Cell Significance Index: -12.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** PPP5C shares significant structural homology with other PP5 subunits, suggesting a conserved evolutionary pathway. 2. **Phosphatase Activity:** PPP5C possesses phosphatase activity, specifically dephosphorylating serine and threonine residues on target proteins. 3. **Cellular Localization:** PPP5C is primarily localized in the cytosol, nucleus, and nucleoplasm, indicating its involvement in various cellular processes. **Pathways and Functions:** 1. **DNA Damage Response:** PPP5C plays a critical role in the recruitment and phosphorylation of repair and signaling proteins at DNA double-strand breaks, mediated by ATM and ERK pathways. 2. **Signaling by Nuclear Receptors:** PPP5C interacts with nuclear receptors, influencing transcriptional regulation and gene expression. 3. **Mitotic Cell Cycle:** PPP5C regulates the mitotic cell cycle by dephosphorylating and activating key proteins involved in cell cycle progression. 4. **Neurotransmitter Signaling:** PPP5C is expressed in neurons, where it modulates neurotransmitter signaling, including GABAergic and glutamatergic neurotransmission. 5. **Apoptosis and Cell Survival:** PPP5C influences apoptosis and cell survival by regulating the activity of pro-survival and pro-apoptotic proteins. **Clinical Significance:** 1. **Cancer:** Altered PPP5C expression has been linked to various cancers, including lung, breast, and colon cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Neurological Disorders:** PPP5C mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, highlighting its role in neuronal development and function. 3. **Neurodegenerative Diseases:** PPP5C is implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, where it regulates protein degradation and aggregation. 4. **Therapeutic Applications:** PPP5C inhibitors have shown promise in preclinical studies as potential therapeutic agents for various diseases, including cancer and neurological disorders. In conclusion, PPP5C is a multifaceted protein phosphatase that plays a critical role in various cellular processes, including DNA damage response, signaling by nuclear receptors, and neurotransmitter signaling. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and neurodegenerative diseases. Further research is necessary to fully elucidate the complexities of PPP5C and its potential therapeutic applications.

Genular Protein ID: 2192094025

Symbol: PPP5_HUMAN

Name: Serine/threonine-protein phosphatase 5

UniProtKB Accession Codes:

P53041 Q16722 Q53XV2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 7 EMDB 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 8 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7925273

Title: A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus.

PubMed ID: 7925273

DOI: 10.1002/j.1460-2075.1994.tb06748.x

PubMed ID: 8666404

Title: Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3.

PubMed ID: 8666404

DOI: 10.1006/geno.1995.9972

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8561788

Title: Chromosomal localization and 5' sequence of the human protein serine/threonine phosphatase 5' gene.

PubMed ID: 8561788

DOI: 10.1006/bbrc.1996.0092

PubMed ID: 9000529

Title: Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain.

PubMed ID: 9000529

DOI: 10.1016/s0014-5793(96)01427-5

PubMed ID: 9405394

Title: The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex.

PubMed ID: 9405394

DOI: 10.1074/jbc.272.51.32011

PubMed ID: 14871926

Title: Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.

PubMed ID: 14871926

DOI: 10.1101/gad.1176004

PubMed ID: 14764652

Title: Protein phosphatase 5 is a negative regulator of estrogen receptor-mediated transcription.

PubMed ID: 14764652

DOI: 10.1210/me.2003-0308

PubMed ID: 14734805

Title: DNA-PKcs function regulated specifically by protein phosphatase 5.

PubMed ID: 14734805

DOI: 10.1073/pnas.0307765100

PubMed ID: 15383005

Title: Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.

PubMed ID: 15383005

DOI: 10.1042/bj20040690

PubMed ID: 15546861

Title: Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.

PubMed ID: 15546861

DOI: 10.1074/jbc.m410775200

PubMed ID: 16260606

Title: Protein phosphatase 5 is required for ATR-mediated checkpoint activation.

PubMed ID: 16260606

DOI: 10.1128/mcb.25.22.9910-9919.2005

PubMed ID: 16892053

Title: Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.

PubMed ID: 16892053

DOI: 10.1038/ncb1465

PubMed ID: 16790549

Title: Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5.

PubMed ID: 16790549

DOI: 10.1073/pnas.0604138103

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19176521

Title: Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage.

PubMed ID: 19176521

DOI: 10.1074/jbc.m809272200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19948726

Title: Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro.

PubMed ID: 19948726

DOI: 10.1074/jbc.m109.088427

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21144835

Title: Protein phosphatase 5 is necessary for ATR-mediated DNA repair.

PubMed ID: 21144835

DOI: 10.1016/j.bbrc.2010.12.005

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 22399290

Title: S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.

PubMed ID: 22399290

DOI: 10.1074/jbc.m111.329771

PubMed ID: 23102700

Title: The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

PubMed ID: 23102700

DOI: 10.1016/j.molcel.2012.09.018

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 29127155

Title: Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

PubMed ID: 29127155

DOI: 10.15252/embj.201796700

PubMed ID: 30699359

Title: Post-translational regulation of FNIP1 creates a rheostat for the molecular chaperone Hsp90.

PubMed ID: 30699359

DOI: 10.1016/j.celrep.2019.01.018

PubMed ID: 9482716

Title: The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.

PubMed ID: 9482716

DOI: 10.1093/emboj/17.5.1192

PubMed ID: 15155720

Title: Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5.

PubMed ID: 15155720

DOI: 10.1074/jbc.m402855200

PubMed ID: 15577939

Title: Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

PubMed ID: 15577939

DOI: 10.1038/sj.emboj.7600496

PubMed ID: 16531226

Title: Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

PubMed ID: 16531226

DOI: 10.1016/j.str.2005.12.009

PubMed ID: 19601647

Title: Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin.

PubMed ID: 19601647

DOI: 10.1021/jm900610k

Sequence Information:

  • Length: 499
  • Mass: 56879
  • Checksum: DB3B2090D8658BB3
  • Sequence:
    • MAMAEGERTE CAEPPRDEPP ADGALKRAEE LKTQANDYFK AKDYENAIKF YSQAIELNPS 
NAIYYGNRSL AYLRTECYGY ALGDATRAIE LDKKYIKGYY RRAASNMALG KFRAALRDYE 
TVVKVKPHDK DAKMKYQECN KIVKQKAFER AIAGDEHKRS VVDSLDIESM TIEDEYSGPK 
LEDGKVTISF MKELMQWYKD QKKLHRKCAY QILVQVKEVL SKLSTLVETT LKETEKITVC 
GDTHGQFYDL LNIFELNGLP SETNPYIFNG DFVDRGSFSV EVILTLFGFK LLYPDHFHLL 
RGNHETDNMN QIYGFEGEVK AKYTAQMYEL FSEVFEWLPL AQCINGKVLI MHGGLFSEDG 
VTLDDIRKIE RNRQPPDSGP MCDLLWSDPQ PQNGRSISKR GVSCQFGPDV TKAFLEENNL 
DYIIRSHEVK AEGYEVAHGG RCVTVFSAPN YCDQMGNKAS YIHLQGSDLR PQFHQFTAVP 
HPNVKPMAYA NTLLQLGMM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.