Details for: PPP6C

Gene ID: 5537

Symbol: PPP6C

Ensembl ID: ENSG00000119414

Description: protein phosphatase 6 catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 227.0722
    Cell Significance Index: -35.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.6302
    Cell Significance Index: -38.4600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 103.8482
    Cell Significance Index: -42.7800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.4045
    Cell Significance Index: -37.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.4169
    Cell Significance Index: -43.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.7869
    Cell Significance Index: -42.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 64.3794
    Cell Significance Index: -43.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.5866
    Cell Significance Index: -37.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.3021
    Cell Significance Index: -41.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1291
    Cell Significance Index: -37.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9096
    Cell Significance Index: -43.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4836
    Cell Significance Index: -32.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.0515
    Cell Significance Index: -19.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2035
    Cell Significance Index: 256.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0805
    Cell Significance Index: 338.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3147
    Cell Significance Index: 263.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9754
    Cell Significance Index: 115.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9445
    Cell Significance Index: 27.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6859
    Cell Significance Index: 136.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6617
    Cell Significance Index: 17.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5830
    Cell Significance Index: 27.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5665
    Cell Significance Index: 203.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4999
    Cell Significance Index: 13.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4742
    Cell Significance Index: 58.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4674
    Cell Significance Index: 84.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4216
    Cell Significance Index: 230.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4113
    Cell Significance Index: 181.8500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4111
    Cell Significance Index: 11.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4029
    Cell Significance Index: 363.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3915
    Cell Significance Index: 29.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3634
    Cell Significance Index: 27.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3511
    Cell Significance Index: 24.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3242
    Cell Significance Index: 224.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2812
    Cell Significance Index: 38.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2719
    Cell Significance Index: 12.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2345
    Cell Significance Index: 13.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2052
    Cell Significance Index: 5.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1929
    Cell Significance Index: 12.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1826
    Cell Significance Index: 9.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1782
    Cell Significance Index: 33.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1743
    Cell Significance Index: 22.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1694
    Cell Significance Index: 3.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1483
    Cell Significance Index: 19.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1354
    Cell Significance Index: 9.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1099
    Cell Significance Index: 18.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1066
    Cell Significance Index: 2.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0589
    Cell Significance Index: 2.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0582
    Cell Significance Index: 109.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0449
    Cell Significance Index: 20.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0268
    Cell Significance Index: 17.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0268
    Cell Significance Index: 0.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0211
    Cell Significance Index: 38.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0161
    Cell Significance Index: 24.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0057
    Cell Significance Index: 0.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0128
    Cell Significance Index: -1.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0223
    Cell Significance Index: -16.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0381
    Cell Significance Index: -28.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0509
    Cell Significance Index: -5.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0672
    Cell Significance Index: -37.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0794
    Cell Significance Index: -49.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1071
    Cell Significance Index: -6.5800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1193
    Cell Significance Index: -34.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1422
    Cell Significance Index: -3.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1449
    Cell Significance Index: -21.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1726
    Cell Significance Index: -7.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1816
    Cell Significance Index: -3.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1963
    Cell Significance Index: -5.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2085
    Cell Significance Index: -13.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2121
    Cell Significance Index: -3.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2152
    Cell Significance Index: -24.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2292
    Cell Significance Index: -7.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2298
    Cell Significance Index: -48.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2573
    Cell Significance Index: -9.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2688
    Cell Significance Index: -6.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3005
    Cell Significance Index: -11.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3341
    Cell Significance Index: -10.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3471
    Cell Significance Index: -36.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3496
    Cell Significance Index: -4.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3672
    Cell Significance Index: -7.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3902
    Cell Significance Index: -20.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3991
    Cell Significance Index: -11.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4320
    Cell Significance Index: -34.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4786
    Cell Significance Index: -9.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5113
    Cell Significance Index: -6.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5341
    Cell Significance Index: -11.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5407
    Cell Significance Index: -33.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5793
    Cell Significance Index: -16.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5864
    Cell Significance Index: -14.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6331
    Cell Significance Index: -16.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6855
    Cell Significance Index: -14.2200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.7106
    Cell Significance Index: -7.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7857
    Cell Significance Index: -11.6000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8209
    Cell Significance Index: -4.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8586
    Cell Significance Index: -27.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8636
    Cell Significance Index: -18.9100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8687
    Cell Significance Index: -28.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8703
    Cell Significance Index: -13.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine/threonine phosphatase activity**: PPP6C is a serine/threonine phosphatase, which means it removes phosphate groups from serine and threonine residues on target proteins, thereby modulating their activity. 2. **Catalytic subunit**: PPP6C is a catalytic subunit of protein phosphatase 6 (PP6), which is a heteromeric phosphatase composed of catalytic and regulatory subunits. 3. **Widespread expression**: PPP6C is expressed in various cell types, including hematopoietic cells, immune cells, and neurons. 4. **Implicated in multiple signaling pathways**: PPP6C has been implicated in several signaling pathways, including the negative regulation of the cGAS/STING pathway, cell cycle regulation, and telomere maintenance. **Pathways and Functions** 1. **Cell cycle regulation**: PPP6C plays a role in regulating the G1/S transition of the cell cycle, ensuring proper cell proliferation and preventing uncontrolled cell growth. 2. **Telomere maintenance**: PPP6C is involved in telomere extension and maintenance by regulating the activity of telomerase, an enzyme responsible for elongating telomeres. 3. **Protein dephosphorylation**: PPP6C removes phosphate groups from target proteins, thereby modulating their activity and function. 4. **Innate immune response**: PPP6C has been implicated in the negative regulation of the cGAS/STING pathway, which is involved in innate immune responses. 5. **Mitochondrial function**: PPP6C has been shown to interact with mitochondrial proteins and regulate mitochondrial function. **Clinical Significance** 1. **Cancer**: Alterations in PPP6C expression or function have been implicated in various cancers, including breast, lung, and colon cancer. 2. **Autoimmune diseases**: PPP6C has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological disorders**: PPP6C has been shown to interact with neurotrophic factors and regulate neuronal function, suggesting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immune-related disorders**: PPP6C has been implicated in immune-related disorders, such as multiple sclerosis and type 1 diabetes. In conclusion, PPP6C is a multifunctional gene that plays a crucial role in various cellular processes, including cell cycle regulation, telomere maintenance, and protein dephosphorylation. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and neurological disorders, highlighting its importance as a potential therapeutic target.

Genular Protein ID: 2904954603

Symbol: PPP6_HUMAN

Name: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed

UniProtKB Accession Codes:

O00743 B2R5V6 B7Z2W9 B7Z5K9 Q5U0A2 Q9UIC9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9013334

Title: The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.

PubMed ID: 9013334

DOI: 10.1242/jcs.109.12.2865

PubMed ID: 10227379

Title: Identification of a type 6 protein Ser/Thr phosphatase regulated by interleukin-2 stimulation.

PubMed ID: 10227379

DOI: 10.1002/(sici)1097-4644(19990501)73:2<153::aid-jcb2>3.3.co;2-z

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9647778

Title: Alpha 4 associates with protein phosphatases 2A, 4, and 6.

PubMed ID: 9647778

DOI: 10.1006/bbrc.1998.8792

PubMed ID: 16769727

Title: Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.

PubMed ID: 16769727

DOI: 10.1074/jbc.m601772200

PubMed ID: 17079228

Title: Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway.

PubMed ID: 17079228

DOI: 10.1074/jbc.m608155200

PubMed ID: 17568194

Title: Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells.

PubMed ID: 17568194

DOI: 10.4161/cc.6.11.4276

PubMed ID: 18186651

Title: Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.

PubMed ID: 18186651

DOI: 10.1021/bi7022877

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27335426

Title: Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.

PubMed ID: 27335426

DOI: 10.1242/jcs.184416

PubMed ID: 29053956

Title: Assembly of the WHIP-TRIM14-PPP6C mitochondrial complex promotes RIG-I-mediated antiviral signaling.

PubMed ID: 29053956

DOI: 10.1016/j.molcel.2017.09.035

PubMed ID: 32753499

Title: PPP6C negatively regulates STING-dependent innate immune responses.

PubMed ID: 32753499

DOI: 10.1128/mbio.01728-20

PubMed ID: 32474700

Title: Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.

PubMed ID: 32474700

DOI: 10.1007/s13238-020-00729-3

Sequence Information:

  • Length: 305
  • Mass: 35144
  • Checksum: 55E95DB6CEA7CFF4
  • Sequence:
    • MAPLDLDKYV EIARLCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD 
LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT 
QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE 
RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV 
HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT 
TPYFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.