Details for: PRKAB2

Gene ID: 5565

Symbol: PRKAB2

Ensembl ID: ENSG00000131791

Description: protein kinase AMP-activated non-catalytic subunit beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.3386
    Cell Significance Index: -17.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.0894
    Cell Significance Index: -18.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.4270
    Cell Significance Index: -15.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.9415
    Cell Significance Index: -15.2200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8180
    Cell Significance Index: -18.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5812
    Cell Significance Index: -17.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6781
    Cell Significance Index: -18.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.4177
    Cell Significance Index: -7.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4576
    Cell Significance Index: 289.2700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.2564
    Cell Significance Index: 14.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1805
    Cell Significance Index: 25.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.1777
    Cell Significance Index: 137.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1022
    Cell Significance Index: 66.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0102
    Cell Significance Index: 109.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9406
    Cell Significance Index: 15.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8237
    Cell Significance Index: 133.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7277
    Cell Significance Index: 145.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5976
    Cell Significance Index: 41.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5827
    Cell Significance Index: 16.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4225
    Cell Significance Index: 26.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3717
    Cell Significance Index: 28.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3586
    Cell Significance Index: 323.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3350
    Cell Significance Index: 20.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3318
    Cell Significance Index: 15.0400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3310
    Cell Significance Index: 2.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2804
    Cell Significance Index: 7.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2420
    Cell Significance Index: 33.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2403
    Cell Significance Index: 86.1800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1786
    Cell Significance Index: 1.1100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1530
    Cell Significance Index: 15.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1481
    Cell Significance Index: 2.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1460
    Cell Significance Index: 5.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1366
    Cell Significance Index: 3.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1320
    Cell Significance Index: 16.2300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1311
    Cell Significance Index: 3.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1301
    Cell Significance Index: 24.7500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1266
    Cell Significance Index: 2.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1251
    Cell Significance Index: 22.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1219
    Cell Significance Index: 6.3300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1180
    Cell Significance Index: 0.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1145
    Cell Significance Index: 3.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1114
    Cell Significance Index: 2.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0981
    Cell Significance Index: 2.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0930
    Cell Significance Index: 41.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0829
    Cell Significance Index: 45.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0792
    Cell Significance Index: 1.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0688
    Cell Significance Index: 1.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0658
    Cell Significance Index: 2.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0643
    Cell Significance Index: 3.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0574
    Cell Significance Index: 6.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0502
    Cell Significance Index: 8.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0477
    Cell Significance Index: 21.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0384
    Cell Significance Index: 1.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0342
    Cell Significance Index: 1.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0146
    Cell Significance Index: 0.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0109
    Cell Significance Index: 0.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0098
    Cell Significance Index: 18.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0072
    Cell Significance Index: 0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0046
    Cell Significance Index: -7.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0147
    Cell Significance Index: -10.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0160
    Cell Significance Index: -11.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0210
    Cell Significance Index: -15.9100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0229
    Cell Significance Index: -2.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0260
    Cell Significance Index: -14.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0301
    Cell Significance Index: -18.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0403
    Cell Significance Index: -2.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0421
    Cell Significance Index: -6.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0434
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0573
    Cell Significance Index: -1.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0574
    Cell Significance Index: -3.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0582
    Cell Significance Index: -5.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0645
    Cell Significance Index: -18.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0745
    Cell Significance Index: -8.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0893
    Cell Significance Index: -18.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1217
    Cell Significance Index: -15.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1239
    Cell Significance Index: -4.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1269
    Cell Significance Index: -13.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1330
    Cell Significance Index: -6.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1389
    Cell Significance Index: -2.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1476
    Cell Significance Index: -1.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1546
    Cell Significance Index: -2.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1673
    Cell Significance Index: -8.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1742
    Cell Significance Index: -3.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1783
    Cell Significance Index: -9.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1881
    Cell Significance Index: -11.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1975
    Cell Significance Index: -15.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1983
    Cell Significance Index: -14.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2004
    Cell Significance Index: -5.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2438
    Cell Significance Index: -7.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2729
    Cell Significance Index: -8.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2766
    Cell Significance Index: -5.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3071
    Cell Significance Index: -9.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3242
    Cell Significance Index: -6.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3311
    Cell Significance Index: -10.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3448
    Cell Significance Index: -9.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3454
    Cell Significance Index: -9.9000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3753
    Cell Significance Index: -4.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-catalytic subunit of AMPK**: PRKAB2 is a non-catalytic subunit of the AMPK complex, which is activated in response to low energy levels within the cell. 2. **Regulation of energy metabolism**: PRKAB2 is involved in regulating energy metabolism by phosphorylating and activating various downstream targets, including PPARGC1α (PGC-1α) and SIRT1. 3. **Autophagy and lipid metabolism**: PRKAB2 is also involved in regulating autophagy and lipid metabolism, which are critical processes for maintaining cellular homeostasis. 4. **Immune response**: PRKAB2 has been implicated in regulating the immune response, particularly in the context of inflammation and immune cell function. **Pathways and Functions:** PRKAB2 is involved in several signaling pathways, including: 1. **Activation of AMPK downstream of NMDARs**: PRKAB2 is activated in response to NMDAR stimulation, which is a key event in neuronal signaling. 2. **Activation of NMDA receptors and postsynaptic events**: PRKAB2 is involved in regulating NMDA receptor-mediated synaptic plasticity and postsynaptic events. 3. **Activation of PPARGC1α by phosphorylation**: PRKAB2 phosphorylates and activates PPARGC1α, which is a transcriptional coactivator involved in regulating energy metabolism. 4. **Regulation of TP53 activity**: PRKAB2 phosphorylates and regulates TP53 activity, which is a key transcription factor involved in maintaining genome stability. **Clinical Significance:** Dysregulation of PRKAB2 has been implicated in various diseases, including: 1. **Type 2 diabetes**: PRKAB2 mutations have been associated with an increased risk of developing type 2 diabetes. 2. **Neurodegenerative diseases**: PRKAB2 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Inflammatory disorders**: PRKAB2 has been implicated in regulating the immune response and has been associated with inflammatory disorders, including rheumatoid arthritis and multiple sclerosis. In conclusion, PRKAB2 is a critical gene that plays a central role in regulating cellular metabolism, autophagy, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and responding to environmental cues.

Genular Protein ID: 891501067

Symbol: AAKB2_HUMAN

Name: 5'-AMP-activated protein kinase subunit beta-2

UniProtKB Accession Codes:

O43741 A8K9V5 B4DH06 Q5VXY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 13 EMDB 3 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9575201

Title: Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.

PubMed ID: 9575201

DOI: 10.1074/jbc.273.20.12443

PubMed ID: 12490143

Title: Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians.

PubMed ID: 12490143

DOI: 10.1006/mcpr.2002.0439

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 17307971

Title: AMP-activated protein kinase in metabolic control and insulin signaling.

PubMed ID: 17307971

DOI: 10.1161/01.res.0000256090.42690.05

PubMed ID: 17712357

Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

PubMed ID: 17712357

DOI: 10.1038/nrm2249

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17851531

Title: Structural basis for AMP binding to mammalian AMP-activated protein kinase.

PubMed ID: 17851531

DOI: 10.1038/nature06161

PubMed ID: 21399626

Title: Structure of mammalian AMPK and its regulation by ADP.

PubMed ID: 21399626

DOI: 10.1038/nature09932

Sequence Information:

  • Length: 272
  • Mass: 30302
  • Checksum: 42B23BD70B92519C
  • Sequence:
    • MGNTTSDRVS GERHGAKAAR SEGAGGHAPG KEHKIMVGST DDPSVFSLPD SKLPGDKEFV 
SWQQDLEDSV KPTQQARPTV IRWSEGGKEV FISGSFNNWS TKIPLIKSHN DFVAILDLPE 
GEHQYKFFVD GQWVHDPSEP VVTSQLGTIN NLIHVKKSDF EVFDALKLDS MESSETSCRD 
LSSSPPGPYG QEMYAFRSEE RFKSPPILPP HLLQVILNKD TNISCDPALL PEPNHVMLNH 
LYALSIKDSV MVLSATHRYK KKYVTTLLYK PI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.