PRKACA | ENSG00000072062 | NCBI 5566

Details for: PRKACA

Gene ID: 5566

Symbol: PRKACA

Ensembl ID: ENSG00000072062

Description: protein kinase cAMP-activated catalytic subunit alpha

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Aquaporin-mediated transport
(R-HSA-445717)
Aurka activation by tpx2
(R-HSA-8854518)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cardiac conduction
(R-HSA-5576891)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Darpp-32 events
(R-HSA-180024)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Disorders of developmental biology
(R-HSA-9675151)
Disorders of nervous system development
(R-HSA-9697154)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
G-protein mediated events
(R-HSA-112040)
G2/m transition
(R-HSA-69275)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hdl assembly
(R-HSA-8963896)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ion homeostasis
(R-HSA-5578775)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Loss of function of mecp2 in rett syndrome
(R-HSA-9005891)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of lipids
(R-HSA-556833)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial protein degradation
(R-HSA-9837999)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Muscle contraction
(R-HSA-397014)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Parasitic infection pathways
(R-HSA-9824443)
Pervasive developmental disorders
(R-HSA-9005895)
Pka-mediated phosphorylation of key metabolic factors
(R-HSA-163358)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Post nmda receptor activation events
(R-HSA-438064)
Rap1 signalling
(R-HSA-392517)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
(R-HSA-9634600)
Regulation of insulin secretion
(R-HSA-422356)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Ret signaling
(R-HSA-8853659)
Rna polymerase ii transcription
(R-HSA-73857)
Robo receptors bind akap5
(R-HSA-9010642)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by robo receptors
(R-HSA-376176)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Triglyceride catabolism
(R-HSA-163560)
Triglyceride metabolism
(R-HSA-8979227)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Vegfa-vegfr2 pathway
(R-HSA-4420097)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 186.1838
Cell Significance Index: -28.9600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 114.9251
Cell Significance Index: -29.1500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 80.5442
Cell Significance Index: -33.1800
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 59.7774
Cell Significance Index: -24.2900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 54.9345
Cell Significance Index: -28.2600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.6509
Cell Significance Index: -24.4900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.0601
Cell Significance Index: -29.6700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.9076
Cell Significance Index: -29.2200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.5924
Cell Significance Index: -29.9600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.3223
Cell Significance Index: -22.4900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.7313
Cell Significance Index: 99.9800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1880
Cell Significance Index: 1072.6400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.0726
Cell Significance Index: 125.0000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0173
Cell Significance Index: 204.0700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8610
Cell Significance Index: 93.6600
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.8582
Cell Significance Index: 12.6700
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.6548
Cell Significance Index: 5.5000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5654
Cell Significance Index: 202.7900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5427
Cell Significance Index: 41.6500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4434
Cell Significance Index: 60.8900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4029
Cell Significance Index: 72.6300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3755
Cell Significance Index: 74.5100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3320
Cell Significance Index: 40.8200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3159
Cell Significance Index: 4.3100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3133
Cell Significance Index: 216.6600
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2857
Cell Significance Index: 5.2800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2569
Cell Significance Index: 140.3100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2239
Cell Significance Index: 10.4400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2134
Cell Significance Index: 21.1100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1808
Cell Significance Index: 9.4200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1603
Cell Significance Index: 70.8900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1514
Cell Significance Index: 3.2800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1454
Cell Significance Index: 4.1900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1182
Cell Significance Index: 20.1900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1129
Cell Significance Index: 5.7100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0826
Cell Significance Index: 15.7200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0633
Cell Significance Index: 3.9900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0554
Cell Significance Index: 2.8800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0501
Cell Significance Index: 6.4200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0332
Cell Significance Index: 62.5300
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0179
Cell Significance Index: 0.8100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0176
Cell Significance Index: 27.0900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0159
Cell Significance Index: 21.6400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0071
Cell Significance Index: 0.2500
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0063
Cell Significance Index: 11.6400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0020
Cell Significance Index: -0.9200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0058
Cell Significance Index: -0.1600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0062
Cell Significance Index: -4.5700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0082
Cell Significance Index: -0.9400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0094
Cell Significance Index: -5.9700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0096
Cell Significance Index: -7.0700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0229
Cell Significance Index: -14.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0233
Cell Significance Index: -13.1500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0256
Cell Significance Index: -19.3500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0585
Cell Significance Index: -5.9800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0728
Cell Significance Index: -3.8200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0745
Cell Significance Index: -8.7900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0767
Cell Significance Index: -5.4300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0770
Cell Significance Index: -16.2100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0781
Cell Significance Index: -5.0400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0782
Cell Significance Index: -1.3400
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0791
Cell Significance Index: -2.2100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0877
Cell Significance Index: -25.2400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1146
Cell Significance Index: -14.8000
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1169
Cell Significance Index: -2.4900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1207
Cell Significance Index: -17.5500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1283
Cell Significance Index: -6.0300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1373
Cell Significance Index: -10.2300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1749
Cell Significance Index: -19.9700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1936
Cell Significance Index: -5.1700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2089
Cell Significance Index: -5.3700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2338
Cell Significance Index: -13.1200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2394
Cell Significance Index: -24.9300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2516
Cell Significance Index: -5.2200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2646
Cell Significance Index: -20.9600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2659
Cell Significance Index: -4.4500
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.3170
Cell Significance Index: -4.0600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3473
Cell Significance Index: -15.3600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3582
Cell Significance Index: -9.7500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3701
Cell Significance Index: -10.6100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3981
Cell Significance Index: -24.4100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4040
Cell Significance Index: -10.1000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4126
Cell Significance Index: -10.8500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4278
Cell Significance Index: -16.2000
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.4566
Cell Significance Index: -11.1400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4811
Cell Significance Index: -15.4100
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.4943
Cell Significance Index: -3.8100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.5352
Cell Significance Index: -11.7200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5452
Cell Significance Index: -22.3400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.5514
Cell Significance Index: -19.1600
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.5541
Cell Significance Index: -7.1100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.5744
Cell Significance Index: -7.1300
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5852
Cell Significance Index: -12.4200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6379
Cell Significance Index: -20.3200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6445
Cell Significance Index: -21.1000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6651
Cell Significance Index: -12.9800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6712
Cell Significance Index: -24.6400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6737
Cell Significance Index: -23.6000
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.7287
Cell Significance Index: -6.7100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.7580
Cell Significance Index: -10.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Catalytic activity**: PRKACA is a protein kinase that catalyzes the phosphorylation of specific amino acid residues, leading to the activation of downstream signaling pathways. 2. **cAMP-dependent**: PRKACA is activated by cyclic adenosine monophosphate (cAMP), a secondary messenger molecule that plays a key role in cellular signaling. 3. **Regulation of energy metabolism**: PRKACA is involved in the regulation of glucose metabolism, glycogenolysis, and lipid metabolism, highlighting its importance in energy homeostasis. 4. **Signal transduction**: PRKACA is a key component of the adenylate cyclase complex, which is responsible for generating cAMP and activating downstream signaling pathways. 5. **Cell cycle regulation**: PRKACA is involved in the regulation of cell cycle progression, particularly during the G2/M phase. **Pathways and Functions** 1. **Adenylate cyclase signaling**: PRKACA is a key component of the adenylate cyclase complex, which generates cAMP and activates downstream signaling pathways. 2. **Energy metabolism**: PRKACA is involved in the regulation of glucose metabolism, glycogenolysis, and lipid metabolism, highlighting its importance in energy homeostasis. 3. **Cell cycle regulation**: PRKACA is involved in the regulation of cell cycle progression, particularly during the G2/M phase. 4. **Signal transduction**: PRKACA is a key component of the adenylate cyclase complex, which is responsible for generating cAMP and activating downstream signaling pathways. 5. **Immune system regulation**: PRKACA is expressed in immune cells and is involved in the regulation of cytokine signaling and immune response. **Clinical Significance** 1. **Diseases of developmental biology**: Mutations in PRKACA have been implicated in disorders of developmental biology, including pervasive developmental disorders and disorders of nervous system development. 2. **Cancer**: PRKACA has been identified as a potential oncogene, with overexpression observed in various types of cancer, including breast and lung cancer. 3. **Metabolic disorders**: PRKACA is involved in the regulation of energy metabolism, and dysregulation of PRKACA has been implicated in metabolic disorders, including diabetes and obesity. 4. **Infectious diseases**: PRKACA is involved in the regulation of immune response, and dysregulation of PRKACA has been implicated in infectious diseases, including Leishmania infection. 5. **Neurological disorders**: PRKACA is expressed in neurons and is involved in the regulation of neurotransmitter signaling, highlighting its potential role in neurological disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, PRKACA is a critical gene that plays a pivotal role in various cellular processes, including energy metabolism, signal transduction, and cell cycle progression. Its dysregulation has been implicated in multiple diseases, including developmental disorders, cancer, metabolic disorders, infectious diseases, and neurological disorders. Further research is needed to fully understand the functions and clinical significance of PRKACA.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3566041801

Symbol: KAPCA_HUMAN

Name: cAMP-dependent protein kinase catalytic subunit alpha

UniProtKB Accession Codes:

P17612 Q32P54 Q9H2Y0 Q9NRB4 Q9NRH9

Database IDs:

Citations:

PubMed ID: 2843813

Title: A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha.

PubMed ID: 2843813

DOI: 10.1093/nar/16.16.8189

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10906071

Title: A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece.

PubMed ID: 10906071

DOI: 10.1095/biolreprod63.2.607

PubMed ID: 10982398

Title: The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative C-alpha mRNA expressed specifically in spermatogenic cells.

PubMed ID: 10982398

DOI: 10.1091/mbc.11.9.3031

PubMed ID: 10841548

Title: Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development.

PubMed ID: 10841548

DOI: 10.1073/pnas.97.12.6433

PubMed ID: 12372837

Title: Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1.

PubMed ID: 12372837

DOI: 10.1074/jbc.m204970200

PubMed ID: 15096524

Title: Rab13 regulates PKA signaling during tight junction assembly.

PubMed ID: 15096524

DOI: 10.1083/jcb.200312118

PubMed ID: 15642694

Title: DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit.

PubMed ID: 15642694

DOI: 10.1074/jbc.m412180200

PubMed ID: 15905176

Title: Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.

PubMed ID: 15905176

DOI: 10.1074/jbc.m502003200

PubMed ID: 16387847

Title: PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.

PubMed ID: 16387847

DOI: 10.1073/pnas.0509969103

PubMed ID: 17565987

Title: Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6.

PubMed ID: 17565987

DOI: 10.1074/jbc.m702439200

PubMed ID: 17693412

Title: Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release.

PubMed ID: 17693412

DOI: 10.1074/jbc.m703510200

PubMed ID: 17909264

Title: Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells.

PubMed ID: 17909264

DOI: 10.1677/jme-07-0048

PubMed ID: 17333334

Title: Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells.

PubMed ID: 17333334

DOI: 10.1007/s10549-007-9536-5

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18836454

Title: Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif.

PubMed ID: 18836454

DOI: 10.1038/nsmb.1497

PubMed ID: 18178622

Title: Allosteric cooperativity in protein kinase A.

PubMed ID: 18178622

DOI: 10.1073/pnas.0709214104

PubMed ID: 19210988

Title: Gravin dynamics regulates the subcellular distribution of PKA.

PubMed ID: 19210988

DOI: 10.1016/j.yexcr.2008.12.026

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20356841

Title: Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex.

PubMed ID: 20356841

DOI: 10.1074/jbc.m109.077602

PubMed ID: 19949837

Title: High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway.

PubMed ID: 19949837

DOI: 10.1007/s11010-009-0344-6

PubMed ID: 21085490

Title: Protein kinase A binds and activates heat shock factor 1.

PubMed ID: 21085490

DOI: 10.1371/journal.pone.0013830

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21514275

Title: Protein kinase A activates and phosphorylates ROR?4 in vitro and takes part in ROR? activation by CaMK-IV.

PubMed ID: 21514275

DOI: 10.1016/j.bbrc.2011.04.046

PubMed ID: 21812984

Title: The testis-specific C?2 subunit of PKA is kinetically indistinguishable from the common C?1 subunit of PKA.

PubMed ID: 21812984

DOI: 10.1186/1471-2091-12-40

PubMed ID: 21423175

Title: Control of PKA stability and signalling by the RING ligase praja2.

PubMed ID: 21423175

DOI: 10.1038/ncb2209

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 24747643

Title: Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.

PubMed ID: 24747643

DOI: 10.1038/ng.2956

PubMed ID: 25807930

Title: Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development.

PubMed ID: 25807930

DOI: 10.1002/anie.201500342

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31112131

Title: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

PubMed ID: 31112131

DOI: 10.7554/elife.43038

PubMed ID: 33934390

Title: The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.

PubMed ID: 33934390

DOI: 10.15252/embj.2020106503

PubMed ID: 16765046

Title: Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies.

PubMed ID: 16765046

DOI: 10.1016/j.bmcl.2006.05.092

PubMed ID: 20137943

Title: Azole-based inhibitors of AKT/PKB for the treatment of cancer.

PubMed ID: 20137943

DOI: 10.1016/j.bmcl.2010.01.067

PubMed ID: 20481595

Title: Design of selective, ATP-competitive inhibitors of Akt.

PubMed ID: 20481595

DOI: 10.1021/jm1003842

PubMed ID: 20732331

Title: Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.

PubMed ID: 20732331

DOI: 10.1016/j.jmb.2010.08.028

PubMed ID: 21774789

Title: Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase.

PubMed ID: 21774789

DOI: 10.1042/bj20110592

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 24571724

Title: Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.

PubMed ID: 24571724

DOI: 10.1056/nejmoa1310359

PubMed ID: 24700472

Title: Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome.

PubMed ID: 24700472

DOI: 10.1126/science.1249480

PubMed ID: 24855271

Title: Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.

PubMed ID: 24855271

DOI: 10.1126/science.1252328

PubMed ID: 33058759

Title: Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.

PubMed ID: 33058759

DOI: 10.1016/j.ajhg.2020.09.005

Sequence Information:

Length: 351
Mass: 40590
Checksum: BF6D3ECD2614E5AB
Sequence:

MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH LDQFERIKTL GTGSFGRVML 
VKHKETGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVKLEFS FKDNSNLYMV 
MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY 
IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 
ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT 
TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFSE F

Genular Protein ID: 3452741176

Symbol: A8K8B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8B9

Database IDs:

Sequence Information:

Length: 343
Mass: 39880
Checksum: 65EC391F0C500804
Sequence:

MASNSSDVKE FLAKAKEDFL KKWESPAQNT AHLDQFERIK TLGTGSFGRV MLVKHKETGN 
HYAMKILDKQ KVVKLKQIEH TLNEKRILQA VNFPFLVKLE FSFKDNSNLY MVMEYVPGGE 
MFSHLRRIGR FSEPHARFYA AQIVLTFEYL HSLDLIYRDL KPENLLIDQQ GYIQVTDFDF 
AKRVKGRTWT LCGTPEYLAP EIILSKGYNK AVDWWALGVL IYEMAAGYPP FFADQPIQIY 
EKIVSGKVRF PSHFSSDLKD LLRNLLQVDL TKRFGNLKNG VNDIKNHKWF ATTDWIAIYQ 
RKVEAPFIPK FKGPGDTSNF DDYEEEEIRV SINEKCGKEF SEF

Genular Protein ID: 1901545914

Symbol: A0A8V8TL59_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8V8TL59

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 427
Mass: 49134
Checksum: FB472254D8EB790E
Sequence:

MFTLGYHGAE EWASGETSLE PALEQCPCDC HGEEQGQLGA KVTAEPPKGT CYPSPRGLHP 
RPGLPREGAR GTAKSQGYKY LGWRRPWPWN VVKEFLAKAK EDFLKKWESP AQNTAHLDQF 
ERIKTLGTGS FGRVMLVKHK ETGNHYAMKI LDKQKVVKLK QIEHTLNEKR ILQAVNFPFL 
VKLEFSFKDN SNLYMVMEYV PGGEMFSHLR RIGRFSEPHA RFYAAQIVLT FEYLHSLDLI 
YRDLKPENLL IDQQGYIQVT DFGFAKRVKG RTWTLCGTPE YLAPEIILSK GYNKAVDWWA 
LGVLIYEMAA GYPPFFADQP IQIYEKIVSG KVRFPSHFSS DLKDLLRNLL QVDLTKRFGN 
LKNGVNDIKN HKWFATTDWI AIYQRKVEAP FIPKFKGPGD TSNFDDYEEE EIRVSINEKC 
GKEFSEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKACA

Associated with

Cells (max top 100)

Other Information

A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit C alpha. PubMed ID: 2843813

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece. PubMed ID: 10906071

The unique catalytic subunit of sperm cAMP-dependent protein kinase is the product of an alternative C-alpha mRNA expressed specifically in spermatogenic cells. PubMed ID: 10982398

Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development. PubMed ID: 10841548

Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. PubMed ID: 12372837

Rab13 regulates PKA signaling during tight junction assembly. PubMed ID: 15096524

DNA binding of repressor nuclear factor-kappaB p50/p50 depends on phosphorylation of Ser337 by the protein kinase A catalytic subunit. PubMed ID: 15642694

Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells. PubMed ID: 15905176

PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. PubMed ID: 16387847

Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6. PubMed ID: 17565987

Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca2+ release. PubMed ID: 17693412

Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. PubMed ID: 17909264

Activation of protein kinase A (PKA) signaling mitigates the antiproliferative and antiinvasive effects of alpha-difluoromethylornithine in breast cancer cells. PubMed ID: 17333334

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif. PubMed ID: 18836454

Allosteric cooperativity in protein kinase A. PubMed ID: 18178622

Gravin dynamics regulates the subcellular distribution of PKA. PubMed ID: 19210988

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. PubMed ID: 20356841

High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway. PubMed ID: 19949837

Protein kinase A binds and activates heat shock factor 1. PubMed ID: 21085490

Initial characterization of the human central proteome. PubMed ID: 21269460

Protein kinase A activates and phosphorylates ROR?4 in vitro and takes part in ROR? activation by CaMK-IV. PubMed ID: 21514275

The testis-specific C?2 subunit of PKA is kinetically indistinguishable from the common C?1 subunit of PKA. PubMed ID: 21812984

Control of PKA stability and signalling by the RING ligase praja2. PubMed ID: 21423175

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors. PubMed ID: 24747643

Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. PubMed ID: 25807930

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. PubMed ID: 31112131

The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation. PubMed ID: 33934390

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies. PubMed ID: 16765046

Azole-based inhibitors of AKT/PKB for the treatment of cancer. PubMed ID: 20137943

Design of selective, ATP-competitive inhibitors of Akt. PubMed ID: 20481595

Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions. PubMed ID: 20732331

Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase. PubMed ID: 21774789

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. PubMed ID: 24571724

Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome. PubMed ID: 24700472

Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome. PubMed ID: 24855271

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. PubMed ID: 33058759

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Database document:

PubMed ID: 2843813

PubMed ID: 14702039

PubMed ID: 15489334

PubMed ID: 10906071

PubMed ID: 10982398

PubMed ID: 10841548

PubMed ID: 12372837

PubMed ID: 15096524

PubMed ID: 15642694

PubMed ID: 15905176

PubMed ID: 16387847

PubMed ID: 17565987

PubMed ID: 17693412

PubMed ID: 17909264

PubMed ID: 17333334

PubMed ID: 18691976

PubMed ID: 18836454

PubMed ID: 18178622

PubMed ID: 19210988

PubMed ID: 19369195

PubMed ID: 19690332

PubMed ID: 20356841

PubMed ID: 19949837

PubMed ID: 21085490

PubMed ID: 21269460

PubMed ID: 21514275

PubMed ID: 21812984

PubMed ID: 21423175

PubMed ID: 24275569

PubMed ID: 25255805

PubMed ID: 24747643

PubMed ID: 25807930

PubMed ID: 25944712

PubMed ID: 31112131

PubMed ID: 33934390

PubMed ID: 16765046

PubMed ID: 20137943

PubMed ID: 20481595

PubMed ID: 20732331

PubMed ID: 21774789

PubMed ID: 17344846

PubMed ID: 24571724

PubMed ID: 24700472

PubMed ID: 24855271

PubMed ID: 33058759

PubMed ID: 11237011

PubMed ID: 15057824

PubMed ID: 15496913