MAPK3 | ENSG00000102882 | NCBI 5595

Details for: MAPK3

Gene ID: 5595

Symbol: MAPK3

Ensembl ID: ENSG00000102882

Description: mitogen-activated protein kinase 3

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Apoptosis
(R-HSA-109581)
Apoptotic factor-mediated response
(R-HSA-111471)
Axon guidance
(R-HSA-422475)
Bacterial infection pathways
(R-HSA-9824439)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Cellular senescence
(R-HSA-2559583)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
G alpha (q) signalling events
(R-HSA-416476)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Growth hormone receptor signaling
(R-HSA-982772)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon signaling
(R-HSA-913531)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Intrinsic pathway for apoptosis
(R-HSA-109606)
L1cam interactions
(R-HSA-373760)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogene induced senescence
(R-HSA-2559585)
Oncogenic mapk signaling
(R-HSA-6802957)
Oxidative stress induced senescence
(R-HSA-2559580)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Parasitic infection pathways
(R-HSA-9824443)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Programmed cell death
(R-HSA-5357801)
Pten regulation
(R-HSA-6807070)
Raf-independent mapk1/3 activation
(R-HSA-112409)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Rho gtpase effectors
(R-HSA-195258)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i transcription
(R-HSA-73864)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Signaling by activin
(R-HSA-1502540)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by gpcr
(R-HSA-372790)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by ltk in cancer
(R-HSA-9842640)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by nodal
(R-HSA-1181150)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by tgf-beta receptor complex
(R-HSA-170834)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-HSA-2173793)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Transmission across chemical synapses
(R-HSA-112315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 180.7834
Cell Significance Index: -28.1200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 104.5168
Cell Significance Index: -26.5100
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 63.1351
Cell Significance Index: -29.8100
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 60.8482
Cell Significance Index: -24.7200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 55.2601
Cell Significance Index: -28.4300
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 44.4695
Cell Significance Index: -29.8400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 26.0175
Cell Significance Index: -24.8400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.3017
Cell Significance Index: -28.7300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.2712
Cell Significance Index: -27.5200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.3212
Cell Significance Index: -28.8900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.1204
Cell Significance Index: -21.8700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.5415
Cell Significance Index: 132.3900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.8353
Cell Significance Index: 27.5000
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.6557
Cell Significance Index: 35.8700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2548
Cell Significance Index: 17.1200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0194
Cell Significance Index: 920.4700
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.9677
Cell Significance Index: 17.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9412
Cell Significance Index: 93.1100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.8918
Cell Significance Index: 56.2100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7190
Cell Significance Index: 32.5900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7039
Cell Significance Index: 76.5600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6822
Cell Significance Index: 19.6600
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.6750
Cell Significance Index: 5.6700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6475
Cell Significance Index: 88.9200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5201
Cell Significance Index: 104.3300
Cell Name: odontoblast (CL0000060)
Fold Change: 0.4407
Cell Significance Index: 56.4900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3341
Cell Significance Index: 63.5900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3120
Cell Significance Index: 56.2400
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3047
Cell Significance Index: 166.4000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3018
Cell Significance Index: 22.4900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2973
Cell Significance Index: 36.5500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.2843
Cell Significance Index: 3.2300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2123
Cell Significance Index: 76.1600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1809
Cell Significance Index: 79.9800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1579
Cell Significance Index: 7.3600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1547
Cell Significance Index: 3.3000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1371
Cell Significance Index: 94.8400
Cell Name: lactocyte (CL0002325)
Fold Change: 0.1257
Cell Significance Index: 16.2400
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1250
Cell Significance Index: 24.8000
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.1241
Cell Significance Index: 1.2900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1209
Cell Significance Index: 4.2500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1008
Cell Significance Index: 5.2900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0716
Cell Significance Index: 3.7200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0015
Cell Significance Index: 0.0400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0005
Cell Significance Index: 0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0008
Cell Significance Index: -1.4400
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0081
Cell Significance Index: -0.5300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0131
Cell Significance Index: -0.8800
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0133
Cell Significance Index: -24.5600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0162
Cell Significance Index: -24.9200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0187
Cell Significance Index: -13.6800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0234
Cell Significance Index: -17.7200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0238
Cell Significance Index: -32.4000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0267
Cell Significance Index: -16.9300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0357
Cell Significance Index: -26.4500
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0478
Cell Significance Index: -5.6400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0492
Cell Significance Index: -27.7200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0502
Cell Significance Index: -22.7700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0545
Cell Significance Index: -34.0500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0580
Cell Significance Index: -5.9200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0638
Cell Significance Index: -4.5100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0842
Cell Significance Index: -24.2200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0874
Cell Significance Index: -10.1900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1106
Cell Significance Index: -16.0800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1118
Cell Significance Index: -19.0900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1198
Cell Significance Index: -2.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1628
Cell Significance Index: -18.6500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1642
Cell Significance Index: -34.5900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2267
Cell Significance Index: -6.1700
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2299
Cell Significance Index: -6.1500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2337
Cell Significance Index: -6.5300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2685
Cell Significance Index: -27.9600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2699
Cell Significance Index: -16.5900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2902
Cell Significance Index: -22.9800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2922
Cell Significance Index: -7.3100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3006
Cell Significance Index: -8.0600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3048
Cell Significance Index: -10.5900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3051
Cell Significance Index: -2.8100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3066
Cell Significance Index: -9.8200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3381
Cell Significance Index: -8.8900
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.3460
Cell Significance Index: -2.1500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3498
Cell Significance Index: -26.8400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3848
Cell Significance Index: -23.5900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.4047
Cell Significance Index: -8.4700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4106
Cell Significance Index: -4.9000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4199
Cell Significance Index: -23.5600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4273
Cell Significance Index: -12.2500
Cell Name: keratocyte (CL0002363)
Fold Change: -0.4532
Cell Significance Index: -7.1900
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4733
Cell Significance Index: -12.0900
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4845
Cell Significance Index: -14.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5263
Cell Significance Index: -23.2800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5954
Cell Significance Index: -16.9900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.6043
Cell Significance Index: -17.8000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6230
Cell Significance Index: -23.5900
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.6373
Cell Significance Index: -23.4000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6525
Cell Significance Index: -22.8600
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6792
Cell Significance Index: -14.0900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.7119
Cell Significance Index: -35.9800
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.7212
Cell Significance Index: -13.3300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7320
Cell Significance Index: -18.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** MAPK3 is a serine/threonine kinase that belongs to the MAPK family, which is characterized by its ability to phosphorylate and activate downstream targets. MAPK3 is specifically involved in the activation of various signaling pathways, including those mediated by growth factors, cytokines, and stress signals. Its expression is tightly regulated by post-transcriptional modifications, such as phosphorylation and ubiquitination, which modulate its activity and localization. MAPK3 is also known to interact with other kinases, including MAPK1 (ERK1), to form complex signaling networks. **Pathways and Functions:** MAPK3 is a key player in several signaling pathways, including: 1. **Activation of NMDA Receptors and Postsynaptic Events:** MAPK3 is involved in the regulation of NMDA receptor signaling, which plays a crucial role in synaptic plasticity and learning. 2. **Advanced Glycosylation Endproduct Receptor Signaling:** MAPK3 is activated by advanced glycosylation endproducts (AGEs), which are implicated in the pathogenesis of various diseases, including diabetes and Alzheimer's disease. 3. **Antiviral Mechanism by IFN-Stimulated Genes:** MAPK3 is involved in the regulation of interferon-stimulated gene expression, which is critical for antiviral responses. 4. **Apoptosis:** MAPK3 is a pro-apoptotic kinase that promotes programmed cell death in response to stress signals. 5. **Axon Guidance:** MAPK3 is involved in the regulation of axon guidance, which is essential for neuronal development and function. **Clinical Significance:** MAPK3 has been implicated in various diseases, including: 1. **Cancer:** MAPK3 is overexpressed in several types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurodegenerative Diseases:** MAPK3 is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Infectious Diseases:** MAPK3 is activated by interferons, which are critical for antiviral responses, and is involved in the regulation of immune responses to infection. 4. **Metabolic Disorders:** MAPK3 is involved in the regulation of glucose and lipid metabolism, and is implicated in the pathogenesis of metabolic disorders, including insulin resistance and type 2 diabetes. In conclusion, MAPK3 is a complex kinase that plays a critical role in various cellular processes, including cell signaling, proliferation, differentiation, and apoptosis. Its expression is widespread, and its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, infectious diseases, and metabolic disorders. Further research is needed to fully understand the mechanisms by which MAPK3 regulates cellular processes and to explore its potential as a therapeutic target for disease prevention and treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Mitogen-activated protein kinase 3
Q9BWJ1_HUMAN

Genular Protein ID: 3191468611

Symbol: MK03_HUMAN

Name: Mitogen-activated protein kinase 3

UniProtKB Accession Codes:

P27361 A8CZ58 B0LPG3 Q8NHX1

Database IDs:

Citations:

PubMed ID: 7687743

Title: Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.

PubMed ID: 7687743

DOI: 10.1128/mcb.13.8.4679-4690.1993

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1540184

Title: Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.

PubMed ID: 1540184

DOI: 10.1016/0006-291x(92)91891-s

PubMed ID: 1319925

Title: Heterogeneous expression of four MAP kinase isoforms in human tissues.

PubMed ID: 1319925

DOI: 10.1016/0014-5793(92)80612-k

PubMed ID: 8325880

Title: Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase.

PubMed ID: 8325880

DOI: 10.1016/s0021-9258(18)82435-8

PubMed ID: 8794306

Title: Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity.

PubMed ID: 8794306

DOI: 10.1128/jvi.70.10.6701-6708.1996

PubMed ID: 9155018

Title: MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.

PubMed ID: 9155018

DOI: 10.1093/emboj/16.8.1921

PubMed ID: 9480836

Title: MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase.

PubMed ID: 9480836

DOI: 10.1006/bbrc.1998.8135

PubMed ID: 10393181

Title: Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes.

PubMed ID: 10393181

DOI: 10.1093/emboj/18.13.3655

PubMed ID: 10224087

Title: Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway.

PubMed ID: 10224087

DOI: 10.1074/jbc.274.19.13271

PubMed ID: 10521408

Title: Identification of a cytoplasmic-retention sequence in ERK2.

PubMed ID: 10521408

DOI: 10.1074/jbc.274.43.30349

PubMed ID: 10617468

Title: Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.

PubMed ID: 10617468

DOI: 10.1126/science.286.5449.2514

PubMed ID: 10747973

Title: c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.

PubMed ID: 10747973

DOI: 10.1074/jbc.m000958200

PubMed ID: 12356731

Title: IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation.

PubMed ID: 12356731

DOI: 10.1093/emboj/cdf488

PubMed ID: 11912194

Title: Insulin receptor substrate 4 associates with the protein IRAS.

PubMed ID: 11912194

DOI: 10.1074/jbc.m111838200

PubMed ID: 15526160

Title: Signal transduction via the stem cell factor receptor/c-Kit.

PubMed ID: 15526160

DOI: 10.1007/s00018-004-4189-6

PubMed ID: 15952796

Title: Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites.

PubMed ID: 15952796

DOI: 10.1021/bi050413i

PubMed ID: 15616583

Title: Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.

PubMed ID: 15616583

DOI: 10.1038/sj.emboj.7600510

PubMed ID: 12110590

Title: Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.

PubMed ID: 12110590

DOI: 10.1093/emboj/cdf361

PubMed ID: 12974390

Title: EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

PubMed ID: 12974390

DOI: 10.1515/bc.2003.134

PubMed ID: 15788397

Title: Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death.

PubMed ID: 15788397

DOI: 10.1074/jbc.m500318200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16581800

Title: Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26.

PubMed ID: 16581800

DOI: 10.1128/mcb.26.8.3282-3294.2006

PubMed ID: 17274988

Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.

PubMed ID: 17274988

DOI: 10.1016/j.febslet.2007.01.039

PubMed ID: 18435604

Title: Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs.

PubMed ID: 18435604

DOI: 10.1042/bj20080685

PubMed ID: 18296648

Title: Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.

PubMed ID: 18296648

DOI: 10.1158/1541-7786.mcr-07-2028

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18794356

Title: Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.

PubMed ID: 18794356

DOI: 10.1128/mcb.00925-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19265199

Title: The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction.

PubMed ID: 19265199

DOI: 10.1074/jbc.m808058200

PubMed ID: 19494114

Title: Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.

PubMed ID: 19494114

DOI: 10.1074/jbc.m109.002758

PubMed ID: 19447520

Title: Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.

PubMed ID: 19447520

DOI: 10.1016/j.jhep.2009.02.027

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19060905

Title: A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy.

PubMed ID: 19060905

DOI: 10.1038/nm.1893

PubMed ID: 16393692

Title: The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions.

PubMed ID: 16393692

DOI: 10.1080/02699050500284218

PubMed ID: 19565474

Title: The ERK signaling cascade--views from different subcellular compartments.

PubMed ID: 19565474

DOI: 10.1002/biof.52

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21779493

Title: The ERK cascade: distinct functions within various subcellular organelles.

PubMed ID: 21779493

DOI: 10.1177/1947601911407328

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24825908

Title: Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.

PubMed ID: 24825908

DOI: 10.1074/jbc.m114.547208

PubMed ID: 32051553

Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

PubMed ID: 32051553

DOI: 10.1038/s41388-020-1206-7

PubMed ID: 34497368

Title: TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination.

PubMed ID: 34497368

DOI: 10.1038/s41556-021-00732-8

PubMed ID: 35216969

Title: Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation.

PubMed ID: 35216969

DOI: 10.1016/j.jbc.2022.101750

PubMed ID: 35939714

Title: Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells.

PubMed ID: 35939714

DOI: 10.1073/pnas.2208522119

PubMed ID: 18983981

Title: Crystal structure of human mono-phosphorylated ERK1 at Tyr204.

PubMed ID: 18983981

DOI: 10.1016/j.bbrc.2008.10.127

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 379
Mass: 43136
Checksum: E6020CE413EC41F7
Sequence:

MAAAAAQGGG GGEPRRTEGV GPGVPGEVEM VKGQPFDVGP RYTQLQYIGE GAYGMVSSAY 
DHVRKTRVAI KKISPFEHQT YCQRTLREIQ ILLRFRHENV IGIRDILRAS TLEAMRDVYI 
VQDLMETDLY KLLKSQQLSN DHICYFLYQI LRGLKYIHSA NVLHRDLKPS NLLINTTCDL 
KICDFGLARI ADPEHDHTGF LTEYVATRWY RAPEIMLNSK GYTKSIDIWS VGCILAEMLS 
NRPIFPGKHY LDQLNHILGI LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD 
SKALDLLDRM LTFNPNKRIT VEEALAHPYL EQYYDPTDEP VAEEPFTFAM ELDDLPKERL 
KELIFQETAR FQPGVLEAP

Genular Protein ID: 2315109671

Symbol: Q9BWJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9BWJ1

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 119
Mass: 13672
Checksum: 63CF84C0C83A86C6
Sequence:

LGSPSQEDLN CIINMKARNY LQSLPSKTKV AWAKLFPKSD SKALDLLDRM LTFNPNKRIT 
VEEALAHPYL EQYYDPTDEP VAEEPFTFAM ELDDLPKERL KELIFQETAR FQPGVLEAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MAPK3

Associated with

Cells (max top 100)

Other Information

Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1. PubMed ID: 7687743

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. PubMed ID: 1540184

Heterogeneous expression of four MAP kinase isoforms in human tissues. PubMed ID: 1319925

Serine 25 of oncoprotein 18 is a major cytosolic target for the mitogen-activated protein kinase. PubMed ID: 8325880

Human immunodeficiency virus type 1 Nef binds directly to LCK and mitogen-activated protein kinase, inhibiting kinase activity. PubMed ID: 8794306

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. PubMed ID: 9155018

MAPKAPK5, a novel mitogen-activated protein kinase (MAPK)-activated protein kinase, is a substrate of the extracellular-regulated kinase (ERK) and p38 kinase. PubMed ID: 9480836

Phosphorylation by CK2 and MAPK enhances calnexin association with ribosomes. PubMed ID: 10393181

Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. PubMed ID: 10224087

Identification of a cytoplasmic-retention sequence in ERK2. PubMed ID: 10521408

Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. PubMed ID: 10617468

c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. PubMed ID: 10747973

IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. PubMed ID: 12356731

Insulin receptor substrate 4 associates with the protein IRAS. PubMed ID: 11912194

Signal transduction via the stem cell factor receptor/c-Kit. PubMed ID: 15526160

Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites. PubMed ID: 15952796

Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. PubMed ID: 15616583

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. PubMed ID: 12110590

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. PubMed ID: 12974390

Phosphorylation of serine 147 of tis21/BTG2/pc3 by p-Erk1/2 induces Pin-1 binding in cytoplasm and cell death. PubMed ID: 15788397

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. PubMed ID: 16581800

ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. PubMed ID: 17274988

Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs. PubMed ID: 18435604

Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma. PubMed ID: 18296648

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. PubMed ID: 18794356

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction. PubMed ID: 19265199

Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. PubMed ID: 19494114

Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration. PubMed ID: 19447520

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. PubMed ID: 19060905

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. PubMed ID: 16393692

The ERK signaling cascade--views from different subcellular compartments. PubMed ID: 19565474

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

The ERK cascade: distinct functions within various subcellular organelles. PubMed ID: 21779493

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling. PubMed ID: 24825908

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically. PubMed ID: 32051553

TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. PubMed ID: 34497368

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation. PubMed ID: 35216969

Early B cell factor 4 modulates FAS-mediated apoptosis and promotes cytotoxic function in human immune cells. PubMed ID: 35939714

Crystal structure of human mono-phosphorylated ERK1 at Tyr204. PubMed ID: 18983981

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Database document:

PubMed ID: 7687743

PubMed ID: 15616553

PubMed ID: 15489334

PubMed ID: 1540184

PubMed ID: 1319925

PubMed ID: 8325880

PubMed ID: 8794306

PubMed ID: 9155018

PubMed ID: 9480836

PubMed ID: 10393181

PubMed ID: 10224087

PubMed ID: 10521408

PubMed ID: 10617468

PubMed ID: 10747973

PubMed ID: 12356731

PubMed ID: 11912194

PubMed ID: 15526160

PubMed ID: 15952796

PubMed ID: 15616583

PubMed ID: 12110590

PubMed ID: 12974390

PubMed ID: 15788397

PubMed ID: 17081983

PubMed ID: 16581800

PubMed ID: 17274988

PubMed ID: 18435604

PubMed ID: 18296648

PubMed ID: 18691976

PubMed ID: 18794356

PubMed ID: 18669648

PubMed ID: 19413330

PubMed ID: 19265199

PubMed ID: 19494114

PubMed ID: 19447520

PubMed ID: 19369195

PubMed ID: 19060905

PubMed ID: 16393692

PubMed ID: 19565474

PubMed ID: 19690332

PubMed ID: 20068231

PubMed ID: 21269460

PubMed ID: 21779493

PubMed ID: 21406692

PubMed ID: 22223895

PubMed ID: 22814378

PubMed ID: 23186163

PubMed ID: 24825908

PubMed ID: 32051553

PubMed ID: 34497368

PubMed ID: 35216969

PubMed ID: 35939714

PubMed ID: 18983981

PubMed ID: 17344846

PubMed ID: 15489334